EKS-CAP-00430
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00430
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR612.91.7E-184593950358
StatusUnreviewed
Ensembl ProteinENSCPOP00000010597
UniProt AccessionH0VJZ3;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000011782ENSCPOP00000010597ENSCPOT00000011897
OrganismCavia porcellus
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTSHQAVLV LGCLLTELSL ICCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVIWKHP 60
VTLGEFPDVD IRNEENNSGL FVAVLEVANA SAAHTGWYTC CYNHTEPEEG EVEGRHIYIY 120
VPDPDVAFLP LEMTDYIVVA NNDDSTIIPC RTTDPRTPVT LHNSQGLVPA SYDSKQGFNG 180
TFNMGPYFCE ATVQGKTFQT MLFNIVTLKA ASQLDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GAMKGKGLLK LQEIRFPTIK LVYTLTVPEA TVKDSGDYEC TARHATEDVK 300
EMKRVSIAVH EKGFVEIKPT FGHVEAVNLH EVRHFVVDIQ AYPPPRISWL KDNLTLIENL 360
TEITTDVEKI REIRYRSKLK LIRAKEEDSG HYTIIVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSGGE QTVRCTAEGL PLPDIEWMVC RDIKRCNNET SWTVLANNVS NIITETHSQG 480
KSIVEGRVTF AKVEETIAVR CLAKNLLGSS SRELKLVVPT LHSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSRHPEK PKKELDIFGL NPADESTRSY 720
VILSFENNGD YMDMKQADAT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYDIMM QCWNSEPEKR PSFYHLSEIV ETLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNTYIG VSYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACAT CCCACCAGGC CGTCTTGGTC CTTGGCTGTC TCCTCACAGA ACTGAGCCTA 60
ATCTGCTGCC AGCTTTCGCT GCCCTCCATC CTGCCCAATG AGAATGAAAA GGTTGTGCAG 120
CTCAATTCAT CCTTTTCTCT GCGATGCTTC GGGGAGAGCG AAGTGATCTG GAAGCACCCC 180
GTGACTCTGG GAGAGTTCCC CGACGTGGAC ATCAGAAACG AAGAAAACAA CAGCGGCCTT 240
TTTGTGGCCG TGCTGGAAGT GGCCAACGCC TCGGCGGCCC ACACCGGCTG GTACACTTGC 300
TGCTACAACC ACACCGAGCC GGAGGAGGGC GAGGTCGAGG GCCGGCATAT CTACATCTAC 360
GTGCCGGACC CGGATGTGGC CTTTTTGCCT CTAGAAATGA CAGACTACAT AGTTGTTGCA 420
AACAACGATG ACTCCACCAT CATACCCTGC CGCACGACAG ACCCCAGGAC TCCCGTGACC 480
TTACACAACA GCCAGGGGTT GGTGCCAGCC TCGTACGACA GCAAACAGGG CTTCAATGGG 540
ACCTTCAACA TGGGGCCCTA CTTCTGTGAG GCCACCGTCC AAGGGAAGAC CTTCCAGACC 600
ATGCTATTTA ATATCGTTAC TTTGAAAGCT GCATCACAGC TGGATCTAGA GATGGAAGCC 660
CTGAAAACTG TGTATAAGTC AGGGGAGACG ATCGTGGTCA CCTGTGCCGT CTTTAACAAT 720
GAAGTGGTTG ACCTTCAGTG GACCTACCCT GGAGCCATGA AAGGCAAAGG CCTCCTGAAG 780
CTGCAGGAAA TCAGATTTCC GACCATCAAG TTGGTGTACA CTTTGACAGT CCCGGAGGCC 840
ACGGTGAAAG ACAGTGGGGA CTATGAATGC ACTGCTCGCC ACGCCACCGA GGATGTCAAG 900
GAAATGAAGA GAGTCAGCAT CGCTGTGCAC GAGAAAGGGT TCGTGGAAAT CAAGCCCACC 960
TTTGGCCACG TGGAAGCTGT CAACCTGCAC GAGGTCAGAC ATTTCGTGGT GGACATACAG 1020
GCCTACCCGC CTCCCAGGAT CTCCTGGCTG AAGGACAACC TGACTCTGAT CGAAAATCTC 1080
ACTGAGATCA CCACTGATGT GGAAAAGATT CGGGAAATAA GGTATCGAAG CAAACTGAAG 1140
CTGATCCGTG CTAAGGAAGA AGACAGTGGC CATTACACTA TTATAGTTCA AAATGAAGAT 1200
GACGTGAAGA GCTACACATT TGAGCTGTTA ACTCAAGTTC CCTCCTCCAT CCTGGACCTG 1260
GTTGATGACC ATCATGGCTC CGGCGGGGAA CAGACTGTGA GGTGCACGGC GGAAGGCCTC 1320
