EKS-CAP-00404
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00404
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src432.73.9E-130239489251
StatusUnreviewed
Ensembl ProteinENSCPOP00000007076
UniProt AccessionH0VB15;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000007861ENSCPOP00000007076ENSCPOT00000007936
OrganismCavia porcellus
Functional Description
Protein Length504
Protein Sequence
(FASTA)
RMGCVKSKFL RDRGKGSKTE SSSNLHTPVY VPDPTSSLKP GPNSHSNPPG LLEGSQDFIV 60
VALYDYDAIH REDLSFQKGD QMVVLEESGE WWRARSLATR KEGYIPSNYV ACVNSLETEE 120
WFFKGISRKD AERQLLAPGN MLGSFMIRDS ETTKGSYSLS VRDYDPQLGD TVKHYKIRTL 180
DNGGFYVSPR STFNSLQELV AHYKKGKDGL CQKLSVPCLS SKPQKPWEKD AWEIPRESLK 240
LEKRLGAGQF GEVWMATYNK HTKVAVKTMK PGSMSVEAFL EEANIMKTLQ HDKLVKLHAV 300
VTQEPIYIIT EFMAKGGSLL DFLKSEEGSR QPLPKLIDFS AQIAEGMAFI EQRNYIHRDL 360
RAANILVSSS LVCKIADFGL ARVIEDNEYT AREGAKFPIK WTAPEAINFG SFTIKSDVWS 420
FGILVMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPDHC PEELYNIMTR CWRNRPEERP 480
TFEYIQSVLD DFYTATESQY QQQP 504
Nucleotide Sequence
(FASTA)
AGGATGGGAT GTGTGAAGTC CAAGTTCCTC CGGGATAGAG GGAAAGGCTC CAAAACCGAG 60
TCTAGCTCCA ACTTGCACAC CCCTGTGTAT GTACCGGATC CCACGTCCTC GCTCAAGCCG 120
GGGCCTAACA GCCACAGCAA CCCCCCGGGG CTCTTGGAGG GTTCCCAGGA CTTCATTGTG 180
GTTGCCCTGT ATGATTACGA TGCCATTCAC AGAGAAGACC TCAGCTTCCA GAAAGGGGAC 240
CAGATGGTGG TCCTGGAGGA GTCAGGGGAG TGGTGGAGGG CACGATCCTT AGCCACCAGG 300
AAAGAGGGTT ACATCCCAAG CAACTATGTG GCCTGTGTTA ACTCTCTGGA GACGGAGGAG 360
TGGTTCTTCA AGGGCATCAG CCGGAAGGAT GCAGAGCGCC AGCTCCTGGC TCCTGGCAAC 420
ATGCTGGGCT CCTTCATGAT CCGAGACAGC GAGACCACCA AAGGAAGCTA CTCTTTGTCT 480
GTTCGAGACT ACGACCCTCA GCTAGGAGAC ACTGTGAAGC ATTACAAGAT CCGGACCCTG 540
GACAATGGGG GTTTCTATGT ATCCCCAAGG AGCACCTTCA ACAGCCTGCA GGAGCTGGTG 600
GCCCACTACA AGAAGGGGAA GGATGGGCTG TGCCAGAAGC TATCAGTGCC CTGCCTGTCC 660
TCCAAGCCCC AGAAGCCGTG GGAGAAAGAT GCCTGGGAGA TCCCCCGGGA ATCCCTCAAG 720
CTGGAGAAGA GACTTGGAGC TGGGCAGTTT GGGGAAGTCT GGATGGCCAC CTACAACAAG 780
CACACCAAGG TGGCCGTGAA GACCATGAAG CCGGGGAGCA TGTCTGTGGA GGCCTTCCTG 840
GAGGAGGCCA ACATCATGAA GACGCTGCAG CACGACAAGC TGGTGAAGCT GCACGCAGTG 900
GTCACGCAGG AACCCATCTA CATCATCACG GAGTTCATGG CCAAAGGTGG AAGTCTGCTG 960
GACTTTTTGA AAAGCGAAGA AGGCAGTAGG CAGCCCTTGC CAAAACTGAT TGACTTCTCT 1020
GCTCAGATTG CAGAAGGCAT GGCCTTCATC GAGCAGAGGA ACTACATTCA CCGAGACCTC 1080
CGAGCTGCCA ACATCTTGGT CTCCTCCTCG CTGGTGTGTA AGATTGCTGA CTTTGGCCTG 1140
GCGCGGGTCA TCGAGGACAA TGAGTACACA GCTCGGGAAG GGGCCAAGTT CCCCATCAAG 1200
TGGACAGCTC CTGAAGCCAT CAACTTTGGC TCCTTCACCA TCAAGTCTGA TGTCTGGTCC 1260
TTTGGCATCC TAGTGATGGA GATTGTCACC TACGGCCGGA TCCCTTACCC AGGAATGTCC 1320
AACCCAGAGG TGATCCGGGC GCTGGAGCAT GGGTACCGGA TGCCTCGACC AGACCACTGT 1380
CCAGAGGAGC TCTACAACAT CATGACACGC TGCTGGAGGA ACCGCCCAGA GGAGCGGCCC 1440
ACCTTCGAGT ATATCCAGAG TGTGCTGGAT GACTTCTACA CAGCCACTGA AAGCCAGTAC 1500
CAACAGCAGC CTTGA 1515
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+k+lG+GqfGevw++++++++kvavkt+k+g++s eafleea+i+k+l+h+klvkl+
Q: 239   LKLEKRLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLEEANIMKTLQHDKLVKLH  298
         689*********************************************************
S: 61    avvseeePiyivtelmak.GslldflkeeegkklklpklvdlaaqvaeGmayleeknlih  119
         avv++ ePiyi+te+mak Gslldflk+eeg++++lpkl+d++aq+aeGma++e++n+ih
Q: 299   AVVTQ-EPIYIITEFMAKgGSLLDFLKSEEGSRQPLPKLIDFSAQIAEGMAFIEQRNYIH  357
         ****9.**********99459***************************************
S: 120   rdlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksd  179
         rdl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksd
Q: 358   RDLRAANILVSSSLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD  417
         ************************************************************
S: 180   vWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpe  239
         vWsfGil++eivt+G++PypGm+n ev++++e+gyr+prp++cpeely+++++cw+++pe
Q: 418   VWSFGILVMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDHCPEELYNIMTRCWRNRPE  477
         ************************************************************
S: 240   erPtfetlqevl  251
         erPtfe++q+vl
Q: 478   ERPTFEYIQSVL  489
         ********9976
Domain Sequence
(FASTA)
LKLEKRLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLEEANIMKT LQHDKLVKLH 60
AVVTQEPIYI ITEFMAKGGS LLDFLKSEEG SRQPLPKLID FSAQIAEGMA FIEQRNYIHR 120
DLRAANILVS SSLVCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV 180
WSFGILVMEI VTYGRIPYPG MSNPEVIRAL EHGYRMPRPD HCPEELYNIM TRCWRNRPEE 240
RPTFEYIQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013