EKS-CAP-00380

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00380

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	392.1	1.0E-117	117	378	262

Status

Unreviewed

Ensembl Protein

ENSCPOP00000008585

UniProt Accession

H0VEW9;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000009564	ENSCPOP00000008585	ENSCPOT00000009650

Organism

Cavia porcellus

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

LSPEASSLWL LQLLRNIQLA QFYRPILEEL NVTRPEHFNF VRPEDLDSIG MGRPAQRRLT 60

EALKRHRSGV KSKNWVYKIL GGFAPEQKET TPPSDSPASL PEPERGLKCL IPEGAVCRRE 120

LLGSGCFGVV HRGLWTLPNG QSVPVAVKSL RVGPEGPVGT ELGDFLREVS IMMKLEHPHV 180

LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPSLPVP LLCLFLRQLA GAMAYLGARG 240

LVHRDLATRN LLLMSPSTIK VADFGLVRPL GGARGHYVMG GPRPIPYAWC APESLRQGAF 300

SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQLLEKDR ARLPRPPLCS RALYSVALRC 360

WAPHPSDRPN FSYLEELLQE AWPSEGCCVR DVTEPGALQM EPGDSITIIE GRSSSHSPDS 420

TIWKGQNGRT LKVGSFPASA VTLADSGGSS ATRPVHRGSP GRGERGQGNT DREKEKPRDL 480

PPAQGQRRKV PLQRTKGISK SLESVLSLGP RPTGGGSSPP ELRRTRAVLL GLQGLPPRPP 540

FTSSSSQPSQ PPREKPPRPK REALHNHRSI NTSGASKATV PSGGPFPDTE WQRRIREVEG 600

SVHGVTHQEC QAALRAAGGD VVAAIRNLKV EQLFHLSSRS RADCQRILEH YQWDLSAASR 660

YVLAQS 666

Nucleotide Sequence
(FASTA)

