EKS-CAP-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	329.7	1.0E-98	1	227	227

Status

Unreviewed

Ensembl Protein

ENSCPOP00000012066

UniProt Accession

H0VNN2;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000013404	ENSCPOP00000012066	ENSCPOT00000013535

Organism

Cavia porcellus

Functional Description

Protein Length

880

Protein Sequence
(FASTA)

QVAIKIIDKS QLDAVNLEKI YREVQIMKML DHPHIIKLYQ VMETKSMLYL VTEYAKNGEI 60

FDYLANHGRL NESEARRKFW QILSAVDYCH GRKVVHRDLK AENLLLDNNM NIKIADFGFG 120

NFFKSGELLA TWCGSPPYAA PEVFEGQQYE GPQLDIWSMG VVLYVLVCGA LPFDGPTLPM 180

LRQRVLEGRF RIPYFMSEDC EHLIRRMLVL DPSKRLTIAQ IKEHKWMLIE VPVQRPVLYP 240

QEQENEPSIG EFNEQVLRLM HSLGIDQQKT IESLQNKSYN HFAAIYFLLV ERLKSHRSSF 300

PVEQRLDGRP RRPSTIAEQT VAKAHTVGLP VTTSAPAARL MPSALPAPAA TVEAFSFPAS 360

SCQAEAAFME AECVDTPKVN GCLLDPVPPV LVRKGCQSLP SNVMETSIDE GLETEGEADE 420

EPGHAFEAFQ ATRSGQRRHT LSEVTNQLVM VPGAGKMFSV SDNPSLDSVD SEYDIGSAQR 480

ELSFLEDNPS LKDIMAANPP SPRMTSPFVS LRPTNPAMQA LSAQKREAHN RSPVSFREGR 540

RASDTSLTQG IVAFRQHLQN LARTKGILEL NKVQLLYEQM GPEADPVLAS ASPQLQDLAG 600

GCPQEEVAPP QEGVPPLSSS VHPQLSPRQS RETQYLPHRL QKPGLLSKAQ NTCQLYCKEA 660

PRSLEQQLQE HRLQQKRLFL QKQSQLQAYF NQMQIAESSY PPPSQQLPLP HPETPPSSQQ 720

PPPFSLTQSL SPVLEPSSEQ MQYSPFLGQY EEMQLRPLPS TPSARAAPPL PTQLQQQPPP 780

SPPPPPQQPG AAPAPLQFSY QTCELSSATS SAPDYPAPCQ YPVDGAPQSS LTGPDCPRSS 840

GLQETPSSYD PLALSELPGL FDCEMLDAVD PQHNGYVLVN 880

Nucleotide Sequence
(FASTA)

