EKS-CAP-00424

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00424

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	548.7	2.0E-165	514	779	266

Status

Unreviewed

Ensembl Protein

ENSCPOP00000008906

UniProt Accession

H0VFP8;

Protein Name

Protein Synonyms/Alias

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000009928	ENSCPOP00000008906	ENSCPOT00000010017

Organism

Cavia porcellus

Functional Description

Protein Length

886

Protein Sequence
(FASTA)

RAVERSASGP AGGRPFRPPL LAGLASLLLP ESAAAGLKLM GAPAKMTLSQ GQSMTLNCSK 60

EGLEEPDIHW MKDGAMVRTG SQVYIAISEQ YWICFLSLKS VERSDAGQYW CQMEDGGKTE 120

ISQSVWLTVE GVPFFTVEPK DLAVPPNAPF QLSCEAVGPP EPVTIFWWRG RTKVGGPAPS 180

PSVLNVTGVT QSTMFSCEAR NRKGLAISRP ATVRLQALPA APFNITVTKL SSSNASVAWL 240

PGADGQAVLQ SCTVQVTQTP GDWEVLAVVV PVPPFTCLLR DLTPATNYSL RVRCANALGP 300

SPYADWVPFQ TKGLDTAPAR APKNLHAIRT DSGLILEWEE VIPEGLWEGP LGPYKVALFQ 360

DNGTQDELTV EGTRANVTGW DPQKDLIVRV CASNAVGCGP WSQPLVVSSH DHAGQQGPPH 420

SPTSWVPVVL GVLTALVTAA ALALILLRKR RKETRFGQAF DSVMARGEPA VHFRAARSFN 480

RERPERIEAT LDSLGISDEL KDKLEDVLIP EQQFTLGRML GKGEFGSVRE AQLKQEDGSF 540

VKVAVKMLKA DIIASSDIEE FLREAACMKE FDHPHVAKLV GVSLRSRAKG RLPIPMVILP 600

FMKHGDLHAF LLASRIGENP FNLPLQTLIR FMVDIACGME YLSSRNFIHR DLAARNCMLA 660

EDMTVCVADF GLSRKIYSGD YYRQGCASKL PVKWLALESL ADNLYTVHSD VWAFGVTMWE 720

IMTRGQTPYA GIENAEIYNY LIGGNRLKQP PECMEDVYDL MYQCWSADPK QRPSFTCLRM 780

ELETILGHLS VLSSSQDPLY INIEKAKQPA EGSDLELPCS DQPGSGAGDG SGVGAVGGIP 840

SDYRYILSPG DLTESSGQTE QQPESPVNEA QRLLFVQQGL LPHSSC 886

Nucleotide Sequence
(FASTA)

