EKS-CAP-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	374.5	3.0E-112	309	601	293

Status

Unreviewed

Ensembl Protein

ENSCPOP00000008917

UniProt Accession

H0VFQ7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000009938	ENSCPOP00000008917	ENSCPOT00000010028

Organism

Cavia porcellus

Functional Description

Protein Length

1115

Protein Sequence
(FASTA)

SPYSPVLRRS AKSRSRSPYS SRHSRSRSRH RLSRSRSRHS SISPSTLTLK SSLAAELNKN 60

KKARAAEAAR AAEAAKAAEA AKAAEAAAKA AKASNTSTPT KVNTETGASS SQTNHVKDVK 120

KVKTELAPSP SSGGTLKNDK AKTKPPLQVT KVDNNLVLDK TTKKTAVVGK ESKSAATKEE 180

PVSLKEKTKP LTPSIGAKEK EQHVTLVTST LPPLPLPPML PEDKDADSLR GNISVKAVKK 240

EVEKKLRCLL ADLPLPPELP GGDDLSKSPE EKKTTTQLHS KRRPKICGPR YGEIKEKDID 300

WGKRCVDKFD IIGIIGEGTY GQVYKARDKD TGEMVALKKV RLDNEKEGFP ITAIREIKIL 360

RQLTHQSIIN MKEIVTDKED ALDFKKDKGA FYLVFEYMDH DLMGLLESGL VHFNENHIKS 420

FMRQLMEGLD YCHKKNFLHR DIKCSNILLN NRGQIKLADF GLARLYSSEE SRPYTNKVIT 480

LWYRPPELLL GEERYTPAID VWSCGCILGE LFTKKPIFQA NQELAQLELI SRICGSPCPA 540

VWPDVIKLPY FNTMKPKKQY RRKLREEFVF IPAAALDLFD YMLALDPSKR CTAEQALQCE 600

FLRDVEPSKM PPPDLPLWQD CHELWSKKRR RQKQMGMTDD VSTIKAPRKE LSLGLDDSRT 660

NTPQGVLPTT QLKSQGNSNV APVITGSGQQ LNHSELAILL NLLQSKTSIN MADFVQVLNI 720

KVNSETQQQL NKITFLLNFG TGEKQTDPST PQQESSKPLG GIQPSSQTVP PKVETDAAQA 780

AVQSAFAVLL TQLIKAQQSK QKDVLLEERE NGSGHDASLQ LRPPPEPSTP VSGQDDLIQQ 840

QDRRRLELTP EPDRPRILPP DQRPPEPPEP PPVTEEDLDY RTENQHVSTT SSSLTDPHAG 900

VKAALLQLLA QHQPQDEPKR EGGIDYPAGD TYVPTSDYKD SFGSSSFSSA PYVSNDGLGS 960

SSAAPLERRS FIGNSDIQPL DNYSTASSHS GGPPQPSAFS ESFPSSVAGY GDIYLNAGPM 1020

LFSGDKDHRF EYSHGPIAVL ANSNDPSAGP ESTHPLPAKM HNYNYGGNLQ ENPGGPSLMH 1080

GQTWTSPAQG PGYSQGYRGH ISTSAGRGRG RGLPY 1115

Nucleotide Sequence
(FASTA)

