EKS-CAP-00037

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00037

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	428.9	6.7E-129	117	383	267

Status

Unreviewed

Ensembl Protein

ENSCPOP00000005566

UniProt Accession

H0V769;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK2

Gene Synonyms/Alias

CHEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000006172	ENSCPOP00000005566	ENSCPOT00000006236

Organism

Cavia porcellus

Functional Description

Protein Length

439

Protein Sequence
(FASTA)

CFTECVNDSY WFGRDKSCDY CFDEPLLKRT DKYRTYSKKH FRIFREVGPK NSYIAYIEDH 60

SGNGTFVNTE LVGKGKRRPL SNNSEIALSL CRNKVFVFFD LTVDDQSVYP KQLRDEYIIS 120

KTLGSGACGE VKLAFERKTC KKVAIKIISK RKFAIGSLKE SDPALNVETE IEILKKLNHP 180

CIIKIKNFFD AEDYYIVLEL MEGGELFDRV VGHKRLKETT CKLYFYQMLL AVQYLHENGI 240

IHRDLKPENV LLSSQEDDCL IKITDFGQSK ILGETSLMRT LCGTPTYLAP EVLLSVGTTG 300

YNRAVDCWSL GVILFICLSG YPPFSEHKTQ VSLKDQITSG KYTFIPEVWA DVSEKALDLV 360

KRLLVVDPKA RFTTEEALGH PWLQDEDMKR KFQSLLAEED KPLALPQVVL QPSTSRKRSL 420

EAEAEDVKTR KRTAVCAAV 439

Nucleotide Sequence
(FASTA)

TGTTTTACAG AGTGTGTTAA TGACAGCTAC TGGTTTGGGA GGGATAAAAG CTGTGACTAT 60

TGCTTTGATG AACCTCTGCT AAAAAGAACA GATAAATACA GGACATATAG CAAGAAACAT 120

TTTCGGATTT TCAGGGAAGT GGGTCCTAAA AACTCTTACA TTGCATACAT AGAAGATCAC 180

AGTGGGAATG GAACCTTTGT AAATACAGAG CTTGTAGGGA AAGGAAAACG TCGTCCTTTG 240

AGTAACAATT CTGAAATTGC ACTTTCACTA TGTAGAAATA AAGTTTTTGT ATTTTTTGAT 300

CTGACTGTAG ATGATCAGTC AGTTTATCCC AAGCAGTTAA GAGATGAATA CATCATATCA 360

AAAACTCTTG GAAGTGGTGC TTGTGGAGAA GTAAAGCTGG CTTTTGAGAG GAAAACGTGT 420

AAGAAAGTAG CCATAAAGAT CATCAGCAAA AGGAAATTTG CTATTGGCTC TTTGAAAGAG 480

TCAGACCCAG CTCTTAATGT TGAAACTGAA ATAGAAATTT TGAAAAAACT GAACCATCCT 540

TGTATCATCA AGATTAAAAA CTTTTTTGAT GCAGAAGATT ATTACATTGT TTTGGAGTTG 600

ATGGAAGGGG GAGAGCTGTT TGACAGGGTT GTGGGACACA AACGTCTGAA GGAAACTACC 660

TGCAAGCTCT ATTTTTACCA GATGCTATTG GCTGTCCAGT ACCTTCATGA AAATGGGATT 720

ATACATCGGG ATTTAAAACC AGAGAATGTT CTACTGTCAT CTCAAGAAGA TGACTGTCTT 780

ATAAAGATTA CTGATTTTGG GCAGTCCAAG ATTTTGGGGG AGACCTCTCT CATGAGAACT 840

TTATGTGGTA CCCCCACTTA CTTGGCTCCT GAGGTTCTTC TTTCTGTTGG GACTACGGGG 900

TATAACCGAG CTGTGGACTG CTGGAGTTTA GGAGTTATTC TTTTTATCTG CCTTAGTGGG 960

TATCCACCTT TCTCTGAGCA TAAGACTCAA GTGTCACTGA AGGATCAGAT CACCAGTGGA 1020

AAGTACACCT TCATTCCTGA AGTCTGGGCA GATGTCTCAG AGAAGGCTCT GGACCTTGTC 1080

AAGAGGTTGT TGGTTGTGGA TCCCAAGGCA CGGTTTACGA CGGAAGAAGC CTTAGGTCAC 1140

CCGTGGCTTC AGGATGAGGA CATGAAGAGA AAGTTTCAGA GTCTACTGGC CGAGGAAGAT 1200

AAGCCGTTGG CTCTTCCCCA GGTTGTGCTG CAGCCTTCCA CTAGTCGAAA ACGGTCTCTC 1260

GAAGCAGAAG CTGAGGATGT AAAGACCAGA AAGCGTACGG CTGTGTGTGC TGCTGTG 1317

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59

         yi+sk+lG+Ga+g+vkla+e+kt+kkva+ki+skrk +i+s +e + a +ve+e+eilkk

Q: 117   YIISKTLGSGACGEVKLAFERKTCKKVAIKIISKRKfAIGSLKESDPALNVETEIEILKK  176

         89*********************************999**********************

S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119

         l+hP+i+k+k++f++e++ y+vlel+egGel+d+vv +k+lke ++kl+f+q+l av+yl

Q: 177   LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDRVVGHKRLKETTCKLYFYQMLLAVQYL  235

         *****************9.*****************************************

S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179

         he+giihrDlkPen+Lls++e+d+l+kitDfG++k+lge+slm+tlCGtp+y+aPevl +

Q: 236   HENGIIHRDLKPENVLLSSQEDDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLLS  295

         ************************************************************

S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239

          g+++y+++vD+WslGv+lf++lsGypPfse++tqvslk+qi++gky+fi+e+w+++se+

Q: 296   VGTTGYNRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYTFIPEVWADVSEK  355

         ************************************************************

S: 240   akdlikklLvvdPeerlsieealnhpWl  267

         a+dl+k+lLvvdP++r+++eeal hpWl

Q: 356   ALDLVKRLLVVDPKARFTTEEALGHPWL  383

         ***************************8

Domain Sequence
(FASTA)

YIISKTLGSG ACGEVKLAFE RKTCKKVAIK IISKRKFAIG SLKESDPALN VETEIEILKK 60

LNHPCIIKIK NFFDAEDYYI VLELMEGGEL FDRVVGHKRL KETTCKLYFY QMLLAVQYLH 120

ENGIIHRDLK PENVLLSSQE DDCLIKITDF GQSKILGETS LMRTLCGTPT YLAPEVLLSV 180

GTTGYNRAVD CWSLGVILFI CLSGYPPFSE HKTQVSLKDQ ITSGKYTFIP EVWADVSEKA 240

LDLVKRLLVV DPKARFTTEE ALGHPWL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013