EKS-CAP-00343
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00343
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20364.82.4E-10925289265
StatusUnreviewed
Ensembl ProteinENSCPOP00000010849
UniProt AccessionH0VKL2;
Protein Name
Protein Synonyms/Alias
Gene NameTNIK
Gene Synonyms/Alias TNIK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000012060ENSCPOP00000010849ENSCPOT00000012176
OrganismCavia porcellus
Functional Description
Protein Length1366
Protein Sequence
(FASTA)
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60
DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 120
KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 300
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 360
NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 420
REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 480
EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPLEKKPLYH YKEGMSPSEK PAWAKEVEER 540
SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPQLVAVKS 600
QGPALTASQS LHEQPTKGLS GFQEALNVTP HRVEMPRQNS DPTSENPPLP TRIEKFDRSS 660
WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPVLES 720
PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPSKVK 780
PEESRDITRP SRPAVSAFLS ELKLLICQDL TALAKELREL RIEETNRPLK KVTDYSSSSE 840
ESESSEEEEE DGESETHDGT VAVSDIPRLI PTGAPGSNEQ YNMGMVGTHG LETSHADTFS 900
SSISREGTLM IRETAGEKKR SGHSDSNGFA GHINLPDLVQ QSHSPAGTPT EGLGRVSTHP 960
QEMDSGTEYG MGSSTKTSFT PFVDPRVYQT SPTDEDEEDE ESSAAALFTS ELLRQEQAKL 1020
NEARKISVVN VNPTNIRPHS DTPEIRKYKK RFNSEILCAA LWGVNLLVGT ENGLMLLDRS 1080
GQGKVYNLIN RRRFQQMDVL EGLNVLVTIS GKKNKLRVYY LSWLRNRILH NDPEVEKKQG 1140
WITVGDLEGC IHYKVVKYER IKFLVIALKN AVEIYAWAPK PYHKFMAFKS FADLQHKPLL 1200
VDLTVEEGQR LKVIFGSHTG FHVIDVDSGN SYDIYIPSHI QGNITPHAIV ILPKTDGMEM 1260
LVCYEDEGVY VNTYGRITKD VVLQWGEMPT SVAYIHSNQI MGWGEKAIEI RSVETGHLDG 1320
VFMHKRAQRL KFLCERNDKV FFASVRSGGS SQVFFMTLNR NSMMNW 1366
Nucleotide Sequence
(FASTA)
ATGGCGAGCG ACTCCCCGGC TCGCAGTCTG GATGAGATCG ATCTCTCAGC TCTGAGGGAC 60
CCTGCAGGGA TCTTTGAATT GGTGGAACTT GTTGGAAATG GAACATATGG GCAGGTTTAT 120
AAGGGTCGTC ATGTCAAAAC AGGCCAACTT GCAGCCATTA AGGTTATGGA TGTCACAGGG 180
GATGAAGAGG AAGAAATAAA ACAAGAAATT AACATGTTGA AGAAATATTC TCATCATCGG 240
AATATAGCTA CATACTATGG TGCTTTTATC AAAAAGAACC CTCCTGGCAT GGATGACCAA 300
CTTTGGTTGG TGATGGAGTT TTGTGGCGCT GGCTCTGTCA CTGATCTCAT CAAGAACACG 360
AAAGGAAACA CACTGAAAGA AGAGTGGATC GCATACATCT GCAGAGAGAT CCTACGGGGG 420
CTGAGTCACC TGCACCAGCA TAAGGTGATT CATCGGGATA TAAAAGGGCA AAATGTCTTG 480
TTGACTGAAA ATGCAGAAGT TAAACTAGTG GACTTTGGGG TCAGTGCCCA GCTTGACCGC 540
ACAGTGGGCA GGAGAAACAC TTTCATTGGG ACGCCCTACT GGATGGCACC GGAAGTCATT 600
GCCTGTGATG AAAACCCAGA TGCCACATAT GATTTCAAGA GTGACTTGTG GTCTCTGGGA 660
ATCACCGCCA TAGAGATGGC AGAAGGTGCT CCCCCTCTCT GTGACATGCA CCCCATGAGA 720