AGCCCCTACA GTCCAGTACT CAGACGGTCT GCCAAATCCC GAAGTAGAAG TCCGTACTCA 60

TCTAGGCATT CAAGGTCTCG TAGCAGGCAC AGATTGTCTA GATCCCGGAG TCGGCATTCT 120

AGCATTTCTC CTAGCACACT GACTCTGAAG AGTAGCCTGG CTGCAGAGTT GAACAAGAAT 180

AAAAAAGCAC GTGCTGCAGA GGCTGCACGA GCTGCAGAGG CAGCGAAAGC TGCAGAAGCG 240

GCCAAGGCTG CAGAGGCAGC TGCGAAAGCT GCAAAAGCCT CCAACACATC TACACCAACG 300

AAGGTGAACA CAGAAACTGG AGCCAGCTCA TCGCAAACCA ACCATGTGAA GGATGTGAAG 360

AAAGTTAAAA CTGAGCTTGC GCCTTCTCCC TCAAGTGGTG GAACTTTAAA AAATGACAAG 420

GCAAAAACAA AGCCACCTCT TCAGGTAACA AAGGTAGACA ATAACTTGGT TTTAGATAAA 480

ACCACCAAGA AAACAGCTGT AGTTGGGAAG GAGAGTAAAT CTGCTGCTAC AAAGGAGGAA 540

CCAGTGTCTC TCAAAGAGAA AACCAAACCA CTGACACCAA GCATTGGCGC CAAGGAGAAG 600

GAGCAACATG TGACTTTAGT GACCTCTACC TTGCCACCGT TACCTTTGCC TCCCATGCTG 660

CCTGAAGATA AAGATGCTGA TAGCTTAAGA GGAAATATTT CAGTAAAAGC AGTTAAAAAA 720

GAAGTAGAAA AGAAACTCCG ATGTCTACTT GCTGATTTAC CACTGCCCCC TGAGTTACCT 780

GGAGGAGATG ATCTTTCCAA GAGTCCAGAG GAAAAGAAAA CTACAACACA GTTGCATAGT 840

AAACGGAGAC CTAAAATATG TGGGCCTCGC TATGGTGAAA TCAAAGAAAA AGATATTGAC 900

TGGGGAAAAC GCTGCGTGGA TAAATTTGAT ATCATCGGAA TTATTGGAGA AGGTACTTAT 960

GGACAAGTTT ACAAAGCCAG GGATAAAGAC ACTGGAGAAA TGGTAGCCTT AAAAAAAGTA 1020

CGTCTGGATA ATGAAAAAGA AGGCTTTCCA ATTACAGCAA TTCGAGAAAT TAAAATTCTC 1080

CGGCAGCTTA CCCACCAGAG TATTATCAAT ATGAAGGAAA TAGTGACTGA TAAAGAAGAT 1140

GCTTTGGATT TTAAGAAAGA CAAAGGTGCA TTTTATCTGG TGTTTGAGTA CATGGACCAT 1200

GACCTGATGG GACTGCTGGA GTCAGGCTTG GTTCATTTTA ATGAAAATCA CATTAAGTCA 1260

TTTATGAGAC AGCTCATGGA AGGTCTAGAT TATTGTCATA AGAAGAACTT TTTGCATAGA 1320

GATATTAAAT GTTCAAATAT CCTTCTAAAT AATAGAGGGC AGATAAAACT TGCAGATTTT 1380

GGACTTGCTC GATTATATAG CTCAGAAGAA AGTCGACCAT ATACCAACAA GGTCATCACT 1440

TTATGGTACC GCCCACCTGA GCTGCTGTTG GGAGAAGAAC GCTATACACC AGCTATTGAT 1500

GTTTGGAGTT GTGGATGTAT CCTTGGTGAA CTCTTCACTA AAAAACCTAT ATTTCAAGCA 1560

AACCAGGAAC TTGCACAACT AGAATTAATA AGCCGTATAT GTGGGAGTCC ATGTCCAGCG 1620

GTGTGGCCTG ATGTAATCAA ACTACCATAT TTCAACACTA TGAAACCAAA GAAGCAGTAT 1680

CGTCGAAAGT TAAGAGAAGA ATTTGTTTTC ATTCCTGCAG CTGCACTAGA CTTATTTGAT 1740

TACATGCTCG CCTTGGATCC CAGTAAGCGC TGCACTGCTG AGCAGGCTCT TCAGTGTGAG 1800

TTCCTACGAG ATGTGGAACC CTCAAAAATG CCTCCACCAG ACCTTCCTTT GTGGCAAGAT 1860

TGTCATGAGT TATGGAGTAA AAAGCGAAGA AGACAGAAAC AGATGGGCAT GACTGATGAT 1920

GTTTCCACTA TTAAGGCTCC CAGAAAGGAA TTGTCTCTGG GTTTGGACGA CAGCAGAACC 1980

AATACGCCAC AAGGTGTGCT GCCAACTACA CAGCTGAAAT CTCAGGGCAA CTCGAATGTA 2040

