EKS-CAP-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	448.3	8.4E-135	45	309	265

Status

Unreviewed

Ensembl Protein

ENSCPOP00000011391

UniProt Accession

H0VLY1;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000012664	ENSCPOP00000011391	ENSCPOT00000012785

Organism

Cavia porcellus

Functional Description

Protein Length

1345

Protein Sequence
(FASTA)

DGLNSLVLDL DFPALRKNKN IDNFLNRYEK VVKKVRDLQM KAEDYDVVKV IGRGAFGEVQ 60

LVRHKASQKV YAMKLLSKFE MIKRSDAAFF WEERDIMAFA SSPWVVELYS FCAFQDDRYL 120

YMVMEYMPGG DLVNLMSNYD VPEKWAKFYT AEVVLALDVI HSMGLIHRDV KPDNMLLDRH 180

GHLKLADFGT CMKMDETGMV HCDTAVGTPD YISPEVLKSQ GGDGYYGREC DWWSVGVFLF 240

EMLVGDTPFY ADSLVGTYSK IMDHKNSLSI PEDAEISKHA KNLICAFLTE REVRLGRNGV 300

EEIKQHPFFK NDQWNWDNIR ETAAPVVPEL SSDIDSSNFD DIEDDKGDVE TFPIPKAFVG 360

NQLPFIGFTY YRDNLLLSNS PPCRESDPVQ SRKNEESQEI QKRLFTLEEH LSNELQAREE 420

LEQKCKSINT RLEKTAKELE EEITLRKTVE STLRQLEREK ALLQHKNAEH QRRADHEADK 480

KRNLENDVNS LKDQLEDLKK RNQNSQVSTE KVNQLQRQLD ETNALLRTES DTAARLRKTQ 540

AESSKQIQQL ESNNRDLQDK NCLLETARLK LEKEFINLQS ALESERRDRT HGSEIINDLQ 600

GRISGLEEDL KNGKVLLAKV ELEKRQLQEK LTDLEKEKSN LEIDMTYRLK VIQQSFEQEE 660

AEHKATKARL ADENKIYESI EEAKSEAMKE MEKKLLEERA LKQKVENLLL ESEKKCSLLD 720

CDLKQSQQKL GELRTQKEVL SEDVRNLTLK IEQETQKRCL TQNDLKLQAQ QVNTLRMSEK 780

QLKQENNHLV EMKLSLEKQN AELRKERQDA DGQMKELQDQ LEAEQYFSTL YKTQVRELKE 840

ECEEKTKLCK ELQQKKQEFQ DERDSLAAQL EITLTKADSE QLARSIAEEQ YSDLEKEKIM 900

KELEIKEMMA RHKQELAEKD ATIASLEETN RTLTSDVANL ANEKEELNNK LKDAQEQLSR 960

LKEEEISAVA IKAQFEKQLL TERTLKTQAV NKLAEIMNRK EPVKRGSDTE ERVRRKEKEN 1020

RKLHMELKSE REKLTQQMIK YQKELNEMQA QIAEESQIRI ELQMTLDSKD SDIEQLRSQL 1080

QALHIGLDSS SIGSGLGDAE AEDGFPESRL EGWLSLPVRN NTKKFGWVKK YVIVSSKKIL 1140

FYDSEQDKEQ SNPYMVLDID KLFHVRPVTQ TDVYRADAKE IPRIFQILYA NEGESKKEQE 1200

FPVEPVGEKS NYICYKGHEF IPTLYHFPTN CEACMKPLWH MFKPPPALEC RRCHIKCHKD 1260

HLDRKEEIVA PCKVYYDIST AKNLLLLANS TEEQQKWVSR LVKKIPKKPP APDPFARSSP 1320

RTSMKIPQNQ SIRRPSRQLA PTMPL 1345

Nucleotide Sequence
(FASTA)

