EKS-CAP-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	363.3	8.2E-109	67	328	262

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009445

UniProt Accession

H0VH26;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000010518	ENSCPOP00000009445	ENSCPOT00000010613

Organism

Cavia porcellus

Functional Description

Protein Length

484

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGD PEFSPADVCP LAELKAAGLE PVGHYEEVEL TESSVNRGPE 60

RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLNSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLVLPP YLTPDARDLV 300

KKFLKRNPSQ RIGGGLGDAA DVQRHPFFRH INWDDLLARR VDPPFRPSLQ SEEDVSQFDT 360

RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRT 420

PISPLKFSPF EGFRPSPGPP EPMEPPLPPL LPPPPPLPSS TAPLPIRPPS GTKKSKKGRG 480

RPGR 484

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TATTTGATCT GGACTTGGAG ACAGAGGAAG GGAGCGAGGG CGAAGGCGAT 60

CCAGAGTTCA GCCCAGCGGA CGTGTGTCCC CTTGCCGAAT TGAAGGCTGC TGGCCTGGAG 120

CCTGTGGGAC ACTATGAGGA GGTGGAGCTG ACGGAGTCCA GTGTGAACCG CGGCCCAGAG 180

CGCATCGGGC CTCACTGCTT TGAACTGCTG CGAGTGCTGG GGAAAGGAGG CTACGGCAAG 240

GTGTTCCAGG TGCGAAAGGT GCAAGGCACT AACTTGGGGA AAATATATGC CATGAAAGTG 300

CTGAGGAAGG CCAAAATTGT GCGCAATGCC AAGGACACAG CACACACACG GGCTGAGCGG 360

AACATTCTAG AGTCAGTGAA GCACCCTTTC ATCGTGGAAC TGGCCTATGC CTTTCAGACA 420

GGTGGCAAAC TCTACCTCAT CCTGGAGTGC CTCAGTGGGG GTGAGCTCTT CACACATCTA 480

GAGCGAGAAG GCATCTTTCT GGAAGACACG GCCTGCTTCT ACCTAGCTGA GATCACCTTG 540

GCTCTGGGCC ATCTCCACTC CCAAGGCATC ATTTACCGAG ACCTCAAGCC TGAAAATATC 600

ATGCTCAACA GCCAGGGCCA CATCAAACTG ACGGACTTTG GACTGTGCAA GGAGTCCATT 660

CATGAGGGTG CCGTGACTCA CACCTTCTGT GGCACCATTG AGTACATGGC CCCTGAGATT 720

CTGGTGCGCA GTGGCCACAA CCGGGCAGTG GACTGGTGGA GCCTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC ACCCTTCACT GCAGAGAACC GGAAAAAGAC CATGGATAAG 840

ATCATCAAGG GGAAGCTGGT GCTGCCCCCC TACCTCACCC CAGATGCCCG GGACCTTGTT 900

AAAAAGTTTT TGAAGCGGAA TCCCAGCCAA CGGATTGGGG GTGGCCTAGG GGATGCTGCT 960

GATGTGCAGA GGCACCCCTT CTTCCGGCAC ATCAATTGGG ATGATCTCCT GGCCCGCCGC 1020

GTGGATCCCC CTTTCAGGCC AAGTCTGCAG TCAGAGGAAG ATGTGAGTCA GTTTGACACC 1080

CGCTTCACAC GGCAGACGCC AGTAGACAGC CCAGACGACA CGGCCCTCAG TGAGAGCGCT 1140

AATCAGGCCT TCCTGGGCTT CACATATGTG GCCCCTTCAG TGCTGGACAG CATCAAAGAG 1200

GGCTTCTCCT TCCAGCCCAA GCTGCGTTCC CCACGGCGCC TCAACAGCAG TCCTCGGACC 1260

CCAATCAGTC CCCTCAAGTT CTCTCCCTTC GAGGGATTCC GGCCCAGCCC AGGTCCACCA 1320

GAACCCATGG AACCTCCTCT ACCTCCACTC CTGCCACCAC CACCGCCACT ACCCTCAAGC 1380

ACTGCTCCTC TCCCCATCCG TCCCCCCTCA GGGACCAAGA AGTCCAAGAA GGGCCGTGGG 1440

CGTCCTGGGC GCTAG 1455

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LVLPPY--LTPDARDLVK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGglgDAADVQRHPFF  328

         ***********999999********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL VLPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGL GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013