EKS-CAP-00432
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00432
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR593.51.5E-178591928338
StatusUnreviewed
Ensembl ProteinENSCPOP00000010258
UniProt AccessionH0VJ44;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000011411ENSCPOP00000019177ENSCPOT00000021510
ENSCPOG00000011411ENSCPOP00000019565ENSCPOT00000021918
ENSCPOG00000011411ENSCPOP00000010258ENSCPOT00000011517
OrganismCavia porcellus
Functional Description
Protein Length981
Protein Sequence
(FASTA)
FQQIKAAWES LCLSWLKWLL LCLRTQAGSS QPSVSPGELS PPSIVPAQSE LIVNAGDQIR 60
LTCTDPAFVR WTFKSLDHTS ENKDSEWVRE KAEASHTGRY TCINKDGLSS SIYVFVRDPA 120
RLFLIGLPLY GKEDNDTLVR CPLTDPEVTN YSLKECDGKP LPEDLTFVPD PKAGITIRNV 180
QRAYHRLCLR CTAYQKGKLI QSDRFILKVR AAIKAIPVVS VSKPSYLLRE GEEFTVTCTI 240
KDVSSSVGAM WIKENSQLTK AQVKRNSWHR GDFNYERQET LTISPTRVND SGVFMCYANN 300
TFGSANVTTT LKVLDKGFIN IFSMMNTTVF VNDGENIDLI VEYEAYPKPG HHQWIYMNRT 360
STNKWDDYPK SKNESNIRYV NELHLTRLKA TEGGTYTFFV SNSDVNASMT FTVYVNTKPE 420
ILTYDRLTNG MLQCVAAGFP EPTIDWYFCP GTEQRCSNSV QPVDVQIQNS SVPPFGKLLV 480
QSSVDSSMFR HNGTVECKAS NDVGKISAYF NFAFKEQTHP HTLFTPLLIG FVITAGMMCI 540
IVMILTYKYL QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG 600
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG NHMNIVNLLG 660
ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDQA EAALYKNLLH SKESSCSDNS 720
TSEYMDMKPG VSYVVPTKAD KRRSARIAGS YIERDVTPAI MEDDELALDL EDLLSFSYQV 780
AKGMAFLASK NCIHRDLAAR NILLTHGRIT KICDFGLARD IKNDSNYVVK GNARLPVKWM 840
APESIFNCVY TFESDVWSYG IFLWELFSLG SSPYPGMPVD SKFYKMIKEG FRMLSPEHAP 900
PEMYDIMKTC WDADPIKRPT FKQIVQLIEK QISDSTIHMY SNLASCTLNP ENPVVVDHSV 960
RVNSVGSSAS STQPLLVHED V 981
Nucleotide Sequence
(FASTA)
TTTCAGCAAA TCAAGGCTGC TTGGGAGTCT CTTTGTCTCA GTTGGCTTAA ATGGCTTTTG 60
CTATGCCTAA GAACTCAAGC AGGCTCTTCT CAACCATCTG TGAGTCCAGG GGAACTGTCT 120
CCCCCATCCA TCGTGCCTGC ACAATCAGAG TTAATAGTCA ACGCTGGTGA CCAGATCAGG 180
CTGACATGCA CGGATCCAGC CTTTGTCAGA TGGACTTTCA AGAGCCTGGA TCACACGAGC 240
GAGAACAAGG ACAGTGAGTG GGTCAGAGAA AAGGCCGAGG CTAGCCACAC GGGCAGGTAC 300
ACGTGCATCA ACAAAGACGG CTTAAGCAGC TCCATCTATG TATTTGTTAG AGATCCTGCC 360
AGACTTTTCC TTATTGGTCT TCCCTTGTAT GGGAAAGAAG ACAATGACAC GCTGGTCCGC 420
TGTCCTCTGA CGGACCCAGA GGTGACCAAT TATTCCCTCA AGGAGTGCGA TGGGAAGCCT 480
CTCCCCGAAG ACCTCACGTT TGTGCCCGAC CCCAAGGCTG GCATCACCAT CAGAAACGTG 540