GCCCTCTTCC TCATCCCCCG GAACCCAGCA CCTCGGCTGA AGTCTAAGAA GTGGTCAAAA 780
AAATTCCAGT CATTTATTGA GAGCTGCTTG GTAAAGAATC ACAGCCAGCG ACCGGCAACA 840
GAGCAACTGA TGAAGCATCC ATTTATACGA GACCAACCGA ACGAGCGCCA GGTCCGCATT 900
CAACTCAAGG ACCATATTGA TAGAACAAAG AAGAAAAGAG GAGAAAAAGA TGAGACTGAG 960
TATGAGTACA GTGGAAGTGA GGAAGAGGAG GAGGAGAACG ACTCTGGAGA GCCCAGCTCC 1020
ATCCTGAACC TGCCTGGAGA GTCTACACTA CGGCGGGACT TCCTGAGACT CCAGCTGGCC 1080
AACAAGGAGC GTTCAGAGGC CCTGCGGAGG CAGCAGCTGG AGCAGCAGCA GCGGGAGAAC 1140
GAGGAACATA AGAGGCAGCT GCTGGCCGAG CGCCAGAAGC GCATTGAGGA GCAGAAGGAG 1200
CAGCGGAGGC GGCTGGAGGA GCAACAGAGG AGAGAGAAAG AGCTGCGGAA GCAGCAGGAG 1260
AGGGAGCAGC GCCGGCACTA TGAGGAGCAA ATGCGCAGGG AGGAGGAGCG GAGGCGTGCG 1320
GAGCACGAGC AGGAGTACAT CAGGCGACAG TTAGAGGAGG AGCAAAGACA GTTAGAAATC 1380
TTGCAGCAGC AGCTTCTGCA TGAACAAGCG CTACTTCTGG AATATAAGCG CAAGCAATTG 1440
GAAGAACAGA GACAAGCAGA AAGGCTGCAG AGACAGCTAA AGCAAGAGAG AGACTACTTG 1500
GTTTCTCTTC AGCACCAGCG GCAGGAACAG AGGCCCCTGG AGAAGAAGCC ATTGTACCAT 1560
TACAAGGAAG GGATGAGTCC TAGTGAGAAG CCGGCATGGG CCAAGGAGGT AGAAGAACGG 1620
TCAAGGCTCA ACCGGCAGAG TTCACCTGCC ATGCCTCACA AGGTTGCCAA CAGGATTTCT 1680
GACCCCAACT TGCCCCCAAG GTCGGAGTCC TTCAGCATCA GTGGGGTTCA GCCTGCTCGA 1740
ACACCCCCTA TGCTGAGACC TGTTGATCCC CAGATTCCAC AACTGGTGGC TGTAAAATCC 1800
CAGGGACCTG CCTTGACCGC TTCCCAGTCA TTGCATGAGC AGCCCACGAA AGGCCTGTCT 1860
GGGTTTCAGG AGGCTCTGAA CGTGACCCCT CACCGTGTTG AGATGCCACG CCAGAACTCA 1920
GATCCCACCT CTGAAAACCC TCCTCTTCCC ACTCGCATTG AGAAGTTTGA CAGAAGCTCT 1980
TGGTTACGAC AGGAAGAAGA CATTCCACCA AAGGTGCCTC AAAGAACTAC TTCCATATCC 2040
CCAGCATTAG CCAGAAAGAA TTCACCTGGA AACGGCAGTG CTTTGGGACC CAGACTAGGA 2100
TCCCAACCCA TCAGAGCAAG CAACCCTGAT CTCCGGAGAA CAGAGCCCGT CTTGGAGAGC 2160
CCCTTGCAGA GGACCAGCAG TGGCAGCTCC TCCAGCTCCA GCACCCCCAG CTCCCAGCCC 2220
AGTTCCCAAG GGGGCTCTCA GCCTGGCTCA CAGGCAGGAT CCAGCGAACG GACCAGAGTT 2280
CGAGCTAACA GTAAGTCAGA AGGATCACCT GTGCTCCCCC ACGAGCCTTC CAAGGTGAAA 2340
CCAGAAGAAT CCAGAGATAT TACCCGACCC AGCCGACCAG CTGTGAGTGC TTTTCTGTCT 2400
GAGTTGAAAC TCTTAATTTG CCAAGATCTG ACGGCATTAG CCAAAGAATT AAGAGAACTG 2460
CGGATTGAAG AAACAAACCG CCCACTGAAG AAGGTGACTG ATTATTCCTC CTCCAGTGAA 2520
GAGTCAGAGA GTAGTGAGGA GGAGGAGGAA GATGGAGAGA GCGAGACCCA CGATGGGACA 2580
GTGGCTGTCA GTGACATACC CAGACTCATA CCAACTGGAG CTCCAGGAAG CAATGAGCAG 2640
TACAATATGG GAATGGTGGG AACACATGGG CTGGAGACCT CTCATGCAGA CACTTTTAGC 2700
AGTAGTATTT CAAGAGAAGG AACCCTGATG ATTAGAGAGA CAGCTGGAGA GAAGAAGCGA 2760
TCTGGCCACA GTGACAGCAA TGGCTTCGCT GGGCACATCA ATCTCCCTGA CCTGGTGCAG 2820
CAGAGCCACT CCCCAGCTGG GACCCCAACC GAGGGCCTGG GACGTGTTTC CACCCATCCC 2880
CAGGAGATGG ACTCTGGGAC TGAATATGGC ATGGGAAGCA GCACGAAAAC CTCCTTCACT 2940
CCCTTTGTGG ACCCCAGAGT ATACCAGACA TCTCCCACTG ATGAAGATGA GGAGGATGAA 3000
GAATCATCAG CTGCAGCTCT GTTTACTAGC GAACTCCTTA GGCAAGAACA GGCCAAACTC 3060
