EKS-CAP-00002

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00002

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	517.1	5.9E-156	664	921	258

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009033

UniProt Accession

H0VG16;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA5

Gene Synonyms/Alias

EPHA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000010060	ENSCPOP00000009033	ENSCPOT00000010151

Organism

Cavia porcellus

Functional Description

Protein Length

1026

Protein Sequence
(FASTA)

RGAGLRRPTA RTPASPAGCC CAPRRAPLWT CLVLCAALRT LLASPSSEVN LLDSRTVMGD 60

LGWIAFPKNG WEEIGEVDEN YAPIHTYQVC KVMEQNQNNW LLTSWISNEG ASRIFIELKF 120

TLRDCNSLPG GLGTCKETFN MYYFESDDAN GRNIKENQYI KIDTIAADES FTELDLGDRV 180

MKLNTEVRDV GPLSKKGFYL AFQDVGACIA LVSVRVYYKK CPSIVRHLAV FPDTITGADS 240

SQLLEVSGAC VNHSVTDEPP KMHCSAEGEW LVPIGKCMCQ AGYEEKNGTC QVCAPGFFKA 300

SPHSQTCSKC PPHSYTHEEA STSCVCEKDY FRRESDPPTM ACTRPPSAPR NAISNVNETS 360

VFLEWIPPAD TGGRRDVSYY IACKKCNSHA GVCEECGGHV RYLPQQIGLK NTSVMMADLL 420

AHTNYTFEIE AVNGVSDLSP GTRQFVSVNV TTNQAAPSPV TNVKKGKIAK NSISLSWQEP 480

DRPNGIILEY EIKYFEKDQE TSYTIIKSKG TTITAEGLKP ASVYVFQIRA RTAAGYGVFS 540

RRFEFETIPV SVAASSDQSQ IPIIAVSVTV GVILLAVVIG FLLSGSCCEC GCGRASSLCA 600

VAHPSLIWRC GYSKAKQDPE EEKMHFHNGH IKLPGVRTYI DPHTYEDPNQ AVHEFAKEIE 660

ASCITIERVI GAGEFGEVCS GRLKLPGKRE LPVAIKTLKV GYTEKQRRDF LGEASIMGQF 720

DHPNIIHLEG VVTKSKPVMI VTEYMENGSL DTFLKKNDGQ FTVIQLVGML RGIAAGMKYL 780

SDMGYVHRDL AARNILINSN LVCKVSDFGL SRVLEDDAEA AYTTRGGKIP IRWTAPEAIA 840

FRKFTSASDV WSYGIVMWEV VSYGERPYWE MTNQDVIKAV EEGYRLPSPM DCPAALYQLM 900

LDCWQKDRNS RPKFEEIVNM LDKLIRNPSS LKTLVNASSR VSSLLAEHGS LGSGAYRSVG 960

EWLEAIKMGR YTEIFMENGY SSMDAVAQVT LEDLRRLGVT LVGHQKKIMN SLQEMKVQLA 1020

NGMVPL 1026

Nucleotide Sequence
(FASTA)

