EPS-CAP-00107

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00107

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PPP_Unique	432.2	8.6E-130	39	338	300

Status

Unreviewed

Ensembl Protein

ENSCPOP00000007213

UniProt Accession

H0VBD6;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CB

Gene Synonyms/Alias

PPP3CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000008013	ENSCPOP00000007213	ENSCPOT00000008088

Organism

Cavia porcellus

Functional Description

Protein Length

524

Protein Sequence
(FASTA)

TAPEPARDEP SPPPPLMPHS GADANITAVP FPPTHRLTSE EVFDMDGIPR VDVLKNHLVK 60

EGRVDEEIAL RIINEGAAIL RREKTMIEVE APITVCGDIH GQFFDLMKLF EVGGSPANTR 120

YLFLGDYVDR GYFSIECVLY LWVLKILYPS TLFLLRGNHE CRHLTEYFTF KQECKIKYSE 180

RVYEACMEAF DSLPLAALLN QQFLCVHGGL SPEIHTLDDI RRLDRFKEPP AFGPMCDLLW 240

SDPSEDFGNE KSQEHFSHNT VRGCSYFYNY PAVCEFLQNN NLLSIIRAHE AQDAGYRMYR 300

KSQTTGFPSL ITIFSAPNYL DVYNNKAAVL KYENNVMNIR QFNCSPHPYW LPNFMDVFTW 360

SLPFVGEKVT EMLVNVLSIC SDDELMTEGE DQFDVGSAAA RKEIIRNKIR AIGKMARVFS 420

VLREESESVL TLKGLTPTGM LPSGVLAGGR QTLQSATVEA IEAEKAIRGF SPPHRICSFE 480

EAKGLDRINE RMPPRKDAVQ QDGFNSLNTA HATENHGTGN HSAQ 524

Nucleotide Sequence
(FASTA)

