EKS-CAP-00398

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00398

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	449.9	2.1E-135	271	519	249

Status

Unreviewed

Ensembl Protein

ENSCPOP00000011542

UniProt Accession

H0VMB4;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000012822	ENSCPOP00000011542	ENSCPOT00000012947

Organism

Cavia porcellus

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240

RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300

LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 360

ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420

TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480

RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQGFL EDYFTATEPQ YQPGENL 537

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGACAAAGAG GCAACAAAAC TGACGGAGGA GAGGGATGGC 60

AGCCTGAACC AGAGCTCCGG GTACCGCTAT GGCACAGACC CCACCCCACA GCACTACCCC 120

AGCTTCGGCG TGACCTCCAT CCCGAACTAC AACAACTTCC ACGCGGCGGG GGGCCAGGGC 180

CTCACCGTCT TTGGAGGGGT GAACTCCTCA TCTCACACGG GGACCTTGCG TACGAGAGGA 240

GGCACAGGAG TGACACTCTT CGTGGCTCTT TACGACTATG AAGCACGGAC AGAAGATGAC 300

CTGAGCTTTC ACAAAGGAGA AAAGTTTCAG ATACTGAACA GCTCGGAAGG AGACTGGTGG 360

GAAGCCCGCT CCTTGACAAC TGGCGAGACC GGTTACATTC CCAGCAATTA TGTGGCACCA 420

GTTGACTCTA TCCAAGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGCAA GGATGCCGAG 480

CGACAGCTTC TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGAGA GAGTGAAACC 540

ACCAAAGGTG CCTACTCACT TTCCATCCGT GACTGGGATG ATATGAAAGG AGACCACGTC 600

AAGCATTACA AAATCCGCAA GCTTGACAAT GGCGGCTACT ATATCACCAC CCGGGCCCAG 660

TTTGAAACGC TCCAGCAGCT TGTGCAACAT TACTCAGAGA GAGCTGCAGG TCTCTGCTGC 720

CGCCTAGTAG TCCCCTGTCA CAAAGGGATG CCACGGCTTA CTGATCTGTC TGTCAAAACC 780

AAAGATGTCT GGGAAATCCC TCGAGAATCC CTGCAGTTGA TCAAGAGACT GGGAAATGGG 840

CAGTTTGGGG AAGTATGGAT GGGTACCTGG AATGGAAACA CAAAAGTAGC CATAAAGACT 900

CTTAAACCAG GCACCATGTC CCCGGAATCG TTCCTCGAGG AAGCACAGAT CATGAAGAAG 960

TTGAAGCACG ACAAGCTGGT CCAGCTGTAC GCGGTGGTGT CTGAAGAGCC CATCTACATT 1020

GTCACCGAGT ATATGAACAA AGGAAGTTTA CTTGATTTCT TAAAAGATGG TGAAGGAAGA 1080

GCTCTGAAGT TACCCAATCT CGTGGACATG GCAGCACAGG TTGCTGCAGG AATGGCCTAC 1140

ATCGAGCGCA TGAATTATAT CCACAGAGAC CTGCGATCAG CAAACATTCT AGTGGGGAAT 1200

GGACTCATTT GCAAAATTGC TGACTTCGGA TTGGCCCGGC TAATTGAAGA CAATGAGTAC 1260

ACAGCAAGAC AAGGTGCAAA GTTCCCCATT AAGTGGACGG CCCCCGAAGC AGCCCTGTAC 1320

GGGAGGTTCA CAATCAAGTC TGACGTGTGG TCTTTTGGAA TCTTACTCAC AGAGCTGGTC 1380

ACCAAAGGAA GAGTGCCATA CCCAGGCATG AACAACCGGG AGGTGCTGGA GCAGGTGGAG 1440

CGCGGCTATC GGATGCCCTG CCCGCAGGAC TGCCCCATCT CTCTGCATGA GCTCATGATC 1500

CACTGCTGGA AAAAGGACCC CGAAGAGCGC CCCACTTTCG AGTACTTGCA GGGCTTTCTG 1560

GAAGACTACT TTACCGCCAC AGAGCCGCAG TACCAGCCCG GAGAGAACCT GTGA 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 390   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee

Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  509

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+lq +

Q: 510   RPTFEYLQGF  519

         *******976

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240

PTFEYLQGF 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013