EKS-CAP-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	265.4	5.8E-79	249	509	261

Status

Unreviewed

Ensembl Protein

ENSCPOP00000010971

UniProt Accession

H0VKW6;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2

Gene Synonyms/Alias

EIF2AK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000012198	ENSCPOP00000010971	ENSCPOT00000012314

Organism

Cavia porcellus

Functional Description

Protein Length

525

Protein Sequence
(FASTA)

MATGLSAGFY IEELNKYQQK HGVKVSYEKL SVTGPPHNSV FTFRVIIEDR TFPQGEGRTK 60

QDAKNSAAKI AFTILNQEKK VGLGNLLLER GLQESANGNY VGLLNRFSQK YRLLINYEYD 120

LGEEGPQRFQ FKCKIGQKVY GFGVASTKKD AKQLAAKLAF DKISKEISMK RAEGSFFFQK 180

TPQMSNEYSS TDSSDSGNSS SKAFSLKSEN GFASKLRSES DMTTGVRVSP QFILHNRFLL 240

NAKIAKDYED IVPIGEGGYG VVFKAKHKLD KTISVIKRVE YTNSKVLREA QALATLNHPN 300

IVQYRYCWKE QLLDGKKAEK SFPYSSAYSE EYLFISMEFC DKGTLEQWIE QRRGNYSDKA 360

LGLELFEQIT TGVCYVHSKN IIHRDLKPGN IFLVDEKQIK IGDFGLATSL KTDEKRTEGT 420

GTKSYMSPEQ IFLLNSQDYG KEVDIFALGL ILSELIHVRA TFQETVAVFK DLRKGIFDNV 480

FDNKEKSLLR KLLAKEPQRR PDTSEILKTL AEWKKVLDKK ERHTY 525

Nucleotide Sequence
(FASTA)

