EKS-CAP-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	500.0	1.5E-150	152	409	258

Status

Unreviewed

Ensembl Protein

ENSCPOP00000010642

UniProt Accession

H0VK35;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT2

Gene Synonyms/Alias

AKT2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000011831	ENSCPOP00000010642	ENSCPOT00000011946

Organism

Cavia porcellus

Functional Description

Protein Length

481

Protein Sequence
(FASTA)

MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 60

QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRVPGEDPM 120

DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 180

KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ TNDRLCFVME YANGGELFFH 240

LSRERVFTED RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 300

ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 360

LILMEEIRFP RTLGPEAKSL LAGLLKKDPK QRLGGGPGDA KEVMEHGFFL SISWQDVVQK 420

KLQPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG SLELDQRTHF PQFSYSASIR 480

E 481

Nucleotide Sequence
(FASTA)

ATGAATGAGG TGTCTGTCAT CAAAGAAGGC TGGCTCCACA AGCGCGGGGA GTACATCAAG 60

ACCTGGAGGC CCCGATATTT CCTGCTGAAG AGTGATGGCT CCTTCATCGG GTATAAGGAG 120

AGGCCTGAGG CTCCTGACCA GACTTTACCT CCCTTAAACA ACTTCTCTGT AGCAGAATGC 180

CAGCTGATGA AGACGGAGAG GCCGCGGCCT AACACCTTTG TCATACGCTG TCTGCAGTGG 240

ACCACGGTCA TTGAGAGGAC CTTCCATGTG GACTCTCCAG ATGAGAGGGA GGAGTGGATG 300

CGGGCCATCC AGATGGTTGC CAACAGCCTT AAGCAGCGAG TTCCTGGTGA GGATCCCATG 360

GACTACAAGT GTGGCTCCCC AAGTGACTCT TCCACGACTG AGGAGATGGA AGTGGCAGTC 420

AGCAAGGCAC GAGCCAAAGT GACCATGAAT GACTTTGATT ATCTCAAACT CCTCGGCAAA 480

GGCACCTTTG GCAAAGTCAT TCTAGTGCGG GAGAAGGCCA CTGGCCGCTA CTATGCCATG 540

AAGATCCTGC GGAAGGAAGT CATCATTGCC AAGGATGAAG TCGCTCACAC AGTCACGGAG 600

AGTCGGGTCC TCCAGAATAC CAGACACCCT TTCCTCACAG CACTGAAGTA CGCCTTCCAG 660

ACCAACGACC GCCTGTGCTT TGTGATGGAG TATGCGAACG GCGGGGAGCT CTTCTTCCAC 720

CTGTCCCGGG AGCGAGTCTT CACAGAGGAT CGGGCACGGT TTTACGGTGC AGAGATCGTC 780

TCGGCTCTCG AGTACCTACA CTCACGGGAC GTGGTGTACC GAGACATCAA GCTGGAGAAC 840

CTCATGCTGG ACAAAGATGG CCACATCAAG ATCACTGACT TCGGCCTGTG CAAAGAGGGC 900

ATCAGTGATG GGGCCACCAT GAAAACCTTC TGTGGGACCC CGGAGTACCT GGCGCCTGAG 960

GTGCTGGAGG ACAACGACTA TGGCCGTGCA GTGGACTGGT GGGGGCTGGG TGTGGTCATG 1020

TATGAGATGA TGTGCGGCCG CCTACCCTTC TACAACCAGG ACCACGAGCG CCTCTTCGAG 1080

CTCATCCTCA TGGAGGAGAT CCGCTTCCCG CGCACGCTGG GCCCCGAGGC CAAGTCCCTG 1140

CTGGCCGGGC TGCTGAAGAA GGACCCCAAA CAGAGGCTTG GTGGGGGGCC TGGCGACGCC 1200

AAGGAGGTCA TGGAGCACGG GTTCTTCCTC AGCATCAGCT GGCAGGATGT GGTGCAAAAG 1260

AAGCTGCAGC CACCCTTCAA GCCTCAGGTC ACTTCTGAGG TTGACACGAG GTACTTCGAT 1320

GACGAATTCA CTGCCCAGTC CATCACAATC ACACCCCCAG ACCGCTATGA CAGCCTGGGC 1380

TCACTGGAGC TGGACCAGCG GACGCACTTC CCCCAGTTCT CCTACTCGGC CAGCATTCGA 1440

GAGTGA 1446

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvrekat+++ya+kil+kevi+akdevaht+te+rvl++t+hpf

Q: 152   FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF  211

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l+alky+fqt+++lc+v+ey+nGGelffhls+ervf+edrarfygaeivsal+ylhs+dv

Q: 212   LTALKYAFQTNDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDV  271

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrd+klenl+ldkdGhikitdfGlcke+i+dg+++ktfcGtpeylapevled+dyg+av

Q: 272   VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV  331

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dhe+lfelil+ee++fpr+l++eaksll+Gllkkdpk+

Q: 332   DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQ  391

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ dake++eh ff

Q: 392   RLGGGPGDAKEVMEHGFF  409

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KATGRYYAMK ILRKEVIIAK DEVAHTVTES RVLQNTRHPF 60

LTALKYAFQT NDRLCFVMEY ANGGELFFHL SRERVFTEDR ARFYGAEIVS ALEYLHSRDV 120

VYRDIKLENL MLDKDGHIKI TDFGLCKEGI SDGATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR TLGPEAKSLL AGLLKKDPKQ 240

RLGGGPGDAK EVMEHGFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013