EKS-CAP-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.1E-167	478	754	277

Status

Unreviewed

Ensembl Protein

ENSCPOP00000005900

UniProt Accession

H0V817;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000006553	ENSCPOP00000005900	ENSCPOT00000006619

Organism

Cavia porcellus

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGAPVEV ESLLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLVESNRTR ITGEEVEVRD SVPADSGLYA CVTSSPSGSD TSYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 180

SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 240

HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 300

GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 360

ALEERPAVMT SPFYLEIIIY CTGAFLISCM VGAVIVYKMK SGTKKSDFHS QMAVHKLAKS 420

IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 480

GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 600

VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 660

RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 720

KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF 780

PDTRSSTCSS GEDSVFSHEP LPEEPCLPRP SAQLANGGLK RR 822

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTGTGCACT 60

GCCCGGCCGG CCCCAACCTT GCCTGAACAA GCCCAGCCCT GGGGGGCCCC AGTGGAAGTG 120

GAATCCCTCC TGGTCCACCC TGGTGACCTG CTGCAGCTTC GCTGTCGGCT GCGGGACGAT 180

GTCCAGAGCA TCAACTGGCT GCGGGACGGG GTACAGCTCG TGGAAAGCAA CCGTACCCGC 240

ATCACAGGGG AGGAGGTGGA GGTGCGGGAC TCCGTGCCTG CCGACTCCGG CCTCTACGCT 300

TGTGTGACCA GCAGTCCCTC TGGCAGCGAC ACCAGCTACT TCTCCGTCAA TGTCTCAGAT 360

GCGCTCCCCT CCTCGGAGGA TGATGATGAC GATGATGATT CCTCTTCCGA GGAGAAGGAG 420

ACAGACAACA CCAAACCAAA CCGTATGCCC GTAGCTCCAT ACTGGACGTC CCCAGAGAAG 480

ATGGAAAAGA AACTGCATGC CGTGCCCGCG GCCAAGACAG TGAAGTTCAA ATGTCCTTCC 540

AGTGGGACCC CCAACCCCAC CCTGCGCTGG CTGAAAAACG GCAAAGAATT CAAACCCGAC 600

CATAGGATTG GAGGCTACAA GGTCCGCTAT GCCACCTGGA GCATCATCAT GGACTCCGTG 660

GTGCCCTCTG ACAAGGGCAA TTACACCTGC ATCGTGGAGA ATGAGTATGG AAGCATCAAC 720

CACACCTACC AGCTGGACGT TGTGGAGCGG TCCCCTCACA GGCCTATCTT GCAGGCAGGG 780

TTGCCTGCCA ACAAGACAGT GGCCCTGGGC AGCAATGTGG AGTTCATGTG TAAAGTGTAC 840

AGTGACCCCC AGCCCCACAT CCAGTGGCTG AAACACATCG AGGTGAACGG AAGTAAGATC 900

GGTCCGGACA ACCTGCCTTA CGTGCAGATC TTGAAGACTG CTGGAGTTAA TACCACCGAC 960

AAGGAGATGG AAGTGCTCCA CTTAAGGAAT GTCTCCTTTG AGGACGCGGG GGAGTATACG 1020

TGCTTGGCGG GTAACTCTAT CGGACTCTCT CATCACTCTG CATGGTTGAC CGTTCTGGAA 1080

GCCCTGGAGG AGAGACCAGC AGTGATGACC TCGCCCTTCT ACCTGGAGAT CATCATCTAC 1140

TGCACAGGGG CCTTCCTCAT CTCCTGCATG GTGGGCGCAG TCATCGTCTA CAAGATGAAG 1200

AGCGGCACCA AGAAGAGTGA CTTCCACAGC CAGATGGCCG TACACAAGCT GGCCAAGAGC 1260

ATCCCTCTGC GCAGACAGGT AACAGTGTCC GCTGACTCCA GTGCATCCAT GAACTCTGGG 1320

GTTCTTCTGG TCCGGCCCTC ACGTCTCTCC TCCAGCGGGA CCCCAATGCT AGCTGGGGTC 1380

TCTGAATATG AGCTTCCTGA AGACCCCCGA TGGGAGCTGC CGAGGGACAG ACTGGTCTTA 1440

GGCAAACCCC TGGGAGAGGG CTGCTTTGGG CAGGTAGTGT TGGCGGAAGC CATTGGGCTG 1500

GACAAGGACA AACCCAACCG CGTGACCAAA GTGGCTGTGA AGATGTTGAA GTCTGATGCA 1560

ACAGAGAAAG ACCTGTCAGA CCTGATCTCT GAGATGGAGA TGATGAAGAT GATTGGAAAG 1620

CACAAAAACA TCATCAACCT GCTGGGGGCC TGCACGCAGG ACGGTCCCCT GTATGTCATC 1680

GTGGAGTATG CCTCTAAGGG CAACCTGCGG GAGTACCTGC AGGCCCGGCG CCCCCCGGGG 1740

CTAGAATACT GTTACAACCC CAGCCACAAT CCAGAGGAGC AGCTGTCCTC TAAGGACCTG 1800

GTGTCCTGTG CCTACCAGGT GGCCCGGGGC ATGGAGTATC TCGCCTCCAA GAAGTGCATC 1860

CACCGAGACC TGGCCGCCAG GAACGTCCTG GTGACGGAGG ACAATGTGAT GAAGATCGCA 1920

GACTTCGGCC TGGCTCGGGA CATTCATCAC ATCGACTACT ACAAGAAGAC AACCAATGGC 1980

CGGCTGCCCG TGAAGTGGAT GGCACCTGAG GCGCTGTTTG ACCGGATTTA CACACACCAG 2040

AGTGACGTGT GGTCTTTTGG GGTCCTCCTG TGGGAAATCT TCACACTGGG TGGCTCCCCA 2100

TATCCTGGGG TGCCTGTGGA GGAGCTTTTC AAGCTGCTGA AGGAGGGTCA TCGGATGGAC 2160

AAGCCCAGTA ACTGCACCAA TGAGCTGTAC ATGATGATGC GGGACTGCTG GCACGCTGTG 2220

CCCTCGCAGA GGCCCACCTT CAAGCAGCTG GTGGAAGACC TGGACCGCAT TGTGGCCCTG 2280

ACCTCTAACC AGGAGTACCT GGACCTGTCG ATGCCCCTGG ACCAGTACTC GCCCAGCTTC 2340

CCTGACACCC GCAGCTCCAC CTGCTCCTCG GGGGAGGATT CAGTCTTCTC ACATGAGCCA 2400

CTCCCCGAGG AACCCTGTCT GCCCCGCCCC TCGGCCCAAC TTGCCAATGG CGGACTCAAG 2460

AGGCGC 2466

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 478   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 538   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 598   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 658   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  717

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 718   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  754

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013