CAGGTGGCAA TAAAAATAAT AGATAAATCT CAGCTGGATG CAGTGAACCT TGAGAAAATC 60

TATCGAGAAG TACAAATAAT GAAAATGTTA GACCACCCTC ACATAATCAA ACTTTATCAG 120

GTAATGGAGA CCAAGAGCAT GTTGTACCTG GTGACAGAAT ATGCCAAAAA TGGGGAAATT 180

TTTGACTACC TTGCTAACCA TGGCCGGTTA AATGAGTCTG AAGCCAGGAG GAAATTCTGG 240

CAAATCCTTT CTGCTGTTGA TTATTGTCAT GGTCGGAAGG TTGTGCACCG TGACCTCAAG 300

GCTGAAAATC TTCTGCTGGA TAACAACATG AATATCAAAA TAGCAGATTT CGGTTTTGGA 360

AACTTCTTTA AAAGTGGTGA ACTGCTGGCA ACATGGTGTG GCAGCCCCCC GTACGCAGCC 420

CCAGAAGTCT TTGAAGGGCA GCAGTATGAA GGACCACAGC TGGACATTTG GAGCATGGGA 480

GTTGTCCTGT ACGTCCTCGT CTGCGGCGCA TTGCCTTTCG ATGGACCGAC CCTTCCAATG 540

TTGAGGCAGA GGGTTTTGGA GGGAAGATTT CGGATCCCAT ATTTCATGTC AGAAGATTGT 600

GAGCATCTCA TTCGGAGAAT GTTGGTCCTA GACCCATCTA AACGGCTAAC CATAGCTCAA 660

ATCAAGGAGC ATAAGTGGAT GCTCATAGAG GTTCCTGTAC AGAGACCTGT ACTCTATCCA 720

CAAGAGCAAG AAAACGAGCC CTCCATTGGG GAGTTTAACG AGCAGGTTCT GCGATTGATG 780

CACAGCCTTG GAATAGATCA GCAGAAAACC ATCGAGTCTT TGCAAAACAA GAGCTACAAC 840

CACTTTGCCG CCATTTATTT CTTGCTGGTG GAGCGCCTGA AGTCACACAG GAGCAGCTTT 900

CCTGTGGAGC AGAGGCTCGA CGGCCGCCCG CGGAGGCCCA GCACCATCGC CGAGCAGACA 960

GTTGCCAAGG CACACACCGT GGGGCTCCCG GTGACCACGT CCGCCCCCGC CGCCAGGCTG 1020

ATGCCGTCCG CCCTGCCCGC GCCCGCGGCC ACCGTGGAGG CCTTCTCCTT CCCCGCGTCC 1080

AGCTGCCAGG CCGAAGCCGC CTTCATGGAG GCCGAGTGTG TGGACACCCC GAAGGTGAAT 1140

GGCTGTTTGC TTGACCCGGT GCCGCCTGTC CTGGTGAGGA AGGGATGCCA GTCGCTGCCC 1200

AGTAACGTGA TGGAGACCTC CATCGACGAA GGGCTGGAGA CAGAAGGAGA AGCTGATGAA 1260

GAGCCCGGCC ATGCCTTTGA GGCGTTTCAG GCCACGCGCA GTGGGCAAAG ACGGCACACT 1320

CTATCGGAAG TGACCAACCA GCTGGTCATG GTGCCAGGAG CAGGAAAAAT GTTCTCCGTG 1380

AGTGACAACC CCTCCCTGGA CAGTGTAGAC TCCGAGTACG ATATAGGGTC TGCTCAGAGG 1440

GAGCTGAGCT TCCTAGAGGA CAACCCTTCC CTGAAGGACA TCATGGCAGC CAATCCGCCC 1500

TCGCCCCGCA TGACGTCGCC CTTCGTGAGC CTGCGACCCA CCAACCCGGC CATGCAGGCT 1560

CTGAGCGCCC AGAAACGAGA GGCGCACAAC AGGTCACCAG TGAGCTTCAG AGAAGGCCGC 1620

CGGGCGTCAG ACACCTCCCT CACCCAAGGA ATTGTAGCGT TCAGACAGCA TCTTCAGAAT 1680

CTCGCTAGAA CCAAAGGCAT CCTGGAACTG AACAAGGTGC AGCTGCTGTA CGAACAGATG 1740

GGGCCCGAAG CTGACCCTGT GCTGGCCTCC GCCTCCCCGC AGCTCCAGGA CCTCGCGGGC 1800

GGCTGCCCTC AGGAGGAAGT TGCCCCGCCG CAGGAAGGCG TCCCCCCGCT CTCCAGCAGC 1860

GTGCATCCCC AGCTGTCCCC GCGGCAAAGC CGGGAAACTC AGTACCTGCC ACACAGGCTT 1920

CAGAAACCCG GCCTTCTATC AAAGGCCCAG AACACCTGTC AGCTGTATTG TAAGGAGGCG 1980

CCACGGAGCC TGGAGCAGCA GCTTCAGGAA CACAGGCTCC AGCAGAAGCG ACTCTTCCTC 2040

CAGAAGCAGT CCCAGCTGCA GGCGTATTTC AATCAGATGC AGATAGCTGA GAGCTCCTAC 2100

CCTCCACCGA GTCAGCAGCT GCCCCTGCCC CACCCGGAGA CTCCACCTTC GTCTCAGCAG 2160

CCCCCGCCAT TCAGCCTGAC CCAGTCCCTG AGCCCTGTCC TGGAGCCTTC TTCTGAGCAA 2220

ATGCAATACA GCCCTTTCCT CGGCCAGTAT GAAGAGATGC AGCTGCGGCC CCTGCCCTCC 2280

ACGCCCAGTG CCCGGGCAGC TCCTCCACTG CCCACGCAGC TGCAGCAGCA GCCGCCACCC 2340

TCACCTCCTC CTCCGCCACA ACAGCCAGGA GCTGCTCCTG CCCCCTTACA GTTCTCCTAT 2400

CAGACTTGCG AGCTGTCAAG TGCCACTTCC TCTGCTCCGG ACTATCCCGC TCCCTGTCAG 2460

TACCCTGTGG ACGGAGCCCC GCAGAGCAGT CTCACAGGCC CGGACTGTCC CCGAAGCTCA 2520

GGACTGCAGG AGACCCCCTC CAGCTATGAC CCACTGGCCC TCTCCGAGTT ACCGGGACTC 2580

TTTGATTGTG AAATGCTAGA TGCTGTGGAT CCACAACACA ATGGGTATGT CCTGGTGAAT 2640

Domain Profile

S: 26    kvavKiikkkklseeslekikrEieilkklkhpniikllevietkkklylvleyasggeL  85

         +va+Kii+k++l++ +leki+rE++i+k+l+hp+iikl++v+etk++lylv+eya++ge+

Q: 1     QVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEI  60

         69**********************************************************

S: 86    fdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkenikiaDFGla  145

         fdy+ ++grl+e+ear+ f q++sav+Y+h +++vHrDlK+eNllld+++nikiaDFG++

Q: 61    FDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLKAENLLLDNNMNIKIADFGFG  120

         ************************************************************

S: 146   nlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlke  205

         n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D+Ws+GvvLy+lv+g+lPfd+++l

Q: 121   NFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPM  180

         ************************************************************

S: 206   llekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR+ti +i++h+w+

Q: 181   LRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM  227

         **********************************************8

Domain Sequence
(FASTA)

QVAIKIIDKS QLDAVNLEKI YREVQIMKML DHPHIIKLYQ VMETKSMLYL VTEYAKNGEI 60

FDYLANHGRL NESEARRKFW QILSAVDYCH GRKVVHRDLK AENLLLDNNM NIKIADFGFG 120

NFFKSGELLA TWCGSPPYAA PEVFEGQQYE GPQLDIWSMG VVLYVLVCGA LPFDGPTLPM 180

LRQRVLEGRF RIPYFMSEDC EHLIRRMLVL DPSKRLTIAQ IKEHKWM 227

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013