EKS-CAP-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20317.65.9E-9516268253
StatusUnreviewed
Ensembl ProteinENSCPOP00000013045
UniProt AccessionH0VR49;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K5
Gene Synonyms/Alias MAP4K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000014479ENSCPOP00000013045ENSCPOT00000014624
OrganismCavia porcellus
Functional Description
Protein Length904
Protein Sequence
(FASTA)
LRPGADILRR NPQQDYELVQ RVGSGTYGDV YKARNIHTGE LAAVKIIKLE PGDDFSLIQQ 60
EIFMVKECKH CNIVAYFGSY LSREKLWICM EYCGGGSLQD IYHVTGPLSE LQIAYVCRET 120
LQGLAYLHTK GKMHRDIKGA NILLTDHGDV KLADFGVAAK ITATIAKRKS FIGTPYWMAP 180
EVAAVEKNGG YNQLCDIWAV GITAIELGEL QPPMFDLHPM RALFLMSKSN FQPPKLKDKT 240
KCKTHFHHFV KIALTKTQKK KPNCRKTSDL HTFVGQPGLS RALAVELLDK VNNPDNHTHY 300
TEGDDDDFEP HAVIRHTIRS ANRNARAERT ASEINFDKLQ FEPPLRKETE ARDEMKEREG 360
EKKIPAQIVL NARTHDTEIV LWECHQTQIF YYGGILLLMV QILASLTCFG HVATITREEQ 420
VKSSISIKAS TAKRAIPPPL PPKEKKIFLV ATNSFPDEEK SSTVKRCPDP DHRAPQLLRR 480
QSSPNCGLVT ETSSMGMASS VTSRGVHTAR YCDLVRQENL HCVNMSAIFK EKKKVPKRNQ 540
SSNGLPPTPK VLMGACFSKV FDGCPLKINC ATSWIHPDTK DQYIIFGTED GIYTLNLNEL 600
HEATMEQLFP RKCTWLYVIN NTLMSLSGKT FQLYSHNLIA LFEQAKKPGL AAHIQTHRFP 660
DRILPRKFAL TTKIPDTKGC HKCCIVRNPY TGHKYLCGAL QSGIVLLQWY EPMQKFMLIK 720
HFDFPLPTPL NVFEMLVIPE QEYPMVCVAI SKGTEANQVV QFETINLNSA SSWFTEIGAG 780
SQQLDSIHVT QLERDTVLVC LDKYVKIVNL QGKLKSSKKL ASELSFDFRI ESVVCLQDSV 840
LAFWKHGMQG KSFKSDEVTQ EISDETRVFR LLGSDRVVVL ESRPTENPTA HSNLYILAGH 900
ENSY 904
Nucleotide Sequence
(FASTA)
CTGCGGCCTG GCGCGGACAT CCTGAGGCGC AATCCGCAGC AAGACTACGA GCTCGTCCAG 60
AGGGTTGGCA GTGGCACCTA CGGGGACGTC TATAAGGCTA GAAATATACA CACAGGAGAG 120
TTGGCAGCAG TAAAAATTAT CAAGTTGGAG CCTGGAGATG ATTTTTCTCT GATTCAACAA 180
GAAATATTTA TGGTTAAAGA ATGTAAACAC TGCAACATCG TTGCCTATTT TGGGAGCTAT 240
CTCAGTCGAG AAAAACTATG GATTTGTATG GAATACTGTG GTGGCGGATC TCTTCAAGAT 300
ATTTACCATG TTACTGGACC ATTATCAGAA TTACAAATAG CCTATGTGTG CAGAGAAACT 360
TTACAGGGCC TTGCTTATTT GCATACCAAA GGCAAAATGC ATAGAGATAT CAAAGGTGCA 420
AATATTTTAT TGACAGACCA TGGTGATGTA AAATTAGCTG ATTTTGGTGT GGCTGCAAAA 480
ATAACAGCTA CCATTGCAAA GAGAAAATCG TTCATTGGCA CTCCTTATTG GATGGCCCCA 540
GAAGTTGCAG CAGTGGAGAA GAATGGCGGC TACAACCAGC TCTGCGATAT CTGGGCAGTG 600
GGAATAACAG CAATTGAACT TGGAGAGCTT CAGCCACCGA TGTTTGACCT TCACCCAATG 660
AGGGCTCTCT TCTTAATGTC AAAAAGTAAT TTTCAGCCTC CAAAACTAAA GGACAAAACA 720
AAATGTAAAA CTCATTTTCA TCACTTTGTC AAAATAGCAC TAACTAAAAC CCAAAAGAAA 780
AAGCCCAACT GCCGAAAGAC TTCTGACTTA CATACTTTTG TTGGACAGCC AGGTCTCTCA 840
AGGGCCCTAG CAGTTGAACT GTTGGACAAA GTAAATAACC CGGACAACCA TACACATTAC 900
ACTGAAGGAG ATGATGATGA TTTTGAGCCT CATGCCGTCA TTCGTCATAC CATCAGATCT 960
GCAAACAGGA ATGCCAGAGC TGAGCGGACA GCTTCAGAAA TAAACTTTGA CAAATTACAG 1020
TTTGAACCTC CTCTAAGAAA AGAAACAGAA GCCCGGGATG AAATGAAAGA GAGGGAGGGA 1080
GAGAAAAAAA TCCCCGCCCA AATTGTCTTG AATGCCAGGA CTCATGACAC TGAAATTGTT 1140
TTGTGGGAAT GTCATCAGAC CCAAATTTTT TATTACGGTG GAATCCTTTT GTTGATGGTG 1200
CAAATACTGG CAAGTCTGAC ATGCTTTGGT CATGTAGCCA CAATTACTAG GGAAGAACAA 1260
GTTAAATCAA GCATAAGTAT AAAGGCATCA ACTGCAAAAC GTGCAATACC ACCTCCCCTA 1320
CCTCCTAAGG AGAAAAAAAT ATTTTTAGTA GCTACTAACA GCTTCCCAGA TGAAGAAAAA 1380
TCATCAACAG TGAAACGTTG CCCTGATCCA GATCACAGAG CTCCCCAACT TCTGAGAAGA 1440
