EKS-CAP-00326

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00326

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	371.4	2.0E-111	786	1052	267

Status

Unreviewed

Ensembl Protein

ENSCPOP00000011845

UniProt Accession

H0VN36;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000013158	ENSCPOP00000011845	ENSCPOT00000013285

Organism

Cavia porcellus

Functional Description

Protein Length

1084

Protein Sequence
(FASTA)

PGTERNTKRM FETHMQSYKG SDPLGEWESY IQWVEENFPD NKDYLVMLLE HLMKEFLDKK 60

RYHNDPRFIN YCLKFAEFNS DLHQFFEFLY NQGIGTQSSP LYISWAGHLE AQGQLQQASA 120

IFRRGIQNQA EPRELLQQQY RLFQTRLTET HLPDQARTSE PLHNAQILNQ MVTSKSSPGK 180

NSACTRKQGS ECSRRVPSAS AKESNTEQRV IMISKSEYST HSSSAAKSDV QQVIMYCKEK 240

LVCGDSEFSF EELRAQKYNQ RRKREQCGNE DRYYVKRKEA NAFEEQLLRQ KVDELHRKLH 300

QVVELSHEHV PTLQESTEAN PAHTGPSVDS QQEQKAPYLP ATNQQTSNNL GEKLRETPLP 360

PVTPPMAHAA LASPAITQSE VPPFPFTAQP VTDPRFQKLY LIARCMSLNS HQLKPQSEAE 420

RGKGCDAQKV TSTSSFHTTP NTSLGTAQAT PSKVQPSPTV HTKEALGFIM NMFQAPALPD 480

ISGDKDEWPT LDENENAFEA QFQKNTSSSE AWGVNKIVSL PSGFPIFEDG NKENYGLPQP 540

KNKPIGTRTF GERSVSAFPS KPNENEVPQP NGEEFLDDST VWGIRYNKTL APCPKSIGDF 600

TSAAQLASTP FHKLPADSVY ILEDKENVVA AQCTPMAVDS CKENVVKPLK EKKFRSSPIQ 660

EESPKQALLT DLSSASLQHL SQPAAGGVLT QEAAQGLEGY KLTDTDPAAV EASAELHTER 720

MQPCSLRNVK APDFTIENPW DEELILKLLS GLSKPVSSYP NMFEWQCRLP AIKPKTEFQL 780

GSVLVYVSQL LGTGAFAQVY EATHGDMNDP KNKQKCVLKV QKPASPWEFY IGTQLMERLK 840

PTARHMFIKF YSAHLFQNGS ILVGDLYSYG TLLNAINLYK NTPEKVMPQA LVIAFALRIL 900

FMIEQVHSCE IIHGDIKPDN FILGNRFLEQ DDEDDDLAAG LALIDLGQSI DMKLFPKGTT 960

FTARCETSGF QCIEMLSNKP WNYQVDYFGV AATVYCMLFG TYMKVKNEGG VWKPEGIFRR 1020

LPHLDTWNEF FHTMLNIPDC QHLPSLDVLR QKLNKLFQEH YANKIKTLRN RLIVLLLEYK 1080

RMKK 1084

Nucleotide Sequence
(FASTA)

