EKS-CAP-00313

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00313

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.5	5.5E-136	173	460	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000006410

UniProt Accession

H0V9C2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000007111	ENSCPOP00000006410	ENSCPOT00000007181

Organism

Cavia porcellus

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

PGLKCVCLLC DSSNFTCQTE GACWASVMLT NGKEQVIKSC VSVPELQAQV FCHSSNNVTK 60

TECCFTDFCN NITLHLPTAA SPESPKLRSM ELTIVITVPV CLLSIVAMLT IWACQGRQCS 120

YRRTNRQSVE EPLSECKLVH AGKTLKDLIY DVTASGSGSG LPLLVQRTIA RTIVLQEIVG 180

KGRFGEVWHG RWCGEDVAVK IFSSRDERSW FREAEIYQTV MLRHENILGF IAADNKDNGT 240

WTQLWLVSEY HEQGSLYDYL NRNVVTAAGM IKLALSIASG LAHLHMEIVG TQGKPAIAHR 300

DIKSKNILVK KCETCAIADL GLAVKHDSIL NTIDIPQNPK VGTKRYMAPE MLDDTMNVSI 360

FESFKRADIY SVGLVYWEIA RRCSIGGIVE EYQLPYYDMV PSDPSIEEMR KVVCDQKLRP 420

SIPNQWQSCE ALRVMGRIMR ECWYANGAAR LTALRIKKTI SQLCVKEDCK A 471

Nucleotide Sequence
(FASTA)

CCAGGATTGA AGTGTGTATG TCTTTTGTGT GACTCTTCAA ATTTTACCTG CCAAACAGAA 60

GGAGCTTGTT GGGCCTCAGT GATGCTAACC AATGGAAAGG AACAGGTGAT CAAATCCTGT 120

GTATCTGTCC CAGAATTACA GGCTCAAGTC TTCTGCCATA GTTCTAACAA TGTTACCAAA 180

ACTGAATGCT GCTTCACAGA TTTTTGCAAC AACATAACAT TGCACCTGCC AACAGCAGCC 240

TCACCAGAGA GCCCCAAACT CAGATCCATG GAGCTGACCA TTGTAATCAC TGTGCCTGTC 300

TGCCTCCTGT CCATAGTTGC CATGCTGACA ATATGGGCAT GCCAAGGCCG ACAGTGCAGC 360

TACCGAAGGA CAAACAGGCA GAGTGTAGAG GAGCCACTCT CTGAATGCAA GTTGGTACAC 420

GCTGGAAAAA CCCTTAAAGA TCTGATTTAT GATGTAACCG CCTCTGGCTC TGGCTCTGGT 480

CTGCCTCTTC TGGTTCAAAG AACAATTGCA AGGACAATTG TACTTCAAGA AATAGTAGGA 540

AAAGGTAGAT TTGGTGAGGT GTGGCATGGA AGGTGGTGTG GGGAAGATGT GGCTGTGAAA 600

ATATTCTCCT CCAGAGATGA AAGATCTTGG TTTCGTGAGG CAGAAATTTA TCAGACAGTT 660

ATGCTTCGAC ATGAAAACAT CCTGGGTTTC ATCGCTGCTG ACAACAAAGA TAATGGAACT 720

TGGACTCAGC TTTGGCTCGT ATCTGAGTAT CATGAACAGG GCTCCTTATA TGACTATCTG 780

AATAGAAACG TAGTCACGGC GGCTGGAATG ATCAAACTGG CACTTTCAAT AGCTAGTGGT 840

CTGGCACACC TCCACATGGA GATTGTTGGT ACACAAGGTA AACCTGCTAT TGCTCATCGA 900

GACATAAAAT CAAAGAATAT CTTAGTGAAA AAATGTGAAA CTTGTGCCAT AGCAGACTTG 960

GGGTTGGCTG TGAAGCATGA TTCCATTCTG AACACTATAG ACATACCTCA GAATCCGAAA 1020

GTGGGAACCA AGAGGTATAT GGCTCCTGAA ATGCTTGATG ATACAATGAA TGTGAGTATC 1080

TTTGAATCCT TCAAAAGAGC TGACATCTAT TCTGTTGGTC TGGTTTACTG GGAAATAGCT 1140

CGAAGGTGTT CAATTGGAGG AATTGTTGAG GAGTACCAAT TGCCTTATTA TGATATGGTG 1200

CCTTCAGACC CCTCAATAGA GGAGATGAGG AAAGTTGTTT GTGACCAGAA GCTTCGACCA 1260

AGTATCCCAA ACCAGTGGCA AAGCTGTGAA GCACTCCGTG TCATGGGGAG GATAATGCGC 1320

GAGTGTTGGT ATGCCAACGG GGCAGCACGC CTAACTGCCC TCCGGATTAA GAAGACTATT 1380

TCGCAACTTT GTGTCAAAGA AGATTGCAAA GCTTGA 1416

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 173   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  232

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r+++++  +++lals+asGlahLH+eivgt+

Q: 233   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNVVTAAGMIKLALSIASGLAHLHMEIVGTQ  292

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 293   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  350

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 351   MLDDTMNVSIFESFKRADIYSVGLVYWEIARRCSI-GGIVEEYQLPYYDMVPSDPSIEEM  409

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 410   RKVVCDQKLRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  460

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NVVTAAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVSIFE SFKRADIYSV GLVYWEIARR CSIGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKLRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013