EKS-CAP-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.4	6.9E-126	221	507	287

Status

Unreviewed

Ensembl Protein

ENSCPOP00000007705

UniProt Accession

H0VCN4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000008575	ENSCPOP00000007705	ENSCPOT00000008652

Organism

Cavia porcellus

Functional Description

Protein Length

542

Protein Sequence
(FASTA)

FYTRRFVSEE DPGNWISSEN FLRLPQRLGK MGAAAKLAFA VFLISCSSGC YTGRSETQEC 60

LFFNANWERD TNQTGVEPCY GDKDKRRHCF ATWKNISGSI EIVKQGCWLD DINCYDRTDC 120

IEKKDSPEVY FCCCEGNMCN EKFSYFPEME VTQPTSNPVT PKAPYYNILL YSLVPLMLIA 180

GIVICAFWVY RHHKMAYPPV LVPTQDPGPP PPSPLLGLKP LQLLEVKARG RFGCVWKAQL 240

LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG AEKRGTSVDV DLWLITAFHE 300

KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK DGHKPAISHR DIKSKNVLLK 360

NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL EGAINFQRDA FLRIDMYAMG 420

LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV VVHKKKRPVL RDYWQKHAGM 480

AMLCETIEEC WDHDAEARLS AGCVGERITQ MQRLTNIITT EDIVTVVTMV TNVDFPPKES 540

SL 542

Nucleotide Sequence
(FASTA)

TTTTACACCA GGAGGTTTGT CTCCGAGGAA GACCCAGGGA ACTGGATTTC TAGCGAGAAC 60

TTCCTACGGC TTCCCCAGCG CCTCGGGAAA ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC 120

GTCTTTCTTA TCTCTTGTTC TTCAGGGTGC TATACTGGTA GATCAGAAAC TCAGGAGTGT 180

CTTTTCTTTA ATGCTAATTG GGAAAGAGAC ACCAATCAAA CTGGTGTGGA ACCCTGTTAT 240

GGTGACAAAG ATAAACGGCG ACATTGTTTT GCTACCTGGA AGAATATTTC TGGTTCCATT 300

GAAATAGTGA AACAAGGTTG TTGGCTGGAT GATATCAACT GCTATGACAG GACTGATTGC 360

ATAGAAAAAA AAGACAGCCC AGAAGTATAT TTTTGTTGCT GTGAAGGCAA CATGTGTAAT 420

GAAAAATTTT CTTACTTTCC AGAAATGGAA GTCACACAGC CTACTTCAAA TCCAGTTACA 480

CCTAAAGCAC CATATTACAA CATTCTGCTT TATTCCTTGG TGCCACTTAT GTTGATTGCG 540

GGGATTGTCA TTTGTGCATT TTGGGTATAT AGGCATCACA AGATGGCCTA CCCTCCTGTA 600

CTTGTTCCAA CTCAAGACCC AGGACCACCT CCACCCTCTC CGTTACTAGG TTTGAAACCA 660

CTGCAATTAT TAGAAGTGAA AGCAAGGGGA AGATTCGGTT GTGTCTGGAA AGCCCAGTTA 720

CTCAATGAGT ATGTGGCTGT CAAAATATTT CCAATACAGG ACAAACAATC GTGGCAAAAT 780

GAATATGAAG TCTATAGTTT GCCTGGAATG AAGCATGAGA ACATATTACA GTTTATTGGT 840

GCAGAAAAAC GAGGTACCAG TGTAGATGTG GATCTTTGGC TTATTACAGC ATTTCATGAA 900

AAGGGTTCAC TATCAGACTT TCTTAAGGCT AATGTGGTCT CTTGGAACGA ACTGTGCCAT 960

ATTGCAGAAA CTATGGCTAG AGGGTTGGCA TATTTACATG AAGATATACC TGGCTTGAAA 1020

GATGGCCACA AACCCGCAAT ATCTCACAGG GACATCAAAA GTAAAAATGT GTTGCTGAAA 1080

AATAATCTGA CAGCTTGTAT TGCTGACTTT GGATTGGCAT TAAAGTTTGA GGCTGGCAAA 1140

TCTGCAGGTG ATACCCATGG ACAGGTTGGT ACTCGGAGAT ATATGGCCCC GGAGGTATTA 1200

GAGGGTGCTA TAAACTTCCA AAGGGATGCA TTTTTGAGGA TAGATATGTA TGCCATGGGA 1260

TTAGTCCTGT GGGAACTGGC TTCTCGCTGT ACTGCTGCAG ATGGACCCGT AGATGAGTAC 1320

ATGTTGCCAT TTGAAGAGGA AATTGGCCAG CATCCATCTC TTGAAGACAT GCAGGAAGTA 1380

GTTGTGCATA AAAAAAAGAG GCCTGTTTTA AGAGACTATT GGCAGAAACA TGCTGGAATG 1440

GCAATGCTTT GTGAAACAAT AGAAGAATGT TGGGATCATG ATGCAGAAGC CAGGTTATCA 1500

GCTGGATGTG TAGGTGAAAG AATTACCCAG ATGCAAAGAC TAACAAATAT CATTACTACA 1560

GAGGACATTG TAACAGTGGT CACAATGGTG ACAAATGTTG ACTTTCCTCC CAAAGAATCT 1620

AGTCTA 1626

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 221   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  280

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 281   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  340

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 341   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  398

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 399   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  457

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 458   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  507

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013