GCACCTGTAA TAACAGGCTC TGGACAGCAG TTAAACCACA GTGAATTGGC AATTCTCCTA 2100

AACCTACTAC AATCTAAAAC AAGTATTAAT ATGGCTGATT TTGTCCAAGT GTTGAACATT 2160

AAGGTAAACT CTGAGACTCA ACAGCAACTA AATAAAATAA CCTTCCTGCT GAATTTTGGC 2220

ACAGGTGAAA AACAGACAGA TCCATCAACA CCACAACAGG AATCTTCGAA ACCATTGGGA 2280

GGAATTCAGC CTTCTTCTCA GACTGTCCCA CCTAAAGTGG AGACTGATGC TGCCCAGGCG 2340

GCTGTGCAGA GTGCATTTGC AGTTCTGTTG ACTCAGTTAA TAAAGGCTCA GCAGTCAAAG 2400

CAGAAGGATG TGCTACTAGA AGAGAGGGAA AATGGTTCGG GACATGATGC ATCATTGCAG 2460

CTCAGGCCAC CTCCAGAACC TAGCACACCA GTGTCGGGGC AAGATGACCT CATCCAGCAA 2520

CAAGATAGGA GGAGATTAGA GCTCACACCA GAACCAGATC GACCTCGGAT TTTGCCTCCT 2580

GATCAACGAC CTCCTGAGCC TCCCGAACCA CCACCAGTCA CTGAGGAAGA CCTTGATTAT 2640

CGGACAGAAA ACCAGCATGT ATCCACTACT AGTTCTTCAT TAACTGACCC TCATGCTGGA 2700

GTGAAAGCAG CCCTGTTACA GCTGCTTGCT CAGCATCAGC CCCAGGATGA ACCCAAACGA 2760

GAAGGTGGTA TTGATTATCC AGCAGGAGAC ACTTATGTGC CCACCTCTGA CTACAAGGAC 2820

AGCTTTGGAT CATCATCTTT CTCTTCTGCT CCTTATGTTA GCAATGATGG TCTAGGAAGT 2880

AGTTCTGCTG CACCATTGGA ACGACGTAGC TTCATTGGGA ACTCAGATAT TCAGCCTTTG 2940

GATAACTACA GTACTGCTTC ATCTCATTCT GGTGGTCCAC CTCAACCTTC TGCCTTTTCT 3000

GAGTCATTTC CCAGTTCGGT AGCTGGATAT GGAGACATTT ACCTCAATGC TGGTCCCATG 3060

TTGTTCAGTG GAGACAAGGA CCACAGATTT GAATACAGCC ATGGTCCTAT TGCAGTGCTG 3120

GCAAACAGCA ATGACCCTTC TGCTGGGCCA GAGAGTACTC ATCCTTTGCC AGCAAAGATG 3180

CACAACTATA ACTATGGTGG TAATTTACAG GAAAATCCTG GTGGCCCCAG CCTCATGCAC 3240

GGGCAGACCT GGACTTCCCC TGCTCAAGGC CCTGGATATT CACAAGGATA CAGGGGACAC 3300

ATCAGCACAT CGGCTGGCAG AGGTCGAGGT AGAGGGTTAC CATAT 3345

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 309   FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  368

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 369   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  427

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 428   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  487

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 488   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  547

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 548   LPYFNTMKPKKQYRrKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF  601

         *****7777777777******999999************************988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRKLREEF VFIPAAALDL FDYMLALDPS KRCTAEQALQ CEF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013