EKS-CAP-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.3	1.5E-134	156	476	321

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009067

UniProt Accession

H0VG45;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000010097	ENSCPOP00000009067	ENSCPOT00000010188

Organism

Cavia porcellus

Functional Description

Protein Length

760

Protein Sequence
(FASTA)

GGETSACKPS SVRLAPSFSF HAAGLQMAGQ MPHSHQYSDR RQPNISDQQV SALPYSDQIQ 60

QPLTNQVMPD IVMLQRRMPQ TFRDPSTAPL RKLSVDLIKT YKHINEVYYA KKKRRHQQGQ 120

GDDSSHKKER KVYNDGYDDD NYDYIVKNGE KWMDRYEIDS LIGKGSFGQV VKAYDRVEQE 180

WVAIKIIKNK KAFLNQAQIE VRLLELMNKH DTEMKYYIVH LKRHFMFRNH LCLVFEMLSY 240

NLYDLLRNTN FRGVSLNLTR KFAQQMCTAL LFLATPELSI IHCDLKPENI LLCNPKRSAI 300

KIVDFGSSCQ LGQRIYQYIQ SRFYRSPEVL LGMPYDLAID MWSLGCILVE MHTGEPLFSG 360

ANEVDQMNKI VEVLGIPPAH ILDQAPKARK FFEKLPDGTW NLKKTKDGKR EYKPPGSRKL 420

HNILGVETGG PGGRRAGESG HTVADYLKFK DLILRMLDYD PKSRIQPYYA LQHSFFKKTA 480

DEGTNTSNSV STSPAMEQSQ SSGTTSSTSS SSGGSSGTSN SGRARSDPTH QHRHSGGHFT 540

AAVQAMDCET HSPQVRQQFP APLGWSGTEA PTQVTVENHP VQETTFHVAP QQNALHHHHG 600

NSSHHHHHHH HHHHHHGQQA LGNRTRPRVY NSPTNSSSTQ DSMEVGHSHH SMTSLSSSTT 660

SSSTSSSSTG NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS 720

ANTGPAHYMT EGHLTMRQGT DREESPMTGV CVQQSPVASS 760

Nucleotide Sequence
(FASTA)

