EKS-CAP-00332

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00332

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	499.4	1.8E-150	183	440	258

Status

Unreviewed

Ensembl Protein

ENSCPOP00000010099

UniProt Accession

H0VIQ0;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4

Gene Synonyms/Alias

ERBB4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000011232	ENSCPOP00000010099	ENSCPOT00000011338

Organism

Cavia porcellus

Functional Description

Protein Length

773

Protein Sequence
(FASTA)

CCCFHSEFRE FENGSVCVEC DPQCEKVEEG LLTCHGPGPD NCTKCSHFKD GPNCVEKCPD 60

GLQGANSFIF KYADQDRECH PCHPNCTQGC NGPTIHDCIY YPWTGHSTLP QHARTPLIAA 120

GVIGGLFILV IVGLTFAVYV RRKSIKKKRA LRRFLETELV EPLTPSGTAP NQAQLRILKE 180

TELKRIKVLG SGAFGTVYKG IWVPEGETVK IPVAIKILNE TTGPKANVEF MDEALIMASM 240

DHPHLVRLLG VCLSPTIQLV TQLMPHGCLL DYVHEHKDNI GSQLLLNWCV QIAKGMMYLE 300

ERRLVHRDLA ARNVLVKSPN HVKITDFGLA RLLEGDEKEY NADGGKMPIK WMALECIHYR 360

KFTHQSDVWS CGVTIWELMT FGGKPYDGIP TREIPDLLEK GERLPQPPIC TIDVYMVMVK 420

CWMIDADSRP KFKELAAEFS RMARDPQRYL VIQGDDRMKL PSPNDSKFFQ NLLDEEDLED 480

MMDAEEYLVP QAFNIPPPIY TSRARIDSNR SEIGHSPPPA YTPMSGNQFV YRDGGFAAEQ 540

GMPVPYRATT STIPEAPAAQ GATAEIFDDS CCNGTLRKPV APHSQEDSST QRYSADPTVF 600

ASERSPRGEL DEEGYMTPMR DKPKQEYLNP VEENPFVSRR KNGNPQALDN PEYHKAANGP 660

PKTEDEYVNE PLYLNTFANA LGKAEYLKNS VLSVPEKAKK AFDNPDYWNH SLPPRSTLQH 720

PDYLQEYSTK YFYKQNGRIR PIVAENPEYL SEFSLKPGTV LPPPPYRHRN TVV 773

Nucleotide Sequence
(FASTA)

