EKS-CAP-00433
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00433
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR578.64.6E-174596929334
StatusUnreviewed
Ensembl ProteinENSCPOP00000006563
UniProt AccessionH0V9R0;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000007285ENSCPOP00000006563ENSCPOT00000007357
OrganismCavia porcellus
Functional Description
Protein Length974
Protein Sequence
(FASTA)
VVFSVMICET ITNQDVPVIK CVLINHKTND SAVGKPSSYP TVPESQEDLG CMLRPESAGA 60
VYGTATVEVD MSASITLQVL VATPGNISCL WVFKHSSLDC QPHFDFLNRG VVSMVILKMT 120
ETQAGEYLLF IQSEVTNYTI LFTVSIRNTL LYTLRRPYFR KLENEDALVC VSEGVPEPTV 180
EWVLCDLQGE SCKEENPAVV KKEEKVLHEL FGTDIRCCAR NELGRECTKL FTIDLNQTPR 240
TTLPQLFLKV GEPLWIRCKA VHVNHGFGLS WELENKALEE GSYFEMSTYS TNRTMIRILF 300
AFVSSVGRNN TGYYTCSSSK HASQSALVTI LEKGFINATN SSEDYAIDQY EEFCFSVKFK 360
AYPQIRCTWT FSRKSFPCEQ SSLEDGYSIS KFCNHKHQPG EYIFHAENDD AQFTKMFTLN 420
IRRKPQVLAE ASASQASCSS DGYPLPSWTW KKCSDKSPNC TEEITEGVWN KKANRKVFGQ 480
WVSSSILNMS EAVKGFLVKC CAYNSVGTSC ETILLNSPGP FPFIQDNISF YATIGLCLPF 540
IVVLIMLICH KYKKQFRYES QLQMVQVTGS LDNEYFYIDF REYEYDLKWE FPRENLEFGK 600
VLGSGAFGKV MNATAYGISK TGVSIQVAVK MLKEKADSSE REALMSELKM LTQLGHHENI 660
VNLLGACTLS GPIYLIFEYC CYGDLLNYLR SKREKFHRTW TEIFKEHNFS FYPTFQSHPN 720
SSMPASREVQ IHQDSDQMSG FNGNSTHSED EVEYENQKRL EEEEDLNVLT FEDLLCFAYQ 780
VAKGMEFLEF KSCVHRDLAA RNVLVTHGKV VKICDFGLAR DILSDSNYVV RGNARLPVKW 840
MAPESLFEGI YTIKSDVWSY GILLWEIFSL GVNPYPGIPV DANFYKLIQS GFKMDQPFYA 900
TEEIYFIMQS CWAFDSRKRP SFPNLTSFLG CQLADAEEAM YQNVDGSIPE RPSIYQNRRA 960
FGREMAPEPP SPQS 974
Nucleotide Sequence
(FASTA)
GTTGTGTTTT CAGTAATGAT ATGTGAGACT ATTACAAATC AAGATGTGCC TGTGATCAAG 60
TGTGTTTTAA TCAATCATAA GACCAACGAT TCGGCAGTGG GGAAACCGTC ATCGTATCCC 120
ACGGTGCCGG AATCTCAGGA AGACCTTGGA TGCATGCTGA GACCTGAGAG TGCGGGGGCA 180
GTGTATGGCA CAGCCACTGT GGAGGTGGAC ATGTCCGCGT CTATCACACT GCAAGTGCTG 240
GTCGCCACCC CCGGGAACAT TTCCTGTCTT TGGGTCTTTA AACACAGCTC GCTGGATTGC 300
CAGCCACACT TTGATTTCCT GAACAGAGGA GTTGTATCCA TGGTCATTTT GAAAATGACA 360
GAGACCCAAG CTGGAGAATA CCTGCTTTTT ATCCAGAGTG AAGTTACCAA TTACACAATA 420
TTGTTTACAG TGAGTATAAG AAATACACTG CTCTACACAT TAAGAAGACC TTACTTCAGA 480
AAGCTGGAGA ATGAGGATGC CCTGGTCTGT GTATCCGAGG GTGTTCCAGA ACCTACTGTC 540
GAGTGGGTAC TCTGTGATCT GCAGGGTGAA AGCTGTAAAG AAGAAAATCC AGCTGTTGTT 600
AAAAAGGAGG AAAAGGTCCT TCATGAATTA TTTGGAACAG ATATAAGGTG CTGTGCAAGA 660
AATGAACTGG GCAGAGAATG CACCAAGCTG TTCACAATAG ATCTAAATCA AACCCCTCGA 720
ACCACACTGC CTCAGTTATT CTTGAAAGTG GGGGAGCCCT TATGGATACG GTGCAAAGCT 780
GTTCATGTGA ACCACGGATT TGGACTCTCC TGGGAATTAG AGAACAAAGC CCTGGAAGAG 840
GGCAGCTACT TTGAGATGAG CACCTACTCG ACAAACAGAA CTATGATACG GATTCTGTTT 900
GCTTTTGTGT CATCAGTGGG AAGAAACAAC ACTGGATATT ACACATGTTC CTCCTCCAAG 960
CATGCCAGTC AGTCGGCTCT GGTTACCATC CTAGAAAAAG GATTTATAAA TGCTACCAAT 1020
TCAAGTGAAG ATTATGCAAT TGACCAATAT GAAGAGTTTT GTTTTTCTGT TAAGTTTAAG 1080
GCTTACCCAC AAATCCGATG TACATGGACC TTCTCTCGAA AATCATTTCC TTGTGAACAG 1140
AGCAGCCTTG AAGATGGATA CAGCATATCT AAGTTTTGCA ACCATAAGCA CCAACCAGGA 1200
GAATATATAT TCCATGCAGA AAATGATGAT GCTCAGTTCA CCAAAATGTT CACACTGAAT 1260
