EKS-CAP-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	463.6	1.8E-139	13	297	285

Status

Unreviewed

Ensembl Protein

ENSCPOP00000006709

UniProt Accession

H0VA42;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000007438	ENSCPOP00000006709	ENSCPOT00000007510

Organism

Cavia porcellus

Functional Description

Protein Length

904

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PAEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRSQAS KGAALQSHHR SNSKDIQNLS VGLPRADEGL 360

PANESFLNGN LAGATLSPMH TKTYQASTQP GSASKDLTNN NMPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSSTRS QQNRHSFMES SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHSDSRT 540

LLSPSGRNNR NEGTLDSRRT TARHSKTMEE LKLPEHMDNS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RPSVKESSRE GTSSFHTRQK SEGGVYHDPH SDDGTGPKEN RHLYNDPIPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESSSGTNHS KRQPAFDPWK SPENISHSDQ LKEKEKQGFF 780

RSMKKKKKKS QTYPNSDGPD LLTLQKLHSA SASSSRPKEW RPEKLSDLQT QSQPLKSLRK 840

LLHLSSASNH PAPSDPRFQP LTAQPTKNSF SEIRIHPLSQ ASGGSSNIRQ EPTPKGRPAL 900

QLPG 904

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGGCACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AGGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGTACTCT CAAACAAGAA AACATTGTGG AGCTGAAAGA AGCCTTCCGT 240

CGGCGGGGGA AATTGTACCT GGTGTTTGAA TATGTGGAAA AAAATATGCT TGAATTGCTG 300

GAAGAAATGC CAAATGGAGT GCCACCTGAA AAAGTAAAAA GCTATATCTA CCAACTAATC 360

AAAGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCACA GAGATATAAA ACCAGAAAAT 420

CTCTTAATCA GCCACAATGA TGTTCTGAAA CTGTGTGACT TTGGTTTTGC ACGGAATCTG 480

TCAGAGGGTA ATAATGCTAA TTACACAGAG TATGTGGCCA CCAGGTGGTA TCGCTCCCCA 540

GAACTGTTAC TTGGAGCTCC CTATGGGAAG TCTGTAGACA TGTGGTCAGT GGGCTGTATT 600

CTCGGGGAGC TTAGTGATGG ACAGCCCTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTT 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCAGCTGAGC AGATGAAGCT CTTCTATAGT 720

AATCCTCGGT TCCACGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGTC ATTGGAGAGA 780

AGATACCTTG GAATTTTAAA TAGTGTTTTA CTTGACCTGA TGAAGAATTT ATTGAAGTTG 840

GACCCAGCCG ACAGATACTT GACTGAACAG TGTTTGAATC ACCCTACATT TCAAACCCAG 900

AGACTTTTGG ATCGGTCTCC TTCAAGGTCA GCAAAAAGGA AACCTTATCA TGTGGAAAGC 960

AGCACTTTGT CTAATAGAAG CCAAGCCAGC AAAGGTGCTG CTTTACAGTC TCACCACAGA 1020

TCTAACAGCA AGGACATTCA GAACCTAAGT GTGGGTCTGC CCCGGGCTGA TGAAGGGCTT 1080

CCTGCCAACG AAAGCTTCCT GAATGGGAAC CTTGCTGGAG CTACTCTTAG TCCGATGCAC 1140

ACCAAAACCT ACCAAGCAAG CACCCAACCT GGGTCTGCCA GCAAAGATCT CACCAATAAC 1200

AACATGCCAC ACCTTCTTAG TCCAAAAGAA GCCAAATCCA AAACAGAGTT TGACTTTAAT 1260

ATTGACCCAA AGCCCTCAGA AGGCCCAGGC ACAAAGTACC TGAAGTCCAG CACCCGATCT 1320

CAGCAGAACC GGCATTCTTT CATGGAAAGC TCTCAGAGCA AAGCAGGGAC ACTACAGCCC 1380

AGTGAGAAGC AGAGTCGGCA CAGCTATATT GACACTATTC CCCAGTCCTC CAGGAGTCCC 1440

TCCTACCGGA CCAAGGCCAA AAGCCATGGG GCATTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCTGAAG CCAGGGCCCA AATTACAGAG ACCAATACCA GTAGGTATTT TCCATCCAGC 1560

TGTTTGGATT TGAATTCTCC CACCAGCCCA ACACCTACCA GGCACAGTGA CTCGAGAACT 1620

TTACTTAGCC CTTCAGGGAG AAACAACCGA AATGAGGGTA CACTGGACTC TCGCCGAACC 1680

ACAGCCAGGC ATTCAAAAAC CATGGAGGAG TTGAAGCTGC CCGAGCACAT GGACAACAGC 1740

CATTCCCACT CTCTGTCTGC ACCTCATGAA TCTTTTTCTT ACGGGCTGGG GTACACCAGC 1800

CCCTTCTCCT CTCAGCAGCG TCCTCACAGG CATTCCATGT ATGTGACCCG GGACAAAGTG 1860

AGAGCCAAAG GCTTGGACGG AAGCCTGAGT ATAGGGCAAG GGATGGCGGC CAGAGCCAAC 1920

AGCCTGCAGC TCTTATCACC GCAGCCTGGA GAGCAGCTCC CACCAGAGAT GACTGTGGCA 1980

AGACCTTCTG TTAAAGAGTC CTCCAGAGAA GGCACCTCTT CATTCCATAC CCGTCAGAAG 2040

TCTGAGGGTG GAGTATACCA TGACCCACAC TCTGATGATG GCACAGGACC CAAAGAAAAC 2100

AGACACCTGT ACAATGATCC CATCCCAAGG AGAGTTGGCA GCTTTTACAG AGTGCCATCT 2160

CCAAGACCAG ACAATTCTTT CCATGAAAAT AATGTATCAA CTAGAGTTTC TTCTCTACCA 2220

TCTGAGAGCA GTTCTGGAAC CAATCATTCA AAGAGACAGC CAGCCTTTGA TCCATGGAAA 2280

AGTCCTGAAA ATATTAGTCA TTCCGATCAA CTCAAGGAAA AGGAGAAACA AGGTTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCT CAAACATACC CTAATTCCGA TGGTCCTGAT 2400

CTTCTGACAC TACAAAAGCT TCACTCTGCT AGCGCTTCAA GCAGCAGACC AAAGGAATGG 2460

CGCCCTGAGA AACTATCAGA TCTACAGACC CAAAGCCAGC CGTTAAAATC ACTGCGCAAG 2520

CTGTTACATC TTTCTTCAGC CTCAAATCAC CCAGCTCCCT CAGATCCCCG TTTCCAGCCC 2580

TTAACAGCTC AACCAACCAA AAATTCCTTC TCAGAAATTC GGATTCACCC CCTGAGCCAA 2640

GCCTCTGGTG GGAGTAGCAA CATCCGACAG GAGCCCACAC CAAAAGGCAG GCCAGCCCTC 2700

CAACTGCCAG GT 2712

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPA EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013