TGCTGCTGTT TTCACAGTGA GTTTCGGGAG TTCGAGAACG GCTCGGTCTG CGTGGAGTGT 60

GACCCCCAGT GTGAGAAGGT GGAAGAGGGG CTCCTCACGT GCCATGGGCC GGGGCCTGAC 120

AACTGCACAA AGTGTTCGCA TTTTAAGGAC GGCCCGAACT GTGTGGAAAA GTGTCCAGAT 180

GGCTTACAGG GGGCAAACAG CTTCATTTTC AAGTACGCGG ACCAGGATCG GGAGTGCCAT 240

CCTTGCCACC CAAACTGCAC CCAAGGGTGT AACGGTCCCA CTATTCATGA CTGCATTTAC 300

TACCCATGGA CGGGCCATTC CACTTTACCA CAGCACGCTA GAACTCCCTT GATTGCTGCT 360

GGAGTCATTG GCGGGCTCTT CATCCTGGTC ATAGTAGGTC TCACGTTTGC AGTTTATGTT 420

AGGAGAAAGA GCATCAAAAA GAAAAGGGCC TTAAGAAGAT TCCTAGAAAC AGAGCTGGTA 480

GAGCCATTAA CTCCTAGTGG CACGGCACCC AATCAAGCTC AACTTCGTAT TTTGAAAGAA 540

ACTGAACTAA AGAGGATAAA AGTCCTTGGC TCAGGTGCTT TTGGAACTGT TTATAAAGGC 600

ATTTGGGTCC CTGAAGGAGA AACAGTGAAG ATTCCTGTGG CTATTAAGAT TCTCAATGAG 660

ACGACTGGTC CCAAGGCCAA TGTTGAGTTC ATGGATGAAG CGCTCATCAT GGCAAGCATG 720

GATCACCCGC ACCTGGTTCG CTTACTGGGC GTGTGCCTGA GCCCTACCAT CCAGCTGGTC 780

ACGCAGCTGA TGCCCCATGG CTGCCTGCTG GATTACGTCC ATGAACACAA GGATAACATC 840

GGATCCCAGC TGCTGCTGAA CTGGTGTGTA CAGATTGCCA AGGGAATGAT GTACCTGGAA 900

GAAAGACGAC TTGTTCATCG TGATTTGGCA GCCCGTAATG TCTTAGTGAA GTCTCCAAAC 960

CATGTGAAAA TCACGGATTT TGGGCTGGCC AGACTCTTGG AAGGAGATGA AAAAGAGTAT 1020

AATGCTGATG GAGGAAAGAT GCCGATTAAG TGGATGGCAT TGGAGTGTAT ACATTACAGG 1080

AAATTCACTC ATCAGAGTGA CGTGTGGAGC TGTGGAGTCA CTATATGGGA ACTGATGACC 1140

TTTGGAGGAA AACCATATGA TGGAATTCCC ACCCGAGAAA TCCCTGACTT ACTAGAAAAA 1200

GGAGAGCGTT TGCCTCAGCC TCCCATCTGC ACTATTGATG TCTACATGGT CATGGTCAAA 1260

TGTTGGATGA TTGATGCAGA CAGTAGACCT AAGTTCAAGG AACTGGCTGC CGAATTCTCA 1320

AGGATGGCTC GAGACCCTCA AAGATACCTA GTTATTCAGG GTGATGATCG GATGAAGCTC 1380

CCCAGTCCAA ATGACAGCAA GTTCTTCCAA AATCTCTTGG ATGAAGAGGA TTTGGAAGAT 1440

ATGATGGATG CTGAGGAATA CCTGGTGCCT CAGGCTTTCA ACATCCCTCC ACCCATCTAC 1500

ACTTCTAGGG CAAGAATTGA CTCAAACAGG AGTGAAATTG GACACAGCCC TCCTCCTGCC 1560

TACACCCCCA TGTCGGGAAA CCAGTTCGTA TACCGGGACG GAGGCTTTGC TGCAGAACAA 1620

GGCATGCCCG TGCCCTACCG GGCCACAACC AGCACCATCC CAGAAGCGCC AGCAGCACAA 1680

GGCGCCACTG CTGAGATTTT CGATGACTCC TGCTGTAACG GGACCCTACG CAAACCAGTG 1740

GCACCCCACT CCCAAGAGGA CAGCAGCACC CAGAGGTACA GCGCAGACCC CACCGTGTTT 1800

GCTTCTGAAC GGAGCCCAAG AGGAGAACTG GATGAAGAGG GCTACATGAC TCCTATGCGA 1860

GACAAACCCA AACAAGAATA CCTGAACCCC GTGGAGGAAA ACCCTTTTGT TTCTCGGAGG 1920

AAAAATGGAA ACCCGCAAGC TCTGGATAAT CCTGAGTATC ACAAAGCTGC CAACGGCCCG 1980

CCCAAGACAG AGGATGAGTA TGTGAATGAG CCGCTGTACC TCAACACCTT TGCCAACGCC 2040

TTGGGGAAGG CCGAGTATCT GAAGAACAGT GTACTGTCTG TGCCAGAGAA GGCCAAAAAA 2100

GCGTTTGACA ACCCTGACTA CTGGAACCAC AGCCTGCCAC CTCGGAGCAC CCTCCAGCAC 2160

CCAGACTACC TGCAGGAGTA CAGCACAAAA TATTTTTATA AACAGAATGG ACGGATCCGG 2220

CCCATCGTGG CAGAGAATCC TGAATACCTC TCTGAGTTCT CCCTGAAGCC AGGCACTGTG 2280

CTGCCTCCTC CTCCCTACAG ACACCGGAAC ACTGTGGTG 2319

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 183   LKRIKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  242

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 243   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  302

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 303   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  362

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvws Gvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw

Q: 363   THQSDVWSCGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  422

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 423   MIDADSRPKFKELAAEFS  440

         ****************96

Domain Sequence
(FASTA)

LKRIKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSCG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00261	; FU; 2.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013