EKS-CAP-00056

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00056

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	438.1	1.2E-131	4	334	331

Status

Unreviewed

Ensembl Protein

ENSCPOP00000008931

UniProt Accession

H0VFS0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK2

Gene Synonyms/Alias

CDK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000009952	ENSCPOP00000008931	ENSCPOT00000010042

Organism

Cavia porcellus

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MENFQKVEKI GEGTYGVVYK AKNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60

PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGVP LPLIKNYLFQ LLQGLAFCHS 120

HRVLHRDLKP QNLLINADGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 180

STAVDIWSLG CIFAEMYLVC TQHHAKCCGE HRRNGRHSLC PLCSYLEVAA SQGGGMTAVS 240

TPHPVTRRAL FPGDSEIDQL FRIFRTLGTP DEVVWPGVTS MPDYKPSFPK WARQDFSKVV 300

PPLDEDGRSL LSQMLHYDPN KRISAKAALA HPFFQDVTKT VPHLRL 346

Nucleotide Sequence
(FASTA)

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 60

GCCAAAAACA AGTTGACGGG CGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 120

ACTGAAGGTG TTCCCAGTAC TGCCATTCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAC 180

CCAAACATTG TCAAGCTGCT GGATGTCATC CACACAGAAA ATAAACTCTA CCTGGTTTTT 240

GAATTTCTGC ACCAAGATCT CAAGAAGTTT ATGGATGCCT CTGCTCTCAC TGGTGTTCCT 300

CTTCCCCTCA TCAAGAACTA TCTGTTTCAG CTACTCCAGG GACTAGCATT TTGCCATTCT 360

CATCGGGTCC TCCACCGAGA CCTTAAACCG CAGAATCTGC TTATCAATGC GGATGGAGCA 420

ATCAAGCTAG CAGACTTCGG GCTAGCCAGA GCCTTTGGAG TCCCGGTTCG CACTTACACG 480

CATGAGGTGG TGACCCTATG GTACCGAGCC CCTGAAATCC TTCTGGGTTG CAAATACTAC 540

TCTACAGCTG TGGACATCTG GAGCCTGGGC TGTATCTTTG CTGAGATGTA CCTAGTGTGT 600

ACCCAGCACC ATGCTAAGTG CTGTGGGGAA CACAGAAGAA ATGGAAGACA CAGTCTCTGC 660

CCGCTGTGCT CCTATCTAGA AGTGGCTGCA TCACAAGGAG GGGGGATGAC CGCAGTGTCT 720

ACCCCACACC CCGTGACCCG TCGTGCCCTG TTCCCTGGAG ATTCTGAGAT TGACCAACTC 780

TTCCGGATCT TTCGGACTCT AGGGACCCCA GATGAGGTAG TTTGGCCAGG AGTTACTTCT 840

ATGCCTGATT ATAAGCCAAG TTTCCCCAAA TGGGCTCGGC AGGATTTTAG CAAAGTTGTG 900

CCTCCCTTGG ATGAAGATGG ACGGAGCTTG TTATCGCAAA TGCTGCACTA CGACCCCAAT 960

AAGCGAATTT CGGCAAAAGC AGCTCTGGCT CACCCATTCT TCCAGGATGT GACCAAAACA 1020

GTACCCCACC TTCGGCTG 1038

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++k+ekigeGtyg+vykak+k tgevvAlKkirl++e+egvp+ta+rEisllkel+h+ni

Q: 4     FQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         vkLl+v++ +++klyLvfefl+qdLkk++++++ ++++l  +k++l+qll+gla++Hs++

Q: 64    VKLLDVIH-TENKLYLVFEFLHQDLKKFMDASALTGVPLPLIKNYLFQLLQGLAFCHSHR  122

         ********.99*************************************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g +klaDfGlaraf++p++tyt+evvTlwYraPe+Llg+k+Yst

Q: 123   VLHRDLKPQNLLINADGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST  182

         ************************************************************

S: 181   avDiWsvgcilael..............................................  194

         avDiWs+gci+ae+

Q: 183   AVDIWSLGCIFAEMylvctqhhakccgehrrngrhslcplcsylevaasqgggmtavstp  242

         ************************************************************

S: 195   ..ltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpkkkkkklkekvkk  252

           +tr++lf+g+seidql+rif++lgtp+e vwp+v+++p+yk sfpk+++++++++v+

Q: 243   hpVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPP  302

         ************************************************************

S: 253   lkekaldllekllaldpkkRisakealqhkyf  284

         l+e++++ll+++l++dp+kRisak+al+h++f

Q: 303   LDEDGRSLLSQMLHYDPNKRISAKAALAHPFF  334

         ******************************98

Domain Sequence
(FASTA)

FQKVEKIGEG TYGVVYKAKN KLTGEVVALK KIRLDTETEG VPSTAIREIS LLKELNHPNI 60

VKLLDVIHTE NKLYLVFEFL HQDLKKFMDA SALTGVPLPL IKNYLFQLLQ GLAFCHSHRV 120

LHRDLKPQNL LINADGAIKL ADFGLARAFG VPVRTYTHEV VTLWYRAPEI LLGCKYYSTA 180

VDIWSLGCIF AEMYLVCTQH HAKCCGEHRR NGRHSLCPLC SYLEVAASQG GGMTAVSTPH 240

PVTRRALFPG DSEIDQLFRI FRTLGTPDEV VWPGVTSMPD YKPSFPKWAR QDFSKVVPPL 300

DEDGRSLLSQ MLHYDPNKRI SAKAALAHPF F 331

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013