GATGGCTTAA ATTCCTTGGT CCTTGATTTG GATTTTCCTG CCTTGAGAAA AAATAAGAAT 60

ATAGATAATT TCTTAAATAG ATATGAGAAA GTTGTGAAGA AAGTCAGAGA CCTGCAAATG 120

AAGGCGGAAG ACTATGATGT CGTGAAAGTC ATCGGGAGAG GAGCCTTCGG GGAAGTGCAG 180

TTGGTTCGTC ATAAGGCATC ACAGAAGGTT TATGCTATGA AGCTGCTTAG TAAGTTTGAA 240

ATGATCAAAA GATCAGATGC TGCTTTTTTC TGGGAAGAAA GAGACATTAT GGCCTTTGCC 300

AGTAGTCCCT GGGTGGTTGA GCTGTACTCT TTCTGTGCCT TCCAGGATGA TAGGTATTTG 360

TACATGGTCA TGGAATACAT GCCCGGTGGG GACCTTGTGA ACCTGATGAG TAACTATGAC 420

GTGCCTGAGA AATGGGCCAA GTTCTACACT GCGGAAGTGG TGCTGGCTCT GGATGTGATT 480

CACTCCATGG GCTTGATCCA CCGGGACGTG AAGCCTGACA ACATGCTGCT GGACAGGCAC 540

GGGCACCTGA AGCTGGCGGA CTTCGGCACT TGCATGAAGA TGGACGAGAC AGGCATGGTG 600

CACTGTGACA CAGCAGTCGG AACCCCGGAC TATATATCGC CCGAGGTTCT GAAGTCTCAA 660

GGCGGCGACG GTTATTATGG GCGGGAGTGC GACTGGTGGT CCGTGGGGGT TTTCCTTTTT 720

GAAATGCTAG TGGGAGATAC TCCATTTTAT GCAGATTCAC TTGTAGGGAC TTACAGCAAA 780

ATTATGGATC ATAAAAATTC ACTGTCTATC CCCGAAGACG CAGAAATCTC TAAACATGCA 840

AAGAATCTCA TCTGTGCCTT CTTAACAGAA AGGGAGGTAC GTCTTGGGAG AAATGGGGTA 900

GAAGAAATCA AACAGCACCC TTTCTTTAAG AATGATCAAT GGAATTGGGA TAACATAAGA 960

GAGACGGCAG CTCCTGTGGT GCCCGAGCTC AGCAGTGACA TAGACAGCAG CAACTTCGAT 1020

GACATCGAAG ATGATAAAGG CGATGTTGAA ACCTTCCCAA TTCCTAAAGC TTTTGTGGGA 1080

AATCAGCTGC CCTTCATAGG ATTTACCTAC TATAGAGACA ATTTGCTGCT GAGCAACTCT 1140

CCACCGTGCA GAGAAAGCGA CCCCGTACAG TCGAGGAAAA ACGAAGAAAG TCAAGAGATT 1200

CAAAAAAGGC TGTTTACCTT AGAAGAACAC CTTAGCAATG AGTTACAAGC CAGAGAAGAG 1260

CTGGAGCAAA AGTGCAAATC TATCAATACT CGCCTGGAGA AAACAGCGAA GGAACTGGAA 1320

GAAGAGATTA CCTTGAGGAA AACTGTGGAG TCAACGTTAA GGCAGCTGGA GAGAGAGAAG 1380

GCGCTGTTAC AGCATAAGAA CGCAGAGCAT CAGAGGAGAG CCGACCACGA GGCAGACAAG 1440

AAACGGAACC TGGAGAATGA TGTTAACAGC TTAAAAGATC AACTTGAAGA TTTGAAAAAA 1500

AGAAATCAGA ACTCTCAGGT ATCTACTGAG AAAGTGAACC AACTGCAGAG ACAGCTGGAT 1560

GAAACAAATG CTTTGCTGCG AACAGAATCT GATACTGCAG CCCGGCTGAG GAAGACTCAG 1620

GCAGAAAGTT CCAAACAGAT TCAGCAGCTG GAATCCAACA ACAGAGACCT GCAAGATAAA 1680

AACTGCCTCT TAGAGACAGC CAGGTTAAAA CTGGAAAAGG AGTTTATCAA CCTTCAATCT 1740

GCTCTAGAGT CAGAAAGGAG GGACCGCACC CACGGATCAG AGATCATTAA TGACTTACAG 1800

GGTAGGATAT CTGGCCTAGA AGAAGATTTA AAGAATGGCA AAGTCTTACT GGCAAAAGTA 1860

GAGCTGGAGA AGAGACAACT TCAGGAGAAG CTAACTGATC TGGAAAAGGA AAAGAGCAAC 1920

CTGGAAATAG ACATGACGTA CCGGCTCAAA GTCATCCAGC AGAGCTTCGA GCAGGAGGAA 1980

GCTGAGCACA AGGCCACCAA AGCACGGCTT GCAGATGAAA ATAAGATCTA TGAATCCATT 2040

GAGGAAGCTA AATCAGAAGC TATGAAAGAG ATGGAAAAGA AGCTGCTGGA GGAAAGAGCT 2100

CTGAAGCAGA AGGTGGAGAA CCTGCTGCTG GAGTCGGAGA AGAAGTGCTC CCTGCTGGAC 2160

TGCGACCTGA AGCAGTCGCA GCAGAAGCTG GGCGAGCTGC GCACGCAGAA GGAGGTGCTC 2220

AGCGAGGACG TTAGAAACTT GACACTAAAG ATAGAGCAGG AGACTCAGAA GCGCTGCCTC 2280

ACACAGAATG ACCTGAAGCT GCAGGCGCAG CAGGTGAACA CACTGAGGAT GTCAGAGAAG 2340

CAGCTGAAGC AGGAGAACAA CCACCTGGTG GAGATGAAGC TGAGCCTGGA GAAGCAGAAT 2400

GCTGAGCTGC GCAAAGAGCG GCAGGACGCC GATGGACAGA TGAAGGAGCT GCAGGACCAG 2460

CTCGAGGCCG AGCAGTATTT CTCCACTCTC TACAAAACCC AAGTCAGGGA GCTTAAAGAA 2520

GAATGTGAAG AAAAGACTAA ACTTTGTAAA GAACTGCAGC AGAAGAAGCA GGAGTTCCAG 2580

GATGAACGGG ACTCCTTGGC TGCCCAGCTG GAGATCACCC TGACCAAAGC GGACTCCGAG 2640

CAGCTGGCTC GCTCCATTGC TGAAGAGCAG TACTCTGATC TGGAAAAGGA GAAAATCATG 2700

AAAGAACTGG AGATCAAGGA GATGATGGCC AGACACAAAC AGGAGCTCGC CGAGAAGGAT 2760