GGAGGAGAGA CTTCAGCATG CAAACCTTCA TCTGTTCGGC TTGCACCGTC ATTTTCATTC 60

CATGCTGCTG GCCTTCAGAT GGCTGGACAG ATGCCCCATT CACATCAGTA CAGTGACCGT 120

CGCCAGCCAA ACATAAGTGA CCAACAGGTT TCTGCCTTAC CGTATTCTGA CCAGATTCAG 180

CAACCTCTAA CTAACCAGGT GATGCCTGAT ATTGTCATGT TACAGAGGCG GATGCCCCAA 240

ACCTTCCGTG ATCCATCAAC TGCTCCTCTG AGAAAACTTT CTGTTGATTT GATCAAAACA 300

TATAAGCATA TTAATGAGGT TTACTATGCA AAAAAGAAGC GAAGACACCA GCAGGGCCAG 360

GGAGACGATT CAAGTCATAA GAAGGAGCGG AAGGTTTACA ATGATGGTTA CGATGACGAC 420

AACTATGATT ATATTGTAAA GAACGGGGAA AAGTGGATGG ATCGTTACGA AATTGACTCC 480

TTGATAGGCA AAGGTTCCTT TGGACAGGTT GTGAAAGCAT ATGATCGGGT GGAGCAAGAA 540

TGGGTTGCCA TTAAAATCAT AAAAAATAAG AAGGCGTTTC TGAATCAAGC CCAGATAGAA 600

GTGCGACTTC TTGAGCTCAT GAACAAACAT GACACGGAAA TGAAATACTA CATAGTGCAT 660

TTGAAACGCC ACTTTATGTT TCGAAACCAT CTCTGTTTGG TGTTTGAAAT GCTGTCCTAC 720

AACCTCTATG ACCTGTTGAG GAACACCAAT TTCCGGGGGG TCTCTTTGAA CCTGACAAGG 780

AAGTTCGCGC AGCAGATGTG CACTGCACTG CTTTTCCTGG CGACTCCAGA GTTGAGTATT 840

ATTCACTGTG ACCTGAAACC TGAGAACATC CTCCTCTGCA ACCCCAAACG AAGCGCCATC 900

AAGATCGTTG ACTTCGGCAG TTCTTGTCAG CTGGGGCAGA GGATATACCA GTATATCCAG 960

AGTCGCTTTT ATCGGTCTCC AGAGGTGCTA TTGGGAATGC CTTATGATCT TGCTATCGAC 1020

ATGTGGTCCC TTGGGTGTAT TTTGGTTGAA ATGCACACTG GAGAACCTCT GTTTAGTGGT 1080

GCCAATGAGG TAGATCAGAT GAATAAAATA GTGGAAGTTC TGGGTATTCC ACCTGCTCAT 1140

ATTCTTGACC AAGCACCAAA AGCAAGAAAG TTCTTTGAGA AGCTGCCAGA TGGCACTTGG 1200

AACTTAAAGA AGACCAAAGA TGGAAAACGG GAGTACAAAC CACCAGGAAG CCGTAAACTT 1260

CATAATATTC TTGGAGTAGA AACAGGAGGG CCTGGTGGCC GGCGTGCTGG GGAGTCGGGT 1320

CACACCGTAG CTGACTACTT GAAGTTCAAA GACCTCATCT TAAGGATGCT GGATTATGAT 1380

CCCAAATCTC GAATTCAACC TTACTATGCC CTGCAGCACA GTTTTTTCAA GAAAACAGCC 1440

GATGAAGGTA CAAATACGAG TAACAGCGTC TCCACAAGCC CTGCGATGGA GCAGTCCCAG 1500

TCTTCAGGCA CCACCTCCAG CACGTCATCC AGCTCAGGTG GATCATCCGG GACAAGCAAC 1560

AGTGGGAGAG CCAGGTCGGA CCCCACGCAC CAGCATCGGC ACAGCGGCGG GCACTTCACG 1620

GCCGCGGTCC AGGCCATGGA CTGCGAGACG CACAGTCCCC AGGTGCGTCA GCAGTTTCCA 1680

GCACCACTCG GCTGGTCAGG CACTGAAGCT CCTACACAGG TCACTGTTGA AAATCATCCC 1740

GTTCAAGAAA CAACCTTTCA CGTAGCCCCT CAGCAGAATG CGTTGCATCA TCACCATGGA 1800

AACAGTTCCC ATCACCACCA CCACCACCAC CACCACCACC ACCACCATGG ACAGCAAGCC 1860

TTGGGTAACC GGACCAGGCC AAGGGTCTAC AATTCTCCAA CAAATAGCTC CTCTACCCAG 1920

GATTCTATGG AGGTTGGCCA CAGTCACCAC TCCATGACAT CTCTGTCTTC CTCAACGACT 1980

TCTTCCTCGA CATCTTCCTC CTCTACTGGT AATCAAGGCA ATCAGGCCTA CCAGAACCGC 2040

CCGGTGGCTG CTAATACCTT GGACTTTGGA CAGAATGGAG CTATGGACGT CAATTTGACC 2100

GTCTACTCCA ATCCCCGCCA AGAGACTGGC ATAGCTGGAC ACCCAACATA CCAGTTTTCT 2160

GCTAACACAG GCCCTGCACA TTACATGACT GAAGGACACC TGACAATGAG GCAAGGGACT 2220

GACAGAGAAG AGTCCCCCAT GACAGGAGTT TGTGTGCAGC AGAGTCCTGT AGCTAGCTCG 2280

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 156   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  215

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 216   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  275

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 276   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  334

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 335   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  394

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 395   LPDGTWNLKKTkdgkreykpPGSRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  449

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 450   KDLILRMLDYDPKSRIQPYYALQHSFF  476

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GSRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKSRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013