EKS-CAP-00320

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00320

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.1	2.3E-116	186	484	299

Status

Unreviewed

Ensembl Protein

ENSCPOP00000008602

UniProt Accession

H0VEY4;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000009586	ENSCPOP00000008602	ENSCPOT00000009672

Organism

Cavia porcellus

Functional Description

Protein Length

1019

Protein Sequence
(FASTA)

VVLFFGILAS QNQERLCAFK DPYQQDLGIG ESRISHENGT VLCSKGSTCY GLWEKSKGDI 60

NLVKQGCWSH IGDPQECHYE ECVVTTTPSS IQNGTYRFCC CSADLCNVNF TENFPPPDTT 120

PLSPPHSFNR DETIIIALAS VSVLAVLIVA LCFGYRMVAG DRKQGLHSIN MMEAAASEPT 180

LDLDNLKLLE LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFINEKNIY RVPLMEHDNI 240

ARFIVGDERV TADGRMEYLL VMEYYPSGSL CKYLSLHTSD WVSSCRLAHS VTRGLAYLHT 300

ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMR LTGNRLVRPG EEDNAAISEV 360

GTIRYMAPEV LEGAVNLRDC ESALKQVDMY ALGLIYWEMF MRCTDLFPGE SVPEYQMAFQ 420

TEVGNHPTFE DMQVLVSREK QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD AEARLTAQCA 480

EERMAELMMI WERNKSVSPT VNPMSTAVQN ERNLSHNRRV PKIGPYPDYS SSSYIEDSVH 540

HTDSIVKNIS SDHPMSSTPL TMGEKNRNSI NYERQQAQAR IPSPETSVTS LSTNTTTTNT 600

TGLTPSTGMT TISELPYPDE TNLHASVAQS IGPTPVCLQL TEEDLETNKL DPKEVDKNLK 660

ESSDENLMEH SLKQFSGPDP LSSTSSSLLY PLIKLAVEAT GQQDFTQGTN GQACLIPDVT 720

PTQLYPLPKQ QNLPKRPTSL PLNTKNSAKE SRLKFGSKHK SNLKQVETGV AKMNTVNAAE 780

PHVVTVTMNG VAGRSHGVHP HAATQYANGA VPSGQTASVV AHRAQDMLQN QFIGEDTRLN 840

INSSPDEHEP LLRREQQASH DEGVLDRLMD RRERPLEGGR TNSNNNNSNP GSEQDVLSQG 900

VSSTVADPGP SKPRRAQRPN SLDLSATNVL DGCGVQIGES AQDGKSGSGE KIKRRVKTPY 960

SLKRWRPSTW AVATEHLGHE VNNGGCDPAA APKSSAAIYL ADGGTATTMV SKDIGMNCL 1019

Nucleotide Sequence
(FASTA)