GCCACCATCG CATCACTTGA AGAAACGAAC AGGACACTGA CCAGTGATGT TGCCAATCTC 2820

GCCAATGAGA AAGAAGAATT AAATAACAAG CTGAAAGATG CTCAGGAACA GCTGTCAAGG 2880

TTAAAAGAGG AGGAGATAAG TGCCGTGGCT ATTAAAGCAC AGTTTGAAAA GCAGCTGCTG 2940

ACAGAGAGGA CCCTCAAGAC TCAAGCTGTG AATAAGTTGG CTGAGATCAT GAATCGAAAA 3000

GAACCTGTCA AGCGTGGCAG TGACACAGAA GAAAGAGTCC GAAGAAAAGA GAAGGAGAAC 3060

AGAAAGCTGC ACATGGAGCT GAAGTCAGAG CGGGAAAAAC TCACCCAGCA GATGATCAAG 3120

TACCAGAAGG AACTGAATGA GATGCAGGCT CAAATAGCTG AGGAGAGCCA GATTCGAATT 3180

GAGCTGCAGA TGACACTGGA CAGCAAGGAC AGCGACATTG AGCAGCTGCG GTCGCAGCTG 3240

CAAGCCCTGC ACATTGGCCT GGACAGTTCC AGTATCGGCA GCGGGCTGGG GGACGCCGAA 3300

GCCGAGGACG GATTTCCAGA GTCAAGATTA GAAGGATGGC TTTCATTACC TGTACGAAAT 3360

AACACTAAGA AATTTGGATG GGTGAAGAAG TATGTAATCG TGAGCAGCAA GAAGATTCTT 3420

TTCTATGACA GCGAACAAGA TAAAGAGCAG TCTAACCCGT ACATGGTTTT AGATATAGAC 3480

AAGTTATTTC ACGTCCGACC GGTGACACAG ACGGATGTAT ACAGAGCAGA TGCTAAAGAG 3540

ATTCCGAGGA TATTCCAGAT CCTGTATGCC AATGAAGGAG AAAGCAAGAA GGAACAGGAG 3600

TTTCCGGTGG AGCCAGTGGG CGAGAAATCG AATTACATCT GCTACAAAGG GCACGAGTTC 3660

ATCCCCACCC TGTACCACTT CCCGACCAAC TGCGAGGCCT GCATGAAGCC GCTGTGGCAC 3720

ATGTTCAAGC CCCCCCCTGC CCTAGAGTGC CGCCGCTGCC ACATCAAGTG TCACAAGGAC 3780

CACTTAGACA GAAAGGAGGA GATTGTCGCA CCATGCAAAG TATACTACGA CATATCCACC 3840

GCCAAGAACC TGCTGCTGCT AGCAAACTCC ACGGAGGAGC AGCAGAAGTG GGTGAGCCGC 3900

CTGGTGAAGA AGATCCCCAA GAAGCCGCCC GCCCCCGACC CCTTCGCGCG CTCCTCGCCC 3960

CGCACCTCCA TGAAGATCCC ACAGAACCAG TCCATCCGGC GGCCCAGCCG GCAGCTGGCA 4020

CCCACCATGC CACTC 4035

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         ++++kviGrGafgev++vr+ka++kvyamk+l+k+e++kr+++aff+eerd++++a s+w

Q: 45    YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDAAFFWEERDIMAFASSPW  104

         799*********************************************************

S: 61    ivql..qyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhe  118

         +v+l  ++afqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald +h+

Q: 105   VVELysFCAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDVIHS  162

         ***94458****************************..9*********************

S: 119   lgyvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee  178

         +g++hrd+kpdn+lld++Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++

Q: 163   MGLIHRDVKPDNMLLDRHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-  221

         **********************************************************9.

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeak  238

         g+g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl++ped+++s++ak

Q: 222   GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLSIPEDAEISKHAK  281

         ************************************************************

S: 239   dlikklltsreerlgregiedlkkhpff  266

         +li+++lt+re rlgr+g+e++k+hpff

Q: 282   NLICAFLTEREVRLGRNGVEEIKQHPFF  309

         ***************************9

Domain Sequence
(FASTA)

YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDAAFFWEER DIMAFASSPW 60

VVELYSFCAF QDDRYLYMVM EYMPGGDLVN LMSNYDVPEK WAKFYTAEVV LALDVIHSMG 120

LIHRDVKPDN MLLDRHGHLK LADFGTCMKM DETGMVHCDT AVGTPDYISP EVLKSQGGDG 180

YYGRECDWWS VGVFLFEMLV GDTPFYADSL VGTYSKIMDH KNSLSIPEDA EISKHAKNLI 240

CAFLTEREVR LGRNGVEEIK QHPFF 265

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013