EKS-CAP-00407

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00407

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	391.3	1.6E-117	194	443	250

Status

Unreviewed

Ensembl Protein

ENSCPOP00000006209

UniProt Accession

H0V8U3;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK6

Gene Synonyms/Alias

PTK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000006885	ENSCPOP00000006209	ENSCPOT00000006954

Organism

Cavia porcellus

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MASRGQVCPG PKYVGLWDFE ARTDEELSFR AGALFHVARK EDEWWWATLL DDLGQALAEG 60

YVPHNYLAEK ETVESEPWFF GNISRSEATH RLQAEGSSPG TFLVRVSEKS GADYVLSGPV 120

RDAQAVRHYR IWQHQGGRLY LNEAVSFFSL VELVDYHKAH SLSHGLRLTT PCWKHEAEPL 180

PHWANWERPQ EEFSLCRKLG AGYFGEVFEG LWKGQVQVAI KVISRDNLLH QHTFKSEIQA 240

MQKLRHKHIL ALYAVASAGD PVYIVTELMP KGNLLELLRD SEKQELPVSE LVDIASQVAE 300

GMCYLESKNY IHRDLAARNI LVGENNICKV GDFGLARLIK EDIYLSHNHK IPYKWTAPEA 360

LSQGHYSIKS DVWSFGILLH EIFSRGQTPY PGMSNHETFL KVDAGYRMPC PQECPPNVYT 420

LMCSCWSRDP EQRPCFKVLC EKLSGFARYE NLV 453

Nucleotide Sequence
(FASTA)

ATGGCGTCCC GGGGCCAGGT CTGCCCAGGC CCCAAGTACG TGGGCCTCTG GGACTTTGAG 60

GCCCGGACAG ATGAGGAGCT GAGCTTCCGG GCAGGGGCCC TGTTCCATGT GGCTAGGAAG 120

GAGGATGAGT GGTGGTGGGC CACCCTGCTG GATGACTTGG GCCAGGCCCT GGCAGAGGGC 180

TATGTGCCCC ACAACTACTT GGCTGAGAAG GAGACGGTGG AGTCCGAGCC ATGGTTCTTT 240

GGCAACATCT CCCGCTCGGA AGCAACACAC CGGCTGCAGG CAGAGGGCAG CTCACCGGGC 300

ACCTTCCTGG TCAGGGTCAG CGAGAAGTCG GGTGCAGACT ATGTTCTCTC TGGCCCAGTG 360

CGGGATGCTC AGGCCGTGCG GCACTACAGG ATCTGGCAGC ACCAGGGCGG CCGGCTGTAC 420

CTAAATGAGG CAGTGTCCTT CTTCAGCCTG GTGGAACTCG TGGACTACCA TAAGGCCCAC 480

AGCCTGTCCC ACGGGCTGCG GCTGACCACA CCCTGCTGGA AGCACGAGGC TGAGCCCCTG 540

CCCCACTGGG CCAACTGGGA GAGGCCGCAG GAGGAGTTCT CGCTCTGCAG GAAGCTGGGG 600

GCTGGCTACT TCGGGGAGGT CTTCGAAGGG CTCTGGAAAG GCCAGGTCCA AGTGGCCATT 660

AAGGTGATTT CCCGAGACAA TCTCCTACAC CAGCACACCT TCAAGTCGGA GATCCAGGCC 720

ATGCAGAAGC TGCGGCACAA GCACATCCTG GCGCTGTACG CGGTGGCCTC TGCAGGGGAC 780

CCTGTCTACA TCGTCACGGA GCTCATGCCC AAGGGGAACC TGCTGGAGCT GCTGCGGGAC 840

TCTGAGAAGC AAGAGCTGCC TGTTTCCGAA CTGGTGGACA TTGCATCGCA GGTGGCTGAG 900

GGCATGTGCT ACTTGGAATC CAAGAATTAC ATCCATCGGG ACTTGGCCGC CAGAAACATT 960

CTTGTGGGAG AGAACAATAT CTGCAAAGTG GGCGACTTTG GGCTGGCCAG GCTCATCAAG 1020

GAGGACATCT ACCTCTCCCA CAACCACAAG ATCCCGTACA AGTGGACAGC CCCTGAAGCG 1080

CTCTCCCAAG GGCATTACTC CATCAAGTCT GATGTCTGGT CCTTTGGGAT CCTGCTCCAT 1140

GAGATCTTTA GCAGGGGCCA GACACCCTAT CCAGGCATGT CCAACCATGA GACCTTCCTG 1200

AAGGTGGATG CTGGCTACCG AATGCCCTGC CCCCAGGAGT GCCCGCCCAA TGTGTACACA 1260

CTGATGTGCT CCTGCTGGAG CAGGGACCCA GAGCAGAGGC CCTGCTTCAA AGTGCTGTGC 1320

GAGAAGCTCT CAGGCTTCGC CAGGTATGAG AACCTGGTCT GA 1362

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60

          l++klG+G+fGev++g+wkg+v+va+k++++++ l++++f +e+q+++klrh+++++ly

Q: 194   SLCRKLGAGYFGEVFEGLWKGQVQVAIKVISRDNlLHQHTFKSEIQAMQKLRHKHILALY  253

         689******************************98999**********************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av+s+++P+yivtelm kG+ll++l+++e+++l++++lvd+a+qvaeGm+yle+kn+ihr

Q: 254   AVASAGDPVYIVTELMPKGNLLELLRDSEKQELPVSELVDIASQVAEGMCYLESKNYIHR  313

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dlaarn+lvge++++kv+dfGlarli++d+y +++ +k+P+kWtaPea+++g+++iksdv

Q: 314   DLAARNILVGENNICKVGDFGLARLIKEDIYLSHN-HKIPYKWTAPEALSQGHYSIKSDV  372

         *******************************9987.9***********************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+ei+++G++PypGm+n+e++ +v++gyr+p+p+ecp ++y+l+++cw++dpe+

Q: 373   WSFGILLHEIFSRGQTPYPGMSNHETFLKVDAGYRMPCPQECPPNVYTLMCSCWSRDPEQ  432

         ************************************************************

S: 241   rPtfetlqevl  251

         rP+f++l+e+l

Q: 433   RPCFKVLCEKL  443

         *******9875

Domain Sequence
(FASTA)

SLCRKLGAGY FGEVFEGLWK GQVQVAIKVI SRDNLLHQHT FKSEIQAMQK LRHKHILALY 60

AVASAGDPVY IVTELMPKGN LLELLRDSEK QELPVSELVD IASQVAEGMC YLESKNYIHR 120

DLAARNILVG ENNICKVGDF GLARLIKEDI YLSHNHKIPY KWTAPEALSQ GHYSIKSDVW 180

SFGILLHEIF SRGQTPYPGM SNHETFLKVD AGYRMPCPQE CPPNVYTLMC SCWSRDPEQR 240

PCFKVLCEKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013