EKS-CAP-00519

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00519

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	428.0	9.2E-129	18	273	256

Status

Unreviewed

Ensembl Protein

ENSCPOP00000006043

UniProt Accession

H0V8E5;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000006708	ENSCPOP00000006043	ENSCPOT00000006776

Organism

Cavia porcellus

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GVVHRALSPH 120

NILLDRKGHI KLAKFGLYHM TAYGDDVDFP IGYPSYLAPE VIAQGIFKTT DHVPNEKPLP 180

SGPKSDVWSL GIILFELCMG RKLFQSLDIS ERLKFLLTLD CVDDTVTVLA EEHGCLDIIK 240

ELPENVIDLL KKCLTFHPSK RPTPDELMKD IVFSEVSPLY TPFSKPAALF SSSLRCADLT 300

LPEDISQLCK DTDTDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFVF 360

EDGESFGQSR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSSNEL 420

SAAATLPLII RERDTEYQLN RIVLFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKLP 720

ADSGALRSPA ACFSAECTEP PRTALSRESI PLNDLKSEVS PRISAEDLID LCELTMTGHF 780

KTPTKKTKSS KPKLLVVDIR NSEDFIRGHI ANSINIPFST AFTAEGELAQ SPYTTTLQSF 840

KGKVIVIVGN VAKHTAEFAA HLVKMKYPRV CILDGGINKI KPTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TGAAAGATGC TGAAATGGGG GCCTTTACCT TCTTTGCCTC AGCTTTGCCA 60

CATGATGTTT GTGGAAGCAA TGGACTTCCT CTCACCCCAA ATTCCATCAA AATTTTAGGG 120

CGCTTTCAAA TCCTTAAGAC AATAACTCAT CCCAGACTGT GCCAATATGT GGATATTTCC 180

AGGGGAAAGC ATGAAAGACT CGTGGTGGTG GCTGAACACT GTGAAAGGAG CCTGGAAGAT 240

TTGCTTCGCG AGAGGAAGCC TGTGAGCTAT TCAAAGGTCT TATGCATAGC ATTTGAAGTA 300

CTTCAGGGTT TGCAGTATAT GAATAAACAT GGCGTGGTAC ACCGGGCACT GTCTCCTCAT 360

AATATCCTGT TGGATCGAAA GGGGCATATT AAATTGGCTA AATTTGGGCT TTATCACATG 420

ACAGCTTATG GTGATGATGT TGATTTCCCA ATAGGGTATC CATCGTACTT GGCACCTGAG 480

GTGATTGCAC AAGGAATTTT CAAAACCACT GATCATGTGC CAAATGAGAA ACCATTGCCT 540

TCCGGCCCCA AATCAGATGT GTGGTCTCTC GGGATCATTT TATTTGAACT TTGTATGGGA 600

AGAAAATTAT TTCAGAGCCT GGATATTTCT GAACGTCTGA AATTTTTGCT TACTTTGGAC 660

TGTGTCGATG ACACCGTAAC AGTGCTGGCT GAAGAGCATG GTTGTCTGGA CATCATAAAG 720

GAGCTTCCTG AAAATGTGAT AGATCTTTTG AAGAAGTGCC TGACCTTCCA TCCATCTAAG 780

AGGCCAACCC CAGATGAACT GATGAAGGAC ATAGTGTTCA GTGAAGTGTC ACCTTTGTAC 840

ACCCCCTTCT CCAAACCTGC CGCTCTGTTT TCGTCTTCTC TGAGATGTGC CGATTTAACT 900

CTGCCTGAGG ATATCAGTCA GCTGTGTAAA GATACAGATA CAGATTACCT GGCAGAAAGA 960

TCCATTGAGG AAGTTTATTA CCTTTGGTGT TTGGCCGGCG GAGACTTGGA GAAAGAGCTT 1020

GTTAATAAGG AAATCATTCG ATCCAAACCC CCTATCTGCA CCCTCCCCAA CTTTGTTTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAAGTCGA GATAGAAGCT CACTTTTAGA TGACACCACT 1140

GTGACACTGT CGTTATGCCA ACTGAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TATCCATTAC TTGAAGATGA CCAGTCTAAC TTACCTCACT CCAACAGCAG TAACGAGCTG 1260