CCTGGGACAG AAAGAAACAC AAAGAGAATG TTTGAAACCC ATATGCAGAG CTACAAGGGC 60

AGTGACCCGC TTGGTGAATG GGAAAGTTAC ATACAGTGGG TAGAAGAGAA TTTTCCTGAC 120

AATAAAGATT ACTTGGTAAT GTTATTAGAA CATTTAATGA AGGAATTTTT AGATAAGAAG 180

AGATACCACA ATGACCCAAG ATTCATCAAT TATTGTCTAA AATTTGCTGA GTTCAACAGT 240

GATCTTCATC AGTTTTTTGA ATTTCTGTAT AACCAAGGGA TCGGAACCCA GTCGTCTCCT 300

CTATACATAT CCTGGGCAGG GCACCTGGAA GCCCAAGGAC AATTACAGCA GGCCAGTGCC 360

ATTTTTCGGA GAGGAATTCA AAACCAGGCT GAACCTAGAG AGCTGTTGCA GCAGCAGTAC 420

AGGTTATTTC AGACACGCCT CACTGAAACC CATTTGCCAG ATCAAGCTAG AACCTCAGAA 480

CCTCTGCATA ATGCTCAGAT CTTAAACCAA ATGGTAACGT CAAAATCAAG TCCAGGAAAG 540

AACTCAGCCT GTACTAGAAA ACAGGGTTCA GAATGTTCTA GAAGGGTTCC TTCAGCTTCT 600

GCTAAAGAGT CAAATACGGA ACAAAGGGTG ATCATGATTT CTAAATCAGA ATACTCCACA 660

CACTCGTCTT CGGCAGCAAA ATCTGATGTC CAACAAGTCA TTATGTACTG CAAGGAGAAA 720

CTTGTTTGTG GAGACTCTGA ATTTTCCTTT GAAGAACTGA GAGCCCAGAA ATACAACCAA 780

CGGAGGAAAC GTGAACAATG CGGAAATGAA GACAGATACT ATGTGAAAAG AAAAGAAGCA 840

AATGCTTTTG AAGAGCAGCT GCTACGGCAG AAAGTGGATG AACTCCACCG GAAGCTGCAT 900

CAAGTGGTGG AGCTCTCCCA TGAGCATGTG CCCACCCTCC AGGAAAGCAC TGAGGCTAAT 960

CCAGCACATA CAGGGCCAAG TGTAGACTCC CAGCAGGAAC AAAAAGCTCC GTATCTTCCA 1020

GCCACCAATC AGCAGACCTC AAACAACTTG GGAGAGAAGC TCAGAGAAAC ACCTCTGCCT 1080

CCTGTCACTC CTCCTATGGC ACATGCTGCT CTGGCTTCCC CAGCCATCAC CCAGAGTGAA 1140

GTTCCTCCTT TTCCCTTCAC AGCCCAGCCA GTGACAGACC CCAGGTTTCA GAAATTATAC 1200

TTAATAGCGC GATGTATGAG TCTAAATTCT CATCAACTCA AGCCACAAAG TGAAGCTGAG 1260

AGAGGGAAAG GATGTGATGC ACAGAAGGTC ACTAGCACAA GTTCTTTTCA CACTACTCCA 1320

AACACCTCCC TGGGAACGGC TCAGGCAACA CCATCCAAAG TGCAGCCATC ACCCACTGTG 1380

CACACGAAGG AAGCCTTGGG TTTTATCATG AATATGTTTC AAGCTCCTGC ACTTCCTGAT 1440

ATTTCTGGTG ACAAAGATGA ATGGCCAACT CTAGATGAAA ATGAAAATGC ATTTGAAGCC 1500

CAGTTTCAAA AAAACACAAG TTCCTCTGAG GCTTGGGGAG TCAATAAGAT TGTCTCTTTG 1560

CCTTCTGGTT TTCCTATTTT TGAAGATGGA AACAAAGAAA ATTATGGATT ACCACAGCCT 1620

AAAAATAAGC CCATAGGGAC CAGGACCTTT GGGGAACGCT CTGTCAGTGC ATTTCCTTCA 1680

AAACCAAATG AAAATGAAGT GCCTCAGCCT AACGGTGAAG AGTTTTTAGA CGATTCAACG 1740

GTATGGGGTA TTCGCTACAA TAAAACCCTG GCACCCTGTC CAAAGAGCAT AGGAGACTTC 1800

ACATCTGCTG CCCAGCTGGC ATCTACACCA TTCCACAAAC TTCCAGCAGA TTCAGTGTAC 1860

ATTCTGGAAG ATAAAGAAAA TGTGGTAGCA GCACAGTGCA CCCCTATGGC TGTGGATTCC 1920

TGTAAAGAAA ACGTGGTGAA ACCCTTGAAA GAGAAGAAGT TCAGATCTAG TCCAATTCAA 1980

GAGGAAAGCC CAAAACAAGC ACTCCTGACG GACCTATCTT CAGCATCCCT GCAGCATCTG 2040

AGCCAGCCTG CTGCAGGTGG TGTGCTCACC CAGGAAGCTG CACAGGGCCT TGAGGGTTAT 2100

AAACTCACAG ACACTGACCC CGCTGCTGTG GAGGCTAGCG CTGAACTCCA CACAGAGCGG 2160

ATGCAGCCCT GCTCACTTAG GAATGTCAAA GCTCCAGACT TCACTATTGA AAACCCATGG 2220

GATGAGGAAT TGATTCTCAA GCTGTTATCT GGGCTTTCTA AACCAGTGAG TTCCTACCCA 2280