CAGAGTAGCC CAAATTGTGG TCTTGTAACT GAGACTTCCT CTATGGGTAT GGCTAGCAGT 1500
GTCACCAGCC GTGGAGTGCA TACGGCTAGA TACTGTGATC TGGTAAGGCA GGAAAATCTG 1560
CATTGTGTGA ATATGAGTGC GATATTTAAA GAGAAGAAAA AGGTACCAAA GAGAAACCAG 1620
TCATCAAATG GTCTCCCACC CACCCCAAAA GTCCTGATGG GAGCATGTTT TTCAAAAGTT 1680
TTTGATGGCT GCCCCTTGAA AATTAATTGT GCGACATCTT GGATACATCC TGATACAAAA 1740
GATCAGTACA TTATTTTTGG AACTGAAGAT GGCATTTACA CATTGAATCT CAACGAACTA 1800
CATGAGGCAA CTATGGAACA GTTATTTCCA CGGAAGTGTA CTTGGCTATA TGTTATCAAT 1860
AATACTTTAA TGTCATTATC AGGAAAAACC TTTCAACTCT ACTCTCATAA TCTTATTGCT 1920
TTGTTTGAAC AAGCCAAAAA ACCAGGATTA GCTGCCCATA TTCAAACTCA CAGGTTTCCA 1980
GACCGCATAC TGCCAAGAAA GTTTGCTTTA ACAACAAAGA TTCCTGATAC AAAAGGGTGC 2040
CACAAATGTT GCATAGTCAG AAACCCTTAC ACGGGACATA AATACCTCTG TGGAGCTTTG 2100
CAGTCTGGAA TTGTTTTACT TCAATGGTAT GAGCCAATGC AGAAATTCAT GTTGATAAAG 2160
CACTTTGATT TTCCTTTGCC GACTCCTTTG AACGTTTTTG AAATGCTGGT GATACCAGAA 2220
CAAGAATACC CCATGGTTTG TGTAGCTATT AGTAAAGGCA CTGAAGCAAA TCAAGTAGTT 2280
CAATTTGAGA CAATCAATTT GAATTCTGCA TCTTCATGGT TTACAGAAAT TGGTGCAGGC 2340
AGCCAACAGT TAGATTCCAT TCACGTAACA CAGTTGGAGC GTGATACCGT TTTAGTGTGT 2400
TTAGACAAAT ATGTAAAAAT TGTAAATCTA CAAGGAAAAC TAAAATCAAG CAAGAAACTG 2460
GCCTCTGAGC TAAGTTTTGA TTTTCGCATT GAATCTGTAG TATGCCTTCA AGACAGTGTG 2520
CTGGCTTTCT GGAAACACGG AATGCAGGGT AAAAGCTTCA AGTCAGATGA GGTTACCCAG 2580
GAGATTTCTG ATGAAACAAG AGTTTTCCGC TTATTAGGAT CAGACAGGGT TGTCGTTTTG 2640
GAAAGTAGGC CAACAGAAAA TCCTACTGCA CACAGCAATC TCTACATTTT GGCTGGACAT 2700
GAAAATAGTT ACTGA 2715
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         yel++++g+G++g+vy+ar+++tgel+a+k+i+le  ++ +++q+ei ++k++kh niv+
Q: 16    YELVQRVGSGTYGDVYKARNIHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVA  75
         99**********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH+k+++
Q: 76    YFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHTKGKM  133
         ****************************..******************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++
Q: 134   HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  193
         ****************************************************98889***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +Diw++GItaiel e +pP++dl+p++al++++k++  ppklk+k+k  ++f++fv+ +
Q: 194   LCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKCKTHFHHFVKIA  253
         ********************************9999988*********************
S: 238   lqknpekRpsasell  252
         l+k  +k+p+ ++ +
Q: 254   LTKTQKKKPNCRKTS  268
         ********9988765
Domain Sequence
(FASTA)
YELVQRVGSG TYGDVYKARN IHTGELAAVK IIKLEPGDDF SLIQQEIFMV KECKHCNIVA 60
YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETLQGLA YLHTKGKMHR 120
DIKGANILLT DHGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180
DIWAVGITAI ELGELQPPMF DLHPMRALFL MSKSNFQPPK LKDKTKCKTH FHHFVKIALT 240
KTQKKKPNCR KTS 253
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CAE-00263
EKS-CII-00179
EKS-DRM-00155
EKS-GAA-00398
EKS-MEG-00270
EKS-MOD-00326
EKS-MYL-00315
EKS-ORN-00412
EKS-ORA-00274
EKS-OTG-00338
EKS-PTV-00074
EKS-TAR-00413
EKS-TEN-00411
EKS-XIM-00409
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013