TCAGCAGCCG CCACGCTCCC TTTGATCATC CGAGAGAGGG ACACCGAGTA TCAGCTCAAC 1320

AGAATCGTTC TCTTTGACAG GCTGCTCAAG GCCTATCCAT ATAAAAAAAA TCAAATTTGG 1380

AAAGAAGCAA GAGTTGACAT TCCTCCTCTG ATGAGAGGTT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GAGCTATACA TGCTAAGTAT GATGCAATTG ATAAAGATAC TCCAATTCCT 1500

ACAGATAGGC AGATCGAAGT GGATATCCCT CGTTGTCATC AGTATGATGA ACTTTTATCA 1560

TCACCTGAAG GCCATGCAAA ATTTAGGCGT GTATTGAAGG CTTGGGTGGT ATCTCATCCT 1620

GATCTTGTAT ACTGGCAAGG TTTGGACTCA CTCTGCGCTC CCTTCCTGTA CCTAAATTTC 1680

AATAATGAAG CCCTGGCTTA TGCGTGTATG TCTGCTTTTA TTCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC ACATGTAATA CAAGAGTACC TGACCGTGTT CTCCCAGATG 1800

ATCGCCTTCC ATGACCCCGA GCTGAGCAAC CACCTCAACG AGATTGGCTT CATTCCAGAT 1860

CTGTATGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCATT GCACAAAATA 1920

TTCCACCTCT GGGACACCTT ACTGCTTGGG AATTCCTCTT TCCCATTCTG TATCGGAGTA 1980

GCAATCCTCC AGCAGTTGCG GGACCGTCTT TTGGCTAATG GCTTTAACGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATTGACATT GAGCGCTGTG TACGAGAATC CATCAACCTC 2100

TTTTGCTGGA CTCCCAAAAG CGCTACTTAC AGACAGCACG CGCAGCCTCC CAAACTGCCT 2160

GCCGACAGCG GCGCCCTGCG GAGTCCCGCC GCCTGCTTCT CCGCGGAGTG CACCGAGCCG 2220

CCCAGGACGG CCCTGTCAAG AGAATCCATC CCATTAAATG ACCTGAAGTC AGAAGTATCA 2280

CCTCGAATTT CCGCGGAGGA CCTGATTGAC TTATGTGAGC TGACCATGAC AGGCCACTTC 2340

AAAACTCCGA CCAAAAAAAC AAAGTCCAGC AAACCAAAGC TGCTGGTGGT TGACATCCGG 2400

AATAGCGAAG ATTTTATTAG GGGTCACATT GCGAACAGCA TCAACATCCC CTTCAGCACC 2460

GCCTTCACTG CAGAAGGAGA GCTCGCCCAG AGCCCTTACA CCACGACGCT CCAGAGCTTC 2520

AAGGGGAAGG TCATCGTCAT TGTGGGGAAC GTGGCGAAGC ACACGGCTGA GTTCGCAGCT 2580

CATCTTGTGA AGATGAAGTA CCCAAGGGTC TGTATTCTAG ACGGGGGCAT CAACAAGATC 2640

AAGCCCACAG GCCTGCTCAC CGTCCCGTCA CCACAGATA 2679

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh++vhral+p++illdrkg+ +kLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGVVHRALSPHNILLDRKGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+tayG+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAYGDDVDFPIGYPSYLAPEVIAQGifkttdhvpNEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+ +laee++cldiik+l+e++++llkkCLt+

Q: 197   LCMGRKLFQSLDISERLKFLLTLDCVDDTVTVLAEEHGCLDIIKELPENVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel+k++vf

Q: 257   HPSKRPTPDELMKDIVF  273

         **************998

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGVVHRAL SPHNILLDRK GHIKLAKFGL 120

YHMTAYGDDV DFPIGYPSYL APEVIAQGIF KTTDHVPNEK PLPSGPKSDV WSLGIILFEL 180

CMGRKLFQSL DISERLKFLL TLDCVDDTVT VLAEEHGCLD IIKELPENVI DLLKKCLTFH 240

PSKRPTPDEL MKDIVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013