ATAAGAAGAA AACCTCAAGT GTTGGCTGAA GCATCAGCAA GTCAAGCATC TTGTTCCTCG 1320
GATGGATACC CATTACCCTC TTGGACCTGG AAGAAATGTT CAGACAAGTC TCCCAACTGC 1380
ACAGAAGAAA TCACAGAAGG GGTCTGGAAT AAAAAGGCCA ACCGGAAAGT GTTCGGGCAG 1440
TGGGTGTCCA GCAGTATCCT AAACATGAGT GAGGCCGTGA AAGGGTTCCT GGTCAAATGC 1500
TGCGCATACA ATTCCGTGGG CACATCTTGT GAAACAATCC TTTTAAACTC CCCAGGCCCA 1560
TTCCCTTTCA TCCAAGACAA CATCTCCTTC TATGCAACGA TTGGGCTCTG TCTTCCGTTC 1620
ATTGTGGTCC TGATTATGCT AATTTGTCAC AAGTACAAAA AGCAATTTAG GTATGAAAGC 1680
CAGTTGCAAA TGGTACAGGT GACTGGCTCG TTGGATAATG AGTACTTCTA CATCGATTTC 1740
AGGGAGTATG AATATGATCT TAAATGGGAA TTTCCAAGAG AAAACTTAGA GTTTGGCAAG 1800
GTACTAGGCT CAGGAGCTTT TGGAAAAGTG ATGAATGCAA CAGCGTACGG AATTAGTAAG 1860
ACAGGAGTCT CCATCCAGGT TGCAGTCAAA ATGCTGAAAG AAAAAGCAGA CAGTTCTGAA 1920
AGAGAGGCGC TCATGTCGGA GCTCAAAATG CTGACTCAGC TGGGGCACCA TGAGAATATC 1980
GTGAACCTGC TGGGGGCGTG CACACTGTCA GGACCAATTT ACTTGATTTT TGAATATTGC 2040
TGTTATGGTG ACCTTCTCAA CTATCTAAGA AGTAAAAGAG AAAAATTTCA CAGGACATGG 2100
ACAGAGATTT TCAAAGAGCA CAATTTTAGT TTTTACCCCA CTTTTCAATC ACATCCAAAT 2160
TCCAGCATGC CTGCTTCAAG AGAAGTTCAA ATACACCAGG ACTCAGACCA GATGTCAGGG 2220
TTCAATGGGA ATTCAACTCA TTCTGAAGAT GAAGTTGAAT ATGAAAACCA AAAGCGGCTG 2280
GAAGAAGAAG AGGACTTGAA CGTGCTTACG TTTGAAGATC TTCTTTGCTT TGCGTATCAA 2340
GTTGCCAAAG GGATGGAATT TCTGGAATTT AAATCGTGTG TGCACAGAGA CCTGGCCGCC 2400
AGGAATGTGC TGGTCACCCA CGGGAAGGTA GTGAAGATCT GTGACTTTGG GCTGGCTCGA 2460
GATATCCTGA GTGACTCCAA CTACGTTGTC AGAGGCAATG CCCGCCTGCC TGTGAAATGG 2520
ATGGCCCCAG AGAGCTTATT TGAAGGGATC TACACAATCA AGAGTGATGT CTGGTCCTAT 2580
GGAATACTGC TCTGGGAGAT ATTCTCGCTG GGTGTGAACC CTTACCCTGG CATTCCAGTG 2640
GATGCTAACT TCTATAAACT CATTCAAAGT GGGTTTAAGA TGGATCAGCC ATTCTACGCT 2700
ACAGAAGAAA TATACTTTAT AATGCAATCC TGCTGGGCCT TTGACTCCAG GAAACGGCCG 2760
TCCTTCCCTA ACCTGACTTC CTTTTTAGGA TGTCAGCTGG CAGATGCAGA AGAAGCGATG 2820
TACCAGAACG TGGATGGCAG CATTCCAGAG CGTCCTTCCA TCTACCAAAA CAGGCGAGCT 2880
TTCGGCAGAG AGATGGCTCC AGAGCCGCCG TCCCCACAGA GC 2922
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+l++lG
Q: 596   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMLTQLG  655
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 656   HHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  714
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++++s ++ ++++se++ +++++++   +eeed
Q: 715   ------FQSHPNSSMPASRE-VQIHQDSDQMSGFNGNSTHSEDEVEYENQKRL--EEEED  765
         ......9*************.***********************999999876..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardi++d
Q: 766   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSD  825
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 826   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  885
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 886   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  929
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMLTQLG 60
HHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPA SREVQIHQDS DQMSGFNGNS THSEDEVEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDILSD SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013