EPS-CAP-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	146.5	1.0E-42	407	563	157

Status

Unreviewed

Ensembl Protein

ENSCPOP00000011834

UniProt Accession

H0VN26;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000013147	ENSCPOP00000011834	ENSCPOT00000013274

Organism

Cavia porcellus

Functional Description

Protein Length

1315

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLSGA TGRDQSDFVG QTVELGELRL RVRRVLAEGG GFAFVYEAQD 60

LGSGREYALK RLLSNEEEKN RAIIQEVCFL KKLSGHPNIV QFCSAASIGK EESDTGQAEF 120

LLLTELCRGQ LVEFLKKIEA KGPLPCDTVL KIFYQTCKAV QHMHRQKPPI IHRDLKVENL 180

LLSSQGTIKL CDFGSATTIS HYPDYSWSAQ KRAMVEEEIT RNTTPMYRTP EIVDLYSNFP 240

IGEKQDIWAL GCILYLLCFR QHPFEDGAKL RIVNGKYSIP ANDTQYCVFH DLIRAMLKVN 300

PEERLSIAEA VRQLQEIAAA RNVNPKAPIT ELLEQNGGYG NPGPSRAPPT PGGPSSSSNS 360

GALALAEYDQ PYGGFFDILR GGTERLFTNL KDTSSKVIQS VANYAKGDLD ISYITSRIAV 420

MSFPAEGMES AIKNNIEDVR LFLDAKHPGH YAVYNLSPRT YRASKFHNRV TECGWAARRT 480

PNLHSLYTIC RNMHAWLRQD HRNICVVHCM DGRAASAVVV CAFLCFCRLF STAEAAVYMF 540

SMKRCPPGIW PSHKRYIEYV CDMVAEEPIT PHSKPMLVKA VIMTPVPLFS KQRNGCRPFC 600

EVYVRDERVT TTSQEYDRMK EFKIEDGKAV IPLGITVQGD VLIVIYHARS TLGGRLQAKM 660

ASMKMFQIQF HTGFVPRNAT TVKFAKYDLD ACDIQEKYPD LFQVNLEVEV EPRDRSCQEA 720

QPWENTSMRG LNPKILFSSR EEQQDILSKF GKPELPRQPG STAQYDAEVV SPEAEPTDSD 780

SPQSSSADVK HFLHMLDWQG EKETETGMEG SSSKESQAVL ITDRDESEAS DEEAASVPNR 840

DSQPGASEDL PGPIAGSWQQ DLMLDTATPA SPQESRPQED GIDLLGLHLE AAPGPAASAY 900

TSPAPSSNTA LLSCLLGPPE STLQGLPNDL LGSEAPLLES PAPPLSVQSN PQGGPPATAD 960

PFDPLLLAPD ADSQPCSQPD LFGEFLHADP VAAPATFPEV PTSSAPLPSS ATFLPLGNLP 1020

AEPSKVTASS SHQDLLGGWD AWAEAAVPEL ASEVYPERSL FPSGAQLTPA GPHPSQTKSQ 1080

SLDPFADLGA LCDLGCSLPG LAAGPPLGGF VPKAAPSPKG GSSWQTSRPP VQGTSWSPQP 1140

KIPAKTCVPP RPNYSMNFSV IGDREERGVR MPSFTQKPKV SENDFEDLLP NQGFSRSDKK 1200

GPKTMAEMRK QDLARDTDPL KLKLLDWIEG KERNIRALLS TLHTVLWDGE HRWTPVSMAD 1260

LVTPGQVKKQ YRRAVLVVHP DKATGQPYEQ YAKMIFMELN DAWSEFENQG SRPLF 1315

Nucleotide Sequence
(FASTA)

