EKS-CAP-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	448.5	5.7E-135	255	504	250

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009898

UniProt Accession

H0VI86;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000011012	ENSCPOP00000009898	ENSCPOT00000011113

Organism

Cavia porcellus

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

MGSNKSKPKD AGPRRRSLEP TESAHGPGGG AFPASQTPSK PASAEPKLFG GFNSSDTVTS 60

PQPRGALAGG VTTFVALYDY ESRTETDLSF KKGERLQIVN NTEGDWWLAH SLSTGQTGYI 120

PSNYVAPSDS IQAEEWYFGK ITRRESERLL LNAENPRGTF LVRESETTKG AYCLSVSDFD 180

NAKGLNVKHY KIRKLDSGGF YITSRTQFNS LQQLVAYYSK HADGLCHRLT TVCPTSKPQT 240

QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTRV AIKTLKPGTM SPEAFLQEAQ 300

VMKKLRHEKL VQLYAVVSEE PIYIVTEYMS KGSLLDFLKG ETGKYLRLPQ LVDMAAQIAS 360

GMAYVERMNY VHRDLRAANI LVGENLVCKV ADFGLARLIE DNEYTARQGA KFPIKWTAPE 420

AALYGRFTIK SDVWSFGILL TELTTKGRVP YPGMVNREVL DQVERGYRMP CPPECPESLH 480

DLMCQCWRKE PEERPTFEYL QAFLEDYFTS TEPQYQPGEN L 521

Nucleotide Sequence
(FASTA)

ATGGGCAGCA ACAAGAGCAA GCCCAAGGAC GCCGGCCCGC GGCGGCGCAG CCTGGAGCCC 60

ACCGAGAGCG CGCACGGCCC AGGCGGCGGC GCCTTCCCCG CCTCGCAGAC GCCCAGCAAG 120

CCGGCCTCGG CCGAGCCCAA GCTCTTCGGG GGCTTCAACT CCTCGGACAC CGTCACCTCC 180

CCGCAGCCGC GCGGGGCGCT GGCCGGTGGA GTGACCACCT TTGTGGCCCT CTATGACTAC 240

GAGTCCCGGA CAGAGACCGA TCTATCCTTC AAGAAAGGGG AGCGGCTCCA GATTGTCAAT 300

AACACAGAGG GAGACTGGTG GCTGGCACAC TCGCTCAGCA CGGGCCAGAC AGGCTACATC 360

CCCAGCAACT ATGTGGCGCC CTCCGACTCT ATCCAGGCTG AGGAGTGGTA CTTCGGCAAG 420

ATCACCAGGC GGGAGTCAGA GCGCTTGCTG CTCAACGCGG AGAACCCGAG AGGGACCTTC 480

CTGGTGCGAG AAAGTGAGAC CACAAAAGGT GCCTACTGCC TCTCTGTGTC CGACTTTGAC 540

AATGCCAAGG GCCTCAATGT GAAGCACTAC AAAATCCGCA AGTTGGACAG TGGCGGCTTC 600

TACATCACTT CACGCACCCA GTTCAACAGC CTGCAGCAGC TTGTCGCCTA TTACTCCAAA 660

CATGCTGACG GCCTGTGTCA TCGCCTCACC ACCGTGTGCC CCACGTCCAA GCCCCAGACC 720

CAGGGCCTGG CCAAGGATGC CTGGGAGATC CCCCGGGAGT CCTTGCGGCT GGAGGTGAAG 780

CTGGGCCAGG GCTGCTTCGG GGAGGTGTGG ATGGGAACCT GGAACGGCAC CACCAGGGTG 840

GCCATCAAGA CCCTGAAGCC GGGCACCATG TCTCCAGAGG CCTTCCTGCA GGAGGCCCAG 900

GTCATGAAGA AACTGAGGCA CGAGAAGCTG GTGCAGCTGT ATGCCGTGGT GTCTGAGGAG 960

CCCATCTACA TCGTCACGGA GTACATGAGC AAGGGGAGTT TGCTGGACTT TCTCAAGGGG 1020

GAAACGGGCA AGTACCTGCG GCTGCCTCAG CTGGTGGACA TGGCTGCTCA GATTGCCTCG 1080

GGCATGGCGT ATGTGGAGCG GATGAACTAC GTCCACCGGG ACCTGCGTGC CGCCAACATC 1140

CTGGTCGGGG AGAACCTGGT GTGCAAAGTG GCTGACTTCG GGCTGGCCCG GCTCATCGAA 1200

GACAATGAGT ACACGGCCCG GCAAGGTGCC AAGTTCCCCA TCAAGTGGAC GGCCCCGGAA 1260

GCTGCCCTCT ACGGCCGCTT CACCATCAAG TCCGATGTGT GGTCCTTTGG CATCCTGCTG 1320

ACTGAGCTCA CGACGAAGGG CCGGGTGCCC TACCCTGGGA TGGTGAACCG AGAGGTGCTG 1380

GACCAGGTGG AGCGGGGCTA CCGCATGCCC TGCCCACCCG AGTGCCCCGA GTCCCTGCAC 1440

GACCTCATGT GCCAGTGCTG GCGGAAGGAG CCAGAGGAGC GGCCCACCTT TGAGTACCTA 1500

CAGGCCTTCC TGGAAGACTA CTTCACGTCC ACCGAGCCGC AGTACCAGCC CGGGGAGAAC 1560

CTATAG 1566

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 255   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  314

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 315   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  373

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 374   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  433

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee

Q: 434   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  493

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 494   RPTFEYLQAFL  504

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013