EKS-CAP-00319

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00319

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	396.4	7.0E-119	211	504	294

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013053

UniProt Accession

H0VR56;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014487	ENSCPOP00000013053	ENSCPOT00000014632

Organism

Cavia porcellus

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

AVNNDMMATE TNSAMKFSKL CKFCDVRSST CDNQKSCLSN CSITSICEKS HEVCVAVWRK 60

NDENITLETV CHDPKLPYHG FALEDAASPK CIMKLGETFF MCSCSADECN DNIIFSEAED 120

AASNTDLWLV IFQVTGISLL PPLGITIAVI IIFYCYRVHR QQKLGPSWES SKPRKHMEFS 180

EHCAIILEDD RSDISSTCAN NINHNTELLP IELDTLVGKG RFAEVYKAKL KQNTSEQFET 240

VAVKIFPYEE YASWKTEKDI FSDINLKHEN ILQFLTAEER KTELGKQYWL ITAFHAKGNL 300

QEYLTRHVIS WEDLRKLGSS LARGIAHLHS DHTPCGRPKM PIVHRDLKSS NILVKNDLTC 360

CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR YMAPEVLESR MNLENVESFK QTDVYSMALV 420

LWEMTSRCNA VGEVKDYEPP FGSKVREHPC VESMKDNVLR DRGRPEIPSF WLNHQGIQMV 480

CETLTECWDH DPEARLTAQC VAERFSELEH LDRLSRRSCS EEKIPEDGSL NTTK 534

Nucleotide Sequence
(FASTA)

GCAGTTAATA ATGACATGAT GGCCACCGAA ACCAACAGTG CAATGAAGTT TTCAAAACTG 60

TGCAAATTTT GTGACGTGCG ATCTTCCACC TGTGACAACC AGAAATCCTG CCTGAGCAAC 120

TGCAGCATCA CCTCCATCTG TGAGAAGTCA CATGAAGTCT GTGTGGCCGT ATGGCGGAAG 180

AATGATGAGA ACATAACACT AGAGACGGTT TGCCATGACC CCAAGCTCCC CTACCATGGA 240

TTTGCTCTGG AAGACGCTGC ATCTCCTAAG TGTATTATGA AGCTTGGCGA GACCTTCTTT 300

ATGTGCTCCT GTAGTGCTGA TGAGTGCAAC GACAACATCA TCTTCTCCGA AGCAGAAGAT 360

GCTGCCAGCA ATACTGACCT GTGGTTAGTC ATATTCCAAG TAACAGGCAT CAGTCTGCTG 420

CCACCTCTAG GCATCACCAT AGCCGTCATC ATCATCTTCT ACTGCTACCG TGTGCACCGG 480

CAGCAGAAGC TGGGTCCATC CTGGGAGAGC AGCAAGCCAC GGAAGCACAT GGAGTTCAGC 540

GAGCACTGCG CCATCATTCT GGAAGATGAC CGCTCTGACA TCAGCTCCAC GTGTGCCAAC 600

AACATCAACC ACAACACGGA GCTGCTGCCC ATCGAGCTGG ACACACTGGT GGGCAAAGGC 660

CGCTTTGCTG AGGTCTATAA GGCCAAGTTG AAGCAGAATA CTTCAGAGCA GTTTGAGACT 720

GTGGCAGTCA AGATCTTCCC CTACGAGGAG TACGCCTCTT GGAAAACAGA GAAAGACATC 780

TTCTCTGACA TCAACCTGAA GCATGAGAAT ATCCTCCAGT TCCTCACAGC TGAGGAGCGG 840

AAGACAGAGC TGGGCAAACA GTACTGGCTG ATCACTGCCT TCCATGCCAA GGGCAACCTG 900

CAGGAGTACC TCACCCGGCA TGTCATCAGC TGGGAGGACC TACGCAAGTT GGGTAGCTCC 960

CTTGCCCGGG GCATCGCCCA CCTCCATAGT GACCACACAC CATGTGGGAG ACCTAAGATG 1020

CCCATTGTGC ACAGAGATCT CAAGAGCTCC AATATCCTGG TGAAGAATGA CCTGACCTGC 1080

TGCCTGTGTG ACTTCGGCCT CTCCCTGCGT CTGGACCCTA CTCTGTCGGT AGACGACCTG 1140

GCTAACAGTG GGCAAGTGGG AACTGCAAGA TACATGGCCC CAGAAGTCCT GGAATCCAGG 1200

ATGAACTTGG AGAATGTTGA GTCCTTCAAG CAGACCGATG TCTACTCCAT GGCATTGGTG 1260

CTCTGGGAAA TGACATCTCG CTGTAACGCG GTGGGAGAAG TAAAAGATTA TGAGCCACCA 1320

TTTGGTTCCA AGGTGCGGGA GCATCCTTGT GTCGAGAGTA TGAAGGACAA TGTATTAAGA 1380

GACAGAGGAC GACCAGAAAT TCCTAGCTTC TGGCTCAATC ACCAGGGCAT CCAGATGGTG 1440

TGTGAGACAC TGACTGAGTG CTGGGACCAT GACCCAGAAG CTCGTCTTAC AGCCCAGTGC 1500

GTGGCAGAAC GCTTTAGCGA GCTGGAGCAC CTGGACAGAC TCTCCAGGAG GAGCTGCTCC 1560

GAGGAGAAGA TTCCCGAAGA TGGCTCGCTG AACACTACCA AATAG 1605

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 211   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  270

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 271   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  330

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 331   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  389

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 390   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  448

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 449   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  504

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013