EKS-CAP-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	255.7	3.8E-76	1026	1278	253

Status

Unreviewed

Ensembl Protein

ENSCPOP00000005659

UniProt Accession

H0V7F2;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000006277	ENSCPOP00000005659	ENSCPOT00000006342

Organism

Cavia porcellus

Functional Description

Protein Length

1350

Protein Sequence
(FASTA)

MEDPSPPDVN ENGRCQSGSV SVPSPAEGPS TQAASEPSKP LSTRRHLSRK DGLSKLCQSR 60

IALSEDRWSS YCLSSLVAQN ICTGRVRCPT APEHVDPAAP LGSASCCSLL RGLSSGCSMP 120

LLPGPVYNPN KAIFTVDAKT TEILVANDKA CGLLGYSSHD LIGQKLVQFF VQPDSEVAEA 180

LSEEHVEADG HAAVVFGTVA DIVSRSGDKI PVSVWMKRVR QERGLCCVVV LEPVERISAW 240

VAFQGEGTIT SCDDLFAHLH GFSSGEDVVG QHITDLIPSL RLPSPGQPVP ENLKIQRSVG 300

RAKDGTTFPL SLKLKPKQDG EAAEGEAVPE QGYWASVWVF CTISGLITLL PDGTIYGINH 360

NFALMLFGYG KTELLGKKIT FLIPGFYHYM DITYDSSSQY PSSCLDFSSE NGHGEMTLDT 420

SQGWSAGVYR NPKFDSVLAG HCVLPPDIMQ KPVGSQGIAG GMQTQLETGC QLPATCSPGS 480

SPGEDSVLDG YPLAQDKRSL PTNQQSTPEE HVLAHEKQSP SENQQDVSEE SPPTHEEWLL 540

RKDPQDSQDG SPPALSVRTL PRDQQDTALG SVGPVVAQSS PQDLLGESGS EPADTKPFVS 600

CEEPNPPVPP EDKCSNVGMG SLHQEAQWAL TAASRPEPHA AGQPAGGDLL TYCPAYRSEW 660

LPWPPGHSGV ACVSFGTPTL DEPWPGRRAS HEELQVCLVK EQLSRLSFEG VSRLESVPTE 720

HHPYTASLSS SLEGRDLCGS HLGSSSACYA LATDLPDALE LVEAREAAMN SYSWNLRELL 780

LSDDTDGTSS NCSYTTSEPG GSPSPSAVSS DFNVHTLHKQ RPGAFGDRER LLLTGTYFNL 840

GEGQGSQESN LEHDSTELPV MDLASERYKM SNSQSSELPA MDASQEDARA SAEDPKLSAW 900

VTSTPVKPGA ASLCREIQEG TYSGYCYHRD GLWLSICFEV KLVELQGPVS LFCCWLVKDL 960

LHSHRSSATR TRLLLASLPS STHSMPDPSG RGLGEVLRTK PWAEEAPTPM ELEGLAACEG 1020

EYSRKYITLR PLGSGAFGFV WIAMDKEQNK EVVVKFIKKE KVLEDCWIED TKLGKVTLEI 1080

AILSHVEHPN IIKVVDVFEN QGFFQLVMEK HGSGLDLFAF IDQHPSLDEP LASHIFRQLL 1140

SAVGYLRSKG IIHRDIKDEN IVIAEDFTIK LIDFGSAAYL ERGKLFYTFC GTIEYCAPEV 1200

LMGNPYRGPE LEMWSLGVTL YTLIFEENPF CEVEETMEAT IHPPYLVSQE LMSLLSGLLH 1260

PDPRQRTTLE KLVTDPWVTQ PVNLAQYTWE EVCRISKPES GLLSTASLQH RTGSRSLSEA 1320

GSEFQAHPAP EEAPSSQHCL GPEDPSPLAS 1350

Nucleotide Sequence
(FASTA)

