EKS-CAP-00001

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00001

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	519.5	1.1E-156	621	878	258

Status

Unreviewed

Ensembl Protein

ENSCPOP00000009930

UniProt Accession

H0VIB1;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA4

Gene Synonyms/Alias

EPHA4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000011048	ENSCPOP00000009930	ENSCPOT00000011150

Organism

Cavia porcellus

Functional Description

Protein Length

986

Protein Sequence
(FASTA)

MAGILYFVFF SCLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 60

DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 120

TFNLYYYESD NDRERFIRES QFAKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 180

FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 240

DVPKMYCGAD GEWLVPIGNC LCNAGHEEQN GECQACKIGY YKALSTDATC AKCPPHSYSV 300

WEGATSCTCD RGFFRAANDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQSTGGRQDI 360

SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS 420

KYNPSPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE 480

KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII 540

GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 600

TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 660

DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTI 720

IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 780

TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 840

YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT 900

ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHMNQDD LARIGITAIT 960

HQNKILSSVQ AMRSQVQQLH GRMVPV 986

Nucleotide Sequence
(FASTA)

ATGGCTGGGA TTTTGTATTT CGTCTTCTTT TCGTGTCTCT TTGGGATTTG CGACGCTGTC 60

ACCGGTTCTA GAGTGTACCC CGCGAATGAA GTTACTTTAT TGGATTCCAG ATCTGTTCAG 120

GGAGAACTTG GGTGGATAGC AAGCCCTCTG GAAGGAGGGT GGGAGGAAGT GAGTATTATG 180

GATGAAAAAA ACACACCAAT CCGAACCTAC CAAGTGTGCA ACGTGATGGA ACCGAGCCAG 240

AATAACTGGC TGCGAACTGA TTGGATCACC CGAGAAGGGG CTCAGAGGGT GTACATCGAG 300

ATTAAGTTCA CCTTGCGGGA CTGTAATAGT CTCCCGGGAG TTATGGGGAC TTGTAAGGAG 360

ACATTTAACC TGTACTACTA CGAGTCAGAC AACGACAGGG AACGCTTCAT CCGAGAGAGC 420

CAGTTTGCTA AGATCGACAC CATTGCTGCC GACGAGAGCT TCACCCAAGT GGACATTGGC 480

GACAGAATCA TGAAGCTCAA CACTGAGATC CGGGATGTTG GGCCTCTGAG CAAGAAGGGG 540

TTTTACCTGG CTTTTCAAGA TGTGGGCGCC TGCATTGCCC TGGTGTCCGT CCGTGTGTTC 600

TATAAGAAAT GTCCACTCAC CGTGCGCAAT CTGGCCCAGT TTCCAGACAC CATCACAGGG 660

GCTGATACCT CCTCCCTGGT GGAGGTTCGA GGATCTTGTG TCAACAACTC GGAAGAGAAG 720

GATGTGCCAA AAATGTACTG TGGGGCAGAT GGTGAATGGC TGGTCCCCAT TGGCAACTGC 780

CTATGCAATG CTGGCCATGA AGAGCAGAAT GGAGAATGCC AAGCTTGCAA AATTGGGTAT 840

TACAAGGCTC TCTCCACGGA TGCCACCTGT GCCAAGTGTC CACCTCACAG CTACTCTGTC 900

TGGGAAGGAG CCACCTCGTG TACCTGTGAC CGAGGCTTTT TCAGAGCTGC CAATGATGCT 960

GCATCCATGC CCTGTACCCG CCCACCATCT GCTCCCCTCA ACTTGATTTC AAATGTCAAT 1020

GAGACATCAG TGAACTTGGA ATGGAGTAGT CCTCAGAGCA CAGGTGGCCG TCAGGACATT 1080

TCTTACAATG TGGTCTGCAA GAAGTGTGGA GCTGGAGACC CCAGCAAGTG CCGACCCTGT 1140

GGAAGTGGGG TCCACTATAC CCCACAGCAG AATGGCCTGA AAACAACCAA AGTCTCCATC 1200

