EKS-CAP-00312

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00312

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.3	3.2E-136	208	495	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000007891

UniProt Accession

H0VD50;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000008791	ENSCPOP00000007891	ENSCPOT00000008869

Organism

Cavia porcellus

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MVLEKLPIHP IGAKLILYSV SFADEKPKVN PKLYMCVCEG LSCGTDHCEG QQCFSSLSIN 60

DGYHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120

HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180

ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240

DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300

DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360

HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420

NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480

NPSARLTALR IKKTLTKIDN SLDKLKTDC 509

Nucleotide Sequence
(FASTA)

ATGGTTTTGG AGAAACTTCC CATTCATCCA ATAGGGGCTA AACTCATCCT TTACTCTGTG 60

TCCTTTGCAG ATGAGAAGCC CAAGGTCAAC CCCAAACTGT ACATGTGTGT GTGTGAAGGC 120

CTTTCTTGTG GGACTGACCA CTGTGAAGGC CAGCAGTGCT TCTCCTCGTT GAGCATCAAT 180

GATGGCTACC ATGTCTACCA GAAAGGCTGC TTCCAGGTGT ACGAGCAGGG CAAGATGACC 240

TGCAAGACTC CACCATCACC TGGCCAAGCC GTGGAATGCT GCCAAGGGGA CTGGTGTAAC 300

AGGAACATCA CGGCCCAGCT ACCCACGAAA GGGAAGTCCT TCCCTGGAAC ACAGAACTTC 360

CACTTGGAGG TCGGCCTCAT TATTCTCTCT GTAGTGTTCG CAGTATGCCT TCTAGCTTGC 420

CTACTGGGAG TTGCTCTCCG AAAATTTAAA AGGCGTAACC AAGAGCGCCT CAATCCCAGG 480

GATGTGGAGT ACGGCACCAT TGAAGGTCTC ATCACCACCA ATGTTGGAGA CAGCACATTA 540

GCAGATTTAT TGGATCATTC ATGTACATCA GGAAGTGGCT CTGGTCTTCC TTTTCTGGTA 600

CAAAGAACAG TGGCTCGCCA GATCACCTTG TTGGAGTGTG TCGGGAAAGG CAGGTATGGT 660

GAGGTGTGGA GAGGCAGTTG GCAAGGGGAA AACGTTGCTG TGAAGATCTT TTCTTCCCGG 720

GATGAGAAGT CATGGTTCAG GGAAACAGAA CTGTATAACA CTGTGATGCT GAGGCATGAA 780

AATATTTTAG GTTTCATCGC TTCAGACATG ACCTCGAGAC ACTCCAGCAC CCAGTTGTGG 840

TTAATTACAC ATTACCATGA AATGGGATCA TTGTATGACT ATCTTCAGCT CACTACTCTG 900

GATACAGTTA GCTGCCTTCG AATAGTGCTG TCCATAGCAA GTGGTCTTGC ACATTTACAC 960

ATAGAGATAT TTGGGACCCA AGGGAAACCA GCCATTGCCC ATCGAGACTT AAAGAGCAAA 1020

AATATCCTAG TGAAGAAGAA TGGACAGTGC TGCATAGCAG ATTTGGGTCT GGCAGTCATG 1080

CATTCCCAGA GTACTAATCA ACTTGATGTG GGGAACAACC CCCGAGTGGG CACCAAGCGC 1140

TACATGGCCC CTGAAGTTCT AGATGAAACC ATCCAGGTGG ATTGTTTTGA CTCGTATAAG 1200

AGGGTCGATA TTTGGGCCTT TGGACTTGTT TTGTGGGAAG TAGCCAGGCG GATGGTGAGC 1260

AATGGTATAG TGGAAGATTA CAAGCCACCA TTTTATGATG TAGTTCCCAA TGACCCAAGT 1320

TTTGAAGATA TGAGGAAAGT AGTCTGTGTG GATCAACAGA GGCCAAACAT ACCCAACAGA 1380

TGGTTCTCAG ACCCGACATT AACTTCTCTG GCCAAGCTGA TGAAAGAATG CTGGTATCAG 1440

AATCCATCTG CAAGACTCAC AGCACTGCGC ATTAAAAAGA CTTTGACCAA AATTGATAAT 1500

TCCCTAGACA AATTGAAAAC TGACTGTTGA 1530

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 328   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013