GTTGTGTTAT TTTTTGGTAT TTTAGCTTCC CAGAATCAAG AACGGCTATG TGCATTTAAA 60

GATCCCTATC AACAAGACCT TGGAATAGGT GAGAGTCGAA TCTCTCATGA AAATGGAACA 120

GTATTATGTT CAAAAGGTAG CACGTGCTAC GGCCTTTGGG AGAAATCAAA AGGCGACATA 180

AATCTGGTAA AACAAGGATG TTGGTCTCAC ATTGGAGATC CCCAGGAGTG TCACTATGAA 240

GAATGTGTGG TAACTACCAC CCCCTCCTCA ATTCAGAATG GAACATACCG TTTTTGCTGC 300

TGTAGCGCAG ATTTATGCAA TGTCAATTTT ACTGAGAATT TCCCACCTCC TGACACAACT 360

CCACTCAGTC CACCTCATTC ATTTAATCGA GATGAGACGA TAATCATTGC TTTGGCATCA 420

GTCTCTGTAT TAGCTGTTTT GATAGTTGCC TTATGCTTCG GGTACCGAAT GGTGGCAGGA 480

GACCGTAAAC AAGGTCTGCA CAGTATCAAC ATGATGGAGG CAGCAGCATC AGAGCCCACT 540

CTTGACTTAG ATAATTTGAA GCTGTTGGAG CTGATTGGCC GAGGTCGATA TGGAGCAGTA 600

TATAAAGGTT CCTTGGATGA GCGTCCAGTT GCTGTAAAAG TGTTTTCTTT TGCAAATCGT 660

CAGAATTTTA TCAATGAAAA AAATATTTAC CGAGTGCCTT TGATGGAGCA TGACAACATT 720

GCTCGCTTTA TAGTTGGAGA TGAGAGAGTC ACTGCAGATG GGCGCATGGA ATACTTGCTT 780

GTGATGGAGT ATTATCCCAG TGGGTCTCTG TGCAAGTATT TAAGTCTCCA TACAAGTGAC 840

TGGGTAAGCT CTTGCCGTCT GGCTCATTCT GTGACTAGAG GACTGGCTTA CCTTCACACA 900

GAATTACCAC GAGGAGATCA TTATAAACCC GCAATTTCCC ATCGAGATTT AAACAGCAGA 960

AATGTCCTGG TGAAAAATGA TGGAACCTGT GTCATCAGTG ACTTTGGGTT ATCCATGAGG 1020

CTGACAGGAA ACAGACTGGT GCGACCAGGG GAGGAGGACA ATGCAGCCAT CAGTGAGGTT 1080

GGAACCATCA GATACATGGC ACCAGAAGTG CTGGAAGGAG CCGTGAACCT GCGGGACTGC 1140

GAGTCTGCAC TGAAGCAGGT GGACATGTAC GCGCTGGGGC TCATCTACTG GGAGATGTTC 1200

ATGCGCTGCA CCGACCTCTT CCCGGGTGAA TCTGTACCAG AATATCAGAT GGCTTTTCAG 1260

ACCGAAGTTG GAAATCATCC CACTTTTGAG GACATGCAAG TTCTTGTGTC TAGGGAAAAA 1320

CAGAGACCCA AGTTCCCAGA AGCCTGGAAA GAAAACAGTC TGGCAGTGAG GTCACTCAAG 1380

GAGACAATTG AAGACTGTTG GGACCAAGAT GCAGAGGCGC GACTGACTGC ACAGTGCGCC 1440

GAGGAGAGAA TGGCCGAGCT CATGATGATA TGGGAAAGAA ACAAATCTGT GAGCCCAACG 1500

GTCAACCCCA TGTCCACTGC CGTCCAGAAT GAGCGCAACC TGTCACATAA TAGGCGTGTG 1560

CCAAAAATTG GCCCTTACCC AGATTACTCC TCTTCCTCGT ACATTGAAGA CTCTGTCCAC 1620

CACACTGACA GCATTGTGAA GAATATCTCC TCTGATCATC CTATGTCCAG CACACCTTTG 1680

ACCATGGGGG AAAAGAACCG AAACTCCATT AATTATGAAC GGCAACAAGC GCAAGCGCGG 1740

ATCCCCAGCC CTGAGACCAG TGTCACCAGC CTGTCCACCA ACACGACCAC CACGAACACC 1800

ACTGGCCTCA CACCAAGCAC TGGCATGACC ACGATATCTG AGCTTCCATA CCCAGATGAA 1860

ACAAATCTCC ATGCCAGTGT CGCACAGTCG ATCGGTCCTA CCCCAGTCTG CTTGCAGCTG 1920

ACAGAAGAGG ACCTAGAGAC CAATAAGCTA GATCCAAAAG AAGTAGACAA GAACCTCAAA 1980

GAGAGCTCTG ATGAGAACCT CATGGAGCAT TCTCTTAAAC AGTTCAGCGG GCCAGATCCA 2040

CTGAGCAGCA CTAGTTCCAG CTTGCTCTAC CCACTCATAA AACTTGCAGT GGAAGCGACT 2100

GGGCAGCAGG ATTTTACCCA GGGCACCAAT GGGCAGGCAT GCTTAATTCC TGACGTTACG 2160

CCTACTCAGC TCTATCCTCT CCCTAAGCAG CAGAACCTGC CTAAGAGACC TACTAGCTTG 2220

CCTTTGAATA CCAAAAATTC AGCAAAGGAG TCCCGACTAA AATTTGGCAG CAAGCACAAA 2280

TCAAACTTGA AACAAGTGGA AACTGGAGTT GCCAAGATGA ATACAGTCAA TGCAGCAGAG 2340

CCTCACGTGG TAACTGTCAC CATGAATGGT GTGGCAGGTC GAAGCCACGG TGTTCACCCC 2400

CATGCTGCCA CCCAGTATGC CAACGGGGCA GTGCCATCTG GCCAGACAGC CAGCGTGGTA 2460

GCACACAGGG CTCAAGACAT GCTGCAGAAT CAGTTTATTG GAGAGGACAC CCGGCTCAAT 2520

ATTAATTCCA GTCCTGATGA GCACGAACCT TTATTGAGAC GTGAACAGCA AGCCAGCCAT 2580

GATGAAGGTG TTCTGGATCG CCTCATGGAC AGGCGGGAAC GGCCGTTAGA AGGTGGCCGA 2640

ACAAATTCCA ACAACAACAA CAGCAATCCA GGCTCCGAAC AAGACGTTCT TTCACAGGGC 2700

GTTTCAAGCA CAGTAGCAGA TCCGGGGCCA TCAAAGCCCA GAAGAGCACA GAGGCCCAAT 2760

TCTCTGGATC TTTCAGCCAC CAATGTCCTG GATGGCTGTG GTGTGCAGAT AGGTGAGTCA 2820

GCACAGGATG GCAAGTCAGG GTCAGGTGAG AAGATCAAGA GACGCGTGAA GACACCCTAC 2880

TCTCTGAAGC GGTGGCGCCC TTCTACCTGG GCTGTGGCCA CAGAGCACCT GGGACACGAG 2940

GTCAACAATG GTGGCTGTGA TCCGGCAGCT GCCCCCAAGT CCAGCGCCGC CATTTACCTT 3000

GCAGATGGAG GCACCGCCAC TACCATGGTG TCTAAAGATA TAGGAATGAA CTGTCTG 3057

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 186   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  245

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 246   GDErVTADGRMEYLLVMEYYPSGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  305

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 306   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  364

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 365   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEMFMRCTDlfPGESVPEYQMAFQTEVG  424

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 425   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  484

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PSGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEMFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013