CGGGGTGCGG GGCTCCGGCG GCCCACGGCC CGCACCCCCG CGTCGCCGGC CGGCTGCTGC 60

TGCGCGCCCC GCAGAGCCCC GCTCTGGACG TGCCTGGTGC TGTGCGCCGC GCTGCGAACG 120

CTCCTCGCTA GCCCCAGCAG CGAAGTGAAT TTGTTGGATT CACGCACTGT CATGGGGGAC 180

CTGGGATGGA TTGCCTTTCC AAAAAATGGG TGGGAAGAGA TTGGAGAAGT TGATGAAAAC 240

TACGCTCCTA TCCACACATA CCAAGTGTGC AAGGTTATGG AACAGAATCA GAATAACTGG 300

CTCTTGACCA GTTGGATCTC CAACGAAGGT GCTTCCAGAA TCTTCATAGA ACTGAAGTTT 360

ACTCTGCGGG ACTGTAACAG TCTCCCTGGG GGCCTGGGGA CGTGCAAGGA AACTTTTAAC 420

ATGTATTATT TTGAGTCTGA TGATGCAAAT GGGAGAAACA TCAAGGAAAA CCAGTACATC 480

AAAATCGACA CCATTGCAGC CGATGAGAGC TTCACAGAAC TGGATCTTGG TGACCGAGTC 540

ATGAAACTGA ACACAGAGGT CAGAGACGTG GGCCCTCTGA GCAAGAAGGG ATTTTACCTG 600

GCTTTCCAAG ACGTGGGAGC ATGCATTGCT CTGGTTTCTG TGCGTGTGTA CTATAAAAAA 660

TGCCCTTCCA TTGTGCGACA CTTAGCAGTC TTCCCCGACA CCATCACTGG AGCAGACTCT 720

TCACAGTTGC TGGAGGTGTC AGGTGCCTGT GTCAATCACT CTGTGACAGA TGAGCCCCCC 780

AAGATGCACT GCAGTGCTGA AGGGGAGTGG CTGGTGCCCA TCGGGAAGTG CATGTGCCAG 840

GCGGGATACG AAGAGAAAAA TGGCACCTGT CAAGTGTGTG CACCGGGGTT CTTCAAAGCC 900

TCGCCTCACA GCCAGACCTG CAGCAAATGC CCACCTCACA GTTACACCCA TGAGGAAGCT 960

TCCACCTCTT GTGTCTGTGA AAAGGATTAT TTCAGGAGGG AATCTGATCC ACCCACAATG 1020

GCATGCACAA GACCCCCCTC AGCTCCTCGG AATGCCATCT CAAATGTTAA TGAGACTAGT 1080

GTCTTTCTGG AATGGATTCC GCCCGCTGAC ACTGGTGGAA GGAGAGATGT GTCCTATTAT 1140

ATTGCATGCA AGAAGTGCAA CTCCCATGCA GGTGTGTGTG AGGAGTGTGG CGGTCATGTC 1200

AGGTACCTCC CCCAGCAAAT CGGCCTGAAA AACACCTCTG TCATGATGGC GGATCTGCTC 1260

GCTCACACAA ACTATACCTT TGAGATTGAG GCAGTGAATG GAGTGTCCGA CTTGAGCCCA 1320

GGAACCCGGC AGTTTGTGTC TGTAAATGTA ACCACAAATC AAGCAGCCCC CTCTCCAGTC 1380

ACCAATGTGA AAAAGGGGAA GATTGCAAAA AACAGCATCT CGTTATCTTG GCAAGAACCG 1440

GACCGACCCA ATGGGATTAT CCTGGAATAT GAAATCAAGT ATTTTGAAAA GGACCAGGAG 1500

ACCAGCTACA CCATTATCAA ATCCAAAGGC ACCACTATCA CCGCAGAGGG CTTGAAGCCA 1560

GCTTCCGTGT ATGTCTTCCA AATTCGAGCA CGAACAGCAG CCGGCTACGG TGTCTTCAGT 1620

CGAAGATTTG AGTTTGAAAC CATCCCAGTG TCAGTTGCAG CATCCAGCGA TCAAAGCCAG 1680

ATTCCTATAA TTGCTGTGTC TGTGACAGTG GGAGTCATTT TGCTGGCAGT GGTTATTGGC 1740

TTCCTCCTCA GTGGAAGTTG CTGCGAATGC GGCTGTGGGA GGGCTTCTTC CCTGTGCGCT 1800

GTTGCCCATC CAAGCTTAAT ATGGCGCTGT GGCTACAGCA AAGCAAAGCA GGATCCAGAA 1860

GAGGAAAAGA TGCACTTTCA TAACGGGCAC ATTAAACTGC CCGGTGTAAG AACCTACATC 1920

GATCCACATA CCTATGAAGA TCCCAACCAA GCTGTCCATG AATTTGCCAA GGAGATAGAA 1980

GCCTCATGCA TCACCATTGA AAGAGTGATC GGGGCAGGTG AATTTGGTGA AGTTTGTAGT 2040

GGACGCTTGA AACTACCAGG AAAAAGAGAA TTACCTGTGG CCATCAAAAC CCTGAAAGTA 2100

