EKS-CAP-00341

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00341

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	527.4	6.3E-159	678	949	272

Status

Unreviewed

Ensembl Protein

ENSCPOP00000007403

UniProt Accession

H0VBV9;

Protein Name

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000008234	ENSCPOP00000007403	ENSCPOT00000008309

Organism

Cavia porcellus

Functional Description

Protein Length

1190

Protein Sequence
(FASTA)

SLGTSPGSKM ALQSSFTCWN GTVLQLGQAC DFHRDCAQGE DEGQLCSQLP ASFYCHFEDG 60

FCGWTQGTFS PDVPRWQVRT LKDAWSQDHQ DHALLLSTTE IPGPESATVT SATFPAPMKN 120

SPCELRMSWL IRGALRGNVS LVLVENKTGK EQSRMVWHVA TNKDLSLWQW TVLPLLNVSD 180

SMDRFWLQMV AWWGQGSRAT VAFDNISISL DCYLTISGED KLLQGEEPKS RNLYDRPPDK 240

EPPSEIVPRQ TATFDPTVHW LFTTCGASGP HGPTQTQCNN AYQNSNLSVM VGSEGPLKGV 300

QIWKVPATDT YRTSMYSQTG TQGSNQGMRH GTGVLVLTFF LRRKDDVLYI LVGQQGEDRL 360

PSTNHLIQKV CVGESNVIEE EIRVNRSVHE WAGGGGGGGG ATYVFKMKDG VPVPLIIAAG 420

GGGRAYGAKT DTFHPERLEN NSSVLGLNGN SGAAGGGGGW DDNTSLLWAG KSLLEGATGG 480

HACPQAMKKC SSGGGGGGYI GGNAASNNDP EMDGEDGVSF ISPLGILYTP ALKVMEGHGE 540

VNIKHYLNCS HCEVDECHMD PESHKVICFC DHGTVLAEDG VSCIVSPTPE PHLPLSLILS 600

VVTSALVAAL VLAFSGIMIV YRRKHQELQA MQMELQSPEY KLSKLRTSTI MTDYNPNYCF 660

AGKTSSISDL KEVPRKNITL IRGLGHGAFG EVYEGQVSGM PNDPSPLQVA VKTLPEVCSE 720

QDELDFLMEA LIISKFNHQN IVRCIGVSLQ ALPRFILLEL MAGGDLKSFL RETRPRPSQP 780

SSLAMLDLLH VARDIACGCQ YLEENHFIHR PRDIAARNCL LTCPGSGRIA KIGDFGMARD 840

IYRASYYRKG GCAMLPVKWM PPEAFMEGIF TSKTDTWSFG ILLWEIFSLG YMPYPSKSNQ 900

EVLEFVTSGG RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF AIILERIEYC TQDPDVINTA 960

LPIEYGPPVE EEEKVPMRPK DPEGMPPLLV SPQPAKQEEA RIPAPALPPP LSTVASSDKA 1020

VKKPTAAGVS VQGPRGPATA GGHVNMAFAQ SNPPPELRRV QGSRNKPTSL WNPTYGSWFT 1080

EKPAKKNNPP PKKEPQPRGS TGRAESCTVP PNATTSTGRL PGASLLLEPS SLTASMKEVP 1140

LFRLRHFPCG NVNYGYQQQG LPLEATTAPG AGHYEDTILK NKSNTGQPGP 1190

Nucleotide Sequence
(FASTA)

