EKS-CAP-00105
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00105
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec467.96.7E-141363613251
StatusUnreviewed
Ensembl ProteinENSCPOP00000009249
UniProt AccessionH0VGK5;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000010299ENSCPOP00000009249ENSCPOT00000010393
OrganismCavia porcellus
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVSKY 120
HPNFWMDGRW RCCSQMEKLA TGCAHYDPTK NASKKPLPPT PEDNRRSLPE PEEILVIALY 180
DYQTNDPQEL ALQRNEEYYL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNSLETYEWY 240
NKSISRDKAE KLLLDSGKEG AFMVRDSRTP GTYTVSVFTK AIVSENSPCI KHYHIKETND 300
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCS WRQKAPVTAG LRYGKWVIHP 360
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420
LYGVCLEQAP ICLVFEFMEH GCLSDYLRNQ RGLFAAETLL GMCLDVCEGM AYLEKACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGRVPYE NRSNSEVVED ISTGFRLYKP RLASAPIYQI MNQCWKERPE 600
DRPPFSRLFG QLAEMAESGL 620
Nucleotide Sequence
(FASTA)
ATGAACAACT TCATCCTCCT GGAAGAACAG CTAATCAAGA AATCCCAACA GAAGAGAAGA 60
ACTTCTCCCT CAAATTTTAA AGTCCGCTTC TTTGTTTTAA CCAAAACCAG CCTGGCATAC 120
TTCGAGGATC GTCATGGGAA AAAGCGCACC TTGAAGGGCT CCATCGAACT CTCCCGAATC 180
AAATGTGTCG AGATTGTGAA AAGTGACATT AGCATTCCAT GCCACTATAA ATACCCATTT 240
CAGGTTGTGC ATGACAACTA CCTCCTGTAT GTCTTTGCTC CAGACCGCGA GAGCCGGCAG 300
CGCTGGGTGC TGGCCCTTAA AGAAGAAACA AGGAACAATA ACAGTCTGGT GTCCAAGTAT 360
CACCCCAATT TCTGGATGGA TGGGAGATGG AGGTGCTGTT CTCAGATGGA GAAGCTTGCA 420
ACAGGTTGTG CCCACTATGA TCCAACCAAG AATGCTTCAA AAAAGCCTCT TCCTCCTACT 480
CCTGAAGACA ACAGGCGATC ACTTCCAGAA CCTGAAGAGA TCCTGGTCAT TGCCTTGTAT 540
GACTACCAAA CCAATGATCC CCAGGAGCTA GCGTTGCAGC GTAATGAAGA ATACTACCTG 600
CTAGACAGCT CTGAGATCCA CTGGTGGAGA GTTCAGGACA GGAATGGGCA TGAAGGGTAT 660
GTACCAAGCA GTTATCTGGT AGAGAAATCT CCGAATAGCC TGGAAACCTA TGAGTGGTAC 720
AATAAGAGCA TCAGTCGAGA CAAGGCTGAA AAACTTCTTT TGGACTCTGG CAAAGAAGGA 780
GCCTTCATGG TCCGAGATTC TAGGACTCCA GGAACATACA CTGTATCTGT TTTCACCAAG 840
GCCATTGTAA GTGAGAACAG CCCCTGTATA AAGCATTATC ACATCAAGGA AACAAACGAC 900
AACCCCAAGC GATACTATGT GGCTGAAAAG TATGTGTTTG ACTCCATCCC TCTCCTCATC 960
AATTACCACC AGCACAATGG AGGAGGCCTG GTCACTCGAC TCCGGTATCC AGTTTGTTCC 1020
TGGAGGCAGA AAGCTCCAGT AACTGCAGGA CTAAGATACG GAAAATGGGT CATCCATCCC 1080
TCAGAGCTCA CTTTTGTGCA GGAGATTGGC AGTGGGCAGT TTGGCTTGGT ACATCTTGGT 1140
TACTGGCTCA ACAAGGACAA GGTGGCTATC AAAACCATCC AGGAGGGGGC TATGTCTGAA 1200
GAGGACTTCA TCGAGGAGGC CGAAGTCATG ATGAAACTCT CTCACCCCAA GCTGGTCCAG 1260
CTGTATGGTG TGTGTCTGGA GCAGGCCCCC ATCTGCCTGG TGTTCGAATT CATGGAACAC 1320
GGCTGTCTAT CAGATTACCT GCGCAACCAG CGGGGGCTCT TCGCAGCAGA GACCCTGCTG 1380
GGCATGTGCC TGGACGTGTG TGAGGGCATG GCCTATCTGG AAAAAGCGTG TGTCATCCAC 1440
AGAGATCTGG CTGCCCGAAA TTGTTTGGTG GGAGAAAACC AAGTCATCAA GGTGTCCGAC 1500
TTTGGGATGA CAAGGTTTGT CCTTGATGAC CAGTACACCA GTTCCACAGG CACCAAGTTC 1560
CCCGTGAAGT GGGCATCCCC AGAGGTGTTC TCTTTCAGTC GCTACAGCAG CAAGTCGGAC 1620
GTGTGGTCAT TCGGTGTGCT GATGTGGGAA GTCTTCAGCG AAGGCCGAGT CCCCTATGAA 1680
AACCGAAGCA ACTCGGAGGT GGTAGAAGAC ATCAGTACCG GATTTCGGTT GTATAAGCCT 1740
CGACTTGCCT CTGCTCCCAT CTACCAAATC ATGAATCAGT GCTGGAAAGA GAGACCAGAA 1800
GACCGGCCGC CCTTCTCCAG ACTATTTGGA CAACTGGCCG AAATGGCAGA ATCGGGACTT 1860
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd
Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRNQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfseg++pye++snsevve++s+g+rly+p+las  +y++m++cwke+pe+r
Q: 543   SFGVLMWEVFSEGRVPYENRSNSEVVEDISTGFRLYKPRLASAPIYQIMNQCWKERPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p f++l+ +l+
Q: 603   PPFSRLFGQLA  613
         ******98875
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRNQRG LFAAETLLGM CLDVCEGMAY LEKACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGRVPYENR SNSEVVEDIS TGFRLYKPRL ASAPIYQIMN QCWKERPEDR 240
PPFSRLFGQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013