CTGTCCCCTG AGGCCAGCTC CCTATGGCTA CTACAGCTGC TCCGGAACAT CCAACTGGCC 60

CAGTTTTATC GACCCATCCT TGAAGAACTT AATGTCACTC GGCCAGAGCA TTTCAACTTT 120

GTACGGCCTG AAGACCTGGA CAGCATCGGC ATGGGCCGAC CTGCCCAGCG CAGATTGACT 180

GAAGCTCTCA AGAGGCACCG ATCAGGGGTC AAGTCCAAGA ATTGGGTCTA TAAGATCCTT 240

GGGGGTTTTG CCCCTGAGCA AAAGGAGACC ACCCCACCCT CAGACAGCCC TGCAAGCCTC 300

CCTGAGCCCG AGAGGGGACT CAAGTGTCTG ATCCCAGAGG GTGCTGTGTG CAGAAGGGAG 360

CTGCTGGGCT CAGGCTGCTT TGGCGTAGTA CATCGGGGAC TGTGGACGCT GCCTAACGGC 420

CAGAGCGTCC CGGTGGCTGT CAAGTCCCTC CGAGTGGGTC CGGAAGGCCC CGTAGGCACA 480

GAGCTGGGAG ACTTCCTGCG GGAGGTGTCC ATCATGATGA AGCTGGAGCA CCCGCATGTG 540

CTGCGTCTGC ACGGCCTGGT ACTGGGCCAG CCTCTGCAGA TGGTGATGGA GCTGGCGCCA 600

CTGGGCTCGC TGCACGCACG GCTGACGGCC CCGGCCCCGA CGCCCTCGCT ACCCGTGCCT 660

CTGCTCTGCC TCTTTCTTCG GCAGCTGGCA GGGGCCATGG CGTACCTGGG GGCCCGCGGG 720

CTAGTGCACC GGGACCTCGC GACGCGAAAC CTGCTGCTGA TGTCGCCCAG CACCATCAAG 780

GTGGCCGACT TTGGGCTGGT GCGGCCGCTG GGCGGCGCTC GCGGCCACTA CGTCATGGGC 840

GGGCCCCGCC CCATCCCGTA CGCCTGGTGT GCCCCAGAGA GCCTGCGCCA GGGAGCTTTC 900

TCCTCGGCCT CCGACGTGTG GATGTTCGGG GTGACGCTGT GGGAGATGTT CTCGGGGGGC 960

GAGGAGCCCT GGGCCGGAGT CCCGCCCTAC CTCATCCTGC AGCTGCTGGA GAAGGACCGA 1020

GCCCGGCTGC CCAGGCCTCC GCTCTGCTCC AGGGCCCTCT ACTCTGTCGC CTTGCGGTGC 1080

TGGGCCCCCC ATCCTTCGGA CAGGCCTAAC TTTTCCTACC TGGAGGAGCT GCTCCAGGAG 1140

GCCTGGCCTT CTGAGGGATG CTGCGTGAGG GACGTCACAG AGCCAGGAGC TTTGCAGATG 1200

GAGCCTGGCG ACTCCATCAC CATCATTGAG GGCAGGTCCT CTTCCCACAG CCCTGACTCT 1260

ACCATCTGGA AGGGACAGAA CGGCCGCACC TTAAAAGTGG GCAGCTTCCC AGCCTCGGCA 1320

GTGACGCTTG CAGACTCGGG GGGCTCCTCG GCTACCCGTC CAGTCCACAG AGGCTCCCCT 1380

GGAAGGGGAG AGCGAGGCCA GGGGAATACA GACAGAGAGA AGGAAAAGCC CCGGGACCTA 1440

CCTCCAGCAC AGGGCCAGAG AAGGAAGGTG CCCCTGCAGA GGACGAAAGG TATTTCCAAG 1500

AGTCTGGAAT CAGTTCTGTC CCTGGGCCCT CGCCCCACAG GGGGTGGATC AAGTCCCCCC 1560

GAACTTCGAC GTACCAGGGC TGTGCTCCTG GGACTCCAAG GCCTGCCTCC ACGCCCACCC 1620

TTCACCTCCA GTTCTTCCCA GCCCAGCCAG CCCCCCAGAG AGAAGCCTCC CAGGCCCAAA 1680

AGAGAAGCCC TCCATAATCA CCGCAGTATT AACACATCTG GAGCCAGTAA AGCCACTGTC 1740

CCCTCTGGAG GCCCCTTCCC CGACACGGAA TGGCAGAGGA GGATAAGAGA GGTGGAGGGG 1800

AGTGTGCATG GTGTCACCCA CCAGGAATGC CAGGCGGCAC TAAGAGCCGC AGGCGGAGAT 1860

GTTGTTGCTG CCATCCGAAA CCTCAAGGTA GAACAGCTCT TCCACCTGAG CAGCCGGTCC 1920

AGGGCTGACT GCCAGCGCAT CCTAGAGCAT TATCAGTGGG ACCTCTCAGC TGCCAGCCGC 1980

TATGTCCTGG CCCAGTCCTG A 2001

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkle  59

         ++ e+lG+G+fgvv+rg W+ p+g+sv+vavk+l+  ++  ++tel+dflrevs+++kle

Q: 117   CRRELLGSGCFGVVHRGLWTLPNGQSVPVAVKSLRvgPEGPVGTELGDFLREVSIMMKLE  176

         67899*****************************9999**********************

S: 60    henlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayl  119

         h++++rl+G+vl+qpl++v+ela+lgsl++rl+++a ++sl+v ll+ +++q+a ++ayl

Q: 177   HPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPSLPVPLLCLFLRQLAGAMAYL  236

         ************************************************************

S: 120   eskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslr  179

         +++ lvhrdla+rnlll+s++++k++dfGlvr+lg ++++yv+  ++++P+aWcaPeslr

Q: 237   GARGLVHRDLATRNLLLMSPSTIKVADFGLVRPLGGARGHYVMGGPRPIPYAWCAPESLR  296

         ************************************************************

S: 180   trkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysl  239

         + +fssasdvW+fGvtlWemfs GeePW+g++++ il+ ++k+++rl++P++c++++ys+

Q: 297   QGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQLLEKDRARLPRPPLCSRALYSV  356

         ************************************************************

S: 240   llkcWakkpadrpkfsalkekl  261

         +l+cWa +p drp+fs l+e l

Q: 357   ALRCWAPHPSDRPNFSYLEELL  378

         *****************99875

Domain Sequence
(FASTA)

CRRELLGSGC FGVVHRGLWT LPNGQSVPVA VKSLRVGPEG PVGTELGDFL REVSIMMKLE 60

HPHVLRLHGL VLGQPLQMVM ELAPLGSLHA RLTAPAPTPS LPVPLLCLFL RQLAGAMAYL 120

GARGLVHRDL ATRNLLLMSP STIKVADFGL VRPLGGARGH YVMGGPRPIP YAWCAPESLR 180

QGAFSSASDV WMFGVTLWEM FSGGEEPWAG VPPYLILQLL EKDRARLPRP PLCSRALYSV 240

ALRCWAPHPS DRPNFSYLEE LL 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013