EKS-CAP-00120

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00120

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	477.3	1.2E-143	1077	1337	261

Status

Unreviewed

Ensembl Protein

ENSCPOP00000012177

UniProt Accession

Q07E11;

Protein Name

Protein Synonyms/Alias

Met proto-oncogene;

Gene Name

MET

Gene Synonyms/Alias

MET; LOC100718790;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000013525	ENSCPOP00000012177	ENSCPOT00000013660

Organism

Cavia porcellus

Functional Description

Protein Length

1380

Protein Sequence
(FASTA)

MKAPTALAPG VLVLLFTLVQ RSDGECAEAL VKSEMNMNMQ YQLPNFTAET PIQHVALHRH 60

HIYLGATNYL YVLNDKDLQK VAEYKTGPVL EHPDCLPCQD CSSKANLSGA IWKDNINMAM 120

LIDTYYDDQL ISCGSVNRGT CQRHVLPLSN TADIQAKVYC MFSQADEESG QCPDCVVSAL 180

GTKVLLSEKS RFINFFVGNT INSSYLPDHS LHSISVRRLK ETLDGFKFLT DQSYIDVLPE 240

FRDSYPIKYV HAFESSHFIY FLTVQKETLD AQTFHTRIIR FCSADSGLHS YMEMPLECIL 300

TEKRRKRSTG QEVFNILQAA YVGTAGAHLA KQIRVGLNDD ILYGVFAQSK PDSAEPMNRS 360

AVCAFPIKYV NEFFNKIVNK NNVKCLQHFY GPNHEHCFNR TLLRNSSGCE VRSDEYRTEF 420

TTALQRVDLF SGQFKQVLLT SISTFVKGDL TIANLGTSEG RFMQVVVSRT VSSTPHVNFR 480

LDSQPVSPEV IVEQPLNQNG YTLVITGKKI TKIPLNGLGC GHFQSCSQCL SAPSFVQCGW 540

CHNQCVRSDE CTNGIWTQEI CLPAIYKIFP TSAPIEGGTT LTICGWDFGF RKNNKFDLKK 600

TKVFLGNESC TLTSSESTTN MLKCTVGPSV NEHFNMSILV SNNRGTAHST FSYVDPVITS 660

ISPNYGPKAG GTLLTLTGKY LNSGNSRHIS IGGKTCTLKS VSSSILECYT PAQTISAEFP 720

IKLKIDLANR ETGSFHYQDD PIVYEIHPTK SFISGGSTIT GIGKNLNSVS VPRLVINVHE 780

AGKNYTVACQ HRSNLEIICC TTPSLQQLNL QLPLKTKAFF MLDGILSKYF DLIYVHNPIF 840

KHFEKPVMIS MGNANVLEIK GNDIDPEAVK GDVLKVGNKS CESVEPHDEA VLCTVPNDLL 900

KLNSELNIEW KQEVSSTLLG KVIVQPDQNF TGLIVSVVSV SVILLVLLGL FLWLKKRKQI 960

KDLGSDLVRY DARVHTPHLD RLVSARSVSP TTEMVSNESV DYRATFPEDQ FPNSSQNGSC 1020

RQVQYPLTDL SPILNSGDSD ISSPLLQNTV HIDLSALNPE LVQAVQHVVI GPSSLIVHFN 1080

EVIGRGHFGC VYHGTLLDSD GKKIHCAVKS LNRITDIGEV SQFLTEGIIM KDFSHSNVLS 1140

LLGICLRSEG SPLVVLPYMK HGDLRNFIRN ETHNPTVKDL IGFGLQVAKG MKYLASKKFV 1200

HRDLAARNCM LDEKFTVKVA DFGLARDMYD KEYYSVHNKT GAKLPVKWMA LESLQTQKFT 1260

TKSDVWSFGV LLWELMTRGA PPYPDVNTFD ITVYLLQGRR LLQPEYCPDP LYEVMLKCWH 1320

PKAEMRPSFS ELVSKISAIF STFIGEHYVH VNATYVNVKC VAPYPSLLSS QENIDGDMDT 1380

Nucleotide Sequence
(FASTA)

