EKS-CAP-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.5	2.4E-111	726	1019	294

Status

Unreviewed

Ensembl Protein

ENSCPOP00000007545

UniProt Accession

H0VC94;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000008392	ENSCPOP00000007545	ENSCPOT00000008467

Organism

Cavia porcellus

Functional Description

Protein Length

1490

Protein Sequence
(FASTA)

MPNSERHGGK KDGSGGASGT SQPSSGGGGS NSRERHRLVS KHKRHKSKHS KDMGLVTPET 60

ASLGTVIKPL VEYDDISSDS DTFSDDMGFK LDRRENDERR GTDRSDRLHR HRHHQHRRSR 120

DLLKTKQAEK EKNQEVSGKS GSVKDRTSGN SKRSNEEDDY GKAPLSKSSG KESRSSKLHK 180

EKTRKERELK SGHKDRSKSH RKRETPKSYK TVDSPKRRSR SPHRKWSDSS KQDDSPSGAS 240

YSQDYDLSPP RSHTSSNYDS YKKSPGSTSR RQSISPPYKE PSAYQSSNRS PSPYSRRQRS 300

VSPYGRRRSS SYERSGSYSG RSPSPYGRRR SSSPFLSKRS LSRSPLPSRK SMKSRSRSPA 360

YSRHSSSHSK KKRSGSRSRH SSISPVRLPL NSSLGAELSR KKKERAAAAA AAKMDGKESK 420

GSPIFLPKKE NSSVEAKDSG LESKKLPKSI KLEKCAPDTE LLNVTHSNTE VKNSLDTGKV 480

KLDENSEKHP IMKDLKVQGT KDSKPVTLKE EIATPKEPEI PEKKTPPPLP TITSPPPLPT 540

TTPPPQTPPL PPLPPLPAVP QQPPLPPPQP TCSQVPAPST STLPPSTHPR TSTLSSQASS 600

QPSVHISVKT QVSVTAAIPH LKTSTLPPLP LPPLLPGDDD IDSPKETLPS KPVKKEKEQR 660

TRHLLTDLPL PPELPGGDPS PPDSPEPKAI TPPQQPFKKR PKICCPRYGE RRQTETDWGK 720

RCVDKFDIIG IIGEGTYGQV YKAKDKDTGE LVALKKVRLD NEKEGFPITA IREIKILRQL 780

IHRSVVNMKE IVTDKQDALD FKKDKGAFYL VFEYMDHDLM GLLESGLVHF SEDHIKSFMK 840

QLMEGLDYCH KKNFLHRDIK CSNILLNNSG QIKLADFGLA RLYNSEESRP YTNKVITLWY 900

RPPELLLGEE RYTPAIDVWS CGCILGELFT KKPIFQANLE LAQLELISRL CGSPCPAVWP 960

DVIKLPYFNT MKPKKQYRRR LREEFSFIPS AALDLLDHML TLDPSKRCTA EQTLQSDFLK 1020

DVELSKMAPP DLPHWQDCHE LWSKKRRRQR QSGVVVEEPP PSKVSRKETT SGTSAEPLKS 1080

SSPAPPQPAT GKVEQPGAGD SVGLGDITQQ LNQSELAVLL NLLHSQTDLS IPQMAQLLNI 1140

HSNPEMQQQL EALNQSISAL TEATSQQQNS EPIAPEESLK EVPPAPAAQP SAEQTTPEAS 1200

STPADMQNML AVFLSQLMKT QEPAGNLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL 1260

PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH 1320

QALRPMEYST RPHPNRTYGN TDGPETGFSG TDTDERSSGP ALTESLVQTL VKNRTFSGSV 1380

SHLGESSSYQ GTGSVQFPGD QDLRFARVPV ALHSVVGQPF LKAEGSSNSV VHTEAKLQNY 1440

GELGPGTSGT TSSGASLHWG APAQSSAYGK LYRGSARVPP RGGRGRGVPY 1490

Nucleotide Sequence
(FASTA)

