EKS-CAP-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	559.5	9.6E-169	276	552	277

Status

Unreviewed

Ensembl Protein

ENSCPOP00000007931

UniProt Accession

H0VD85;

Protein Name

Protein Synonyms/Alias

Gene Name

Fgfr2

Gene Synonyms/Alias

Fgfr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000008833	ENSCPOP00000007931	ENSCPOT00000008912
ENSCPOG00000008833	ENSCPOP00000018467	ENSCPOT00000024486

Organism

Cavia porcellus

Functional Description

Protein Length

616

Protein Sequence
(FASTA)

FQVRNQHWSL IMESVVPSDK GNYTCVVENE YGSINHTYHL DVVERSPHRP ILQAGLPANV 60

STVVGGDVEF VCKVYSDAQP HIQWIKHVEK NGSKYGPDGL PYLKVLKHSG INSSNAEVLA 120

LFNVTEADAG EYICKVSNYI GQANQSAWLT VLPKQQAPVR EKEITPSPDY LEIAIYCIGV 180

FLIACMVVTV IVCRMKTTTK KPDFSSQPAV HKLTKRIPLR RQVTVSAESS SSMNSNTPLV 240

RITTRLSSTA DTPMLAGVSE YELPEDPKWE FPRDKLTLGK PLGEGCFGQV VMAEAVGIDK 300

DKPKEAVTVA VKMLKDDATE KDLSDLVSEM EMMKMIGKHK NIINLLGACT QDGPLYVIVE 360

YASKGNLREY LRARRPPGME YSYDINRVPE EQMTFKDLVS CTYQLARGME YLASQKCIHR 420

DLAARNVLVT ENNVMKIADF GLARDINNID YYKKTTNGRL PVKWMAPEAL FDRVYTHQSD 480

VWSFGVLMWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP ANCTNELYMM MRDCWHAVPS 540

QRPTFKQLVE DLDRILTLTT NEEYLDLSQP LEQYSPSSPD TRSSCSSGDD SVFSPDPMPY 600

EPCLPQFPHI NGSVKT 616

Nucleotide Sequence
(FASTA)

TTTCAGGTAC GAAACCAGCA CTGGAGCCTT ATTATGGAAA GTGTGGTCCC ATCTGACAAA 60

GGCAATTATA CCTGCGTGGT AGAGAACGAA TATGGCTCCA TCAATCACAC GTACCACCTC 120

GATGTTGTTG AACGATCGCC ACACAGACCT ATCCTCCAAG CTGGACTGCC AGCCAATGTC 180

TCCACGGTTG TCGGAGGGGA CGTGGAATTT GTCTGCAAAG TTTACAGTGA CGCTCAGCCT 240

CACATCCAGT GGATCAAACA TGTGGAAAAG AACGGCAGTA AATATGGGCC TGATGGGCTG 300

CCCTACCTCA AGGTTCTGAA GCACTCGGGG ATAAATAGTT CCAATGCAGA AGTGCTGGCT 360

CTGTTCAATG TGACTGAGGC GGATGCTGGG GAGTATATAT GTAAGGTCTC CAATTATATA 420

GGGCAGGCCA ACCAGTCTGC CTGGCTCACT GTCCTGCCAA AACAGCAAGC TCCTGTAAGA 480

GAAAAGGAGA TTACACCTTC CCCAGATTAT CTGGAGATAG CCATTTACTG CATAGGGGTC 540

TTCTTAATCG CCTGTATGGT GGTGACAGTC ATCGTGTGCC GAATGAAGAC CACGACCAAG 600

AAGCCAGACT TCAGCAGCCA GCCGGCTGTG CACAAGCTGA CCAAGCGCAT CCCCCTGCGG 660

AGACAGGTAA CAGTTTCTGC TGAGTCTAGC TCCTCCATGA ACTCCAACAC CCCACTGGTG 720

AGGATAACAA CACGTCTCTC CTCAACAGCA GACACCCCAA TGCTGGCTGG GGTCTCTGAG 780

TATGAACTGC CAGAGGATCC AAAATGGGAG TTCCCCAGAG ATAAGCTGAC GCTGGGCAAA 840

CCCCTTGGGG AAGGTTGCTT CGGGCAAGTG GTCATGGCGG AAGCAGTGGG AATCGATAAA 900

GACAAGCCCA AGGAGGCAGT CACCGTGGCA GTGAAGATGC TGAAAGATGA TGCCACGGAG 960

AAAGATCTTT CTGATCTAGT GTCAGAGATG GAGATGATGA AGATGATTGG AAAACACAAA 1020

AATATCATCA ATCTTCTAGG AGCCTGCACA CAGGATGGGC CCCTCTATGT CATAGTTGAA 1080

TATGCCTCCA AAGGCAACCT CCGGGAATAC CTTCGCGCAC GGAGGCCTCC AGGCATGGAA 1140

TACTCCTATG ATATTAACCG TGTTCCTGAG GAACAGATGA CCTTTAAGGA CTTGGTGTCG 1200

TGCACCTACC AGCTGGCCAG AGGCATGGAG TACTTGGCTT CCCAAAAATG CATTCATCGA 1260

GATTTAGCAG CCAGAAATGT TTTGGTTACA GAAAACAATG TGATGAAAAT AGCAGACTTT 1320

GGACTGGCCA GAGACATCAA CAATATAGAC TATTACAAAA AGACAACAAA TGGGCGTCTT 1380

CCAGTGAAAT GGATGGCTCC CGAAGCCCTT TTCGATAGAG TGTACACACA TCAGAGTGAC 1440

GTCTGGTCCT TTGGGGTGTT AATGTGGGAG ATCTTCACTT TAGGGGGCTC GCCTTACCCA 1500

GGGATTCCCG TGGAGGAACT TTTTAAGCTG CTAAAGGAAG GACACAGGAT GGATAAGCCA 1560

GCCAACTGCA CCAATGAGCT GTACATGATG ATGAGAGACT GCTGGCACGC AGTGCCCTCG 1620

CAGAGACCAA CGTTCAAGCA GTTGGTAGAA GACCTGGACC GAATTCTTAC TCTCACAACC 1680

AATGAGGAAT ACTTGGACCT CAGTCAGCCT CTGGAACAGT ACTCACCTAG TTCCCCTGAC 1740

ACAAGGAGTT CTTGTTCTTC AGGAGATGAC TCTGTGTTTT CTCCGGACCC CATGCCTTAT 1800

GAACCCTGCC TGCCTCAGTT TCCACACATA AATGGCAGTG TTAAAACA 1848

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 276   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  335

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 336   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  395

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 396   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  455

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 456   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  515

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 516   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  552

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Canis familiaris"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013