AATGAAGCAA GAAAGATTTC TGTGGTAAAC GTAAACCCAA CCAACATTCG ACCTCATAGT 3120
GACACACCAG AAATCAGAAA ATACAAGAAA CGATTCAATT CAGAAATACT TTGTGCAGCT 3180
CTGTGGGGTG TAAACCTTCT GGTGGGAACT GAAAATGGCC TGATGCTTTT GGACCGAAGT 3240
GGGCAAGGCA AAGTGTACAA TCTGATCAAC AGAAGGCGAT TTCAGCAGAT GGATGTGCTA 3300
GAGGGACTGA ATGTTCTTGT GACAATATCA GGAAAAAAGA ATAAGCTACG CGTTTACTAT 3360
CTGTCATGGT TAAGAAACAG AATACTGCAC AATGACCCAG AAGTGGAGAA GAAACAAGGC 3420
TGGATCACCG TTGGGGACTT GGAAGGCTGC ATACATTACA AAGTTGTTAA ATATGAAAGG 3480
ATCAAATTCT TGGTGATTGC CTTAAAGAAT GCTGTAGAGA TATATGCTTG GGCTCCTAAA 3540
CCATATCATA AGTTCATGGC ATTTAAGTCT TTTGCAGATC TTCAGCACAA GCCTCTACTT 3600
GTTGACCTCA CTGTAGAAGA AGGTCAGAGA TTAAAGGTTA TTTTTGGCTC ACACACTGGT 3660
TTCCATGTAA TTGATGTTGA TTCAGGAAAC TCTTATGATA TCTACATACC ATCTCATATT 3720
CAGGGCAATA TCACTCCTCA TGCTATTGTC ATCTTGCCTA AAACAGATGG AATGGAAATG 3780
CTTGTTTGCT ATGAGGATGA GGGGGTGTAT GTGAACACCT ATGGTCGGAT AACTAAAGAT 3840
GTGGTGCTCC AATGGGGAGA AATGCCCACC TCTGTGGCTT ACATTCATTC CAATCAGATA 3900
ATGGGCTGGG GCGAGAAAGC TATTGAGATC CGGTCAGTGG AAACAGGACA TTTGGATGGA 3960
GTATTTATGC ATAAGCGAGC TCAAAGGTTA AAGTTTCTAT GTGAAAGAAA TGATAAGGTA 4020
TTTTTTGCAT CCGTGCGATC TGGAGGAAGT AGCCAAGTGT TTTTCATGAC CCTCAACAGA 4080
AATTCCATGA TGAACTGG 4098
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni 
Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIA  83
         899********************************8.999*************998****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++
Q: 84    TYYGAFIKknppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH  143
         ************************************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++
Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f
Q: 204   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
         ++f+e+cl kn ++Rp++++l+kh+F+
Q: 263   QSFIESCLVKNHSQRPATEQLMKHPFI  289
         **************************7
Domain Sequence
(FASTA)
FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKQEINMLK KYSHHRNIAT 60
YYGAFIKKNP PGMDDQLWLV MEFCGAGSVT DLIKNTKGNT LKEEWIAYIC REILRGLSHL 120
HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240
FIESCLVKNH SQRPATEQLM KHPFI 265
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00288
EKS-ANC-00307
EKS-BOT-00325
EKS-CAE-00258
EKS-CAJ-00314
EKS-CAF-00329
EKS-DAR-00667
EKS-DRM-00154
EKS-EQC-00300
EKS-FEC-00295
EKS-GAG-00270
EKS-GAA-00382
EKS-GOG-00305
EKS-HOS-00315
EKS-ICT-00307
EKS-LAC-00328
EKS-LOA-00329
EKS-MAM-00312
EKS-MOD-00303
EKS-MUM-00340
EKS-MUP-00305
EKS-MYL-00320
EKS-NOL-00284
EKS-ORN-00400
EKS-ORA-00286
EKS-ORC-00291
EKS-ORL-00382
EKS-OTG-00324
EKS-PAT-00292
EKS-PES-00274
EKS-PEM-00170
EKS-POA-00300
EKS-RAN-00324
EKS-SUS-00290
EKS-TAG-00323
EKS-TAR-00403
EKS-TEN-00419
EKS-XET-00385
EKS-XIM-00416
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013