ATGCCCAATT CCGAGAGACA TGGGGGCAAG AAGGACGGGA GTGGAGGAGC CTCTGGAACT 60

TCGCAGCCGT CATCGGGAGG TGGCGGCTCC AACAGCAGAG AGCGTCACCG CCTGGTGTCG 120

AAGCACAAGC GGCACAAGTC CAAGCACTCC AAAGACATGG GCTTGGTGAC CCCGGAGACG 180

GCATCCTTGG GCACAGTTAT CAAACCTTTG GTGGAGTACG ATGACATCAG CTCCGATTCC 240

GACACCTTCT CTGACGACAT GGGCTTCAAA CTGGACAGGA GGGAGAATGA TGAGCGGCGT 300

GGAACGGATC GGAGCGACCG CCTGCACAGA CACCGTCACC ACCAGCACCG ACGTTCCCGG 360

GACTTGCTCA AAACCAAACA GGCCGAAAAA GAAAAGAACC AGGAAGTGTC CGGCAAGTCG 420

GGCTCGGTGA AGGACCGGAC GTCGGGAAAT TCCAAGCGCT CAAATGAAGA GGACGACTAT 480

GGGAAGGCAC CCCTGTCTAA AAGCAGCGGC AAGGAATCGC GGTCGTCTAA GCTGCACAAG 540

GAGAAGACCC GGAAAGAACG AGAGCTGAAG TCCGGGCACA AGGACCGGAG TAAGAGTCAT 600

CGGAAAAGGG AAACACCCAA AAGTTACAAA ACCGTGGACA GCCCCAAGCG GAGATCCCGG 660

AGTCCCCACC GGAAATGGTC TGACAGCTCC AAGCAAGATG ACAGCCCCTC AGGCGCCTCT 720

TACAGCCAAG ATTATGATCT TAGTCCCCCC AGATCGCACA CCTCTAGCAA TTATGACTCC 780

TACAAGAAGA GTCCTGGAAG CACTTCGAGA AGGCAGTCGA TCAGCCCCCC GTACAAAGAG 840

CCCTCTGCCT ACCAGTCCAG CAACCGCTCG CCAAGTCCCT ACAGTAGACG ACAGAGGTCC 900

GTGAGTCCCT ACGGTCGCAG GCGGTCGTCC AGCTATGAAA GGAGCGGCTC ATACAGCGGG 960

AGGTCCCCCA GTCCCTACGG GCGGAGGCGA TCCAGCAGCC CTTTCCTGAG CAAGCGGTCC 1020

CTGAGCCGGA GTCCACTTCC CAGTAGGAAA TCCATGAAGT CCAGAAGTAG AAGTCCTGCA 1080

TATTCAAGAC ATTCATCTTC CCATAGTAAA AAGAAGAGAT CTGGGTCACG CAGTCGTCAT 1140

TCCAGTATTT CACCTGTCAG GCTTCCGTTG AATTCCAGCC TGGGAGCTGA ACTTAGTAGA 1200

AAAAAGAAGG AAAGAGCTGC TGCTGCTGCA GCAGCAAAAA TGGATGGAAA GGAGTCCAAG 1260

GGTTCACCTA TATTTTTGCC TAAAAAAGAG AATAGTTCAG TGGAGGCTAA GGATTCAGGC 1320

TTGGAGTCTA AAAAGTTACC CAAAAGTATA AAGTTGGAAA AATGTGCCCC AGACACTGAA 1380

CTGCTGAATG TAACCCATTC AAACACAGAG GTCAAAAATT CTTTAGATAC AGGGAAAGTA 1440

AAGTTGGATG AGAACTCTGA GAAGCATCCT ATTATGAAAG ATTTGAAAGT ACAGGGAACA 1500

AAAGACTCTA AACCTGTAAC ACTGAAAGAG GAAATTGCTA CTCCAAAGGA GCCAGAGATA 1560

CCAGAAAAGA AGACCCCTCC ACCTCTCCCC ACAATTACTT CTCCACCTCC TTTACCAACT 1620

ACTACCCCTC CCCCTCAGAC ACCTCCATTA CCACCTTTGC CTCCACTACC AGCTGTTCCA 1680

CAGCAACCAC CTCTGCCTCC TCCTCAACCA ACCTGTAGTC AGGTTCCTGC TCCCAGTACG 1740

TCAACTTTGC CCCCCTCTAC TCACCCAAGG ACATCTACTC TGTCCTCTCA GGCAAGTTCT 1800

CAGCCCTCTG TACACATTTC TGTGAAGACT CAAGTTTCTG TAACAGCTGC TATTCCACAT 1860

CTGAAAACTT CAACATTGCC TCCTCTGCCT CTCCCACCCT TGTTACCTGG AGACGATGAC 1920

ATAGATAGTC CAAAAGAAAC TCTTCCTTCA AAACCTGTAA AGAAAGAGAA GGAACAGAGG 1980

ACACGCCATT TACTCACAGA CCTTCCTCTT CCTCCTGAGC TCCCTGGTGG GGACCCATCT 2040

CCCCCAGACT CTCCAGAGCC AAAGGCAATT ACACCACCTC AGCAACCATT TAAAAAGAGA 2100

CCAAAAATTT GTTGTCCTCG CTATGGAGAA AGACGACAAA CAGAAACTGA CTGGGGGAAA 2160

CGCTGTGTGG ACAAGTTCGA CATTATTGGA ATTATTGGAG AGGGAACCTA TGGTCAGGTG 2220

TATAAAGCTA AAGACAAAGA TACAGGAGAG CTAGTGGCTC TGAAGAAGGT GAGACTAGAC 2280

AATGAGAAAG AGGGCTTCCC AATCACTGCC ATCCGTGAGA TCAAGATTCT CCGTCAGCTA 2340

ATCCACCGAA GTGTTGTCAA CATGAAGGAG ATTGTCACAG ATAAGCAAGA TGCACTGGAT 2400

TTCAAGAAAG ACAAAGGTGC CTTTTACCTT GTATTTGAGT ATATGGACCA TGACTTAATG 2460

GGACTGCTTG AATCTGGCTT GGTGCACTTT TCTGAGGACC ACATTAAGTC GTTCATGAAA 2520