AATATGTTTG AATGGCAATG TAGACTTCCA GCCATCAAGC CCAAGACTGA ATTTCAGCTG 2340

GGTTCTGTGC TGGTCTACGT CAGTCAGCTT CTTGGAACAG GTGCCTTTGC TCAAGTCTAC 2400

GAAGCTACCC ACGGAGATAT GAATGATCCC AAAAATAAAC AGAAGTGCGT TTTAAAGGTG 2460

CAGAAGCCTG CCAGCCCCTG GGAATTCTAC ATTGGGACCC AGCTGATGGA GAGATTAAAG 2520

CCAACTGCGC GGCACATGTT TATCAAATTC TATTCTGCCC ATTTATTTCA AAATGGTAGC 2580

ATTTTAGTGG GCGATCTCTA TAGCTACGGA ACATTATTAA ATGCCATTAA CCTCTATAAA 2640

AATACCCCTG AAAAAGTGAT GCCTCAAGCT CTCGTCATTG CCTTTGCTCT CAGAATACTC 2700

TTCATGATTG AACAAGTCCA CAGCTGTGAA ATCATTCATG GAGACATTAA GCCAGACAAT 2760

TTCATACTGG GAAATAGATT TTTGGAGCAG GATGATGAAG ATGACGATTT AGCTGCTGGC 2820

TTGGCACTGA TTGACCTGGG TCAGAGTATA GATATGAAAC TTTTTCCAAA AGGAACTACA 2880

TTTACAGCAC GGTGTGAAAC ATCTGGTTTT CAGTGTATCG AGATGCTCAG TAATAAACCA 2940

TGGAACTACC AGGTTGATTA CTTTGGTGTT GCTGCAACAG TGTACTGCAT GCTTTTTGGC 3000

ACTTACATGA AAGTGAAAAA TGAGGGAGGA GTCTGGAAGC CTGAGGGCAT TTTTAGAAGG 3060

CTCCCTCATC TGGATACGTG GAATGAATTT TTTCACACCA TGCTGAATAT ACCAGACTGT 3120

CAACATCTTC CATCTTTGGA TGTGTTAAGG CAAAAGCTAA ACAAACTATT TCAGGAACAT 3180

TATGCAAACA AGATTAAAAC CCTGCGTAAC AGGCTAATTG TACTGCTCTT AGAGTATAAG 3240

CGTATGAAAA AATAA 3255

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++g Ga+a+vy+a+h    d k++++++lKv+kpa++WefYI +ql+eRlk ++

Q: 786   YVSQLLGTGAFAQVYEATHgdmnDPKNKQKCVLKVQKPASPWEFYIGTQLMERLK-PTAR  844

         799*****************999999*****************************.88**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+lfq++s+lv +++sygtll++in++k++ +kvm+++lv+ +++++l ++e

Q: 845   HMFIKFYSAHLFQNGSILVGDLYSYGTLLNAINLYKNTPEKVMPQALVIAFALRILFMIE  904

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lgnr+ ++ d +d+ ++gl+liD+g+siDmkl+p+gt+f+++

Q: 905   QVHSCEIIHGDIKPDNFILGNRFLEQDDeDDDLAAGLALIDLGQSIDMKLFPKGTTFTAR  964

         *************************99945667788************************

S: 177   aktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkk  236

         ++t++f+cieml++k+w+YqvD+fg+aa+++++lfg+y++v++egg wk++  ++rl++

Q: 965   CETSGFQCIEMLSNKPWNYQVDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGIFRRLPHL  1024

         ************************************************************

S: 237   elwekiferlLNisdastlpsleelveek  265

         + w+++f+++LNi+d+++lpsl+ l++ k

Q: 1025  DTWNEFFHTMLNIPDCQHLPSLDVLRQ-K  1052

         *************************95.4

Domain Sequence
(FASTA)

YVSQLLGTGA FAQVYEATHG DMNDPKNKQK CVLKVQKPAS PWEFYIGTQL MERLKPTARH 60

MFIKFYSAHL FQNGSILVGD LYSYGTLLNA INLYKNTPEK VMPQALVIAF ALRILFMIEQ 120

VHSCEIIHGD IKPDNFILGN RFLEQDDEDD DLAAGLALID LGQSIDMKLF PKGTTFTARC 180

ETSGFQCIEM LSNKPWNYQV DYFGVAATVY CMLFGTYMKV KNEGGVWKPE GIFRRLPHLD 240

TWNEFFHTML NIPDCQHLPS LDVLRQK 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013