ATGGCGACTG GTCTTTCAGC AGGTTTCTAC ATAGAAGAAC TTAATAAATA CCAGCAGAAG 60

CATGGAGTAA AAGTTTCATA TGAGAAACTG TCTGTGACAG GACCGCCACA CAACTCAGTG 120

TTTACATTTC GAGTTATTAT AGAAGACAGA ACATTTCCAC AAGGTGAAGG TAGAACAAAG 180

CAGGATGCAA AAAATTCTGC CGCCAAAATA GCTTTTACTA TACTTAATCA AGAAAAAAAG 240

GTAGGCCTTG GTAACTTACT TTTAGAAAGA GGCTTACAAG AATCAGCCAA TGGAAATTAT 300

GTAGGCCTTC TCAATAGGTT TTCCCAGAAG TACAGATTAC TTATAAATTA TGAATATGAT 360

TTGGGGGAAG AGGGACCTCA AAGATTTCAA TTTAAATGCA AAATTGGGCA GAAAGTATAT 420

GGTTTTGGAG TAGCTTCAAC TAAAAAGGAT GCAAAACAGT TGGCTGCCAA ACTTGCATTT 480

GATAAGATTT CGAAAGAAAT CTCGATGAAA CGTGCTGAGG GCAGCTTTTT CTTTCAGAAA 540

ACTCCCCAGA TGTCTAATGA GTATTCTTCT ACTGACTCCA GTGACTCTGG AAACAGCTCT 600

TCCAAAGCAT TTTCTTTAAA ATCAGAAAAT GGTTTTGCCA GCAAGCTAAG GAGTGAGAGT 660

GACATGACCA CAGGAGTCCG AGTGAGTCCC CAGTTTATCC TGCACAATAG GTTTTTGCTG 720

AATGCAAAGA TTGCCAAAGA CTATGAAGAC ATAGTACCAA TTGGTGAAGG TGGATATGGA 780

GTAGTTTTCA AAGCAAAACA CAAATTAGAT AAAACCATTT CTGTTATTAA ACGTGTTGAA 840

TACACCAATA GTAAAGTATT GCGTGAAGCA CAAGCGTTGG CGACTCTTAA TCATCCCAAT 900

ATTGTTCAGT ATCGTTATTG TTGGAAAGAA CAACTTCTTG ATGGTAAGAA GGCTGAAAAA 960

TCTTTCCCTT ATTCCTCTGC CTATTCTGAA GAGTACCTTT TCATCTCAAT GGAATTCTGC 1020

GATAAAGGGA CCCTGGAGCA ATGGATTGAG CAGAGGAGGG GCAACTACTC AGACAAAGCT 1080

TTGGGTTTGG AATTGTTTGA GCAAATAACA ACGGGAGTGT GTTATGTACA CTCAAAAAAC 1140

ATAATTCACA GAGACCTTAA GCCAGGTAAC ATATTCTTAG TAGATGAAAA ACAAATAAAG 1200

ATTGGCGACT TTGGACTTGC CACATCCCTG AAAACAGATG AAAAGCGAAC AGAGGGTACT 1260

GGAACTAAGA GTTACATGAG CCCAGAACAG ATATTTCTTC TGAATTCACA AGATTATGGA 1320

AAGGAAGTGG ATATTTTTGC TCTGGGACTA ATTCTCTCTG AACTTATTCA CGTACGTGCG 1380

ACTTTCCAAG AAACAGTTGC GGTTTTCAAA GATCTAAGGA AAGGCATCTT TGATAATGTG 1440

TTTGATAACA AAGAAAAAAG CCTTCTACGG AAATTACTAG CGAAGGAGCC TCAAAGACGA 1500

CCTGACACAT CTGAAATACT GAAGACCTTG GCTGAGTGGA AGAAAGTCTT AGATAAAAAG 1560

GAAAGGCATA CCTATTAG 1578

Domain Profile

S: 2     eeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpnivr  61

         e+i  +G+Gg+gvV+kak+kldk+   ikr+++++     +kv+re++aLa l+hpniv+

Q: 249   EDIVPIGEGGYGVVFKAKHKLDKTISVIKRVEYTN-----SKVLREAQALATLNHPNIVQ  303

         667779***************************99.....67******************

S: 62    YfaawleekeesltdsseveaeaeleesesseesdtkllyiqmelceketLkdwiderkl  121

         Y ++w+e+  ++       +ae++      s+ ++ ++l+i me+c+k tL++wi++r+

Q: 304   YRYCWKEQLLDGK------KAEKSFP---YSSAYSEEYLFISMEFCDKGTLEQWIEQRRG  354

         ********99888......2222222...23344556*********************87

S: 122   lesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaeal  181

         + s + l ++lf+q+ +g+ y+Hsk +iHrdLkp niFl +++q+KigDFgLat+l+ ++

Q: 355   NYSDKALGLELFEQITTGVCYVHSKNIIHRDLKPGNIFLVDEKQIKIGDFGLATSLKTDE  414

         766666666**********************************************99887

S: 182   kedvkqdaqskeakhtgqvgtklymsPeql...eksqYnkkvDifsLGlilfeLlypfst  238

         k+             t+ +gtk+ymsPeq+   ++++Y+k+vDif+LGlil eL++   t

Q: 415   KR-------------TEGTGTKSYMSPEQIfllNSQDYGKEVDIFALGLILSELIHVRAT  461

         75.............99*************9999**************************

S: 239   emervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellks  289

          +e+v ++++lr+g + + fd+   kek+ll+kll ++p++Rp++se+lk+

Q: 462   FQETVAVFKDLRKGIFDNVFDN---KEKSLLRKLLAKEPQRRPDTSEILKT  509

         **********************...9***********************96

Domain Sequence
(FASTA)

EDIVPIGEGG YGVVFKAKHK LDKTISVIKR VEYTNSKVLR EAQALATLNH PNIVQYRYCW 60

KEQLLDGKKA EKSFPYSSAY SEEYLFISME FCDKGTLEQW IEQRRGNYSD KALGLELFEQ 120

ITTGVCYVHS KNIIHRDLKP GNIFLVDEKQ IKIGDFGLAT SLKTDEKRTE GTGTKSYMSP 180

EQIFLLNSQD YGKEVDIFAL GLILSELIHV RATFQETVAV FKDLRKGIFD NVFDNKEKSL 240

LRKLLAKEPQ RRPDTSEILK T 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 2.

Prosites

PS50137	; DS_RBD; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013