ATGGAAGACC CAAGTCCCCC AGATGTAAAT GAGAATGGCA GGTGCCAGTC TGGCAGTGTC 60

TCTGTGCCTT CTCCTGCCGA GGGACCATCC ACACAGGCTG CTTCTGAGCC CAGCAAGCCG 120

CTCTCGACTC GAAGACACCT GAGCAGGAAG GATGGGCTCT CCAAGCTCTG CCAGAGCAGG 180

ATAGCACTCT CAGAAGACAG ATGGAGCTCC TACTGCCTCT CTTCCCTGGT TGCCCAGAAC 240

ATCTGCACTG GCAGAGTGCG CTGCCCCACA GCGCCTGAGC ATGTGGACCC AGCTGCACCC 300

CTGGGCAGTG CCTCCTGCTG CTCCCTGCTG CGTGGCTTGT CTTCGGGATG CTCTATGCCT 360

CTTCTTCCGG GTCCTGTGTA CAACCCCAAC AAGGCCATCT TCACTGTGGA TGCCAAGACC 420

ACAGAGATCC TGGTGGCCAA TGACAAAGCC TGTGGGCTCC TGGGGTACAG CAGCCACGAC 480

CTGATTGGCC AGAAGCTGGT GCAGTTCTTT GTTCAGCCGG ACTCCGAGGT GGCAGAAGCC 540

CTCAGTGAGG AGCATGTGGA GGCTGATGGC CACGCTGCAG TGGTGTTCGG CACAGTGGCG 600

GACATCGTCA GCCGCAGTGG GGACAAGATT CCTGTCTCTG TGTGGATGAA GAGGGTGCGG 660

CAGGAGCGCG GCCTGTGCTG TGTGGTGGTC CTGGAGCCTG TGGAGAGGAT CTCTGCGTGG 720

GTTGCCTTCC AGGGTGAGGG AACTATCACA TCCTGCGATG ATCTCTTTGC TCACCTTCAT 780

GGGTTCTCGT CTGGGGAGGA TGTGGTTGGG CAGCACATCA CAGACCTGAT CCCGTCCCTG 840

CGACTCCCTT CTCCTGGCCA GCCTGTCCCA GAGAATCTGA AGATTCAGAG GTCTGTTGGG 900

AGAGCCAAAG ATGGCACCAC CTTCCCTCTG AGCCTGAAGC TGAAGCCCAA GCAGGATGGG 960

GAGGCGGCGG AGGGTGAGGC AGTGCCCGAG CAGGGCTACT GGGCATCCGT GTGGGTTTTC 1020

TGCACCATCA GCGGCCTCAT CACGCTTCTG CCTGACGGCA CCATCTACGG CATCAATCAC 1080

AACTTTGCCC TGATGTTGTT CGGCTATGGA AAAACCGAGC TCTTAGGCAA GAAAATTACT 1140

TTCCTGATTC CTGGCTTCTA CCATTACATG GACATCACCT ATGACAGCTC TTCACAATAT 1200

CCTAGTAGCT GTCTAGACTT CAGCAGTGAG AATGGACATG GGGAGATGAC CTTGGACACC 1260

TCCCAGGGCT GGAGTGCAGG TGTCTATAGA AATCCAAAGT TTGATTCAGT GCTTGCTGGT 1320

CATTGTGTGC TGCCACCAGA CATAATGCAG AAGCCAGTGG GAAGCCAAGG AATTGCTGGT 1380

GGGATGCAGA CGCAGCTAGA AACTGGATGC CAGCTCCCAG CCACCTGCTC CCCAGGGTCC 1440

TCTCCAGGGG AGGATAGTGT CCTGGACGGG TACCCACTGG CCCAGGACAA ACGATCACTA 1500

CCTACAAACC AGCAGAGTAC TCCAGAGGAG CATGTGCTGG CCCATGAGAA ACAGTCCCCA 1560

TCTGAGAACC AGCAGGATGT CTCAGAGGAA AGCCCACCTA CCCACGAAGA ATGGCTGTTG 1620

CGCAAGGACC CTCAGGACAG CCAAGACGGA AGCCCTCCAG CCCTCAGTGT GAGGACACTG 1680

CCCAGGGACC AGCAGGACAC TGCTTTGGGG AGTGTGGGGC CTGTAGTAGC ACAGAGCTCC 1740

