EKS-CAP-00219

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00219

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	414.9	1.2E-124	61	309	249

Status

Unreviewed

Ensembl Protein

ENSCPOP00000011211

UniProt Accession

H0VLH6;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000012459	ENSCPOP00000011211	ENSCPOT00000012578

Organism

Cavia porcellus

Functional Description

Protein Length

546

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRVERLE EFEGGGGGDV NVAQAGRVWP SSYRALISAF SRLTRLDDFT 60

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 120

VHQGQLHALT EYINSGNLEQ LLDSNVHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180

NCLIKKDENG YSAVVADFGL AEKIPDMSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 240

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 300

SFVEIGKTLE EIMRRLRLQD EELEKDRLTL CCSSGILEKV PGGKRLSSLD DKIPNKSPRP 360

RRTIWLSRSQ SDIFSRKAPR TVSVLDPYYR PQDGATHTPK VNPFSARQDL KGGKIKFFDL 420

PSKSVISLVF DLNAPGPGNV PASGWQEPPA LPARRWRSLP GSPEFLRHKV CPFVSCEESL 480

SDGPPPRLSS LKYRVREIPP FQGPTLPVTP AHEAMDCCNP QEENGLGPSS CYRVASEEME 540

VEEERP 546

Nucleotide Sequence
(FASTA)

ATGGATCGGA GCAAGCGGAA CTCAATTGCG GGATTTCCCC CTAGAGTGGA GCGTCTGGAG 60

GAGTTCGAAG GAGGTGGTGG AGGGGATGTG AATGTGGCCC AGGCAGGGAG AGTTTGGCCA 120

TCTTCATATC GAGCTCTTAT AAGTGCCTTT TCCAGACTGA CACGTTTGGA TGACTTCACT 180

TGTGAAAAAA TAGGGTCCGG CTTCTTCTCT GAAGTATTCA AGGTTCGCCA CCGAGCGTCT 240

GGTCAGGTGA TGGCTTTGAA GATGAACACG CTGAGCAGTA ACCGGGCGAA CATGCTGAAG 300

GAAGTGCAGC TCATGAACAG ACTCTCGCAT CCCAACATCC TCAGGTTCAT GGGTGTGTGT 360

GTACATCAAG GACAGCTGCA TGCGCTTACA GAGTATATCA ACTCCGGGAA TCTGGAACAG 420

TTGTTGGATA GCAACGTGCA CTTGCCGTGG ACTGTGAGGG TGAAACTGGC CTATGATATA 480

GCAGTGGGCC TCAGCTACCT TCACTTTAAA GGCATTTTCC ATCGCGACCT CACATCAAAG 540

AACTGCCTGA TAAAGAAAGA TGAGAATGGT TACTCTGCAG TGGTGGCTGA CTTTGGCCTG 600

GCTGAGAAGA TCCCTGATAT GAGCATGGGG AGTGAGAAGC TGGCTGTGGT GGGCTCACCC 660

TTCTGGATGG CACCAGAGGT TCTCCGAGAT GAGCCCTATA ATGAGAAGGC AGACGTGTTC 720

TCTTATGGCA TCATCCTCTG TGAGATCATC GCCCGCATCC AGGCTGATCC GGACTACCTT 780

CCCCGTACTG AGAATTTCGG GCTGGACTAT GACGCTTTCC AGCACATGGT GGGAGACTGT 840

CCCCCAGACT TTCTGCAGCT CACCTTCAAC TGCTGTAATA TGGACCCCAA ACTGCGACCA 900

TCCTTTGTGG AGATTGGGAA GACCCTGGAG GAAATTATGA GGCGCCTACG CCTACAGGAT 960

GAAGAGCTAG AAAAGGATAG ACTGACTCTC TGTTGTTCCT CAGGTATTTT GGAGAAAGTG 1020

CCTGGTGGGA AGAGACTGAG CTCACTGGAT GACAAGATTC CCAACAAGTC ACCACGTCCA 1080

AGACGCACTA TCTGGCTATC TCGTAGCCAG TCAGATATCT TTTCTAGAAA GGCACCACGT 1140

ACAGTGAGCG TCTTGGACCC TTACTACCGG CCACAAGATG GTGCTACCCA CACCCCAAAA 1200

GTCAACCCTT TTAGTGCCCG ACAGGACCTC AAGGGTGGTA AAATCAAGTT CTTTGACCTC 1260

CCTAGTAAGT CTGTTATCTC CCTAGTATTT GACCTGAATG CACCAGGGCC TGGAAATGTG 1320

CCAGCGTCTG GCTGGCAGGA ACCCCCAGCC CTACCAGCTC GCCGATGGCG TTCTTTGCCG 1380

GGTTCACCCG AATTCTTGCG TCATAAAGTC TGTCCGTTTG TGAGTTGTGA AGAATCACTA 1440

TCGGATGGGC CTCCACCACG CCTCAGCAGT CTCAAGTACA GAGTGAGAGA GATCCCGCCA 1500

TTCCAAGGGC CTACGCTGCC AGTTACTCCA GCCCATGAAG CAATGGACTG CTGCAATCCC 1560

CAGGAGGAAA ACGGTTTGGG GCCCAGCTCA TGTTACAGAG TTGCCTCTGA GGAGATGGAG 1620

GTGGAAGAAG AAAGACCA 1638

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+f+G

Q: 61    CEKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMG  118

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+ +lpwt+rv+la+dia+Glsylh+kgi+hrdl+

Q: 119   VCVHQGQLHALTEYINSGNLEQLLDSNVHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vvadfGla          ek+++++++  +++l+vvGsP+wmaPe

Q: 179   SKNCLIKKdenGYSAVVADFGLA----------EKIPDMSMG--SEKLAVVGSPFWMAPE  226

         *******9887899*********..........9****9988..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  284

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+l+++cc++dp+ rpsf+e+ k+l

Q: 285   LQLTFNCCNMDPKLRPSFVEIGKTL  309

         *********************9876

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 60

VHQGQLHALT EYINSGNLEQ LLDSNVHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120

NCLIKKDENG YSAVVADFGL AEKIPDMSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 240

SFVEIGKTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013