CGGGCCGTTG AAAGAAGCGC CAGCGGCCCC GCAGGGGGCC GCCCTTTTCG GCCTCCCCTC 60

CTGGCGGGTC TGGCCTCGCT GCTGCTCCCG GAGTCCGCGG CCGCAGGCTT GAAACTCATG 120

GGAGCCCCAG CAAAGATGAC TTTGTCTCAG GGGCAATCAA TGACACTCAA CTGCAGCAAG 180

GAAGGGCTAG AGGAGCCAGA CATACACTGG ATGAAAGACG GGGCTATGGT CCGGACCGGG 240

AGCCAGGTGT ACATTGCCAT CAGTGAGCAG TACTGGATTT GCTTCCTCAG CCTGAAGTCA 300

GTGGAGCGTT CTGATGCAGG CCAATACTGG TGCCAGATGG AGGATGGGGG AAAGACCGAG 360

ATCTCCCAGT CAGTGTGGCT CACAGTAGAA GGTGTGCCAT TTTTCACTGT GGAGCCCAAA 420

GATCTGGCAG TGCCCCCCAA TGCCCCTTTC CAACTCTCTT GTGAGGCCGT GGGTCCTCCA 480

GAACCTGTTA CCATTTTCTG GTGGAGAGGA AGAACGAAGG TTGGGGGACC TGCTCCCTCT 540

CCCTCAGTTT TAAATGTAAC AGGGGTGACC CAGAGCACAA TGTTTTCCTG TGAAGCTCGC 600

AACAGAAAAG GCCTGGCTAT TTCCCGCCCG GCCACTGTTC GCCTTCAAGC TCTGCCTGCA 660

GCCCCCTTCA ACATCACAGT GACAAAGCTC TCCAGCAGCA ATGCTAGCGT GGCCTGGTTG 720

CCAGGTGCTG ATGGTCAAGC TGTGCTTCAG TCCTGTACAG TGCAGGTGAC ACAGACCCCA 780

GGAGACTGGG AGGTCCTGGC TGTTGTGGTC CCTGTACCAC CCTTTACCTG CCTGCTTCGG 840

GACTTGACAC CTGCTACCAA TTATAGCCTC AGGGTGCGCT GTGCCAATGC TTTGGGACCC 900

TCTCCCTATG CCGACTGGGT GCCCTTTCAG ACAAAGGGTC TAGATACAGC TCCAGCTAGA 960

GCTCCGAAGA ACCTCCATGC CATCCGCACA GATTCTGGCC TCATCCTGGA GTGGGAAGAA 1020

GTGATCCCTG AGGGCCTTTG GGAAGGCCCC CTGGGACCCT ATAAAGTTGC CTTGTTTCAA 1080

GACAATGGAA CCCAGGATGA GCTGACAGTG GAGGGGACTA GGGCCAATGT GACAGGCTGG 1140

GATCCCCAGA AGGACCTGAT CGTGCGTGTG TGCGCCTCCA ACGCAGTTGG CTGTGGGCCC 1200

TGGAGTCAGC CATTGGTGGT CTCTTCTCAT GACCATGCAG GCCAGCAGGG CCCTCCCCAC 1260

AGCCCCACAT CCTGGGTGCC CGTGGTCTTG GGTGTGCTCA CGGCTCTGGT GACAGCTGCT 1320

GCCTTGGCTC TCATCCTGCT TCGAAAGAGG CGGAAGGAGA CACGTTTCGG GCAAGCCTTT 1380

GACAGTGTCA TGGCCCGTGG GGAGCCAGCT GTTCACTTCC GGGCCGCCCG GTCCTTCAAT 1440

AGAGAAAGGC CAGAGCGCAT CGAAGCTACA TTGGACAGCC TGGGCATCAG TGATGAACTG 1500

AAAGATAAGC TAGAAGATGT GCTCATTCCA GAGCAGCAGT TTACTCTGGG CCGGATGCTG 1560

GGCAAAGGAG AGTTTGGCTC TGTGCGGGAG GCCCAGCTAA AACAGGAGGA TGGCTCCTTC 1620

GTGAAAGTGG CTGTTAAGAT GCTGAAAGCT GACATCATCG CCTCAAGTGA CATAGAAGAG 1680

TTCCTCAGGG AGGCAGCTTG CATGAAGGAG TTTGACCATC CACATGTGGC CAAGCTTGTT 1740

GGTGTGAGCC TCCGCAGCAG GGCCAAAGGC CGCCTCCCCA TCCCTATGGT CATCCTGCCA 1800

TTCATGAAGC ATGGAGACCT GCATGCCTTC CTGCTCGCCT CCCGGATTGG GGAGAACCCC 1860

TTTAACCTGC CCCTCCAGAC TCTGATCCGG TTCATGGTGG ACATTGCCTG TGGCATGGAG 1920

TACCTGAGTT CCCGGAACTT CATCCACCGA GACCTGGCTG CTCGGAACTG CATGCTGGCA 1980

GAGGACATGA CAGTGTGTGT AGCTGACTTT GGACTATCCC GAAAAATCTA TAGTGGGGAC 2040

TACTATCGTC AGGGCTGTGC CTCCAAATTG CCTGTCAAGT GGCTGGCACT GGAGAGCCTG 2100

GCGGACAACT TGTACACTGT GCACAGTGAT GTGTGGGCCT TTGGGGTCAC CATGTGGGAG 2160

ATCATGACTC GTGGGCAGAC GCCTTATGCT GGAATCGAAA ACGCTGAGAT TTACAACTAC 2220

CTCATTGGCG GGAACCGCCT GAAACAGCCT CCGGAGTGCA TGGAGGACGT GTATGATCTC 2280

ATGTACCAGT GCTGGAGTGC TGATCCGAAG CAACGCCCCA GCTTCACATG CCTGCGGATG 2340

GAATTGGAGA CCATCCTGGG TCACCTGTCT GTGCTGTCCA GCAGTCAGGA CCCTTTGTAT 2400

ATCAACATCG AGAAGGCCAA GCAGCCTGCC GAGGGCAGCG ACCTAGAGTT GCCCTGCAGT 2460

GACCAGCCTG GCAGTGGAGC TGGGGATGGC AGTGGGGTGG GGGCAGTTGG AGGCATCCCC 2520

AGTGACTATC GGTACATCCT CAGCCCTGGG GACCTGACTG AGTCATCTGG GCAGACTGAG 2580

CAGCAGCCAG AGAGCCCCGT CAATGAGGCC CAGAGACTGC TGTTTGTGCA GCAAGGGCTC 2640

CTGCCCCATA GTAGTTGTTA G 2661

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh

Q: 514   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  573

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv

Q: 574   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  633

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk

Q: 634   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  693

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c

Q: 694   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  753

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ++++ydlmy+cw+adpk+rpsf+ lr

Q: 754   MEDVYDLMYQCWSADPKQRPSFTCLR  779

         ***********************998

Domain Sequence
(FASTA)

FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120

DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180

WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240

MEDVYDLMYQ CWSADPKQRP SFTCLR 266

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013