GGCTACACTG AAAAGCAGCG CAGAGATTTC CTAGGAGAAG CCAGTATCAT GGGACAGTTC 2160

GATCACCCTA ACATCATCCA CCTAGAAGGC GTTGTGACCA AAAGCAAACC AGTGATGATA 2220

GTGACAGAGT ACATGGAGAA TGGCTCTTTA GATACATTTT TAAAGAAGAA CGATGGGCAG 2280

TTCACTGTGA TTCAGCTTGT GGGCATGCTG AGAGGCATCG CAGCAGGAAT GAAGTACCTC 2340

TCAGACATGG GCTATGTGCA CAGAGACCTC GCCGCCAGGA ACATTTTAAT CAACAGTAAC 2400

CTCGTGTGCA AAGTGTCTGA CTTTGGACTT TCCAGGGTAC TGGAAGATGA TGCTGAGGCG 2460

GCCTACACCA CAAGGGGAGG CAAAATTCCA ATCAGATGGA CTGCCCCAGA GGCCATAGCT 2520

TTCCGAAAGT TCACCTCAGC CAGCGATGTC TGGAGCTACG GCATCGTGAT GTGGGAAGTG 2580

GTATCCTACG GAGAGAGACC TTACTGGGAG ATGACCAACC AAGATGTGAT TAAAGCAGTC 2640

GAGGAAGGCT ACAGGCTGCC AAGCCCCATG GATTGTCCTG CTGCTCTCTA TCAATTAATG 2700

CTGGATTGCT GGCAGAAGGA CCGCAATAGC AGGCCCAAGT TTGAGGAAAT AGTCAACATG 2760

CTGGACAAGC TGATACGCAA CCCGAGCAGT CTGAAGACGT TGGTGAATGC GTCGAGCAGA 2820

GTTTCAAGTT TATTGGCAGA GCATGGATCC CTGGGGTCTG GGGCCTACAG ATCAGTGGGA 2880

GAATGGCTAG AAGCCATCAA GATGGGCCGC TATACAGAGA TTTTCATGGA AAATGGATAC 2940

AGTTCAATGG ACGCTGTGGC TCAGGTGACC TTGGAGGATT TGAGACGTCT TGGAGTGACT 3000

CTTGTCGGTC ACCAGAAGAA GATCATGAAC AGCCTTCAAG AAATGAAGGT GCAGCTGGCA 3060

AATGGGATGG TGCCACTG 3078

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         ++ie+viGaGefGevcsGrlklpgkre++vaiktlk g+tekqrrdfl easi+Gqfdhp

Q: 664   ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  723

         78**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         nii+leGvvtkskpvmivteymeng+ld+fl+k+dgqftviqlvgmlrGia+gmkylsdm

Q: 724   NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDM  783

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+rk

Q: 784   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDAEAAYTTRGGKIPIRWTAPEAIAFRK  843

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpyw+m+nqdvika+eegyrlp+pmdcpaalyqlmldc

Q: 844   FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC  903

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqkdr++rpkfe+iv++l

Q: 904   WQKDRNSRPKFEEIVNML  921

         ***************985

Domain Sequence
(FASTA)

ITIERVIGAG EFGEVCSGRL KLPGKRELPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60

NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI AAGMKYLSDM 120

GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDAEAAYT TRGGKIPIRW TAPEAIAFRK 180

FTSASDVWSY GIVMWEVVSY GERPYWEMTN QDVIKAVEEG YRLPSPMDCP AALYQLMLDC 240

WQKDRNSRPK FEEIVNML 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013