EKS-CAP-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	443.6	1.8E-133	247	497	251

Status

Unreviewed

Ensembl Protein

ENSCPOP00000010517

UniProt Accession

H0VJS5;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000011693	ENSCPOP00000010517	ENSCPOT00000011806

Organism

Cavia porcellus

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSKGKS NLNGDEIDLK TQPVRNTDRT IYVRDPTSNK QPRPVPESQL LPGQRFQAKD 60

PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM RVLEEHGEWW KAKSLSTKRE GFIPSNYVAK 120

VNTLETEEWF FKDITRKDAE RQLLAPGNSP GAFLIRESET LKGSFSLSVR DFDPMHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW 240

EIPRESIKLV KKLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT KEEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPE ELYDIMKMCW 480

KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AGGGAAATCC AATCTGAATG GCGATGAAAT AGATTTGAAG 60

ACTCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGACCCAAC GTCCAATAAG 120

CAGCCAAGGC CAGTTCCAGA ATCTCAGCTT TTACCAGGAC AGAGGTTTCA AGCTAAAGAT 180

CCAGAGGAAC AAGGGGACAT CGTAGTGGCC TTGTACCCGT ACGATGGCAT CCACCCGGAT 240

GACTTGTCTT TCAAGAAGGG AGAGAAGATG AGAGTCCTTG AGGAACATGG AGAGTGGTGG 300

AAAGCTAAGT CCCTTTCAAC CAAGAGAGAA GGCTTCATTC CCAGCAACTA CGTGGCCAAG 360

GTCAACACCC TGGAAACGGA AGAGTGGTTT TTCAAGGACA TAACCAGGAA AGATGCAGAA 420

CGGCAGCTGC TGGCACCAGG GAACAGCCCG GGTGCATTTC TCATCAGAGA AAGTGAAACC 480

TTAAAAGGAA GCTTCTCTCT GTCTGTCAGA GATTTTGATC CTATGCATGG TGATGTTATT 540

AAGCACTACA AAATTCGAAG TCTGGACAAT GGAGGTTATT ACATCTCTCC ACGAATTACT 600

TTTCCCTGTA TCAGTGACAT GATTAAGCAT TACCAAAAGC AGGCAGATGG CCTGTGCAGG 660

AGACTGGAGA AGGCATGTAT CAGTCCCAAA CCGCAGAAAC CGTGGGATAA AGACGCCTGG 720

GAAATCCCCC GCGAGTCCAT AAAGCTGGTG AAGAAGCTCG GTGCAGGACA GTTTGGGGAA 780

GTCTGGATGG GTTACTACAA CAACAGCACG AAGGTGGCTG TGAAGACCCT GAAGCCAGGC 840

ACAATGTCTG TGCAAGCCTT CCTCGAGGAA GCCAATCTTA TGAAGACGCT GCAGCACGAC 900

AAGCTAGTGA GACTGTATGC GGTGGTCACC AAGGAAGAAC CTATCTACAT CATCACCGAG 960

TACATGGCCA AGGGCAGTTT GCTGGACTTC CTCAAGAGTG ACGAAGGAGG CAAAGTGCTG 1020

CTCCCAAAGC TCATTGACTT TTCTGCCCAG ATTGCAGAGG GCATGGCCTA CATAGAGCGG 1080

AAGAACTACA TTCACCGCGA CCTGCGAGCG GCTAACGTCC TGGTCTCGGA GTCACTCATG 1140

TGCAAGATTG CAGATTTTGG CCTCGCTAGA GTAATCGAAG ACAACGAATA CACAGCACGG 1200

GAAGGTGCCA AGTTCCCTAT TAAGTGGACC GCTCCGGAAG CAATCAACTT CGGATGTTTC 1260

ACCATCAAGT CCGACGTGTG GTCCTTTGGA ATTCTCCTGT ATGAAATTGT CACCTATGGG 1320

AAGATTCCCT ATCCAGGGAG AACCAATGCG GACGTAATGA CCGCTCTGTC CCAGGGCTAC 1380

CGGATGCCCC GCATGGAGAA CTGCCCAGAG GAGCTCTATG ACATCATGAA AATGTGCTGG 1440

AAGGAAAAGG CAGAGGAGAG GCCGACGTTT GATTACCTAC AGAGCGTCCT GGACGACTTC 1500

TACACGGCCA CGGAGGGGCA GTACCAGCAG CAGCCC 1536

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvkklG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTKEEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cpeely+++++cwk+++ee

Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPEELYDIMKMCWKEKAEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 487   RPTFDYLQSVL  497

         ********986

Domain Sequence
(FASTA)

IKLVKKLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTKEEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRME NCPEELYDIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013