ATGTCACTGC TACAATCTGC GCTCGACTTC CTGGCGGGTC CTGGCTCCCT GAGCGGAGCT 60

ACCGGCCGCG ACCAGAGCGA CTTCGTGGGC CAGACTGTGG AGCTGGGCGA GCTGCGCCTG 120

CGGGTGCGGC GAGTCTTGGC AGAGGGTGGA GGATTTGCTT TTGTGTATGA AGCTCAAGAT 180

CTGGGAAGTG GCAGAGAGTA TGCATTAAAG CGATTACTGT CCAATGAAGA GGAAAAGAAC 240

AGAGCCATCA TTCAAGAAGT TTGCTTCTTG AAAAAACTCT CTGGCCACCC CAACATCGTC 300

CAGTTCTGCT CTGCAGCATC CATAGGAAAA GAGGAATCTG ACACGGGGCA GGCAGAGTTC 360

CTGCTGCTCA CAGAGCTCTG CAGAGGGCAG CTGGTAGAAT TTCTAAAGAA AATTGAAGCT 420

AAAGGCCCTC TGCCCTGTGA CACCGTCCTG AAGATCTTCT ACCAGACATG CAAAGCTGTG 480

CAGCATATGC ACAGGCAGAA GCCGCCCATC ATCCACAGAG ACCTCAAGGT TGAGAACTTG 540

TTACTCAGCA GCCAGGGGAC CATTAAGCTG TGTGATTTTG GCAGTGCTAC CACCATCTCC 600

CACTACCCCG ACTATAGCTG GAGTGCCCAG AAGCGAGCCA TGGTGGAGGA GGAGATCACA 660

AGGAACACCA CACCTATGTA CAGGACACCA GAGATTGTAG ACCTGTATTC CAACTTCCCC 720

ATTGGTGAGA AGCAGGATAT CTGGGCCCTG GGCTGCATCC TGTACCTGCT GTGTTTCCGG 780

CAGCATCCTT TTGAGGATGG TGCAAAACTG CGAATTGTCA ATGGGAAGTA CTCAATCCCG 840

GCAAATGACA CACAGTACTG CGTCTTCCAC GACCTCATCC GCGCCATGCT TAAGGTCAAC 900

CCTGAGGAGC GGCTGTCCAT TGCAGAGGCC GTACGCCAGC TGCAGGAGAT TGCAGCTGCA 960

AGGAATGTGA ACCCCAAGGC GCCCATCACA GAGCTGCTGG AGCAGAATGG AGGCTATGGG 1020

AACCCAGGGC CATCCCGGGC ACCACCCACT CCTGGGGGAC CTTCAAGCAG CAGCAACAGT 1080

GGAGCCCTGG CCTTAGCAGA ATATGACCAG CCCTATGGCG GTTTCTTTGA CATCCTACGG 1140

GGCGGGACAG AGCGGCTCTT CACCAACCTC AAGGATACCT CCTCCAAGGT CATCCAGTCT 1200

GTGGCCAACT ATGCAAAGGG CGATCTGGAC ATATCTTACA TCACTTCTAG GATTGCTGTG 1260

ATGTCATTCC CTGCTGAGGG CATGGAGTCA GCTATCAAAA ATAATATTGA AGATGTGCGG 1320

TTGTTTCTGG ACGCCAAACA CCCGGGCCAC TATGCTGTCT ACAACCTGTC CCCGAGGACC 1380

TACCGGGCAT CCAAGTTCCA TAACCGGGTT ACCGAGTGTG GCTGGGCTGC CAGGCGGACC 1440

CCAAACCTCC ATAGCCTGTA CACCATCTGC AGGAATATGC ATGCCTGGCT GCGGCAGGAC 1500

CACAGGAACA TCTGCGTCGT ACACTGTATG GATGGGAGAG CAGCATCTGC CGTGGTTGTC 1560

TGTGCCTTCC TGTGCTTTTG TCGCCTCTTC AGCACTGCTG AGGCCGCTGT GTACATGTTC 1620

AGCATGAAGC GCTGTCCACC AGGCATTTGG CCGTCCCACA AAAGGTACAT CGAGTACGTG 1680

TGTGACATGG TAGCAGAGGA GCCCATCACG CCGCACAGCA AGCCGATGCT GGTAAAGGCT 1740

GTGATCATGA CCCCCGTGCC GCTATTCAGC AAGCAGAGGA ATGGCTGCAG GCCCTTCTGT 1800

GAAGTCTACG TGAGGGATGA GCGCGTGACT ACCACCTCCC AGGAGTACGA CAGGATGAAG 1860

GAGTTTAAGA TCGAGGACGG CAAGGCAGTC ATCCCCTTGG GCATAACGGT TCAAGGCGAT 1920

GTGCTCATTG TCATTTACCA TGCCAGGTCT ACTCTTGGTG GGCGGCTGCA GGCCAAGATG 1980

GCGTCCATGA AGATGTTCCA GATTCAATTC CATACTGGTT TCGTGCCTCG GAACGCAACC 2040

ACTGTAAAGT TCGCCAAGTA TGACTTGGAT GCGTGTGACA TTCAGGAGAA GTACCCGGAT 2100

CTGTTCCAAG TAAACCTGGA GGTGGAGGTG GAGCCCAGGG ATAGGTCATG CCAGGAGGCC 2160

CAACCGTGGG AGAACACCAG CATGAGAGGG CTGAACCCCA AGATCCTGTT TTCTAGCCGA 2220

GAGGAGCAGC AGGACATCTT GTCCAAGTTT GGGAAGCCAG AGCTGCCCCG GCAGCCGGGC 2280

TCCACAGCTC AATATGACGC CGAGGTGGTG TCTCCAGAGG CTGAGCCTAC GGACTCGGAC 2340