CCACAGGATC TTTTGGGAGA AAGCGGGTCA GAACCGGCGG ACACAAAACC ATTTGTTTCC 1800

TGTGAAGAAC CCAACCCTCC AGTCCCACCT GAGGACAAGT GCAGCAATGT TGGAATGGGG 1860

AGCCTCCATC AGGAGGCTCA GTGGGCACTG ACAGCTGCCA GCAGGCCTGA GCCCCATGCT 1920

GCAGGGCAGC CAGCAGGAGG GGACCTCCTG ACCTACTGCC CCGCTTATAG GAGCGAGTGG 1980

CTCCCCTGGC CGCCAGGCCA CTCAGGGGTG GCCTGTGTCT CTTTTGGGAC ACCCACCCTG 2040

GATGAGCCAT GGCCAGGAAG GAGAGCCAGC CATGAAGAGC TGCAGGTGTG CTTGGTTAAG 2100

GAGCAGCTGT CCAGGTTGAG CTTTGAGGGT GTCTCCCGCC TGGAGTCTGT TCCCACAGAG 2160

CACCATCCCT ATACTGCCTC CCTGTCTAGC AGCCTGGAGG GAAGAGACCT TTGTGGCAGC 2220

CACCTGGGCA GCTCCTCTGC CTGCTATGCC TTGGCCACCG ACCTCCCTGA TGCCCTGGAG 2280

TTGGTGGAAG CCCGGGAGGC TGCCATGAAC TCTTACTCCT GGAACCTTAG GGAGCTCCTT 2340

CTCAGTGACG ACACCGATGG AACTTCCTCC AATTGTTCCT ATACCACATC TGAACCTGGG 2400

GGCTCACCTT CTCCTTCGGC GGTGAGCTCT GATTTCAATG TGCACACACT GCACAAGCAG 2460

AGGCCAGGTG CTTTTGGTGA CCGAGAGCGG TTACTACTGA CAGGCACCTA TTTCAATCTT 2520

GGGGAGGGCC AAGGGTCCCA GGAGAGCAAC CTGGAACATG ATTCAACAGA ACTGCCTGTG 2580

ATGGACTTGG CCTCTGAACG TTACAAAATG AGTAACTCAC AAAGCTCAGA ACTTCCTGCT 2640

ATGGATGCCA GCCAGGAGGA TGCACGGGCC TCTGCAGAGG ACCCAAAGCT GAGTGCCTGG 2700

GTCACCTCTA CTCCTGTGAA ACCTGGGGCT GCCAGCCTGT GTCGGGAGAT CCAGGAGGGC 2760

ACCTACTCAG GGTACTGCTA CCACCGAGAT GGCTTGTGGC TGAGCATATG CTTTGAGGTG 2820

AAGCTGGTGG AACTCCAGGG CCCTGTGAGC CTGTTCTGCT GCTGGCTGGT AAAGGATCTA 2880

CTGCATAGCC ACCGCAGCTC TGCCACCAGG ACCCGCCTGC TGCTCGCCAG CCTGCCCAGC 2940

TCCACCCACT CCATGCCCGA TCCCTCAGGA CGTGGTCTCG GGGAGGTGCT CAGAACCAAG 3000

CCCTGGGCTG AGGAGGCTCC CACACCTATG GAGCTAGAGG GACTGGCGGC CTGTGAGGGC 3060

GAGTACTCAC GCAAGTATAT CACCCTGCGT CCACTCGGCA GCGGGGCCTT CGGCTTTGTG 3120

TGGATCGCCA TGGACAAGGA GCAGAACAAG GAGGTGGTAG TGAAGTTTAT TAAGAAGGAG 3180

AAAGTTTTGG AGGATTGTTG GATTGAGGAC ACCAAACTTG GAAAAGTCAC TTTAGAAATT 3240

GCAATTCTGT CCCACGTGGA GCATCCCAAC ATCATCAAGG TAGTGGATGT GTTTGAAAAC 3300

CAAGGGTTCT TCCAGCTGGT GATGGAGAAG CATGGCTCCG GCCTGGACCT CTTTGCTTTC 3360

ATTGACCAGC ACCCCAGCCT GGATGAGCCC CTGGCCAGCC ACATCTTCCG GCAGCTGTTG 3420

TCAGCAGTGG GGTACCTGCG CTCAAAAGGC ATCATTCACC GGGACATCAA GGACGAGAAC 3480

ATTGTGATTG CTGAGGACTT CACTATCAAG CTGATCGACT TCGGCTCAGC TGCTTACTTG 3540

