EKS-CAP-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	370.4	5.1E-111	136	432	297

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009305

UniProt Accession

H0VGQ5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000010359	ENSCPOP00000009305	ENSCPOT00000010453

Organism

Cavia porcellus

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

MQRDAPPRAP APAPRLPAPP IGAAAGGGGG GGGGSSGGGG GASAAPAPPG LPGTTSPRGP 60

GGGRRPEEAG SAPRGRKWPW RRKWRGRGGA WSAAAGPGAA AAAAAAGGGG GGALEAAMAK 120

QYDSVECPFC DEVTKYEKLA KIGQGTFGEV FKAKHRQTGQ KVALKKVLME NEKEGFPITA 180

LREIKILQLL KHENVVNLIE ICRTKASPYN RCKGSIYLVF DFCEHDLAGL LSNVLVKFTL 240

SEIKRVMQML LNGLYYIHRN KILHRDMKAA NVLITRDGVL KLADFGLARA FSLAKNSQPN 300

RYTNRVVTLW YRPPELLLGE RDYGPPIDLW GAGCIMAEMW TRSPIMQGNT EQHQLALISQ 360

LCGSITPEVW PNVDKYELFE KLELVKGQKR KVKDRLKAYV RDPYALDLID KLLVLDPAQR 420

IDSDDALNHD FFWSDPMPSD LKGMLSTHLT SMFEYLAPPR RKGSQITQQT TNQSRNPATT 480

NQTEFERVF 489

Nucleotide Sequence
(FASTA)

ATGCAGCGGG ACGCACCGCC CCGAGCCCCA GCCCCAGCGC CCCGGCTTCC TGCGCCCCCG 60

ATCGGGGCCG CCGCCGGCGG TGGTGGTGGC GGAGGCGGGG GCAGCAGCGG CGGCGGCGGA 120

GGCGCCTCTG CAGCTCCCGC TCCCCCTGGC CTCCCGGGAA CTACAAGTCC CAGGGGGCCT 180

GGCGGCGGGC GGCGGCCGGA AGAGGCGGGA TCAGCGCCGC GAGGCAGGAA GTGGCCCTGG 240

AGGCGGAAGT GGCGCGGCCG CGGAGGGGCT TGGAGTGCGG CGGCGGGACC CGGAGCGGCT 300

GCGGCTGCTG CTGCGGCTGG AGGTGGCGGC GGCGGCGCTT TGGAGGCAGC CATGGCAAAG 360

CAGTACGACT CAGTGGAATG CCCCTTTTGT GATGAGGTGA CCAAGTACGA GAAGCTTGCC 420

AAGATCGGCC AAGGGACCTT TGGGGAGGTG TTTAAAGCCA AGCACCGCCA GACCGGCCAG 480

AAGGTGGCAT TGAAGAAGGT ACTGATGGAG AACGAGAAGG AAGGGTTCCC CATCACAGCC 540

TTGCGGGAGA TCAAGATTCT TCAGCTTCTC AAACATGAGA ATGTGGTCAA CTTGATTGAG 600

ATTTGTCGAA CCAAAGCTTC CCCGTATAAC CGCTGCAAGG GCAGCATATA CTTGGTGTTC 660

GACTTCTGCG AGCATGATCT TGCGGGGCTG CTGAGCAACG TCCTAGTCAA GTTCACGCTG 720

TCTGAGATCA AGAGGGTGAT GCAGATGCTG CTCAACGGCC TCTACTACAT CCACAGGAAC 780

AAGATTCTGC ACAGGGACAT GAAGGCTGCT AACGTGCTCA TCACTCGGGA TGGGGTCCTG 840

AAGCTGGCAG ACTTCGGGCT GGCCCGGGCC TTCAGCCTGG CCAAGAACAG CCAGCCTAAC 900

CGCTACACCA ACCGTGTGGT GACGCTCTGG TACCGGCCCC CGGAGCTGCT GCTCGGGGAG 960

CGGGACTACG GTCCGCCCAT TGACCTGTGG GGTGCAGGGT GCATCATGGC CGAGATGTGG 1020

ACCCGCAGCC CCATCATGCA GGGCAACACG GAGCAGCACC AGCTCGCCCT CATCAGCCAG 1080

CTCTGTGGCT CCATCACGCC GGAGGTGTGG CCGAATGTGG ACAAATATGA GCTGTTTGAG 1140

AAGCTGGAGC TGGTCAAGGG CCAGAAGCGC AAGGTGAAGG ACAGGCTGAA GGCCTATGTG 1200

CGTGACCCCT ACGCGCTGGA CCTCATTGAC AAGCTGCTGG TCCTGGACCC TGCGCAGCGC 1260

ATCGACAGCG ATGATGCCCT CAACCACGAC TTCTTCTGGT CCGACCCCAT GCCCTCGGAC 1320

CTCAAGGGCA TGCTGTCCAC CCACCTGACA TCCATGTTTG AGTACCTAGC GCCGCCGCGT 1380

CGAAAGGGCA GCCAGATCAC ACAGCAGACC ACCAACCAGA GCCGCAACCC AGCCACCACG 1440

AACCAGACGG AGTTCGAGCG CGTGTTC 1467

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yekl+kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+

Q: 136   YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV  195

         99**********************************************************

S: 61    vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         v+L+e++        + k ++yLvf+f+e+dL+ ll++    k++l+e+k+++++ll+gl

Q: 196   VNLIEICRtkaspynRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSEIKRVMQMLLNGL  254

         ********99999988889*********************9.******************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP  169

          y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+P

Q: 255   YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPP  314

         *************************************7776555557*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Y+  +D+W++gci+ae++tr+p++qg++e++ql  i++l+g+++ +vwp+v

Q: 315   ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD  374

         ************************************************************

S: 230   klpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         k++ ++  ++ k +k+k+k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 375   KYELFEkLELVKGQKRKVKDRLKAYVRDpyALDLIDKLLVLDPAQRIDSDDALNHDFF  432

         ******7799999999999999887755469*************************98

Domain Sequence
(FASTA)

YEKLAKIGQG TFGEVFKAKH RQTGQKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60

VNLIEICRTK ASPYNRCKGS IYLVFDFCEH DLAGLLSNVL VKFTLSEIKR VMQMLLNGLY 120

YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQPNRYTNR VVTLWYRPPE 180

LLLGERDYGP PIDLWGAGCI MAEMWTRSPI MQGNTEQHQL ALISQLCGSI TPEVWPNVDK 240

YELFEKLELV KGQKRKVKDR LKAYVRDPYA LDLIDKLLVL DPAQRIDSDD ALNHDFF 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013