ATGAAGGCCC CCACTGCGCT TGCACCTGGC GTCCTGGTGC TGCTGTTTAC CTTGGTGCAG 60

AGGAGCGATG GGGAATGTGC GGAGGCACTA GTGAAGTCTG AGATGAACAT GAACATGCAG 120

TATCAGCTTC CCAACTTCAC TGCAGAAACA CCCATCCAGC ACGTTGCTCT ACACAGGCAC 180

CACATTTACC TGGGGGCCAC CAACTACCTT TATGTTTTAA ATGACAAAGA CCTTCAGAAG 240

GTAGCTGAGT ATAAGACTGG ACCTGTGCTG GAGCATCCGG ATTGTCTTCC ATGTCAGGAC 300

TGCAGCAGTA AAGCCAATTT ATCAGGAGCC ATTTGGAAAG ATAACATCAA CATGGCTATG 360

CTTATTGACA CGTACTATGA TGACCAGCTC ATTAGTTGTG GCAGTGTCAA CAGAGGGACC 420

TGCCAGCGAC ACGTCCTTCC ACTCAGTAAT ACTGCTGACA TACAGGCAAA AGTATATTGC 480

ATGTTCTCAC AGGCAGATGA AGAGTCCGGC CAGTGTCCTG ACTGTGTGGT GAGCGCTCTG 540

GGAACCAAAG TCCTTCTGTC TGAAAAGAGT CGGTTCATCA ACTTCTTTGT GGGCAATACC 600

ATAAATTCTT CTTACCTGCC AGATCACTCA TTGCATTCAA TATCAGTGAG AAGGCTAAAA 660

GAAACACTAG ATGGTTTTAA GTTTTTGACA GACCAGTCCT ATATTGATGT TTTACCTGAG 720

TTCCGAGATT CTTACCCCAT TAAGTACGTC CATGCCTTTG AAAGCAGCCA TTTCATTTAC 780

TTTCTAACTG TCCAAAAGGA AACTCTGGAT GCTCAGACTT TTCACACAAG AATCATCAGG 840

TTCTGTTCTG CAGACTCTGG ACTGCACTCG TACATGGAAA TGCCTCTGGA GTGTATTCTT 900

ACGGAAAAAA GAAGAAAAAG ATCCACAGGG CAGGAAGTGT TTAACATCCT TCAGGCTGCA 960

TATGTTGGTA CAGCCGGGGC CCATCTCGCT AAGCAAATCC GAGTGGGTCT GAATGATGAC 1020

ATTTTATATG GGGTGTTTGC ACAAAGCAAG CCAGATTCTG CTGAACCAAT GAATCGATCT 1080

GCTGTCTGTG CATTCCCTAT CAAATATGTC AATGAATTCT TCAATAAGAT CGTCAACAAA 1140

AACAATGTGA AATGTCTGCA GCATTTCTAT GGGCCAAATC ACGAGCACTG CTTTAATAGG 1200

ACACTGCTGA GAAATTCATC AGGCTGTGAA GTACGCAGTG ATGAGTATCG AACAGAGTTT 1260

ACCACAGCTT TACAGCGTGT TGATCTATTC TCGGGCCAAT TCAAACAGGT GCTTCTAACA 1320

TCTATATCAA CCTTCGTTAA AGGAGACCTC ACCATTGCTA ATCTTGGGAC ATCAGAGGGT 1380

CGTTTCATGC AGGTTGTGGT TTCTCGAACA GTATCATCTA CCCCTCATGT GAATTTTCGC 1440

CTGGATTCCC AGCCTGTGTC TCCAGAAGTC ATCGTGGAGC AACCGTTAAA CCAAAATGGC 1500

TACACTCTGG TTATCACTGG GAAAAAGATC ACAAAGATCC CACTGAATGG TTTGGGCTGT 1560

GGACATTTCC AGTCCTGTAG TCAGTGTCTC TCTGCTCCAT CTTTTGTGCA GTGTGGCTGG 1620

TGCCACAATC AATGTGTGAG ATCAGATGAG TGCACCAATG GGATATGGAC ACAAGAGATC 1680

TGTCTGCCTG CAATCTACAA GATTTTCCCT ACTAGTGCAC CCATTGAAGG AGGGACAACG 1740

TTGACCATAT GTGGCTGGGA CTTTGGATTC AGGAAGAATA ACAAATTTGA TTTAAAGAAA 1800

ACCAAAGTTT TTCTTGGAAA TGAGAGCTGC ACCTTGACGT CAAGTGAGAG CACAACAAAT 1860

ATGTTGAAAT GCACAGTTGG TCCTTCAGTG AATGAGCATT TCAATATGTC CATACTTGTT 1920

TCAAACAATC GTGGAACAGC ACATAGCACC TTTTCCTATG TAGATCCTGT AATAACAAGT 1980

ATTTCTCCAA ATTATGGTCC TAAGGCTGGT GGCACTTTAC TTACTTTAAC TGGAAAATAC 2040

CTGAATAGTG GAAATTCTAG ACACATTTCA ATTGGTGGAA AAACATGCAC TTTAAAAAGT 2100

GTATCAAGTA GTATTCTTGA ATGTTACACA CCAGCCCAGA CCATTTCAGC TGAGTTTCCT 2160

ATTAAGCTGA AAATTGACTT AGCCAACCGA GAGACTGGCA GCTTCCATTA CCAGGATGAC 2220

CCCATTGTCT ATGAAATTCA CCCGACCAAG TCTTTTATTA GTGGTGGGAG CACAATAACG 2280

GGTATTGGAA AAAACCTGAA TTCAGTCAGC GTCCCAAGAC TCGTAATAAA TGTGCATGAA 2340

GCGGGAAAGA ACTACACAGT GGCATGCCAA CATCGCTCTA ATTTAGAGAT AATCTGCTGT 2400

ACCACGCCTT CACTGCAACA GCTGAACCTG CAACTCCCCC TGAAGACCAA AGCCTTTTTC 2460