TCTCTAGGAA CGTCCCCAGG CTCCAAGATG GCCCTGCAGA GCTCCTTCAC TTGTTGGAAT 60

GGGACAGTCC TCCAGCTCGG GCAGGCCTGC GACTTCCACC GGGACTGCGC CCAGGGAGAA 120

GATGAGGGCC AGCTGTGCAG TCAACTTCCT GCTAGTTTTT ACTGCCACTT TGAGGATGGT 180

TTCTGCGGCT GGACCCAAGG CACCTTCTCA CCCGATGTGC CCCGGTGGCA GGTCAGGACC 240

CTGAAGGATG CTTGGTCCCA GGACCACCAA GACCATGCCC TGTTGCTCAG CACCACTGAG 300

ATCCCGGGTC CTGAAAGTGC TACCGTTACC AGTGCCACAT TTCCTGCACC AATGAAGAAT 360

TCTCCATGTG AGCTCAGAAT GTCCTGGCTC ATCCGTGGAG CCTTAAGGGG AAACGTGTCC 420

TTGGTGCTGG TGGAGAATAA AACCGGCAAG GAACAAAGCA GGATGGTCTG GCACGTGGCC 480

ACCAACAAAG ACTTGAGCTT GTGGCAGTGG ACAGTGCTTC CTCTCCTCAA CGTGTCCGAC 540

AGCATGGACA GGTTCTGGCT GCAGATGGTC GCTTGGTGGG GACAAGGATC CAGAGCCACG 600

GTGGCTTTTG ACAACATCTC CATCAGTCTG GACTGCTACC TCACCATCAG TGGAGAGGAC 660

AAGCTGCTCC AGGGTGAAGA GCCCAAATCA AGAAACCTGT ATGACAGACC CCCTGACAAG 720

GAGCCACCTT CGGAAATCGT ACCGAGACAG ACGGCCACCT TTGACCCTAC AGTTCACTGG 780

CTATTCACCA CGTGCGGGGC GAGTGGGCCC CACGGCCCCA CTCAGACCCA GTGCAACAAC 840

GCCTACCAGA ACTCCAACCT GAGCGTGATG GTGGGGAGCG AAGGGCCCTT GAAGGGCGTC 900

CAGATCTGGA AAGTGCCAGC CACCGACACC TACAGAACCT CCATGTATTC TCAAACAGGA 960

ACCCAGGGAA GTAATCAAGG CATGAGACAT GGGACGGGGG TCCTCGTCCT CACTTTCTTC 1020

CTTAGGAGAA AGGACGACGT GCTCTACATC CTCGTCGGGC AGCAGGGAGA GGACCGCCTG 1080

CCCAGCACAA ACCACTTAAT CCAGAAAGTC TGTGTTGGAG AGAGCAATGT GATAGAAGAA 1140

GAAATTCGCG TGAACAGAAG CGTGCATGAG TGGGCAGGAG GAGGCGGAGG CGGGGGTGGA 1200

GCCACCTACG TGTTTAAGAT GAAGGACGGA GTGCCCGTGC CCCTCATCAT TGCAGCTGGT 1260

GGCGGTGGCA GGGCCTACGG GGCCAAGACA GACACGTTCC ACCCAGAGAG ACTGGAGAAT 1320

AACTCCTCGG TTCTGGGGCT GAACGGCAAT TCCGGAGCCG CAGGTGGTGG AGGTGGCTGG 1380

GATGATAACA CTTCCTTGCT CTGGGCCGGA AAATCTTTGT TGGAGGGCGC TACTGGAGGA 1440

CATGCCTGCC CCCAGGCCAT GAAGAAGTGC TCCTCAGGTG GAGGAGGCGG AGGATATATA 1500

GGTGGCAATG CAGCCTCCAA CAATGACCCT GAAATGGACG GGGAAGATGG GGTTTCCTTC 1560

ATCAGCCCCC TGGGCATCCT GTACACCCCA GCTTTAAAAG TGATGGAGGG CCATGGGGAA 1620

GTGAATATTA AGCATTACCT AAACTGCAGT CACTGTGAGG TAGACGAATG TCACATGGAC 1680

CCTGAGAGCC ACAAGGTCAT CTGCTTCTGT GACCATGGGA CGGTGCTGGC TGAGGATGGA 1740

GTCTCCTGCA TTGTGTCGCC CACCCCAGAA CCCCACCTGC CTCTCTCGCT GATCCTCTCC 1800

GTGGTGACCT CTGCCCTGGT GGCCGCCCTT GTCCTGGCTT TCTCTGGCAT CATGATAGTG 1860

TACCGACGCA AGCACCAGGA GCTGCAAGCC ATGCAGATGG AGCTGCAGAG CCCTGAGTAC 1920

AAGCTCAGCA AGCTGCGCAC CTCCACCATC ATGACTGACT ACAATCCCAA CTACTGCTTT 1980

GCTGGCAAGA CCTCCTCCAT CAGTGACCTA AAAGAGGTGC CCCGGAAAAA CATCACCCTC 2040

ATTCGGGGTC TGGGCCACGG TGCATTTGGC GAGGTGTATG AAGGCCAGGT GTCTGGGATG 2100

CCCAACGATC CGAGCCCCCT GCAAGTGGCC GTGAAGACGC TGCCGGAAGT GTGCTCTGAA 2160

CAGGACGAGC TCGACTTCCT CATGGAAGCT CTGATCATCA GCAAATTCAA CCACCAGAAC 2220

ATTGTGCGCT GTATCGGGGT GAGTCTGCAA GCCCTGCCCC GCTTCATCCT TCTGGAGCTC 2280

ATGGCAGGTG GAGACCTCAA GTCCTTCCTC CGGGAGACAC GCCCTCGCCC AAGTCAGCCC 2340

TCCTCCCTGG CCATGCTGGA CCTTCTGCAT GTGGCTCGGG ACATTGCCTG TGGCTGTCAG 2400