GAAAGGGGCA AATTGTTTTA CACGTTCTGT GGGACAATCG AGTACTGTGC CCCTGAAGTT 3600

CTCATGGGGA ATCCCTACAG GGGACCAGAG CTGGAGATGT GGTCCCTGGG TGTCACACTG 3660

TACACGCTGA TCTTCGAGGA GAACCCCTTT TGTGAGGTGG AGGAGACCAT GGAAGCCACC 3720

ATCCACCCCC CGTACCTGGT GTCCCAAGAA CTCATGAGCC TCTTGTCTGG GCTGTTGCAT 3780

CCTGACCCCA GACAGCGCAC CACTTTGGAA AAGCTGGTGA CAGACCCATG GGTGACGCAG 3840

CCTGTGAACC TTGCTCAGTA TACCTGGGAG GAGGTGTGTA GGATCAGCAA GCCAGAGAGT 3900

GGCCTACTGT CCACTGCCAG TCTGCAGCAC AGGACAGGCA GCAGAAGCCT GAGTGAAGCA 3960

GGCTCGGAGT TCCAGGCACA CCCTGCCCCT GAAGAGGCTC CCAGCAGCCA GCACTGCTTG 4020

GGTCCTGAGG ACCCCTCTCC ACTGGCCAGC TGA 4053

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y +l+ lG+g+fg V  a++ke++++v+vK+ikk+k+      ++++l k++ Ei+il++

Q: 1026  YITLRPLGSGAFGFVWIAMDKEQNKEVVVKFIKKEKVledcwiEDTKLGKVTLEIAILSH  1085

         778999******************************99999999999*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++hpniik+++v+e++ +++lv+e + sg +Lf  i ++ +l+e  a+++f+ql+sav Y

Q: 1086  VEHPNIIKVVDVFENQGFFQLVMEkHGSGLDLFAFIDQHPSLDEPLASHIFRQLLSAVGY  1145

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+skgi+HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y+aPe+l+g++

Q: 1146  LRSKGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP  1205

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++WslGv+Ly+l++++ Pf e       e++++ +++ p+ +s+el+sLl+ lL

Q: 1206  YRGPELEMWSLGVTLYTLIFEENPFCEV------EETMEATIHPPYLVSQELMSLLSGLL  1259

         **************************98......78899999******************

S: 234   vvdpekRatieeilkhewl  252

         + dp++R+t+e++++++w+

Q: 1260  HPDPRQRTTLEKLVTDPWV  1278

         ******************7

Domain Sequence
(FASTA)

YITLRPLGSG AFGFVWIAMD KEQNKEVVVK FIKKEKVLED CWIEDTKLGK VTLEIAILSH 60

VEHPNIIKVV DVFENQGFFQ LVMEKHGSGL DLFAFIDQHP SLDEPLASHI FRQLLSAVGY 120

LRSKGIIHRD IKDENIVIAE DFTIKLIDFG SAAYLERGKL FYTFCGTIEY CAPEVLMGNP 180

YRGPELEMWS LGVTLYTLIF EENPFCEVEE TMEATIHPPY LVSQELMSLL SGLLHPDPRQ 240

RTTLEKLVTD PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 2.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013