ATGTTGGATG GGATTCTTTC CAAATACTTT GATCTCATTT ATGTACATAA TCCCATCTTC 2520

AAGCATTTTG AAAAGCCAGT GATGATCTCA ATGGGCAATG CAAATGTGCT GGAAATTAAG 2580

GGAAATGATA TTGACCCTGA AGCAGTTAAA GGTGACGTGT TAAAAGTTGG AAATAAGAGC 2640

TGTGAGAGTG TAGAGCCACA TGATGAAGCT GTTTTATGCA CGGTCCCCAA TGACCTGCTG 2700

AAACTGAACA GCGAGCTAAA TATAGAGTGG AAGCAAGAAG TCTCTTCAAC TCTCCTTGGA 2760

AAAGTAATAG TTCAACCAGA TCAGAATTTC ACGGGATTGA TTGTTAGCGT TGTCTCGGTA 2820

TCAGTAATAC TTTTAGTATT ACTTGGGCTT TTCCTGTGGC TGAAAAAGAG AAAGCAAATT 2880

AAAGATCTGG GCAGTGACTT AGTTCGCTAT GATGCAAGAG TGCACACTCC TCATTTGGAT 2940

AGGCTTGTAA GTGCCCGAAG TGTAAGTCCA ACTACAGAAA TGGTTTCAAA TGAATCTGTA 3000

GACTACCGAG CTACTTTTCC AGAAGATCAG TTTCCTAACT CATCTCAGAA TGGATCATGC 3060

AGACAAGTGC AGTATCCTCT GACGGACTTG TCCCCCATCC TAAATAGTGG AGACTCTGAT 3120

ATATCCAGTC CATTACTACA AAATACAGTC CACATTGACC TCAGTGCTCT AAATCCAGAG 3180

CTGGTGCAAG CAGTCCAGCA TGTAGTGATT GGGCCCAGCA GCCTGATAGT GCATTTCAAT 3240

GAAGTCATAG GAAGAGGACA TTTTGGTTGT GTCTATCATG GGACTTTGTT GGACAGTGAT 3300

GGCAAGAAAA TCCACTGTGC TGTGAAATCC TTGAATAGAA TCACTGACAT AGGAGAAGTT 3360

TCCCAGTTTC TGACCGAAGG AATTATCATG AAAGATTTCA GCCATTCCAA TGTTCTCTCG 3420

CTCTTGGGCA TCTGCCTGCG GAGTGAAGGG TCCCCGCTAG TAGTCCTACC ATACATGAAG 3480

CATGGAGACC TTCGCAACTT CATTCGAAAT GAGACTCACA ACCCAACTGT AAAAGATCTT 3540

ATAGGCTTTG GTCTTCAAGT AGCCAAAGGC ATGAAATATC TTGCAAGCAA AAAGTTTGTC 3600

CACAGAGATT TGGCTGCAAG AAACTGTATG TTGGATGAAA AATTCACTGT CAAGGTTGCT 3660

GACTTTGGTC TTGCCAGAGA CATGTATGAT AAAGAATACT ACAGTGTACA CAATAAAACA 3720

GGTGCAAAGC TACCAGTGAA GTGGATGGCT TTAGAAAGCC TGCAAACTCA GAAGTTCACC 3780

ACCAAATCAG ATGTGTGGTC CTTTGGCGTG CTCCTCTGGG AACTGATGAC AAGAGGAGCC 3840

CCCCCTTATC CTGATGTGAA CACCTTTGAT ATCACGGTTT ACTTGCTACA AGGCAGAAGG 3900

CTCTTACAGC CCGAATACTG TCCAGATCCC TTGTACGAAG TGATGTTAAA ATGCTGGCAC 3960

CCCAAAGCTG AAATGCGCCC ATCCTTTTCC GAGCTGGTCT CCAAGATATC AGCCATCTTT 4020

TCCACTTTCA TCGGGGAGCA TTACGTCCAT GTGAATGCTA CTTACGTCAA TGTAAAATGT 4080

GTTGCTCCAT ATCCTTCTCT GTTATCATCA CAAGAAAACA TCGATGGTGA CATGGACACG 4140

TGA 4143

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+ds++kki++avksl+ritdi++v++fl+eg++mk+++h

Q: 1077  VHFNEVIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHS  1136

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1137  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1196

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1197  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1256

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1257  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1315

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1316  LKCWHPKAEMRPSFSELVSKIS  1337

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDSDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHS 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAEMR PSFSELVSKI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013