TATCTAGAGG AAAACCACTT CATCCACCGC CCCAGAGACA TTGCTGCCAG GAACTGCCTC 2460

TTGACCTGTC CAGGCAGCGG AAGAATAGCA AAGATTGGAG ATTTTGGGAT GGCCCGAGAC 2520

ATCTACAGAG CCAGCTACTA CAGAAAAGGA GGGTGCGCCA TGCTGCCTGT CAAATGGATG 2580

CCCCCCGAGG CTTTCATGGA AGGGATATTT ACTTCGAAAA CGGACACTTG GTCCTTCGGC 2640

ATCCTGCTGT GGGAAATCTT CTCTCTGGGC TACATGCCGT ACCCCAGCAA AAGCAACCAG 2700

GAGGTTCTGG AGTTCGTCAC CAGCGGAGGA CGGATGGACC CACCTAAGAA CTGCCCCGGG 2760

CCTGTGTACC GGATAATGAC CCAGTGCTGG CAACACCAGC CTGAAGACAG ACCCAATTTT 2820

GCCATAATTT TGGAGAGGAT TGAATACTGC ACACAGGATC CAGATGTCAT CAACACTGCT 2880

CTGCCCATAG AGTATGGCCC GCCAGTGGAG GAGGAGGAGA AAGTGCCCAT GCGGCCCAAA 2940

GACCCTGAGG GGATGCCTCC TCTGTTGGTG TCTCCCCAGC CGGCTAAGCA GGAGGAGGCA 3000

CGCATCCCGG CCCCAGCTCT GCCGCCACCC CTGTCCACCG TGGCCTCCTC TGATAAGGCT 3060

GTGAAGAAGC CCACAGCTGC AGGGGTCTCG GTGCAGGGTC CCCGGGGGCC GGCTACAGCA 3120

GGGGGACATG TTAACATGGC ATTCGCTCAG TCGAACCCAC CACCGGAGCT GCGCAGGGTC 3180

CAGGGATCCA GAAACAAGCC GACCAGCTTG TGGAACCCAA CTTATGGCTC GTGGTTTACA 3240

GAGAAACCTG CCAAAAAGAA CAATCCTCCC CCCAAAAAGG AGCCGCAGCC GCGGGGCAGC 3300

ACAGGCCGTG CAGAAAGCTG CACTGTGCCA CCCAATGCCA CCACCTCCAC TGGCAGACTT 3360

CCTGGGGCCT CCTTGCTGCT GGAGCCGTCC TCGCTGACCG CCAGCATGAA GGAGGTGCCT 3420

CTGTTCCGGC TGCGTCACTT CCCTTGCGGG AATGTCAACT ACGGCTACCA ACAGCAGGGC 3480

TTACCTTTAG AGGCCACCAC CGCCCCTGGG GCTGGTCATT ACGAGGACAC CATTCTGAAG 3540

AACAAAAGCA ACACTGGCCA ACCTGGGCCC TGA 3573

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 678   ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  737

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 738   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC  797

         ************************************************************

S: 121   Gckyleenkfihr..diaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpv  178

         Gc+yleen+fihr  diaarn+ll+++G++r+aki+dfGmardiyra+yyrkgg+a+lpv

Q: 798   GCQYLEENHFIHRprDIAARNCLLTCPGSGRIAKIGDFGMARDIYRASYYRKGGCAMLPV  857

         ************555*********************************************

S: 179   kwmppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspke  238

         kwmppeaf+eGiftsktd+wsfG+llwe+fslG++pyp+ksnqevle+v++Ggr+d+pk+

Q: 858   KWMPPEAFMEGIFTSKTDTWSFGILLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN  917

         ************************************************************

S: 239   ipgsvyrimtdcwkhepedrpkfvsilerlqa  270

         +pg+vyrimt+cw+h+pedrp+f++iler+++

Q: 918   CPGPVYRIMTQCWQHQPEDRPNFAIILERIEY  949

         *****************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP SQPSSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRPRDIAAR NCLLTCPGSG RIAKIGDFGM ARDIYRASYY RKGGCAMLPV 180

KWMPPEAFME GIFTSKTDTW SFGILLWEIF SLGYMPYPSK SNQEVLEFVT SGGRMDPPKN 240

CPGPVYRIMT QCWQHQPEDR PNFAIILERI EY 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013