ACCGCCCCGG AGCCGGCCCG GGATGAACCG TCTCCGCCGC CCCCTCTAAT GCCCCATTCT 60

GGGGCTGACG CAAATATTAC AGCTGTCCCT TTCCCTCCAA CTCATCGATT GACATCTGAA 120

GAAGTATTTG ATATGGATGG GATACCCAGG GTTGATGTTC TGAAGAACCA CCTAGTAAAA 180

GAAGGTCGGG TTGATGAAGA AATTGCACTT AGAATTATCA ATGAGGGTGC TGCTATTCTT 240

CGGAGAGAGA AAACCATGAT AGAAGTAGAA GCTCCAATTA CAGTGTGTGG TGACATCCAT 300

GGCCAATTTT TTGATCTGAT GAAACTTTTT GAAGTAGGAG GATCACCTGC TAATACCCGA 360

TACCTTTTTC TTGGTGATTA TGTGGACAGA GGTTATTTTA GTATAGAGTG TGTCTTATAT 420

TTATGGGTCC TGAAGATTCT ATACCCAAGC ACATTATTTC TTCTGAGAGG CAACCATGAA 480

TGCAGACATC TTACTGAATA TTTTACCTTT AAACAGGAAT GTAAAATTAA ATATTCAGAA 540

AGAGTCTATG AAGCTTGTAT GGAAGCTTTT GATAGCTTGC CCCTTGCTGC ACTTTTAAAC 600

CAACAGTTTC TTTGTGTACA TGGTGGACTT TCACCAGAAA TACACACACT GGATGACATT 660

AGGAGATTAG ATAGATTCAA AGAACCACCT GCATTTGGAC CAATGTGTGA CTTGCTATGG 720

TCCGATCCTT CTGAAGATTT TGGAAATGAG AAATCACAGG AACATTTTAG TCACAATACA 780

GTACGAGGAT GTTCCTATTT TTATAACTAT CCAGCAGTGT GTGAATTTTT GCAAAACAAT 840

AATTTGTTAT CGATTATTAG AGCTCATGAA GCTCAAGATG CAGGCTATAG AATGTACAGA 900

AAAAGTCAAA CTACAGGGTT CCCTTCATTA ATAACAATTT TTTCGGCACC TAATTACTTA 960

GATGTCTACA ATAATAAAGC TGCTGTATTA AAGTATGAAA ATAATGTGAT GAATATTCGA 1020

CAGTTTAATT GTTCTCCACA TCCTTACTGG TTGCCCAATT TTATGGATGT CTTCACATGG 1080

TCTTTACCAT TTGTTGGAGA AAAAGTGACA GAAATGTTGG TAAATGTTCT GAGTATTTGC 1140

TCTGATGATG AACTAATGAC TGAAGGTGAA GACCAGTTTG ATGTAGGTTC AGCTGCAGCC 1200

CGGAAAGAAA TCATAAGAAA CAAAATTCGA GCAATTGGGA AGATGGCAAG AGTCTTCTCT 1260

GTTCTCAGGG AGGAGAGTGA AAGTGTGCTG ACACTCAAGG GCCTGACTCC CACAGGGATG 1320

TTGCCTAGTG GAGTGTTGGC TGGAGGACGG CAGACCCTAC AAAGTGCCAC AGTTGAGGCT 1380

ATTGAGGCTG AAAAAGCAAT ACGAGGATTC TCTCCACCAC ATAGAATCTG CAGTTTTGAA 1440

GAGGCAAAGG GTTTGGATAG GATCAATGAG AGAATGCCAC CTCGGAAAGA TGCTGTACAG 1500

CAAGATGGTT TCAATTCTCT GAACACCGCA CATGCCACTG AGAACCACGG GACTGGCAAC 1560

CATAGTGCCC AG 1572

Domain Profile

S: 2     kkevfdidlllevfkekkhlkleaklveevllevkkvlkkllnlekvslevskpvtvcGD  61

         ++evfd+d++++v++ k+hl++e++++ee++l+++++++++l++ek+++ev++p+tvcGD

Q: 39    SEEVFDMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGD  98

         789*********************************************************

S: 62    iHGqfedllklfevgGlpsetkylflGDyvDRGkfsievlllLlalklkypeklfllrGN  121

         iHGqf+dl+klfevgG+p++t+ylflGDyvDRG+fsie++l+L++lk+ yp++lfllrGN

Q: 99    IHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN  158

         ************************************************************

S: 122   HEsrslnevygFkdEvkrkykarvyealtevfdlLplaallnekilcvHGGlspelktld  181

         HE+r+l+e+++Fk+E+k+ky++rvyea++e+fd Lplaalln+++lcvHGGlspe++tld

Q: 159   HECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLD  218

         ************************************************************

S: 182   dirkieRnkevPdegplcDlLWsDP......dksqeglvent.RGvsvlfgkdvvkkfle  234

         dir+++R+ke+P+ gp+cDlLWsDP      +ksqe++++nt RG+s+++++ +v++fl+

Q: 219   DIRRLDRFKEPPAFGPMCDLLWSDPsedfgnEKSQEHFSHNTvRGCSYFYNYPAVCEFLQ  278

         ************************************************************

S: 235   knnlkliiRaHevkdegyellrdskv......vtifsasnyyeegsnkgayiklasstlp  288

         +nnl +iiRaHe++d+gy+++r+s++      +tifsa+ny +  +nk+a +k +++ ++

Q: 279   NNNLLSIIRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVLKYENNVMN  338

         ************************97333333689******************9998775

Domain Sequence
(FASTA)

SEEVFDMDGI PRVDVLKNHL VKEGRVDEEI ALRIINEGAA ILRREKTMIE VEAPITVCGD 60

IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWVLKILY PSTLFLLRGN 120

HECRHLTEYF TFKQECKIKY SERVYEACME AFDSLPLAAL LNQQFLCVHG GLSPEIHTLD 180

DIRRLDRFKE PPAFGPMCDL LWSDPSEDFG NEKSQEHFSH NTVRGCSYFY NYPAVCEFLQ 240

NNNLLSIIRA HEAQDAGYRM YRKSQTTGFP SLITIFSAPN YLDVYNNKAA VLKYENNVMN 300

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005509	; F:calcium ion binding
GO:0005516	; F:calmodulin binding
GO:0008144	; F:drug binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0030346	; F:protein phosphatase 2B binding
GO:0035690	; P:cellular response to drug

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013