CAGCTAATGG AAGGGCTGGA TTACTGTCAC AAAAAGAATT TCCTGCATCG GGATATTAAG 2580

TGTTCAAACA TTTTGCTGAA CAACAGCGGA CAAATCAAAC TAGCAGATTT TGGACTTGCT 2640

CGGCTCTATA ATTCTGAAGA GAGTCGCCCT TACACGAACA AAGTCATTAC TCTGTGGTAC 2700

CGCCCACCAG AGCTGCTGCT GGGAGAGGAG CGTTATACGC CAGCCATAGA TGTTTGGAGC 2760

TGTGGGTGCA TCCTTGGGGA ACTGTTCACT AAGAAGCCTA TTTTTCAAGC TAATCTGGAA 2820

CTGGCTCAGC TGGAACTGAT CAGCCGTCTC TGTGGTAGCC CTTGTCCAGC TGTGTGGCCT 2880

GATGTTATCA AGCTGCCCTA CTTCAACACC ATGAAGCCAA AGAAGCAATA CAGACGCCGT 2940

CTACGAGAGG AATTCTCTTT CATTCCTTCA GCAGCACTTG ATTTATTGGA TCACATGCTG 3000

ACTCTGGATC CTAGCAAGCG CTGCACAGCG GAACAGACCC TACAGAGTGA CTTCCTTAAA 3060

GACGTTGAGC TCAGCAAAAT GGCTCCGCCC GACCTCCCTC ACTGGCAGGA TTGCCATGAA 3120

TTGTGGAGTA AGAAACGGCG ACGGCAGCGA CAAAGTGGTG TTGTGGTGGA AGAGCCACCT 3180

CCGTCCAAAG TTTCTCGGAA AGAAACTACC TCAGGGACAA GTGCTGAGCC TCTGAAGAGC 3240

AGTAGCCCAG CACCCCCTCA GCCTGCTACT GGCAAAGTGG AGCAGCCTGG GGCTGGGGAT 3300

TCAGTAGGCC TTGGTGACAT CACACAGCAG CTGAATCAAA GTGAATTAGC AGTGTTATTG 3360

AACCTGCTGC ATAGTCAGAC TGACCTGAGC ATCCCTCAAA TGGCACAGCT GCTTAACATC 3420

CACTCTAACC CGGAGATGCA GCAGCAGCTG GAAGCCCTCA ACCAATCCAT CAGTGCCCTG 3480

ACAGAAGCCA CTTCCCAGCA GCAGAATTCA GAGCCCATAG CCCCAGAGGA GTCTTTGAAG 3540

GAAGTACCCC CTGCCCCAGC AGCCCAGCCT TCAGCAGAGC AGACAACCCC TGAAGCTTCC 3600

AGCACACCAG CTGACATGCA GAATATGTTG GCAGTTTTCT TGAGTCAGCT GATGAAAACC 3660

CAGGAGCCAG CAGGCAACCT AGAGGAAAAC AACAGTGACA AGAATAGTGG GCCACAGGGG 3720

CCCCGAAGAA CTCCCACAAT GCCACAGGAG GAGGCAGCAG CATGTCCTCC TCACATTCTT 3780

CCACCAGAGA AGAGGCCCCC TGAACCCCCC GGACCTCCAC CGCCGCCACC TCCACCCCCT 3840

CTGGTTGAAG GCGATCTTTC CAGCGCCCCC CAGGAGTTGA ACCCCGCCGT GACAGCCGCC 3900

TTGCTACAAC TTTTATCCCA GCCTGAAGCA GAGCCTCCTG GCCACCTGCC ACATGAGCAC 3960

CAGGCCTTGA GACCAATGGA GTACTCCACC CGACCCCATC CCAACAGGAC TTACGGCAAC 4020

ACTGATGGGC CTGAAACAGG GTTCAGTGGC ACTGACACTG ATGAACGCAG CTCTGGTCCA 4080

GCCTTGACAG AATCCTTGGT CCAGACCCTG GTGAAGAACA GGACCTTCTC AGGCTCTGTG 4140

AGCCACCTTG GGGAGTCCAG CAGTTACCAG GGCACAGGGT CAGTGCAGTT CCCTGGGGAC 4200

CAGGATCTCC GTTTTGCCAG GGTTCCCGTA GCATTACACT CAGTGGTCGG GCAACCATTT 4260

CTGAAGGCAG AGGGCAGCAG CAACTCTGTG GTGCACACAG AGGCCAAATT GCAAAACTAT 4320

GGGGAGCTGG GGCCAGGAAC TTCTGGGACC ACCAGCTCAG GAGCAAGTCT TCACTGGGGG 4380

GCCCCAGCTC AGTCTTCTGC TTACGGAAAA CTCTATCGGG GATCTGCAAG AGTTCCGCCA 4440

CGAGGGGGAC GAGGGAGAGG AGTTCCTTAC 4470

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 726   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  785

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 786   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  844

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 845   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  904

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 905   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  964

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++

Q: 965   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1019

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013