TCACCGCAGA GCAGCAGCGC AGATGTGAAA CACTTCCTCC ACATGCTGGA TTGGCAGGGA 2400

GAGAAAGAAA CAGAGACTGG TATGGAAGGA TCGTCTTCTA AGGAGAGCCA GGCTGTCCTG 2460

ATCACAGATA GAGACGAAAG CGAGGCATCA GATGAAGAGG CGGCCTCAGT CCCTAACAGA 2520

GACAGCCAGC CTGGGGCCAG TGAGGACTTA CCAGGCCCCA TTGCAGGGAG CTGGCAGCAA 2580

GACCTGATGC TCGACACAGC CACCCCAGCC TCACCACAGG AATCCAGGCC TCAGGAAGAT 2640

GGCATTGACC TCCTGGGGCT GCACTTGGAG GCAGCCCCAG GACCAGCTGC CTCTGCATAT 2700

ACCTCTCCGG CCCCCTCCAG CAACACTGCC CTGCTCAGCT GCCTCCTGGG GCCACCTGAA 2760

TCCACTCTGC AGGGGCTGCC CAATGACCTG CTGGGCAGCG AGGCCCCACT CCTGGAGAGT 2820

CCAGCCCCTC CTCTGAGTGT ACAGAGCAAC CCACAGGGAG GACCCCCTGC CACAGCTGAC 2880

CCATTTGACC CCCTCCTTCT GGCTCCTGAT GCTGACTCCC AGCCCTGTTC CCAGCCTGAC 2940

CTCTTTGGCG AGTTCCTGCA TGCAGACCCT GTGGCAGCTC CAGCAACCTT CCCCGAAGTG 3000

CCCACCAGCA GTGCCCCGCT GCCATCCAGT GCCACCTTCC TGCCCCTAGG GAACCTGCCA 3060

GCAGAGCCCA GCAAGGTGAC AGCCTCGTCC AGTCACCAAG ACCTGCTGGG AGGATGGGAT 3120

GCCTGGGCCG AGGCTGCTGT GCCCGAGCTG GCCTCAGAAG TATACCCAGA AAGATCCCTC 3180

TTTCCTTCTG GAGCTCAACT GACCCCTGCC GGTCCCCACC CCAGCCAGAC CAAGTCTCAG 3240

AGCCTGGATC CATTTGCTGA CCTCGGTGCC CTCTGTGACC TTGGCTGCAG CCTCCCAGGC 3300

TTGGCTGCTG GACCCCCACT TGGAGGCTTT GTTCCCAAAG CAGCCCCTTC ACCCAAAGGC 3360

GGTAGCTCCT GGCAGACAAG TCGGCCACCA GTCCAGGGCA CGTCATGGTC CCCCCAGCCC 3420

AAGATTCCTG CCAAAACTTG CGTACCGCCA AGGCCAAACT ACTCCATGAA CTTCAGTGTG 3480

ATTGGGGACC GAGAGGAACG GGGCGTCCGC ATGCCCAGCT TCACTCAAAA GCCAAAAGTC 3540

TCAGAGAATG ACTTTGAAGA TCTGCTGCCC AACCAAGGCT TCTCCAGGTC TGACAAGAAG 3600

GGGCCAAAGA CCATGGCAGA GATGAGGAAG CAGGACCTCG CCCGAGACAC AGACCCCCTC 3660

AAGCTGAAGC TCTTGGACTG GATCGAGGGC AAGGAGAGGA ACATCCGTGC GCTGCTGTCC 3720

ACGTTGCATA CAGTGCTGTG GGATGGGGAG CACCGCTGGA CCCCTGTGAG TATGGCTGAC 3780

TTGGTGACAC CAGGGCAGGT GAAGAAGCAG TACCGCCGTG CGGTGCTGGT CGTGCATCCG 3840

GACAAGGCCA CAGGGCAGCC CTATGAGCAG TATGCCAAGA TGATCTTCAT GGAGCTCAAT 3900

GACGCCTGGT CTGAGTTTGA GAACCAGGGC TCGAGGCCCC TCTTCTGA 3948

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ y+t ri  +sfPae+ e+  +nn+++v  +ld kh ++y +ynl s r y  +k

Q: 407   GDLDISYITSRIAVMSFPAEGMESAIKNNIEDVRLFLDAKHPGHYAVYNL-SPRTYRASK  465

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g+   ++P+l+ l +ic++++ Wl +d++n+ v+hc  g+    v+vca+l

Q: 466   FHNRVTECGWAARRTPNLHSLYTICRNMHAWLRQDHRNICVVHCMDGRAASAVVVCAFLC  525

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsql  170

         + + +++a+ a+++f+++r           Ps +ry++y + +

Q: 526   FCRLFSTAEAAVYMFSMKRCPPG-----IWPSHKRYIEYVCDM  563

         ******************97654.....59*********8876

Domain Sequence
(FASTA)

GDLDISYITS RIAVMSFPAE GMESAIKNNI EDVRLFLDAK HPGHYAVYNL SPRTYRASKF 60

HNRVTECGWA ARRTPNLHSL YTICRNMHAW LRQDHRNICV VHCMDGRAAS AVVVCAFLCF 120

CRLFSTAEAA VYMFSMKRCP PGIWPSHKRY IEYVCDM 157

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013