EKS-CAP-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.5	1.4E-122	190	477	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000008178

UniProt Accession

H0VDV4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000009106	ENSCPOP00000008178	ENSCPOT00000009189

Organism

Cavia porcellus

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 60

ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 120

GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 180

PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 240

HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 300

LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 360

TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 420

HPSLEELQEV VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 480

IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI 512

Nucleotide Sequence
(FASTA)

ATGACGGCGC CCTGGGCGGC CCTCGCCCTC CTTTGGGGAT CGCTGTGCGC TGGTTCTGGG 60

CGTGGGGAGG CCGAGACAAG GGAGTGCATC TACTACAACG CCAACTGGGA GCTGGAGCGC 120

ACCAACCAGA GCGGCCTGGA GCGCTGCGAG GGCGAGCAGG ACAAGCGGCT GCACTGCTAC 180

GCCTCCTGGC GCAACAGCTC GGGCACCATC GAGCTTGTCA AGAAGGGCTG CTGGCTGGAC 240

GACTTCAACT GCTACGACAG GCAGGAGTGT GTGGCCACCG AGGAGAACCC CCAAGTGTAT 300

TTCTGCTGCT GTGAAGGCAA CTTCTGCAAC GAGCGCTTCA CCCACCTGCC GGAAGCAGGG 360

GGCCCAGAAG TCACGTACGA GCCACCCCCG ACAGCCCCCA CCCTGCTCAC GGTGCTGGCC 420

TACTCGCTGC TGCCCATTGG GGGCCTCTCC CTCATTGTCC TGCTGGCCTT CTGGATGTAT 480

CGACATCGCA AGCCCCCCTA TGGCCATGTG GATATCCATG AGGACCCTGG GCCTCCGCCT 540

CCATCCCCTC TGGTGGGCCT GAAGCCACTG CAGCTGTTGG AGATCAAGGC TCGGGGGCGC 600

TTTGGCTGTG TTTGGAAGGC CCAGCTCATG AACGACTTTG TGGCTGTTAA GATCTTTCCA 660

CTCCAGGACA AGCAGTCATG GCAGAGTGAA CGAGAGATCT TCAGCACACC TGGCATGAAG 720

CACGAGAACT TGTTGCAGTT CATTGCTGCC GAGAAGCGAG GCTCCAACCT CGAGGTGGAG 780

CTGTGGCTCA TCACGGCCTT CCATGACAAG GGCTCCCTCA CGGATTACCT CAAGGGGAAC 840

ATCATCACGT GGAATGAACT GTGTCACGTG GCAGAGACGA TGTCGCGAGG CCTCTCGTAC 900

CTGCATGAGG ATGTACCTTG GTGCCGTGGC GAGGGCCACA AGCCGTCTAT CGCCCACAGG 960

GACTTTAAGA GCAAGAATGT ATTGCTGAAG AGTGACCTCA CAGCTGTGCT GGCTGACTTT 1020

GGCCTGGCCG TTCGGTTTGA GCCAGGGAAA CCACCAGGGG ACACCCACGG CCAGGTAGGC 1080

ACCAGACGGT ACATGGCGCC CGAGGTGCTA GAGGGCGCTA TCAACTTCCA ACGAGACGCC 1140

TTCCTGCGCA TCGACATGTA CGCTATGGGC CTGGTGCTCT GGGAGCTTGT GTCTCGCTGT 1200

AAGGCTGCAG ATGGACCTGT GGATGAGTAT ATGCTTCCCT TTGAGGAAGA GATTGGCCAG 1260

CACCCTTCTC TAGAGGAGCT GCAGGAGGTG GTTGTGCACA AGAAGATGAG GCCTACCATT 1320

AAGGATCACT GGCTGAAGCA CCCGGGCCTG GCCCAGCTCT GCGTGACCAT CGAGGAGTGC 1380

TGGGACCACG ATGCAGAGGC TCGCCTGTCT GCGGGCTGTG TGGAGGAGCG AGTATCCCTG 1440

ATCCGGAGGT CGGTCAACGG CACTACCTCG GACTGTCTTG TCTCCTTGGT GACCTCCGTC 1500

ACCAATGTGG ACCTGCCCCC TAAGGAGTCC AGCATC 1536

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 190   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  249

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 250   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  309

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 310   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  367

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 368   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  426

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP+i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 427   LQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  477

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013