CAGCGTGCCT ATCATCGACT CTGTCTACGC TGCACTGCCT ATCAGAAGGG CAAGTTGATA 600
CAGTCGGACA GATTCATCCT GAAAGTGAGG GCAGCCATCA AAGCTATACC AGTTGTGTCT 660
GTGTCTAAAC CCAGCTATCT TCTGAGGGAA GGGGAAGAAT TTACAGTGAC ATGCACAATA 720
AAAGATGTGT CTAGTTCCGT GGGTGCAATG TGGATAAAAG AGAACAGTCA GCTAACTAAA 780
GCCCAGGTGA AACGTAATAG CTGGCATCGG GGTGACTTCA ATTATGAGCG CCAAGAAACA 840
TTGACAATCA GCCCAACAAG AGTTAATGAT TCTGGAGTGT TCATGTGTTA CGCCAATAAT 900
ACTTTTGGAT CAGCAAATGT CACAACAACC TTGAAAGTAT TAGATAAAGG ATTCATTAAT 960
ATCTTCTCCA TGATGAACAC CACTGTATTT GTAAATGATG GAGAAAACAT AGATTTGATT 1020
GTTGAATATG AGGCATACCC CAAACCTGGA CACCATCAGT GGATATATAT GAACAGGACC 1080
TCCACCAACA AATGGGACGA TTATCCCAAG TCTAAGAATG AAAGTAACAT CAGATATGTC 1140
AATGAGCTTC ATCTAACCCG GCTAAAAGCG ACCGAAGGAG GCACTTACAC ATTTTTCGTG 1200
TCTAACTCTG ATGTCAATGC TTCCATGACA TTTACTGTTT ACGTGAACAC AAAACCAGAA 1260
ATCCTGACTT ACGACAGGCT CACGAATGGC ATGCTCCAGT GTGTGGCAGC GGGATTCCCA 1320
GAGCCCACAA TAGATTGGTA TTTTTGTCCA GGAACAGAGC AGAGATGTTC TAACTCTGTT 1380
CAACCAGTGG ATGTCCAGAT TCAAAACTCC TCTGTGCCGC CGTTTGGAAA ACTCCTGGTT 1440
CAGAGTTCTG TAGATTCCAG TATGTTCCGG CACAATGGCA CGGTTGAGTG TAAGGCTTCC 1500
AACGATGTGG GCAAGATTTC TGCCTATTTT AACTTTGCAT TTAAAGAACA AACCCATCCC 1560
CACACCCTGT TCACCCCATT GCTGATTGGT TTTGTGATCA CAGCTGGTAT GATGTGCATC 1620
ATTGTGATGA TTCTCACCTA CAAATATTTA CAGAAACCCA TGTATGAAGT GCAGTGGAAG 1680
GTTGTCGAGG AGATAAATGG AAACAATTAT GTTTACATAG ACCCAACACA ACTTCCTTAT 1740
GATCACAAAT GGGAGTTTCC CAGAAACAGG CTGAGTTTTG GAAAGACCTT GGGTGCCGGC 1800
GCCTTTGGGA AAGTTGTAGA GGCCACTGCA TATGGCCTAA TTAAATCAGA TGCAGCCATG 1860
ACTGTTGCTG TCAAGATGCT CAAACCAAGT GCCCACTTAA CGGAAAGAGA AGCCCTCATG 1920
TCTGAACTCA AGGTCCTGAG TTACCTGGGG AATCATATGA ACATCGTGAA TCTCCTTGGA 1980
GCATGCACTG TTGGAGGGCC CACCCTGGTC ATTACAGAAT ATTGTTGCTA TGGTGATCTT 2040
TTGAATTTTT TGAGAAGAAA ACGTGATTCA TTTATTTGCT CAAAGCAGGA AGACCAGGCA 2100
GAAGCAGCAC TTTATAAGAA CCTTTTGCAT TCAAAGGAGT CTTCCTGCAG TGACAACAGT 2160
ACCAGTGAGT ACATGGATAT GAAGCCTGGA GTGTCTTATG TCGTCCCAAC CAAGGCAGAC 2220
AAAAGGAGAT CGGCAAGAAT AGCAGGCTCC TACATAGAAA GAGACGTGAC TCCCGCCATC 2280
ATGGAGGACG ATGAGCTGGC CCTGGACCTA GAAGACTTGC TGAGCTTCTC CTATCAGGTG 2340
GCAAAGGGCA TGGCTTTCCT CGCCTCAAAG AATTGTATTC ACAGAGACTT GGCAGCCAGA 2400
AATATCCTCC TTACTCATGG TCGAATCACA AAGATTTGCG ATTTTGGTCT AGCCAGAGAC 2460
