EKS-CAP-00491

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00491

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	505.5	3.4E-152	26	310	285

Status

Unreviewed

Ensembl Protein

ENSCPOP00000006783

UniProt Accession

H0VAB0;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000007515	ENSCPOP00000006783	ENSCPOT00000007588

Organism

Cavia porcellus

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLNS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELECMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDLSIRELV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGR 360

DLPEKAEGEP KEHGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSSDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNSEEIDEVT QPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK SHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVAHQISTAD VYCKLMPYLN PYITQPVIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNRA KANIIDQSHL HDSSQKGVID LATLGITGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPSS LPQALPKGSD QEVTQAGKPP RLESSAGICV 900

PLSSSPQFSE VTSIQNKKPA IQVLSSTVLP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG VEASKLPKSP 1080

KIHPLQSRVL DLKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHY HPSRARIRRL SMHPLYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYIVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AACTTGCTGG CATTGCTCCT TCACAGATCC TGTCTGTGGA GAGTTACTTC 60

TCAGACATCC ATGACTTTGA GTATGATAAA AGCCTAGGGA GTACTCGATT TTTTAAAGTT 120

GCTCGAGCAA AGCACCGAGA AGGCTTGGTG GTTGTGAAAG TTTTTGCAAT TCAGGATCCC 180

ACGTTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG ACTTAATTCT 240

GCACAGAATT GTCTACCTTT CCAGAAAGCA GCAGAGAAAG CATCTGAGAA AGCAGCTATG 300

CTGTTTAGGC AGTATGTGCG AGATAACCTG TATGACCGCA TCAGTACTCG GCCATTCTTA 360

AATAACATTG AGAAGCGCTG GATCGCCTTC CAGATCCTCA CAGCGGTGGA CCAAGCACAC 420

AAATCTGGAG TCCGTCATGG GGATATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAC 480

TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAACCTACAT ATCTTCCAGA GGACAACCCA 540

GCAGATTTCA ACTATTTCTT TGACACTTCA AGGAGAAGGA CTTGCTATAT TGCTCCTGAA 600

CGCTTTGTGG ATGGTGGTAT GTTTGCCACT GAGTTAGAAT GCATGAGAGA TCCTTCAACT 660

CCACTTGTGG ACTTAAATAG TAATCAGAGA ACAAGAGGAG AGTTGAAAAG AGCAATGGAC 720

ATCTTTTCAG CAGGTTGTGT GATAGCTGAA CTTTTTACAG AAGGTGTACC ACTGTTTGAT 780

CTCTCTCAGC TTTTGGCTTA CAGAAATGGA CATTTTTTCC CCGAACAAGT GCTAAATAAA 840

ATTGAAGATC TCAGTATCAG GGAACTGGTA ACTCAGATGA TTCATCGAGA GCCAGATAAA 900

CGTTTAGAGG CTGAAGATTA CTTAAAGCAA CAGCGTGGCA ATGCGTTTCC TGAGATATTT 960

TATACTTTCC TTCAGCCTTA CATGGCCCAG TTTGCCAAGG AAACATTTCT TTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACGC 1080

GATCTGCCAG AAAAAGCAGA AGGAGAGCCT AAGGAACATG GGCTAGTTAT CTTGGTGTCG 1140

GTGATAACAT CCTGCCTACA GACCCTGAAG TACTGTGATT CCAAACTTGC AGCTTTGGAA 1200

CTTATTCTCC ACTTAGCGCC AAGATTAAGT GTAGAAATCC TTTTGGATCG TATTACTCCC 1260

TATCTTTTGC ATTTCAGCAG TGACTCTGTG CCTAGAGTGA GAGCTGAAGC TTTGAGAACA 1320

TTGACCAAAG TTCTTGCCCT TGTCAAAGAA GTTCCTCGAA ATGATATCAA TATCTATCCA 1380

GAATACATTC TTCCAGGAAT AGCCCACTTA GCCCAAGATG ATGCTACTAT TGTTAGGCTG 1440

GCCTATGCGG AAAACATAGC TTTGCTGGCA GAAACAGCTC TGAGATTTCT GGAATTAGTA 1500

CAGTTAAAAA ATCTTAACAT GGAAAATGAC CCTAATAGTG AAGAAATAGA TGAAGTTACA 1560

CAGCCAAATG GAAATTATGA CACAGAGCTC CAAGCCTTGC ATGAAATGGT CCAGCAGAAA 1620

GTTGTCACTT TGTTAAGTGA TCCTGAAAAT ATTGTGAAAC AGACTTTAAT GGAAAATGGC 1680

ATAACACGGC TCTGTGTATT CTTTGGACGT CAGAAAGCCA ATGATGTTTT GTTGTCTCAC 1740

ATGATCACTT TCCTAAATGA TAAGAATGAT TGGCACCTGC GTGGAGCTTT CTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAGAGTTCCT CAATTCTCAA GCCCCTGTTG 1860

