EKS-CAP-00496

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00496

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.3	5.7E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSCPOP00000012569

UniProt Accession

H0VPX4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK9

Gene Synonyms/Alias

MAPK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000013948	ENSCPOP00000012569	ENSCPOT00000014089

Organism

Cavia porcellus

Functional Description

Protein Length

424

Protein Sequence
(FASTA)

MSDNKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP 60

FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ 240

LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK 300

MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV 360

MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS TEQTLASDTD SSLDASTGPL 420

EGCR 424

Nucleotide Sequence
(FASTA)

ATGAGTGACA ATAAATGTGA TAGTCAGTTT TATAGTGTGC AAGTGGCAGA CTCAACTTTC 60

ACTGTCCTAA AACGTTACCA GCAGTTGAAA CCAATAGGCT CTGGGGCCCA AGGAATTGTT 120

TGTGCTGCTT TTGATACAGT TCTTGGGATT AATGTTGCAG TCAAGAAGCT AAGCCGTCCT 180

TTTCAAAACC AAACTCATGC AAAAAGAGCT TATCGGGAAC TTGTCCTCTT AAAATGTGTC 240

AATCATAAAA ATATCATTAG TTTGTTAAAT GTGTTTACAC CACAAAAAAC TCTAGAAGAA 300

TTTCAAGACG TGTATTTGGT TATGGAATTA ATGGATGCTA ACTTATGTCA GGTTATTCAT 360

ATGGAATTAG ACCATGAAAG AATGTCCTAC CTTCTTTACC AGATGCTTTG TGGCATTAAA 420

CATCTGCATT CAGCTGGTAT AATTCATAGA GATTTGAAGC CTAGCAACAT TGTAGTAAAA 480

TCGGATTGTA CCCTTAAGAT CCTTGACTTT GGTCTAGCCC GGACAGCATG TACCAACTTT 540

ATGATGACCC CCTATGTGGT AACGCGGTAT TACCGGGCCC CTGAAGTCAT CCTGGGCATG 600

GGCTACAAAG AGAACGTTGA TATCTGGTCA GTGGGTTGCA TCATGGGAGA GCTGGTGAAA 660

GGTTGTGTGA TATTCCAAGG CACTGACCAT ATTGATCAGT GGAATAAAGT TATCGAGCAG 720

CTTGGAACAC CATCAGCAGA GTTCATGAAA AAACTTCAAC CAACTGTGAG GAATTACGTA 780

GAAAATCGAC CAAAGTATCC TGGAATCAAA TTCGAAGAAC TTTTTCCAGA TTGGATATTC 840

CCATCAGAAT CTGAACGAGA CAAAATAAAA ACAAGTCAAG CCAGAGATCT GTTATCAAAA 900

ATGTTAGTGA TCGATCCCGA CAAGCGGATC TCTGTGGACG AAGCCTTGCG TCACCCTTAC 960

ATCACTGTGT GGTATGACCC TGCTGAGGCA GAAGCGCCAC CACCTCAGAT TTACGATGCC 1020

CAGTTGGAAG AAAGAGAACA CGCGATTGAA GAGTGGAAAG AGCTAATTTA CAAAGAAGTA 1080

ATGGATTGGG AAGAAAGAAG CAAGAATGGT GTTGTAAAAG ATCAACCTTC AGATGCAGCA 1140

GTAAGTAGCA ACGCCACACC TTCCCAGTCG TCCTCTATCA ATGACATTTC ATCCATGTCC 1200

ACCGAGCAGA CACTGGCCTC GGACACAGAC AGCAGTCTGG ATGCCTCCAC AGGACCCCTC 1260

GAAGGTTGTC GA 1272

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  + +va+kklsrpfq++t+akr++REl llk+++h+Ni

Q: 26    YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFM--MTPYVVTRYYRAPEVILG-MG  201

         ********************************99976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++El++g ++f+g+d+idq++k++e+lgtps+ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +feelfp+            ++++a+dLl+k+Lv+dpdkRisv+eaL+hpY

Q: 261   ENRPKYPGIKFEELFPDwifpseserdkiKTSQARDLLSKMLVIDPDKRISVDEALRHPY  320

         *****************************9******************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQQLKPIGSG AQGIVCAAFD TVLGINVAVK KLSRPFQNQT HAKRAYRELV LLKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIHMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART ACTNFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GELVKGCVIF QGTDHIDQWN KVIEQLGTPS AEFMKKLQPT VRNYVENRPK 240

YPGIKFEELF PDWIFPSESE RDKIKTSQAR DLLSKMLVID PDKRISVDEA LRHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013