ATCAAGAATG ATTCTAATTA TGTGGTTAAA GGAAATGCCC GACTGCCTGT GAAGTGGATG 2520
GCCCCGGAAA GCATCTTTAA CTGCGTGTAC ACGTTTGAAA GCGATGTCTG GTCCTATGGG 2580
ATTTTCCTGT GGGAGCTCTT CTCTTTAGGG AGCAGCCCCT ACCCTGGAAT GCCGGTCGAT 2640
TCCAAGTTCT ACAAGATGAT CAAGGAAGGG TTCCGGATGC TCAGCCCCGA GCATGCACCT 2700
CCTGAAATGT ATGACATAAT GAAAACTTGC TGGGATGCTG ATCCTATCAA AAGGCCAACA 2760
TTCAAGCAGA TTGTCCAGCT CATTGAGAAG CAGATTTCTG ATAGCACCAT TCACATGTAC 2820
TCCAACTTGG CCAGTTGCAC CCTCAACCCA GAGAACCCCG TGGTGGTGGA CCATTCTGTG 2880
CGGGTCAACT CGGTTGGCAG CAGTGCCTCC TCCACACAGC CTCTCCTTGT GCACGAAGAT 2940
GTCTGA 2946
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 591   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  650
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 651   NHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDQAEAALYKN  707
         ******************************************...99999999999***9
S: 121   lladkslrsksslsse.sseeyvdlkkdvsdvssskadklasekkk.salerevkaalee  178
         l     l+sk+s++s+ s++ey+d+k++vs+v ++kadk++s+++  s++er+v++a++e
Q: 708   L-----LHSKESSCSDnSTSEYMDMKPGVSYVVPTKADKRRSARIAgSYIERDVTPAIME  762
         9.....777777766516789*******************99987439************
S: 179   edsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardim  238
         +d+ +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi+
Q: 763   DDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIK  822
         ************************************************************
S: 239   kdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdsk  298
         +dsnyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdsk
Q: 823   NDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK  882
         ************************************************************
S: 299   fyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         fyk+ikeG+rm +p++a+ e+y+im++cw+a+p krp+fkq+v+l+
Q: 883   FYKMIKEGFRMLSPEHAPPEMYDIMKTCWDADPIKRPTFKQIVQLI  928
         *******************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDQA EAALYKNLLH 120
SKESSCSDNS TSEYMDMKPG VSYVVPTKAD KRRSARIAGS YIERDVTPAI MEDDELALDL 180
EDLLSFSYQV AKGMAFLASK NCIHRDLAAR NILLTHGRIT KICDFGLARD IKNDSNYVVK 240
GNARLPVKWM APESIFNCVY TFESDVWSYG IFLWELFSLG SSPYPGMPVD SKFYKMIKEG 300
FRMLSPEHAP PEMYDIMKTC WDADPIKRPT FKQIVQLI 338
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013