EKS-CAP-00251

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00251

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.5	8.6E-118	69	334	266

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013031

UniProt Accession

H0VR36;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014465	ENSCPOP00000013031	ENSCPOT00000014610

Organism

Cavia porcellus

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

ICYFSGKRKA LKLNFANPPV KSTARFTLNP NTTGVQNPHI ERLRTHSIES SGKLKISPEQ 60

HWDFTAEDLK DLGEIGRGAY GSVNKMVHKP SGQIMAVKRI RSTVDEKEQK QLLMDLDVVM 120

RSSDCPYIVQ FYGALFREGD CWICMELMST SFDKFYKYVY SVLDDVIPEE ILGKITLATV 180

KALNHLKENL KIIHRDIKPS NILLDRSGNI KLCDFGISGQ LVDSIAKTRD AGCRPYMAPE 240

RIDPSASRQG YDVRSDVWSL GITLYELATG RFPYPKWNSV FDQLTQVVKG DPPQLSNSEE 300

REFSPSFINF VNLCLTKDES KRPKYKELLK HPFILMYEER TVEVACYVCK ILDQMPATPS 360

SPMYVD 366

Nucleotide Sequence
(FASTA)

ATTTGTTATT TCTCAGGTAA ACGCAAAGCA CTGAAGTTGA ATTTTGCAAA CCCACCTGTC 60

AAATCTACAG CAAGGTTTAC TCTGAATCCC AATACTACAG GAGTCCAAAA CCCACACATA 120

GAAAGACTGA GAACACACAG CATTGAGTCA TCAGGAAAAC TGAAGATCTC CCCTGAACAA 180

CACTGGGATT TCACTGCAGA GGACTTGAAA GACCTTGGAG AAATTGGACG AGGAGCTTAT 240

GGTTCTGTCA ACAAAATGGT CCACAAACCA AGTGGGCAAA TAATGGCAGT TAAAAGAATA 300

CGGTCAACAG TGGATGAAAA AGAACAAAAA CAACTTCTTA TGGATTTGGA TGTAGTAATG 360

CGGAGTAGTG ATTGCCCGTA CATTGTTCAG TTTTATGGTG CACTCTTCAG AGAGGGTGAC 420

TGTTGGATCT GTATGGAACT CATGTCTACC TCGTTTGATA AGTTTTACAA ATATGTATAT 480

AGTGTATTAG ATGATGTTAT TCCAGAAGAA ATTTTAGGCA AAATCACTTT AGCAACTGTG 540

AAAGCACTAA ACCACTTAAA AGAAAACTTG AAAATTATTC ACAGAGATAT CAAACCTTCA 600

AATATTCTTC TGGACAGAAG TGGAAACATT AAACTCTGTG ACTTTGGTAT CAGTGGACAG 660

CTTGTGGACT CCATTGCCAA GACAAGAGAT GCTGGGTGTA GACCATATAT GGCGCCTGAA 720

AGAATAGACC CTAGTGCATC TCGACAAGGA TATGATGTCC GCTCTGATGT CTGGAGTTTG 780

GGGATCACAT TGTATGAGTT AGCCACAGGC CGATTTCCGT ATCCAAAATG GAATAGTGTA 840

TTTGATCAAC TAACACAAGT GGTGAAAGGA GATCCTCCAC AGCTGAGTAA TTCTGAGGAA 900

AGAGAATTCT CCCCAAGTTT CATCAACTTT GTCAACTTGT GCCTTACGAA GGATGAATCC 960

AAAAGGCCAA AGTATAAAGA ACTTTTGAAA CATCCCTTTA TTTTGATGTA TGAAGAACGT 1020

ACTGTTGAGG TCGCATGCTA CGTTTGTAAA ATCCTGGATC AGATGCCAGC TACTCCCAGC 1080

TCTCCCATGT ATGTTGAT 1098

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 69    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  128

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 129   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  187

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 188   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  247

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 248   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  307

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 308   INFVNLCLTKDESKRPKYKELLKHPFI  334

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013