CCTCTGCCTG ACATCGAGTG GATGGTCTGC AGGGACATTA AGCGATGTAA TAATGAGACT 1380
TCCTGGACAG TTTTGGCCAA CAATGTCTCA AATATCATCA CAGAGACACA TTCCCAGGGC 1440
AAGAGTATTG TGGAGGGCCG AGTGACGTTT GCCAAAGTGG AGGAGACCAT TGCTGTTCGA 1500
TGCTTGGCCA AGAATCTCCT TGGGTCCAGC AGCCGGGAGC TGAAGCTGGT GGTTCCCACC 1560
CTGCATTCTG AGCTCACAGT GGCCGCTGCG GTGCTGGTGT TGCTGGTGAT TGTGATCATC 1620
TCACTTATTG TCCTGGTTGT AATTTGGAAG CAGAAACCGA GGTATGAAAT TCGCTGGAGG 1680
GTCATTGAAT CAATCAGCCC TGATGGACAT GAATATATTT ACGTGGACCC GATGCAACTG 1740
CCTTATGACT CGAGATGGGA ATTTCCAAGA GATGGATTGG TGCTTGGTCG CATCCTGGGA 1800
TCCGGTGCCT TTGGGAAAGT GGTGGAGGGA ACAGCATATG GGCTCAGTCG CTCCCAGCCT 1860
GTTATGAAGG TGGCTGTGAA GATGCTCAAA CCCACAGCCA GATCCAGTGA AAAACAAGCT 1920
CTCATGTCTG AACTGAAGAT AATGACTCAC CTGGGGCCAC ACTTAAACAT TGTGAACCTG 1980
TTGGGAGCTT GTACCAAGTC AGGCCCCATT TACATCATCA CCGAATACTG CTTCTATGGA 2040
GATTTGGTCA ACTATTTGCA TAAGAATAGA GATAGCTTCC TGAGCCGACA CCCAGAGAAG 2100
CCCAAGAAAG AGCTGGACAT CTTTGGACTG AACCCCGCGG ATGAGAGCAC AAGGAGCTAT 2160
GTGATTTTAT CTTTCGAAAA CAATGGCGAC TACATGGACA TGAAGCAAGC TGATGCCACG 2220
CAGTACGTCC CCATGCTGGA AAGGAAAGAG GTTTCTAAAT ACTCGGATAT CCAGAGATCG 2280
CTGTACGATC GTCCTGCCTC GTATAAGAAG AAATCTATGC TAGATTCAGA AGTCAAAAAC 2340
CTCCTCTCAG ATGATAACTC TGAAGGCCTT ACTTTGTTGG ATTTGTTGAG CTTCACCTAT 2400
CAAGTTGCCC GAGGAATGGA GTTTTTGGCT TCAAAAAATT GTGTCCACCG TGACCTGGCT 2460
GCTCGCAACG TCCTCCTGGC ACAAGGGAAA ATCGTGAAGA TCTGTGACTT TGGCCTGGCC 2520
AGAGACATCA TGCATGATTC GAACTACGTG TCAAAAGGCA GCACTTTCTT GCCTGTGAAG 2580
TGGATGGCTC CTGAGAGCAT CTTCGACAAC CTCTACACCA CCCTGAGTGA CGTCTGGTCT 2640
TACGGCATTC TGCTCTGGGA GATCTTCTCT CTTGGTGGCA CGCCCTACCC TGGCATGATG 2700
GTAGATTCTA CATTCTACAA CAAGATCAAG AGCGGGTACC GGATGGCCAA GCCTGACCAC 2760
GCCACCAGTG AAGTCTATGA CATCATGATG CAGTGCTGGA ACAGTGAACC CGAGAAGAGA 2820
CCCTCTTTTT ACCACCTGAG TGAGATAGTG GAGACCCTGC TGCCTGGACA GTATAAAAAG 2880
AGTTATGAGA AAATCCACCT GGACTTCCTG AAGAGTGACC ATCCCGCTGT GGCACGTATG 2940
CGCGTGGACT CAGACAACAC GTACATCGGT GTTTCCTACA AAAATGAGGA AGACAAGCTG 3000
AAAGACTGGG AGGGTGGCCT GGATGAGCAG AGACTGAGCG CTGACAGTGG CTACATCATC 3060
CCTCTGCCCG ACATCGACCC TGTGCCTGAG GAGGAAGACC TGGGCAAGAG GAACAGGCAC 3120
AGCTCTCAGA CCTCTGAAGA AAGCGCCATT GAGACAGGCT CCAGCAGTTC CACTTTCATC 3180
AAGAGAGAGG ACGAGACCAT CGAGGACATT GACATGATGG ATGACATTGG CATAGACTCC 3240
TCGGACCTGG TGGAGGACAG CTTCCTGTAA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  709
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 710   LnPADESTRSYVILSFENNGDYMDMKQAdatqyvpmlerkevskYSDIQRSLYDRPASYK  769
         *9*************************99*******************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+y+im +cw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYDIMMQCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADATQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYDIMMQC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00290; IG_MHC; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013