ACTGACCTCC TGGCACACAC CAACTATACT TTTGAAATCT GGGCCGTGAA TGGAGTGTCC 1260

AAGTATAACC CAAGTCCAGA CCAATCAGTG TCTGTCACTG TGACAACCAA CCAAGCAGCA 1320

CCATCATCAA TTGCTTTGGT TCAGGCCAAA GAAGTAACCA GATACAGCGT GGCTCTGGCT 1380

TGGTTGGAAC CAGATCGGCC CAATGGGGTT ATCCTGGAGT ATGAAGTCAA GTATTATGAA 1440

AAGGATCAGA ATGAACGAAG CTACCGTATA GTTCGGACAG CAGCCAGGAA CACAGACATC 1500

AAGGGTCTGA ACCCTCTGAC TTCCTATGTT TTCCATGTGC GAGCCCGGAC AGCAGCTGGC 1560

TATGGAGACT TCAGTGAGCC CTTGGAAGTC ACGACCAACA CAGTGCCTTC CAGGATCATC 1620

GGAGATGGGG CCAACTCCAC CGTCCTCCTG GTGTCTGTGT CGGGCAGCGT GGTGCTGGTG 1680

GTCATTCTTA TTGCAGCTTT TGTCATCAGC AGAAGACGGA GTAAATATAG TAAAGCAAAA 1740

CAAGAAGCAG ATGAAGAAAA GCATTTGAAT CAAGGTGTCA GAACTTATGT GGATCCCTTT 1800

ACATATGAAG ATCCTAACCA AGCAGTTCGA GAATTTGCCA AGGAAATTGA TGCATCCTGC 1860

ATTAAGATTG AAAAAGTCAT AGGAGTTGGT GAATTTGGTG AAGTCTGCAG TGGGCGTCTC 1920

AAAGTGCCTG GCAAGAGAGA GATCTGTGTT GCCATCAAGA CCCTGAAAGC TGGTTATACA 1980

GACAAGCAGA GGAGAGACTT CCTGAGTGAG GCCAGCATCA TGGGACAGTT TGATCACCCA 2040

AACATAATTC ACTTGGAAGG CGTCGTCACC AAATGTAAAC CAGTAATGAT CATTACAGAG 2100

TACATGGAGA ATGGCTCTTT GGATGCGTTC CTCCGGAAGA ATGATGGTCG ATTCACAATC 2160

ATCCAGCTAG TGGGCATGCT CCGTGGTATC GGTTCTGGAA TGAAGTACCT ATCTGACATG 2220

AGCTATGTAC ATCGTGACCT GGCTGCACGG AACATCCTGG TAAACAGCAA CTTGGTCTGC 2280

AAAGTGTCTG ATTTCGGCAT GTCACGAGTG CTAGAGGATG ACCCGGAAGC AGCTTATACC 2340

ACTAGGGGTG GCAAGATTCC TATCCGGTGG ACCGCGCCAG AAGCAATCGC CTATCGTAAA 2400

TTCACATCAG CGAGTGATGT ATGGAGCTAT GGAATCGTTA TGTGGGAAGT GATGTCGTAT 2460

GGAGAGAGAC CCTACTGGGA TATGTCCAAT CAAGATGTGA TTAAAGCCAT CGAGGAAGGC 2520

TATCGGCTAC CCCCACCCAT GGACTGTCCC ATTGCGCTCC ACCAGCTGAT GCTGGACTGC 2580

TGGCAGAAGG AGAGAAGCGA TAGGCCTAAA TTTGGGCAGA TTGTCAACAT GTTGGACAAA 2640

CTCATCCGCA ACCCCAACAG CTTGAAGAGG ACAGGGACAG AGAGCTCCAG ACCTAACACT 2700

GCCTTGTTGG ATCCCAGCTC CCCTGAATTC TCTGCGGTTG TATCAGTAGG TGACTGGCTG 2760

CAGGCCATTA AAATGGACCG GTATAAGGAT AACTTCACAG CTGCTGGTTA TACCACACTA 2820

GAGGCTGTGG TGCACATGAA CCAGGATGAC CTGGCGAGAA TTGGCATCAC GGCCATCACA 2880

CACCAGAATA AGATTTTGAG CAGCGTCCAG GCAATGCGAA GCCAGGTGCA GCAGCTGCAC 2940

GGCAGAATGG TTCCTGTC 2958

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp

Q: 621   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  680

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ft+iqlvgmlrGi+sgmkylsdm

Q: 681   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTIIQLVGMLRGIGSGMKYLSDM  740

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk

Q: 741   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  800

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc

Q: 801   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  860

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqk+r++rpkf qiv++l

Q: 861   WQKERSDRPKFGQIVNML  878

         ***************985

Domain Sequence
(FASTA)

IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60

NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTI IQLVGMLRGI GSGMKYLSDM 120

SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240

WQKERSDRPK FGQIVNML 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013