EKS-CAP-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	389.2	7.1E-117	56	307	252

Status

Unreviewed

Ensembl Protein

ENSCPOP00000012567

UniProt Accession

H0VPX2;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000013946	ENSCPOP00000012567	ENSCPOT00000014087

Organism

Cavia porcellus

Functional Description

Protein Length

754

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHTS LGDGRQEVTS RPGRSGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGNKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300

IMKDRWINAG HEEDELKPFI EPELNISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360

YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLSSSTGQS PHHKVQRSVS SSQKQRRYSD 420

HAGPAIPSVV AYPKRSQTST ADSDLKEDGI PSRKSSSSAV GGKGIAPASP MLGNASNPNK 480

ADIPERKKSP AVTSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKETST VPDQRTPVAS 540

THSISSAATP DRIHFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600

STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN REAKPRSLRF 660

TWSMKTTSSM DPSDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHATEN LVQWEMEVCK 720

LPRLSLNGVR FKRISGTSIA FKNIASKIAN ELKL 754

Nucleotide Sequence
(FASTA)

ATGTCCACGA GGACCCCCTT GCCCACGGTG AATGAACGAG ACACCGAAAA CCATACCTCG 60

CTTGGAGATG GACGGCAAGA AGTCACCTCC CGCCCTGGGC GCTCTGGAGC TCGGTGTAGA 120

AACTCGATAG CTTCCTGTGC AGATGAACAG CCTCACATAG GAAACTACAG ACTATTGAAA 180

ACAATCGGCA AGGGGAACTT TGCAAAAGTG AAATTAGCGA GACACATCCT TACTGGCAGA 240

GAGGTTGCCA TAAAAATAAT TGACAAAACA CAGTTGAATC CAACAAGTCT ACAGAAGCTC 300

TTCAGAGAAG TAAGAATAAT GAAGATTTTA AATCATCCAA ACATAGTAAA GTTGTTTGAA 360

GTCATTGAAA CTGAAAAGAC ACTCTACTTA ATCATGGAGT ATGCAAGTGG AGGTGAAGTA 420

TTTGACTATT TGGTTGCACA TGGAAGAATG AAGGAAAAAG AAGCAAGAGC TAAATTTAGA 480

CAGATCGTGT CTGCAGTGCA ATATTGCCAC CAAAAACGGA TCGTTCACAG AGACCTCAAG 540

GCTGAAAATC TATTGTTAGA TGCGGATATG AACATTAAAA TAGCAGATTT TGGTTTTAGC 600

AATGAATTTA CTGTTGGCAA TAAACTAGAC ACGTTTTGTG GTAGTCCTCC ATATGCAGCC 660

CCAGAGCTCT TCCAGGGCAA GAAGTATGAT GGGCCAGAGG TGGACGTGTG GAGTCTTGGC 720

GTGATTCTCT ACACCCTAGT TAGTGGGTCG CTTCCCTTTG ATGGACAAAA TCTGAAGGAA 780

CTGAGAGAAA GAGTATTAAG AGGGAAATAC AGAATCCCTT TCTACATGTC CACAGACTGT 840

GAAAACCTTC TCAAACGCTT CCTGGTGCTA AACCCAATTA AACGTGGCAC TCTAGAGCAA 900

ATCATGAAGG ACAGATGGAT CAATGCAGGG CATGAGGAAG ATGAACTTAA ACCATTCATT 960

GAACCAGAAC TAAACATCTC AGACCAGAAA AGAATAGATA TTATGGTAGG AATGGGATAT 1020

TCACAGGAAG AAATCCAAGA ATCTCTTAGT AAAATGAAAT ATGATGAAAT AACAGCTACA 1080

TATTTGTTGC TGGGGAGAAA ATCTTCTGAG CTGGACGCTA GTGACTCCAG TTCTAGCAGC 1140

AACCTTTCAC TTGCTAAGGT GCGGCCAAGC AGCGACCTCA GCAGCAGCAC CGGCCAGTCT 1200

CCTCACCACA AAGTGCAGAG AAGCGTTTCT TCCAGCCAGA AGCAGCGGCG GTACAGTGAC 1260

CATGCTGGAC CAGCTATTCC TTCAGTTGTT GCATATCCAA AGAGGAGTCA GACCAGCACT 1320

GCAGACAGTG ACCTCAAAGA AGATGGAATT CCCTCCCGAA AATCTAGCAG CAGTGCTGTG 1380

GGAGGAAAAG GGATTGCGCC AGCCAGCCCC ATGCTTGGGA ATGCAAGTAA TCCCAACAAG 1440

GCAGATATTC CTGAACGCAA GAAAAGCCCT GCTGTCACCA GCAGTAATAC AGCGTCTGGT 1500

GGAATGACCC GGCGAAACAC TTACGTTTGC AGTGAGAGAA CTACTGCAGA CAGACACTCA 1560

GTGATTCAGA ATGGCAAGGA GACCAGCACT GTTCCTGATC AGAGAACTCC AGTTGCTTCA 1620

ACCCACAGTA TTAGCAGTGC GGCCACCCCA GATCGAATTC ACTTCCCACG AGGCACTGCC 1680

AGTCGTAGCA CTTTCCACGG CCAGCCCCGG GAGCGGCGAA CCGCAACGTA TAATGGCCCA 1740

CCTGCCTCAC CCAGCCTGTC CCACGAAGCC ACACCACTGT CTCAGACTCG AAGTCGAGGT 1800

TCCACTAATC TTTTTAGTAA ATTAACTTCA AAACTCACAA GGCGAAACAT GTCATTCAGG 1860

TTTATCAAAA GGCTTCCAAC TGAATATGAG AGGAACGGGA GATATGAGGG CTCAAGTCGC 1920

AATGTGTCTG CTGAGCAAAA GGACGAGAAC AGAGAAGCAA AGCCTCGCTC TCTGCGCTTC 1980

ACCTGGAGCA TGAAAACCAC TAGTTCCATG GACCCCAGTG ACATGATGCG GGAGATCCGC 2040

AAAGTGCTGG ACGCCAACAA CTGCGACTAC GAGCAAAGGG AGCGCTTCCT GCTCTTCTGT 2100

GTCCATGGCG ATGGGCATGC CACTGAGAAC CTGGTGCAGT GGGAGATGGA AGTGTGCAAG 2160

CTGCCAAGAC TGTCTCTGAA CGGTGTCCGG TTTAAGCGGA TATCAGGGAC ATCCATAGCT 2220

TTCAAAAATA TCGCTTCCAA AATTGCCAAT GAGCTAAAGC TG 2262

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013