EKS-CAP-00503

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00503

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	333.9	6.9E-100	22	312	291

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009485

UniProt Accession

H0VH64;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000010565	ENSCPOP00000009485	ENSCPOT00000010660

Organism

Cavia porcellus

Functional Description

Protein Length

461

Protein Sequence
(FASTA)

MAEKGDCFAS VYGYDLGGRF VDFKPLGFGV NGLVLSAVDS RACRKVAVKK ITLSDTRSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKYSV AYIVQEYMET DLARLLEQGT 120

LTEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKDELLRVM PCFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDIVLM ATNQSQLSNW DRYPVSLSSD 360

LEWRPDRCQD ASEVQRDPRA GSAPLAEDVQ VDPRKDSKSS SERFLEQSHS SMERAFEADY 420

GRSCDYKVGS PSYLDKLLWR DNKPHHYSEP KLILDLSHWK Q 461

Nucleotide Sequence
(FASTA)

ATGGCTGAGA AGGGTGACTG CTTCGCCAGT GTCTACGGGT ACGACCTTGG TGGGCGCTTT 60

GTTGACTTCA AACCCCTGGG CTTTGGTGTC AACGGGCTGG TTCTGTCAGC TGTGGACAGC 120

CGGGCCTGCC GGAAGGTAGC TGTGAAGAAG ATCACCTTGA GCGACACCCG CAGCATGAAG 180

CACGCACTCC GGGAGATCAA GATCATCCGG CGCCTGGACC ACGATAACAT TGTGAAGGTG 240

TACGAGGTGC TGGGGCCCAA GGGCACCGAC CTGCAGGGTG AGCTGTTCAA GTACAGTGTG 300

GCCTACATCG TCCAGGAATA CATGGAGACT GACCTGGCAC GCCTGCTGGA GCAGGGAACA 360

CTGACGGAAG AGCACGCCAA GCTGTTCATG TACCAGCTGC TCCGCGGGCT CAAATACATC 420

CACTCCGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTTGTGC TCAAGATTGG GGATTTTGGG TTGGCAAGGA TTGTTGATCA GCATTACTCA 540

CACAAGGGTT ATCTGTCAGA GGGGTTGGTG ACAAAGTGGT ACCGCTCTCC ACGACTGCTC 600

CTGTCACCCA ACAACTATAC GAAAGCCATC GACATGTGGG CAGCTGGCTG CATCCTGGCT 660

GAGATGCTCA CAGGGAGGAT GCTTTTTGCT GGAGCTCATG AACTGGAGCA GATGCAGCTG 720

ATCCTGGAGA CCATCCCTGT GATCCGTGAA GAGGACAAGG ACGAGCTGCT CCGGGTCATG 780

CCGTGCTTCG TCAGCAGCAC CTGGGAAGTG AAGAGGCCGC TGCGCAAGCT GCTCCCCGAA 840

GTGAACAGTG AAGCCATTGA CTTTCTGGAA AAGATTTTGA CCTTTAACCC CATGGACCGT 900

CTGACAGCTG AGATGGGGCT GCAGCATCCC TACATGAGTC CATACTCATG CCCCGAGGAT 960

GAGCCCACCT CACAACACCC CTTCCGCATA GAGGATGAGA TTGACGACAT CGTGCTGATG 1020

GCTACCAACC AGAGCCAGCT GTCCAACTGG GACAGGTACC CAGTGAGTTT GTCGTCAGAC 1080

CTGGAGTGGC GACCCGACCG GTGCCAGGAT GCCAGCGAGG TGCAGCGCGA CCCACGAGCT 1140

GGCTCTGCAC CGCTGGCCGA GGATGTGCAG GTGGACCCGC GCAAGGACTC GAAGAGCAGC 1200

TCGGAGCGCT TCCTGGAGCA GTCGCACTCG TCCATGGAGC GCGCCTTCGA GGCCGACTAT 1260

GGGCGCTCCT GCGACTACAA GGTGGGGTCG CCGTCCTACC TGGACAAGCT GCTGTGGCGT 1320

GACAACAAGC CGCACCACTA CTCGGAACCC AAGCTCATTT TAGATCTGTC GCATTGGAAG 1380

CAG 1383

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + kplg G +g+v+savd+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFKPLGFGVNGLVLSAVDSRACRKVAVKKIT--LSDTRSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +++  Y+v+e+metdL++++++ +l++eh+kl++yq+lrglky

Q: 80    VYEVLGPKGtdlqgELFKYSVAYIVQEYMETDLARLLEQGTLTEEHAKLFMYQLLRGLKY  139

         *******9887777899999****************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          +  +++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPCFVSSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9999999999887.***************************************7

Domain Sequence
(FASTA)

DFKPLGFGVN GLVLSAVDSR ACRKVAVKKI TLSDTRSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPKGTDL QGELFKYSVA YIVQEYMETD LARLLEQGTL TEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKDELLRVMP 240

CFVSSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013