CAACAAGGTC TTAGTGATGC TGAGGAATTT GTTATTGTGA AAGCTCTTAA TGCCCTTACC 1920

TGTATGTGCC AGTTAGGGCT GCTGCAAAAA TCCCATGTCT ACGAATTTGC CAGTGACATT 1980

GCCCCATTCT TATGTCATCC TAATCTGTGG ATACGCTATG GTGCCGTAGG ATTTATCACA 2040

GTGGTCGCCC ACCAAATAAG TACAGCTGAC GTCTACTGTA AACTGATGCC CTACCTTAAC 2100

CCGTACATTA CCCAACCAGT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTTTTA 2160

AAAGAACCAG TGAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 2220

TTGTTCAGAC ATCTACACAT GCGTCAGAAG AAACGAAACG GCTCTCTCCC CGACTGCCCT 2280

CCACCTGAGG ACCCTGCCAT TGCACAGCTT CTGAAGAAAT TGCTCTCACA GGGAATGACA 2340

GAAGAAGAAG AGGATAAACT TCTGGCATTA AAAGACTTCA TGATGAAATC TAATAGAGCA 2400

AAAGCAAATA TAATAGACCA GAGCCATCTT CATGATAGTA GTCAGAAGGG TGTAATTGAT 2460

TTGGCAACTC TGGGCATAAC TGGAAGACAA GTTGACCTTG TTAAAACCAA ACAAGAACCA 2520

GATGACAAAC GGGCTAGAAA ACATGTAAAG CAAGACTCCA ATGTAAATGA AGAGTGGAAA 2580

AGCATGTTTG GGTCACTGGA ACCTTCCAGC CTCCCACAGG CCCTGCCTAA AGGAAGTGAC 2640

CAGGAGGTGA CTCAGGCTGG GAAGCCTCCC CGTTTGGAGT CCTCTGCTGG CATCTGTGTT 2700

CCTTTGTCAT CTTCTCCACA GTTTTCAGAA GTAACAAGCA TCCAAAATAA AAAACCAGCA 2760

ATACAAGTGT TAAGTAGCAC AGTTTTACCA TCTACTTACC AGATTCGAAT TACCACTTGT 2820

AAAACTGAAC TTCAGCAGCT CATCCAGCAA AAGCGGGAGC AGTGCAACGC TGAGAGGATA 2880

GCGAAGCAGA TGATGGAAAA CGCTGAATGG GAGAGTAAAC CGCCACCACC TGGGTGGCGT 2940

CCTAAAGGGC TACTAGTTGC ACATCTTCAT GAACACAAAT CTGCTGTGAA TCGAATTAGA 3000

GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 3060

AACAGCCAGA AGATGGAGGG AAAGACCACT ACAACTAGAT CTATCCTTAC ATATAGTCGA 3120

ATTGGAGGAC GAGTCAAGAC ACTAACATTT TGCCAAGGCT CCCACTACTT AGCCATTGCG 3180

TCAGATAATG GTGCTGTCCA GCTTCTTGGA GTTGAGGCTT CTAAGCTGCC CAAGTCGCCT 3240

AAAATCCATC CTCTACAAAG CAGAGTTCTG GATCTAAAAG AGGATGGCTG CGTTGTGGAC 3300

ATGCATCACT TCAACTCCGG GGCACAGTCC GTCCTCGCCT ACGCCACTGT GAACGGCTCT 3360

CTGGTCGGCT GGGACCTCAG GTCTTCAAGC AATGCCTGGA CATTAAAGCA TGATTTGAAG 3420

TCAGGCCTCA TCACCTCCTT TGCCGTGGAC ATCCACCAGT GCTGGCTCTG CATTGGTACA 3480

AGCAGTGGTA CTATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC CAGTCACTAT 3540

CACCCTTCCA GGGCACGAAT CAGGCGCCTC TCCATGCACC CGCTGTACCA GTCTTGGGTG 3600

ATTGCAGCTG TTCAAGGGAA TAATGAAGTA TCCATGTGGG ACATGGAGAC TGGTGACAGA 3660

AGGTTTACAC TCTGGGCCAG CAGCGCACCG CCACTTTCTG AGCTACAGCC TTCTCCTCAT 3720

AGTGTTCATG GTATCTACTG CAGTCCTGCA GATGGGAATC CTATCCTGCT AACAGCTGGT 3780

TCAGACATGA AAATAAGGTT TTGGGACTTG GCTTACCCGG AAAGATCTTA TATTGTGGCA 3840

GGAAGTACCA GTTCCCCATC TGTGTCCTAC TATAGAAAAA TAATAGAAGG CACCGAGGTT 3900

GTCCAGGAAA TTCAGAATAA ACAGAAAGTA GGACCAAGTG ATGATACCCC TCGAAGGGGC 3960

CCAGAATCTT TGCCTGTGGG GCATCATGAC ATCATCACAG ATGTTGCTAC TTTCCAGACA 4020

ACACAAGGTT TCATCGTGAC TGCTTCTAGA GATGGGATTG TAAAGGTGTG GAAG 4074

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKAAEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         ++++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GMFATELecmRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied ++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGHFFPEQVLNKIEDLSIRELVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLNSAQNCL 60

PFQKAAEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GMFATELECM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGHFFPE QVLNKIEDLS IRELVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013