EKS-CAP-00406

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00406

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	405.2	9.8E-122	107	358	252

Status

Unreviewed

Ensembl Protein

ENSCPOP00000015452

UniProt Accession

H0V900;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000006954	ENSCPOP00000015452	ENSCPOT00000026318
ENSCPOG00000006954	ENSCPOP00000006273	ENSCPOT00000007023

Organism

Cavia porcellus

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

QMLLDCVKQS GRTVAQESCI LRGPLELLVA ICVLDGKVVK HYRIGRLDGG NFFITPRKTF 60

STLNEFVSYY STISDGLCVR LGKPCLKKWA NYGPWTVDHW EIDRSSVQLL KRLGTGQFGE 120

VWEGLWNNTV SVAVKTLKPG SMDPKKFLGE AEIMKTLRHP KLIQLYAVCS SEEPIYIITE 180

LLRHGSLREY LQIDAGSKIH LAQQVDMATQ VASGMAYLEL NNYIHRDLAA RNVLVGEHNI 240

YKIADFGLAR ILKVDNEDMY KMKDQEKLPI KWTAPEALQN NTFSIKSDVW SFGILLYEII 300

TYGKVPYSGK THNEVVLMLR QNYRLPQPPN CPQKFYNIMM ECWHENPKER PTFERLHLTF 360

EDYFQA 366

Nucleotide Sequence
(FASTA)

CAGATGCTGC TAGATTGTGT GAAGCAATCT GGCAGGACAG TTGCACAGGA GAGCTGCATC 60

CTTCGTGGGC CCCTAGAATT GCTTGTAGCA ATCTGTGTTT TAGATGGAAA AGTTGTGAAA 120

CACTACAGAA TCGGAAGACT GGATGGAGGG AACTTTTTTA TTACTCCGAG AAAGACATTT 180

TCAACTTTAA ATGAATTTGT GAGCTATTAC AGCACAATAA GTGATGGCCT GTGTGTCAGG 240

CTAGGAAAAC CATGCTTAAA GAAATGGGCA AACTATGGCC CATGGACTGT GGACCACTGG 300

GAGATAGACC GCAGCTCTGT GCAGCTTCTG AAGCGGCTTG GAACTGGTCA GTTCGGCGAG 360

GTCTGGGAAG GCCTGTGGAA CAACACCGTG TCAGTGGCTG TGAAAACACT AAAACCAGGT 420

TCAATGGATC CGAAGAAGTT CCTGGGGGAG GCAGAGATAA TGAAGACTCT GAGACATCCG 480

AAGCTTATCC AGCTCTATGC TGTTTGCAGT TCAGAAGAGC CGATTTATAT TATTACAGAA 540

TTGTTGAGAC ATGGAAGTCT GCGAGAGTAT CTCCAAATTG ATGCTGGGTC AAAAATCCAT 600

CTGGCTCAAC AAGTAGACAT GGCGACGCAG GTGGCATCTG GGATGGCCTA CCTGGAGCTC 660

AACAACTACA TCCACAGAGA TCTGGCTGCT AGAAACGTCC TCGTTGGTGA ACATAATATC 720

TACAAAATAG CAGACTTTGG ACTTGCAAGA ATTTTAAAGG TAGATAATGA AGACATGTAT 780

AAAATGAAAG ACCAAGAAAA GCTGCCCATA AAGTGGACTG CGCCTGAAGC CCTTCAGAAT 840

AATACATTTA GCATTAAATC CGATGTATGG TCCTTTGGAA TTCTTCTTTA TGAAATCATT 900

ACTTACGGCA AAGTGCCTTA CAGTGGCAAG ACACATAATG AAGTTGTCCT GATGTTGCGT 960

CAAAACTATC GGCTCCCACA ACCACCTAAC TGTCCCCAGA AATTCTACAA CATCATGATG 1020

GAATGCTGGC ATGAGAACCC TAAGGAACGA CCGACATTTG AGAGACTGCA TTTGACATTT 1080

GAGGATTATT TTCAGGCA 1098

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++v+vavktlk+g+++p++fl ea+i+k+lrh+kl++ly

Q: 107   VQLLKRLGTGQFGEVWEGLWNNTVSVAVKTLKPGSMDPKKFLGEAEIMKTLRHPKLIQLY  166

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av+s+eePiyi+tel+++Gsl ++l+ + g+k++l ++vd+a+qva+Gmayle +n+ihr

Q: 167   AVCSSEEPIYIITELLRHGSLREYLQIDAGSKIHLAQQVDMATQVASGMAYLELNNYIHR  226

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++k+adfGlar+++   +d y++k+++klPikWtaPea++ ++f+ik

Q: 227   DLAARNVLVGEHNIYKIADFGLARILKvdnEDMYKMKDQEKLPIKWTAPEALQNNTFSIK  286

         ************************998878899***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+GkvPy+G t++ev+ ++ ++yrlp+p +cp+++y++++ecw+++

Q: 287   SDVWSFGILLYEIITYGKVPYSGKTHNEVVLMLRQNYRLPQPPNCPQKFYNIMMECWHEN  346

         ************************************************************

S: 238   peerPtfetlqe  249

         p+erPtfe+l+

Q: 347   PKERPTFERLHL  358

         ********9975

Domain Sequence
(FASTA)

VQLLKRLGTG QFGEVWEGLW NNTVSVAVKT LKPGSMDPKK FLGEAEIMKT LRHPKLIQLY 60

AVCSSEEPIY IITELLRHGS LREYLQIDAG SKIHLAQQVD MATQVASGMA YLELNNYIHR 120

DLAARNVLVG EHNIYKIADF GLARILKVDN EDMYKMKDQE KLPIKWTAPE ALQNNTFSIK 180

SDVWSFGILL YEIITYGKVP YSGKTHNEVV LMLRQNYRLP QPPNCPQKFY NIMMECWHEN 240

PKERPTFERL HL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013